{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:53:50Z","timestamp":1783702430496,"version":"3.55.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NICHD U10-HD047890"],"award-info":[{"award-number":["NICHD U10-HD047890"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urogynecol J"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s00192-019-04008-6","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T16:02:41Z","timestamp":1561564961000},"page":"1435-1441","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Age-associated impairments in tissue strength and immune response in a rat vaginal injury model"],"prefix":"10.1007","volume":"31","author":[{"given":"David","family":"Shveiky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl B.","family":"Iglesia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srilekha","family":"Sarkar Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofra","family":"Ben Menachem-Zidon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry H.","family":"Chill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Sandberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"issue":"11","key":"4008_CR1","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1001\/jama.300.11.1311","volume":"300","author":"I Nygaard","year":"2008","unstructured":"Nygaard I, Barber MD, Burgio KL, et al. Pelvic floor disorders network. Prevalence of symptomatic pelvic floor disorders in US women. JAMA. 2008;300(11):1311\u20136.","journal-title":"JAMA"},{"issue":"6","key":"4008_CR2","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1097\/AOG.0b013e3181c2ce96","volume":"114","author":"JM Wu","year":"2009","unstructured":"Wu JM, Hundley AF, Fulton RG, Myers ER. Forecasting the prevalence of pelvic floor disorders in U.S. women: 2010 to 2050. Obstet Gynecol. 2009;114(6):1278\u201383.","journal-title":"Obstet Gynecol"},{"key":"4008_CR3","first-page":"CD004014","volume":"11","author":"C Maher","year":"2016","unstructured":"Maher C, Feiner B, Baessler K, Christmann-Schmid C, Haya N, Brown J. Surgery for women with anterior compartment prolapse. Cochrane Database Syst Rev. 2016;11:CD004014.","journal-title":"Cochrane Database Syst Rev"},{"key":"4008_CR4","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/s00268-002-6737-2","volume":"27","author":"KM Bullard","year":"2003","unstructured":"Bullard KM, Longaker MT, Lorenz HP. Fetal wound healing: current biology. World J Surg. 2003;27:54\u201361.","journal-title":"World J Surg"},{"issue":"6","key":"4008_CR5","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1023\/A:1021399228395","volume":"3","author":"GS Ashcroft","year":"2002","unstructured":"Ashcroft GS, Mills SJ, Ashworth JJ. Ageing and wound healing. Biogerontology. 2002;3(6):337\u201345.","journal-title":"Biogerontology"},{"issue":"6","key":"4008_CR6","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1016\/S0002-9440(10)61241-2","volume":"167","author":"MJ Hardman","year":"2005","unstructured":"Hardman MJ, Waite A, Zeef L, Burow M, Toshinori N, Ashcroft GS. Macrophage migration inhibitory factor\u2014a central regulator of wound healing. Am J Pathol. 2005;167(6):1561\u201374.","journal-title":"Am J Pathol"},{"key":"4008_CR7","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1046\/j.1469-7580.1997.19030351.x","volume":"190","author":"GS Ashcroft","year":"1997","unstructured":"Ashcroft GS, Horan MA, Ferguson MWJ. The effects of ageing on wound healing: immunolocalisation of growth factors and their receptors in a murine incisional model. J Anat. 1997;190 (Pt. 3):351\u201365.","journal-title":"J Anat"},{"key":"4008_CR8","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1126\/science.153.3731.80","volume":"153","author":"BR Bloom","year":"1966","unstructured":"Bloom BR, Bennett B. Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science. 1966;153:80\u20132.","journal-title":"Science"},{"key":"4008_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0925-4439(99)00080-0","volume":"1500","author":"R Abe","year":"2000","unstructured":"Abe R, Shimizu T, Ohkawara A, Nishihira J. Enhancement of macrophage migration inhibitory factor (MIF) expression in injured epidermis and cultured fibroblasts. Biochim Biophys Acta. 2000;1500:1\u20139.","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"4008_CR10","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1016\/S0002-9440(10)61238-2","volume":"167","author":"Y Zhao","year":"2005","unstructured":"Zhao Y, Shimizu T, Nishihira J, et al. Tissue regeneration using macrophage migration inhibitory factor-impregnated gelatin microbeads in cutaneous wounds. Am J Pathol. 2005;167(6):1519\u201329.","journal-title":"Am J Pathol"},{"issue":"6","key":"4008_CR11","doi-asserted-by":"publisher","first-page":"589.e1","DOI":"10.1016\/j.ajog.2010.04.003","volume":"202","author":"M Alperin","year":"2010","unstructured":"Alperin M, Feola A, Meyn L, Duerr R, Abramowitch S, Moalli P. Collagen scaffold: a treatment for simulated maternal birth injury in the rat model. Am J Obstet Gynecol. 2010;202(6):589.e1\u20138.","journal-title":"Am J Obstet Gynecol"},{"issue":"12","key":"4008_CR12","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/S0015-0282(16)42986-9","volume":"28","author":"JC McPherson 3rd","year":"1977","unstructured":"McPherson JC 3rd, Costoff A, Mahesh VB. Effects of aging on the hypothalamic-hypophyseal-gonadal axis in female rats. Fertil Steril. 1977;28(12):1365\u201370.","journal-title":"Fertil Steril"},{"issue":"5","key":"4008_CR13","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1210\/endo-103-5-1855","volume":"103","author":"HH Huang","year":"1978","unstructured":"Huang HH, Steger RW, Bruni JF, Meites J. Patterns of sex steroid and gonadotropin secretion in aging female rats. Endocrinology. 1978 Nov;103(5):1855\u20139.","journal-title":"Endocrinology"},{"key":"4008_CR14","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1111\/1523-1747.ep12289705","volume":"108","author":"GS Ashcroft","year":"1997","unstructured":"Ashcroft GS, Horan MA, Ferguson MWJ. Aging is associated with reduced deposition of specific extracellular matrix components, an upregulation of angiogenesis, and an altered inflammatory response in a murine incisional wound healing model. J Invest Dermatol. 1997;108:430\u20137.","journal-title":"J Invest Dermatol"},{"key":"4008_CR15","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1172\/JCI16288","volume":"111","author":"GS Ashcroft","year":"2003","unstructured":"Ashcroft GS, Mills SJ, Lei K, et al. Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor. J Clin Invest. 2003;111:1309\u201318.","journal-title":"J Clin Invest"},{"issue":"4","key":"4008_CR16","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1097\/SPV.0b013e31825e6401","volume":"18","author":"DR Karp","year":"2012","unstructured":"Karp DR, Jean-Michel M, Johnston Y, Suciu G, Aguilar VC, Davila GW. A randomized clinical trial of the impact of local estrogen on postoperative tissue quality after vaginal reconstructive surgery. Female Pelvic Med Reconstr Surg. 2012;18(4):211\u20135.","journal-title":"Female Pelvic Med Reconstr Surg"},{"issue":"7","key":"4008_CR17","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1097\/GME.0000000000000840","volume":"24","author":"CM Ripperda","year":"2017","unstructured":"Ripperda CM, Maldonado PA, Acevedo JF, et al. Vaginal estrogen: a dual-edged sword in postoperative healing of the vaginal wall. Menopause. 2017;24(7):838\u201349.","journal-title":"Menopause"},{"issue":"5","key":"4008_CR18","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1016\/j.ajog.2006.01.063","volume":"194","author":"Y Abramov","year":"2006","unstructured":"Abramov Y, Webb AR, Miller JJ, et al. Biomechanical characterization of vaginal versus abdominal surgical wound healing in the rabbit. Am J Obstet Gynecol. 2006;194(5):1472\u20137.","journal-title":"Am J Obstet Gynecol"}],"container-title":["International Urogynecology Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00192-019-04008-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00192-019-04008-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00192-019-04008-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T23:11:13Z","timestamp":1593040273000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00192-019-04008-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,26]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["4008"],"URL":"https:\/\/doi.org\/10.1007\/s00192-019-04008-6","relation":{},"ISSN":["0937-3462","1433-3023"],"issn-type":[{"value":"0937-3462","type":"print"},{"value":"1433-3023","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,26]]},"assertion":[{"value":"12 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The findings and conclusions in this paper have not been formally disseminated by the Food and Drug Administration and should not be construed to represent any agency determination or policy. The mention of commercial products, their sources, or their use in connection with material reported herein, is not to be construed as either an actual or implied endorsement of such products by the Department of Health and Human Services.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}