{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:53:45Z","timestamp":1785884025721,"version":"3.56.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urogynecol J"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s00192-022-05113-9","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T16:30:21Z","timestamp":1648225821000},"page":"2241-2249","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["WGCNA and molecular docking reveal key hub genes and potential natural inhibitor in interstitial cystitis\/bladder pain syndrome"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-3045","authenticated-orcid":false,"given":"Kuiqing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuohang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"issue":"7","key":"5113_CR1","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1111\/iju.14234","volume":"27","author":"Y Homma","year":"2020","unstructured":"Homma Y, Akiyama Y, Tomoe H, Furuta A, Ueda T, Maeda D, Lin AT, Kuo HC, Lee MH, Oh SJ. Clinical guidelines for interstitial cystitis\/bladder pain syndrome. Int J Urol. 2020;27(7):578\u201389.","journal-title":"Int J Urol"},{"issue":"6","key":"5113_CR2","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1007\/s00404-017-4364-2","volume":"295","author":"SS Patnaik","year":"2017","unstructured":"Patnaik SS, Lagan\u00e0 AS, Vitale SG, Buttic\u00e8 S, Noventa M, Gizzo S, Valenti G, Rapisarda AMC, La Rosa VL, Magno C. Etiology, pathophysiology and biomarkers of interstitial cystitis\/painful bladder syndrome. Arch Gynecol Obstet. 2017;295(6):1341\u201359.","journal-title":"Arch Gynecol Obstet"},{"issue":"6","key":"5113_CR3","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1111\/iju.14229","volume":"27","author":"Y Akiyama","year":"2020","unstructured":"Akiyama Y, Luo Y, Hanno PM, Maeda D, Homma Y. Interstitial cystitis\/bladder pain syndrome: the evolving landscape, animal models and future perspectives. Int J Urol. 2020;27(6):491\u2013503.","journal-title":"Int J Urol"},{"issue":"2","key":"5113_CR4","doi-asserted-by":"publisher","first-page":"99","DOI":"10.5213\/inj.2142084.042","volume":"25","author":"T Ueda","year":"2021","unstructured":"Ueda T, Hanno PM, Saito R, Meijlink JM, Yoshimura N. Current understanding and future perspectives of interstitial cystitis\/bladder pain syndrome. Int Neurourol J. 2021;25(2):99\u2013110.","journal-title":"Int Neurourol J"},{"issue":"4","key":"5113_CR5","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.euf.2020.02.014","volume":"7","author":"NI Osman","year":"2020","unstructured":"Osman NI, Bratt DG, Downey AP, Esperto F, Inman RD, Chapple CR. A systematic review of surgical interventions for the treatment of bladder pain syndrome\/interstitial cystitis. European Urol Focus. 2020;7(4):877\u201385.","journal-title":"European Urol Focus"},{"key":"5113_CR6","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/bs.mie.2016.09.016","volume":"585","author":"G Pei","year":"2017","unstructured":"Pei G, Chen L, Zhang W. WGCNA application to proteomic and metabolomic data analysis. Method Enzymol. 2017;585:135\u201358.","journal-title":"Method Enzymol"},{"issue":"1","key":"5113_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9(1):1\u201313.","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"5113_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2164-10-199","volume":"10","author":"M Gamper","year":"2009","unstructured":"Gamper M, Viereck V, Geissb\u00fchler V, Eberhard J, Binder J, Moll C, Rehrauer H, Moser R. Gene expression profile of bladder tissue of patients with ulcerative interstitial cystitis. BMC Genomics. 2009;10(1):1\u201317.","journal-title":"BMC Genomics"},{"issue":"9","key":"5113_CR9","first-page":"1487","volume":"30","author":"L Shengzhuo","year":"2018","unstructured":"Shengzhuo L, Shijian F, Deyi L. Analysis of key genes and micro-RNA-mRNA regulatory networks in women with ulcerative interstitial cystitis\/pain bladder syndrome. Int Urogynecol J. 2018;30(9):1487\u201395.","journal-title":"Int Urogynecol J"},{"issue":"6","key":"5113_CR10","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.3390\/jcm9061935","volume":"9","author":"SK Saha","year":"2020","unstructured":"Saha SK, Jeon TI, Jang SB, Kim J, Cho SG. Bioinformatics approach for identifying novel biomarkers and their signaling pathways involved in interstitial cystitis\/bladder pain syndrome with Hunner lesion. J Clin Med. 2020;9(6):1935.","journal-title":"J Clin Med"},{"issue":"4","key":"5113_CR11","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1590\/s1677-5538.ibju.2020.1104","volume":"47","author":"H Wu","year":"2021","unstructured":"Wu H, Su QX, Zhang ZY, Zhang Z, Gao SL, Lu C, Zuo L, Zhang LF. Exploration of the core genes in ulcerative interstitial cystitis\/bladder pain syndrome. Int Braz J Urol. 2021;47(4):843\u201355.","journal-title":"Int Braz J Urol"},{"issue":"10","key":"5113_CR12","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/s41423-018-0056-5","volume":"16","author":"GL Moschovakis","year":"2019","unstructured":"Moschovakis GL, Bubke A, Friedrichsen M, Ristenpart J, Back JW, Falk CS, Kremmer E, F\u00f6rster R. The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy. Cell Mol Immunol. 2019;16(10):791\u20139.","journal-title":"Cell Mol Immunol"},{"key":"5113_CR13","first-page":"1","volume":"2014","author":"EJ Gonzalez","year":"2014","unstructured":"Gonzalez EJ, Arms L, Vizzard MA. The role (s) of cytokines\/chemokines in urinary bladder inflammation and dysfunction. Biomed Res Int. 2014;2014:1\u201317.","journal-title":"Biomed Res Int"},{"issue":"6","key":"5113_CR14","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1016\/j.juro.2012.01.034","volume":"187","author":"P Tyagi","year":"2012","unstructured":"Tyagi P, Killinger K, Tyagi V, Nirmal J, Chancellor M, Peters KM. Urinary chemokines as noninvasive predictors of ulcerative interstitial cystitis. J Urol. 2012;187(6):2243\u20138.","journal-title":"J Urol"},{"issue":"4","key":"5113_CR15","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0022-5347(09)60071-9","volume":"181","author":"P Tyagi","year":"2009","unstructured":"Tyagi P, Nikolavsky D, Vodovotz Y, Barclay D, Tyagi V, Peters KM, Chancellor MB. Urine levels of selected chemokines positively correlate with lower bladder capacity and psychometric scores in IC\/PBS patients. J Urol. 2009;181(4):21.","journal-title":"J Urol"},{"issue":"3","key":"5113_CR16","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1002\/nau.23431","volume":"37","author":"A Niimi","year":"2018","unstructured":"Niimi A, Igawa Y, Aizawa N, Honma T, Nomiya A, Akiyama Y, Kamei J, Fujimura T, Fukuhara H, Homma Y. Diagnostic value of urinary CXCL10 as a biomarker for predicting Hunner type interstitial cystitis. Neurourol Urodynam. 2018;37(3):1113\u20139.","journal-title":"Neurourol Urodynam"},{"key":"5113_CR17","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3389\/fcell.2019.00212","volume":"7","author":"Y Yan","year":"2019","unstructured":"Yan Y, Chen R, Wang X, Hu K, Huang L, Lu M, Hu Q. CCL19 and CCR7 expression, signaling pathways, and adjuvant functions in viral infection and prevention. Front Cell Dev Biol. 2019;7:212\u20134.","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"5113_CR18","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.cytogfr.2013.03.001","volume":"24","author":"I Comerford","year":"2013","unstructured":"Comerford I, Harata-Lee Y, Bunting MD, Gregor C, Kara EE, McColl SR. A myriad of functions and complex regulation of the CCR7\/CCL19\/CCL21 chemokine axis in the adaptive immune system. Cytokine Growth F R. 2013;24(3):269\u201383.","journal-title":"Cytokine Growth F R"},{"issue":"6","key":"5113_CR19","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1189\/jlb.2MR0815-380R","volume":"99","author":"MA Hauser","year":"2016","unstructured":"Hauser MA, Legler DF. Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes. J Leukoc Biol. 2016;99(6):869\u201382.","journal-title":"J Leukoc Biol"},{"issue":"6","key":"5113_CR20","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.immuni.2011.10.017","volume":"35","author":"M Wendland","year":"2011","unstructured":"Wendland M, Willenzon S, Kocks J, Davalos-Misslitz AC, Hammerschmidt SI, Schumann K, Kremmer E, Sixt M, Hoffmeyer A, Pabst O. Lymph node T cell homeostasis relies on steady state homing of dendritic cells. Immunity. 2011;35(6):945\u201357.","journal-title":"Immunity"},{"key":"5113_CR21","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.ejmech.2019.05.032","volume":"176","author":"W Hou","year":"2019","unstructured":"Hou W, Liu B, Xu H. Triptolide: medicinal chemistry, chemical biology and clinical progress. Eur J Med Chem. 2019;176:378\u201392.","journal-title":"Eur J Med Chem"},{"key":"5113_CR22","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.3389\/fphar.2019.01469","volume":"10","author":"K Yuan","year":"2019","unstructured":"Yuan K, Li X, Lu Q, Zhu Q, Jiang H, Wang T, Huang G, Xu A. Application and mechanisms of triptolide in the treatment of inflammatory diseases-a review. Front Pharmacol. 2019;10:1469.","journal-title":"Front Pharmacol"},{"issue":"3","key":"5113_CR23","first-page":"267","volume":"1","author":"R Matta","year":"2009","unstructured":"Matta R, Wang X, Ge H, Ray W, Nelin LD, Liu Y. Triptolide induces anti-inflammatory cellular responses. Am J Transl Res. 2009;1(3):267\u201382.","journal-title":"Am J Transl Res"},{"issue":"6","key":"5113_CR24","first-page":"795","volume":"59","author":"W Yifan","year":"2007","unstructured":"Yifan W, Dengming W, Zheng L, Yanping L, Junkan S. Triptolide inhibits CCR5 expressed in synovial tissue of rat adjuvant-induced arthritis. Pharmacol Rep. 2007;59(6):795\u20139.","journal-title":"Pharmacol Rep"},{"issue":"7","key":"5113_CR25","doi-asserted-by":"publisher","first-page":"2346","DOI":"10.1167\/iovs.05-0010","volume":"46","author":"Y Lu","year":"2005","unstructured":"Lu Y, Fukuda K, Nakamura Y, Kimura K, Kumagai N, Nishida T. Inhibitory effect of triptolide on chemokine expression induced by proinflammatory cytokines in human corneal fibroblasts. Invest Ophth Vis Sci. 2005;46(7):2346\u201352.","journal-title":"Invest Ophth Vis Sci"},{"issue":"4","key":"5113_CR26","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1039\/D0NP00054J","volume":"38","author":"L Tong","year":"2021","unstructured":"Tong L, Zhao Q, Datan E, Lin G, Minn I, Pomper MG, Yu B, Romo D, He Q, Liu JO. Triptolide: reflections on two decades of research and prospects for the future. Nat Prod Rep. 2021;38(4):843\u201360.","journal-title":"Nat Prod Rep"},{"issue":"2","key":"5113_CR27","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.tips.2014.12.001","volume":"36","author":"Y Chen","year":"2015","unstructured":"Chen Y. Beware of docking! Trends Pharmacol Sci. 2015;36(2):78\u201395.","journal-title":"Trends Pharmacol Sci"},{"key":"5113_CR28","doi-asserted-by":"publisher","first-page":"923","DOI":"10.3389\/fphar.2018.00923","volume":"9","author":"V Salmaso","year":"2018","unstructured":"Salmaso V, Moro S. Bridging molecular docking to molecular dynamics in exploring ligand-protein recognition process: an overview. Front Pharmacol. 2018;9:923.","journal-title":"Front Pharmacol"}],"container-title":["International Urogynecology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00192-022-05113-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00192-022-05113-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00192-022-05113-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T14:11:50Z","timestamp":1659363110000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00192-022-05113-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,25]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["5113"],"URL":"https:\/\/doi.org\/10.1007\/s00192-022-05113-9","relation":{},"ISSN":["0937-3462","1433-3023"],"issn-type":[{"value":"0937-3462","type":"print"},{"value":"1433-3023","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,25]]},"assertion":[{"value":"26 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}