{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:15:29Z","timestamp":1786979729780,"version":"build-2736575974"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100009933","name":"Ethicon","doi-asserted-by":"publisher","award":["Ethicon IIS 13-215: VROUW 1 follow-up study"],"award-info":[{"award-number":["Ethicon IIS 13-215: VROUW 1 follow-up study"]}],"id":[{"id":"10.13039\/100009933","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urogynecol J"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and hypothesis<\/jats:title>\n                    <jats:p>The present study describes an extended follow-up study after 12 years and focusses on subjective outcomes of women who underwent surgery for recurrent pelvic organ prolapse in the randomized index study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and ninety-four (194) women had been randomized in the original study and in the present study, 45 (47%) in the vaginal mesh repair versus 43 (43%) women with conventional vaginal native tissue repair completed the long-term questionnaires. The mesh used was a first-generation non-absorbable mesh kit. All types of conventional vaginal native tissue repairs were allowed, and additional vaginal native tissue repairs were allowed in the mesh group. The questionnaires as applied at baseline were used. The Patient Global Impression of Improvement questionnaire (PGI-I) was the primary outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 12 years, 30 (71%) women in the mesh group versus 23 (59%) women in the native tissue repair group reported to be PGI-I (very) much improved (\n                      <jats:italic>p<\/jats:italic>\n                      =0.24). There were no differences found in any of the questionnaire domains. There was, however, a higher number of women who had had additional operations for recurrent pelvic organ prolapse, stress urinary incontinence, and\/or exposure in the mesh group: 18 women (40%) in the mesh group versus 8 women (19%) in the native tissue repair group (\n                      <jats:italic>p<\/jats:italic>\n                      =0.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There was no difference in subjective outcome between the groups, but there was a statistically significant higher number of women who had needed further operations. This study confirms that vaginal mesh should not be used in all women with recurrent pelvic organ prolapse.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00192-022-05442-9","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T22:19:50Z","timestamp":1674253190000},"page":"1645-1651","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Subjective outcomes 12 years after transvaginal mesh versus native tissue repair in women with recurrent pelvic organ prolapse; a randomized controlled trial"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4681-4304","authenticated-orcid":false,"given":"Kirsten B.","family":"Kluivers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metteke","family":"Kamping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo L.","family":"Milani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"IntHout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariella I.","family":"Withagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"issue":"6","key":"5442_CR1","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1097\/AOG.0b013e3181c2ce96","volume":"114","author":"JM Wu","year":"2009","unstructured":"Wu JM, Hundley AF, Fulton RG, Myers ER. Forecasting the prevalence of pelvic floor disorders in U.S. women: 2010 to 2050. Obstet Gynecol. 2009;114(6):1278\u201383.","journal-title":"Obstet Gynecol"},{"key":"5442_CR2","doi-asserted-by":"publisher","first-page":"555.e1","DOI":"10.1016\/j.ajog.2008.01.051","volume":"198","author":"MA Denman","year":"2008","unstructured":"Denman MA, Gregory WT, Boyles SH, Smith V, Edwards SR, Clark AL. Reoperation 10 years after surgically managed pelvic organ prolapse and urinary incontinence. Am J Obstet Gynecol 2008;198:555.e1\u20135.","journal-title":"Am J Obstet Gynecol"},{"key":"5442_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-022-05308-0","author":"FM Reid","year":"2022","unstructured":"Reid FM, Aucott L, Glazener CMA, Elders A, Hemming C, Cooper KG, et al. PROSPECT: 4- and 6-year follow-up of a randomised trial of surgery for vaginal prolapse. Int Urogynecol J. 2022. https:\/\/doi.org\/10.1007\/s00192-022-05308-0.","journal-title":"Int Urogynecol J"},{"key":"5442_CR4","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/S0368-2315(04)96598-2","volume":"33","author":"P Debodinance","year":"2004","unstructured":"Debodinance P, Berrocal J, Clave H, et al. Changing attitudes on the surgical treatment of urogenital prolapse: birth of the tension-free vaginal mesh. J Gynecol Obstet Biol Reprod (Paris). 2004;33:577\u201388.","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"key":"5442_CR5","unstructured":"UPDATE on Serious Complications Associated with Transvaginal Placement of Surgical Mesh for Pelvic Organ Prolapse: FDA Safety Communication. July 13, 2011. http:\/\/www.fda.gov\/MedicalDevices\/Safety\/AlertsandNotices\/ucm262435.htm"},{"issue":"10","key":"5442_CR6","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1177\/0003134820964459","volume":"86","author":"N Fadaee","year":"2020","unstructured":"Fadaee N, Huynh D, Towfigh S. #mesh: social media and its influence on perceptions in hernia repair. Am Surg. 2020;86(10):1351\u20137.","journal-title":"Am Surg"},{"key":"5442_CR7","first-page":"CD012079","volume":"2","author":"C Maher","year":"2016","unstructured":"Maher C, Feiner B, Baessler K, Christmann-Schmid C, Haya N, Marjoribanks J. Transvaginal mesh or grafts compared with native tissue repair for vaginal prolapse. Cochrane Database Syst Rev. 2016;2:CD012079.","journal-title":"Cochrane Database Syst Rev"},{"issue":"8","key":"5442_CR8","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1002\/pds.5239","volume":"30","author":"LE Gressler","year":"2021","unstructured":"Gressler LE, dosReis S, Chughtai B. Opioid prescribing and risks among commercially insured women undergoing pelvic organ prolapse repair. Pharmacoepidemiol Drug Saf. 2021;30(8):993\u20131002.","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"3","key":"5442_CR9","doi-asserted-by":"publisher","first-page":"233.e1","DOI":"10.1016\/j.ajog.2019.06.004","volume":"221","author":"MD Barber","year":"2019","unstructured":"Barber MD, Brubaker L, Nygaard I, Wai CY, Dyer KY, Ellington D, et al. Pain and activity after vaginal reconstructive surgery for pelvic organ prolapse and stress urinary incontinence. Am J Obstet Gynecol 2019;221(3):233.e1\u201316.","journal-title":"Am J Obstet Gynecol"},{"key":"5442_CR10","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1097\/AOG.0b013e318203e6a5","volume":"117","author":"MI Withagen","year":"2011","unstructured":"Withagen MI, Milani AL, den Boon J, Vervest HA, Vierhout ME. Trocar-guided mesh compared with conventional vaginal repair in recurrent prolapse: a randomized controlled trial. Obstet Gynecol. 2011;117:242\u201350.","journal-title":"Obstet Gynecol"},{"issue":"6","key":"5442_CR11","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s00192-017-3512-3","volume":"29","author":"AL Milani","year":"2018","unstructured":"Milani AL, Damoiseaux A, IntHout J, Kluivers KB, Withagen MIJ. Long-term outcome of vaginal mesh or native tissue in recurrent prolapse: a randomized controlled trial. Int Urogynecol J. 2018;29(6):847\u201358.","journal-title":"Int Urogynecol J"},{"key":"5442_CR12","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00192-009-1069-5","volume":"21","author":"S Srikrishna","year":"2010","unstructured":"Srikrishna S, Robinson D, Cardozo L. Validation of the patient global impression of improvement (PGI-I) for urogenital prolapse. Int Urogynecol J. 2010;21:523\u20138.","journal-title":"Int Urogynecol J"},{"key":"5442_CR13","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0168-8510(90)90421-9","volume":"16","author":"EuroQol Group","year":"1990","unstructured":"EuroQol Group. EuroQol\u2014a new facility for the measurement of health-related quality of life. Health Policy 1990;16:199\u2013208.","journal-title":"Health Policy"},{"key":"5442_CR14","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1002\/nau.10038","volume":"22","author":"CH Van der Vaart","year":"2003","unstructured":"Van der Vaart CH, de Leeuw JR, Roovers JP, Heintz AP. Measuring health-related quality of life in women with urogenital dysfunction: the urogenital distress inventory and incontinence impact questionnaire revisited. Neurourol Urodyn. 2003;22:97\u2013104.","journal-title":"Neurourol Urodyn"},{"issue":"1","key":"5442_CR15","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/0304-3959(83)90126-4","volume":"17","author":"DD Price","year":"1983","unstructured":"Price DD, Patricia A, McGrath PA, Rafii A, Buckingham B. The validation of visual analogue scales as ratio scale measures for chronic and experimental pain. Pain. 1983;17(1):45\u201356.","journal-title":"Pain"},{"key":"5442_CR16","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1007\/s00192-015-2692-y","volume":"26","author":"LA \u2019t Hoen","year":"2015","unstructured":"\u2019t Hoen LA, Utomo E, Steensma AB, Blok BF, Korfage IJ. The pelvic organ prolapse\/urinary incontinence sexual questionnaire (PISQ-12): validation of the Dutch version. Int Urogynecol J. 2015;26:1293\u2013303.","journal-title":"Int Urogynecol J"},{"key":"5442_CR17","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s00192-009-1028-1","volume":"21","author":"MI Withagen","year":"2010","unstructured":"Withagen MI, Vierhout ME, Milani AL. Does trocar-guided tension-free vaginal mesh (Prolift) repair provoke prolapse of the unaffected compartments? Int Urogynecol J. 2010;21:271\u20138.","journal-title":"Int Urogynecol J"},{"key":"5442_CR18","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1111\/j.1471-0528.2011.03231.x","volume":"119","author":"MI Withagen","year":"2012","unstructured":"Withagen MI, Milani AL, de Leeuw JW, Vierhout ME. Development of de novo prolapse in untreated vaginal compartments after prolapse repair with and without mesh: a secondary analysis of a randomised controlled trial. BJOG. 2012;119:354\u201360.","journal-title":"BJOG"},{"issue":"9","key":"5442_CR19","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1007\/s00192-020-04270-z","volume":"31","author":"N Dykes","year":"2020","unstructured":"Dykes N, Karmakar D, Hayward L. Lightweight transvaginal mesh is associated with lower mesh exposure rates than heavyweight mesh. Int Urogynecol J. 2020;31(9):1785\u201391.","journal-title":"Int Urogynecol J"},{"issue":"2","key":"5442_CR20","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00192-018-3713-4","volume":"30","author":"P Bakas","year":"2019","unstructured":"Bakas P, Papadakis E, Karachalios C, Liapis I, Panagopoulos N, Liapis A. Assessment of the long-term outcome of TVT procedure for stress urinary incontinence in a female population: results at 17 years' follow-up. Int Urogynecol J. 2019;30(2):265\u20139.","journal-title":"Int Urogynecol J"},{"key":"5442_CR21","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1097\/AOG.0b013e3181b2b1ae","volume":"114","author":"MD Barber","year":"2009","unstructured":"Barber MD, Brubaker L, Nygaard I, et al. Defining success after surgery for pelvic organ prolapse. Obstet Gynecol. 2009;114:600\u20139.","journal-title":"Obstet Gynecol"},{"key":"5442_CR22","first-page":"ED000108","volume":"2","author":"C Farquhar","year":"2016","unstructured":"Farquhar C. No implementation without evaluation: the case of mesh in vaginal prolapse surgery. Cochrane Database Syst Rev. 2016;2:ED000108.","journal-title":"Cochrane Database Syst Rev"}],"container-title":["International Urogynecology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00192-022-05442-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00192-022-05442-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00192-022-05442-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:22:52Z","timestamp":1687479772000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00192-022-05442-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["5442"],"URL":"https:\/\/doi.org\/10.1007\/s00192-022-05442-9","relation":{},"ISSN":["0937-3462","1433-3023"],"issn-type":[{"value":"0937-3462","type":"print"},{"value":"1433-3023","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,20]]},"assertion":[{"value":"3 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}