{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:44:49Z","timestamp":1787312689419,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007797","name":"University of Helsinki","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007797","name":"Helsingin Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Severe cartilage damage and advanced knee osteoarthritis (OA) might be associated with poor outcomes of meniscal allograft transplantation (MAT). The purpose of this prospective follow\u2010up study was to explore MAT survivorship and patient satisfaction among young patients with symptomatic meniscal deficiency and radiological OA of different Kellgren\u2013Lawrence (K\u2013L) grades.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010five consecutive MAT patients were prospectively followed up for 2\u00a0years. The lateral meniscus was replaced in 29 patients and the medial meniscus in 6 patients. Outcomes were assessed using the KOOS\n                      <jats:sub>4<\/jats:sub>\n                      composite score, KOOS subscales, Lysholm knee score, and OA K\u2013L grade progression from weight\u2010bearing knee radiographs. For the outcome analysis, patients were categorized into two groups: 19\u00a0in Group A (K\u2013L classification 0\u20131) and 16\u00a0in Group B (K\u2013L classification 2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In terms of KOOS\n                      <jats:sub>4<\/jats:sub>\n                      and Lysholm scores, the patients showed a clinically significant improvement from baseline to the 1\u2010year follow\u2010up (22.2 points, 95% CI 16.6\u201327.8 for KOOS\n                      <jats:sub>4<\/jats:sub>\n                      and 16.8 points, 95% CI 8.9\u201324.6 for Lysholm), and the improvement remained at 2\u00a0years (20.6 points, 95% CI 13.2\u201328.1 for KOOS\n                      <jats:sub>4<\/jats:sub>\n                      and 21.5, 95% CI 12.5\u201330.7 for Lysholm). At the 6\u2010month follow\u2010up, this improvement was not yet observed. Minor between\u2010group differences were observed in the KOOS\n                      <jats:sub>4<\/jats:sub>\n                      and Lysholm scores for the K\u2013L 0\u20131 and K\u2013L 2 OA groups, but the estimates were imprecise with wide confidence intervals. A clinically relevant difference between these two study groups could not be found at any timepoint. The reoperation rate was higher in the K\u2013L 2\u00a0group than in the K\u2013L 0\u20131\u00a0group (31% vs. 11%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MAT yielded improved patient\u2010reported outcomes and subjective satisfaction at 1 and 2\u00a0years postoperatively. The differences from baseline exceeded the minimal clinically important difference (MCID) at all timepoints. The severity of cartilage damage and knee OA in terms of the K\u2013L grade at the time of surgery did not affect the KOOS and Lysholm scores after the MAT procedure.\u00a0Knee OA progression in terms of K\u2013L grade worsening was not observed in any patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of evidence<\/jats:title>\n                    <jats:p>III.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00167-023-07625-3","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T12:01:45Z","timestamp":1699358505000},"page":"5765-5772","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Meniscal allograft transplantation improves patient\u2010reported outcomes in both minimal and moderate knee osteoarthritis at 1 and 2\u00a0years postoperatively"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8501-6735","authenticated-orcid":false,"given":"Anni","family":"Aavikko","sequence":"first","affiliation":[{"name":"Department of Surgery P\u00e4ij\u00e4t\u2010H\u00e4me Central Hospital Lahti Finland"},{"name":"University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Bister","sequence":"additional","affiliation":[{"name":"Department of Surgery, Clinicum Faculty of Medicine University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksi","family":"Reito","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lindahl","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2017.08.003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2010016\u20104770\u2010y"},{"key":"e_1_2_11_4_1","volume-title":"Discoid meniscus","author":"Birchard 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March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This research was funded by Helsinki University Hospital, Helsinki, Finland, through grants by the Ministry of Social Affairs and Health in Finland.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Permission for the study (HUS\/234\/2020) was obtained from the research board of the Department of Musculoskeletal and Plastic Surgery, Helsinki University Hospital.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from every patient for meniscal transplant surgery, and the decision to operate was based on the clinical decision only. Patients were also informed that postoperative follow-up via questionnaires and outpatient clinic visits would be scheduled.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}