{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:29:30Z","timestamp":1784053770590,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T00:00:00Z","timestamp":1521504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urogynecol J"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1007\/s00192-018-3569-7","type":"journal-article","created":{"date-parts":[[2018,3,10]],"date-time":"2018-03-10T02:46:10Z","timestamp":1520649970000},"page":"1035-1043","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Recalcitrant chronic bladder pain and recurrent cystitis but negative urinalysis: What should we do?"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9039-1073","authenticated-orcid":false,"given":"Sheela","family":"Swamy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Barcella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"De Iorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiren","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajvinder","family":"Khasriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony S.","family":"Kupelian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Rohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Malone-Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,20]]},"reference":[{"issue":"7","key":"3569_CR1","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1128\/JCM.03314-12","volume":"51","author":"R Khasriya","year":"2013","unstructured":"Khasriya R, Sathiananthamoorthy S, Ismail S, Kelsey M, Wilson M, Rohn JL, et al. Spectrum of bacterial colonization associated with urothelial cells from patients with chronic lower urinary tract symptoms. J Clin Microbiol. 2013;51(7):2054\u201362.","journal-title":"J Clin Microbiol"},{"issue":"4","key":"3569_CR2","doi-asserted-by":"publisher","first-page":"e01283","DOI":"10.1128\/mBio.01283-14","volume":"5","author":"MM Pearce","year":"2014","unstructured":"Pearce MM, Hilt EE, Rosenfeld AB, Zilliox MJ, Thomas-White K, Fok C, et al. The female urinary microbiome: a comparison of women with and without urgency urinary incontinence. MBio. 2014;5(4):e01283\u201314.","journal-title":"MBio"},{"key":"3569_CR3","volume-title":"Urinary incontinence: the management of urinary incontinence in women","author":"NICE","year":"2006","unstructured":"NICE. Urinary incontinence: the management of urinary incontinence in women. London: National Institute for Health and Care Excellence; 2006."},{"key":"3569_CR4","doi-asserted-by":"crossref","unstructured":"Brubaker L, Wolfe AJ. The Female Urinary Microbiota\/Microbiome: Clinical and Research Implications. Rambam Maimonides medical journal. 2017;8(2).","DOI":"10.5041\/RMMJ.10292"},{"issue":"5","key":"3569_CR5","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1128\/JCM.00044-16","volume":"54","author":"TK Price","year":"2016","unstructured":"Price TK, Dune T, Hilt EE, Thomas-White KJ, Kliethermes S, Brincat C, et al. The clinical urine culture: enhanced techniques improve detection of clinically relevant microorganisms. J Clin Microbiol. 2016;54(5):1216\u201322.","journal-title":"J Clin Microbiol"},{"issue":"2","key":"3569_CR6","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/j.1464-410X.2012.11694.x","volume":"112","author":"AS Kupelian","year":"2013","unstructured":"Kupelian AS, Horsley H, Khasriya R, Amussah RT, Badiani R, Courtney AM, et al. Discrediting microscopic pyuria and leucocyte esterase as diagnostic surrogates for infection in patients with lower urinary tract symptoms: results from a clinical and laboratory evaluation. BJU Int. 2013;112(2):231\u20138.","journal-title":"BJU Int"},{"issue":"17","key":"3569_CR7","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1056\/NEJM197810262991705","volume":"299","author":"DF Ransohoff","year":"1978","unstructured":"Ransohoff DF, Feinstein AR. Problems of spectrum and bias in evaluating the efficacy of diagnostic tests. N Engl J Med. 1978;299(17):926\u201330.","journal-title":"N Engl J Med"},{"issue":"5","key":"3569_CR8","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.1093\/cid\/ciq257","volume":"52","author":"K Gupta","year":"2011","unstructured":"Gupta K, Hooton TM, Naber KG, Wullt B, Colgan R, Miller LG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis. 2011;52(5):e103\u201320.","journal-title":"Clin Infect Dis"},{"issue":"8","key":"3569_CR9","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1056\/NEJM198208193070802","volume":"307","author":"WE Stamm","year":"1982","unstructured":"Stamm WE, Counts GW, Running KR, Fihn S, Turck M, Holmes KK. Diagnosis of coliform infection in acutely dysuric women. N Engl J Med. 1982;307(8):463\u20138.","journal-title":"N Engl J Med"},{"key":"3569_CR10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12894-015-0001-1","volume":"15","author":"K Gill","year":"2015","unstructured":"Gill K, Horsley H, Kupelian AS, Baio G, De Iorio M, Sathiananamoorthy S, et al. Urinary ATP as an indicator of infection and inflammation of the urinary tract in patients with lower urinary tract symptoms. BMC Urol. 2015;15:7.","journal-title":"BMC Urol"},{"issue":"4","key":"3569_CR11","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1128\/JCM.05852-11","volume":"50","author":"AJ Wolfe","year":"2012","unstructured":"Wolfe AJ, Toh E, Shibata N, Rong R, Kenton K, Fitzgerald M, et al. Evidence of uncultivated bacteria in the adult female bladder. J Clin Microbiol. 2012;50(4):1376\u201383.","journal-title":"J Clin Microbiol"},{"key":"3569_CR12","first-page":"CD004682","volume":"2","author":"G Milo","year":"2005","unstructured":"Milo G, Katchman EA, Paul M, Christiaens T, Baerheim A, Leibovici L. Duration of antibacterial treatment for uncomplicated urinary tract infection in women. Cochrane Database Syst Rev. 2005;2:CD004682.","journal-title":"Cochrane Database Syst Rev"},{"key":"3569_CR13","doi-asserted-by":"crossref","unstructured":"Foxman B. The epidemiology of urinary tract infection. Nat Rev Urol. 2010;7","DOI":"10.1038\/nrurol.2010.190"},{"issue":"3","key":"3569_CR14","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1007\/s15010-007-6180-2","volume":"35","author":"KB Laupland","year":"2007","unstructured":"Laupland KB, Ross T, Pitout JD, Church DL, Gregson DB. Community-onset urinary tract infections: a population-based assessment. Infection. 2007;35(3):150\u20133.","journal-title":"Infection"},{"issue":"16","key":"3569_CR15","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1056\/NEJM198104163041608","volume":"304","author":"WE Stamm","year":"1981","unstructured":"Stamm WE, Running K, McKevitt M, Counts GW, Turck M, Holmes KK. Treatment of the acute urethral syndrome. N Engl J Med. 1981;304(16):956\u20138.","journal-title":"N Engl J Med"},{"key":"3569_CR16","doi-asserted-by":"crossref","unstructured":"Khasriya R, De Iorio M, Barcella W, Malone-Lee J. Lower urinary tract symptoms that predict microscopic pyuria. International urogynecology journal. 2017;In press.","DOI":"10.1007\/s00192-017-3472-7"},{"issue":"3","key":"3569_CR17","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.juro.2007.10.075","volume":"179","author":"S Buheissi Al","year":"2008","unstructured":"Al Buheissi S, Khasriya R, Maraj BH, Malone-Lee J. A simple validated scale to measure urgency. J Urol. 2008;179(3):1000\u20135.","journal-title":"J Urol"},{"issue":"Suppl 1","key":"3569_CR18","first-page":"189","volume":"22","author":"A Kupelian","year":"2009","unstructured":"Kupelian A, Chaliha C, Gill K, Brackenridge L, Horsley H, Malone-Lee J. Pain symptoms as part of the OAB complex. Int Urogynecol J. 2009;22(Suppl 1):189\u201390.","journal-title":"Int Urogynecol J"},{"issue":"2","key":"3569_CR19","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/1471-0528.12069","volume":"120","author":"DG Tincello","year":"2013","unstructured":"Tincello DG, Owen RK, Slack MC, Abrams KR. Validation of the patient global impression scales for use in detrusor overactivity: secondary analysis of the RELAX study. BJOG: Int J Obstet Gynaecol. 2013;120(2):212\u20136.","journal-title":"BJOG: Int J Obstet Gynaecol"},{"key":"3569_CR20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1471-2490-12-30","volume":"12","author":"L Viktrup","year":"2012","unstructured":"Viktrup L, Hayes RP, Wang P, Shen W. Construct validation of patient global impression of severity (PGI-S) and improvement (PGI-I) questionnaires in the treatment of men with lower urinary tract symptoms secondary to benign prostatic hyperplasia. BMC Urol. 2012;12:30.","journal-title":"BMC Urol"},{"key":"3569_CR21","unstructured":"Popper K. Two faces of common sense: An argument for commonsense realism and against the commonsense theory of knowledge. Objective knowledege, an evolutionary approach. 1. Revised edition ed. Oxford: Oxford University Press; 1973. p. 32\u2013105."},{"issue":"8","key":"3569_CR22","doi-asserted-by":"publisher","first-page":"e1001042","DOI":"10.1371\/journal.ppat.1001042","volume":"6","author":"TJ Hannan","year":"2010","unstructured":"Hannan TJ, Mysorekar IU, Hung CS, Isaacson-Schmid ML, Hultgren SJ. Early severe inflammatory responses to uropathogenic E. Coli predispose to chronic and recurrent urinary tract infection. PLoS Pathog. 2010;6(8):e1001042.","journal-title":"PLoS Pathog"},{"key":"3569_CR23","first-page":"1","volume":"187","author":"KE Hartmann","year":"2009","unstructured":"Hartmann KE, McPheeters ML, Biller DH, Ward RM, McKoy JN, Jerome RN, et al. Treatment of overactive bladder in women. Evid Rep\/Technol Assess. 2009;187:1\u2013120. v","journal-title":"Evid Rep\/Technol Assess"},{"issue":"3","key":"3569_CR24","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1097\/01.ju.0000170235.22776.1a","volume":"174","author":"M Ghei","year":"2005","unstructured":"Ghei M, Malone-Lee J. Using the circumstances of symptom experience to assess the severity of urgency in the overactive bladder. J Urol. 2005;174(3):972\u20136.","journal-title":"J Urol"},{"key":"3569_CR25","volume-title":"The role of chronic and recurrent infection in the generation of lower urinary tract symptoms in multiple sclerosis","author":"A Kupelian","year":"2016","unstructured":"Kupelian A. The role of chronic and recurrent infection in the generation of lower urinary tract symptoms in multiple sclerosis. London: University College London; 2016."},{"key":"3569_CR26","volume-title":"The role of bacterial infection and inflammation in the generation of overactive bladder symptoms","author":"K Gill","year":"2016","unstructured":"Gill K. The role of bacterial infection and inflammation in the generation of overactive bladder symptoms. London: University College London; 2016."},{"key":"3569_CR27","doi-asserted-by":"crossref","unstructured":"Horsley H, Malone-Lee J, Holland D, Tuz M, Hibbert A, Kelsey M, et al. Enterococcus faecalis subverts and invades the host urothelium in patients with chronic urinary tract infection. Plos One. 2013;8(12).","DOI":"10.1371\/journal.pone.0083637"},{"key":"3569_CR28","unstructured":"Horsley H, Holland DC, Sathiananthamoorthy S, Tuz M, Kupelian A, Malone-Lee J, et al. The Invasive Strategies of Uropathogens in LUTS. PLOS Pathogens, Manuscript submitted for referees. 2013."},{"issue":"9","key":"3569_CR29","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.tim.2004.07.005","volume":"12","author":"GG Anderson","year":"2004","unstructured":"Anderson GG, Dodson KW, Hooton TM, Hultgren SJ. Intracellular bacterial communities of uropathogenic Escherichia Coli in urinary tract pathogenesis. Trends Microbiol. 2004;12(9):424\u201330.","journal-title":"Trends Microbiol"},{"key":"3569_CR30","doi-asserted-by":"crossref","unstructured":"Kibble TWB, Berkshire FH. Linear Motion - The Damped Oscillator Classical mechanics. 5th ed. \/ Tom W.B. Kibble, Frank H. Berkshire. ed. London: Imperial College Press; 2004. p. 27\u201330.","DOI":"10.1142\/p310"}],"container-title":["International Urogynecology Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00192-018-3569-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00192-018-3569-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00192-018-3569-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T12:55:05Z","timestamp":1570884905000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00192-018-3569-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,20]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["3569"],"URL":"https:\/\/doi.org\/10.1007\/s00192-018-3569-7","relation":{},"ISSN":["0937-3462","1433-3023"],"issn-type":[{"value":"0937-3462","type":"print"},{"value":"1433-3023","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,20]]},"assertion":[{"value":"28 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"No author has a conflict of interest, except Dr. Jennifer Rohn, who is paid 1.5\u00a0days a week by AtoCap Ltd. (a startup Biotech company developing novel therapies for chronic UTI)","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}