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The funders of the study had no influence in the study design, data collection, data analysis, data interpretation or writing of the report"]}]},{"name":"Helsinki University Hospital Research grant."},{"name":"University of Helsinki including Helsinki University Central Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urogynecol J"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction and hypothesis<\/jats:title>\n                <jats:p>To assess quality of life (QoL) and sexual function outcomes at 3\u00a0years after tension-free vaginal tape (TVT) and polyacrylamide hydrogel injection (PAHG) for stress urinary incontinence (SUI).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this randomized trial comparing TVT (<jats:italic>n<\/jats:italic>\u2009=\u2009104) and PAHG (<jats:italic>n\u2009<\/jats:italic>=\u2009108), we assessed changes in QoL and sexuality using the Urogenital Distress Inventory (UDI-6), Incontinence Impact Questionnaire, Short Form (IIQ-7), Pelvic Organ Prolapse\/Urinary Incontinence Sexual Questionnaire (PISQ-12) and RAND-36 Item Health Survey (RAND-36) at baseline and at 3\u00a0years. This is a secondary analysis of a randomized, noninferiority trial comparing patient satisfaction after TVT and PAHG.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In both groups, incontinence-related QoL improved from the baseline (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00), except for difficulty emptying the bladder and pain\/discomfort. Total scores of UDI-6 and IIIQ-7 were lower for TVT compared to PAHG (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00) indicating better QoL at 3\u00a0years. Urinary incontinence with sexual activity or fear of incontinence restricting sexual activity improved in both groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00), with higher scores for physical section subscale in PISQ-12 (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) for TVT. Physical and social functioning (RAND-36) improved from the baseline in both groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) with a better outcome in the TVT group for physical functioning (<jats:italic>p<\/jats:italic>\u2009=\u20090.00).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Both TVT and PAHG improve QoL and sexual function in primary SUI with better incontinence and health-related QoL scores in the TVT group compared to the PAHG group at 3\u00a0years.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00192-023-05626-x","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T14:01:31Z","timestamp":1694008891000},"page":"2977-2984","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Quality of life and sexual function after tension-free vaginal tape and polyacrylamide hydrogel injection for primary stress urinary incontinence: 3-year follow-up from a randomized clinical trial"],"prefix":"10.1007","volume":"34","author":[{"given":"Anna-Maija","family":"Itkonen Freitas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Isaksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"Rahkola-Soisalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarit","family":"Mentula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomi S.","family":"Mikkola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"issue":"1","key":"5626_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00192-009-0976-9","volume":"21","author":"BT Haylen","year":"2010","unstructured":"Haylen BT, de Ridder D, Freeman RM, et al. 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Rahkola-Soisalo has received research grants from the Finnish Medical Foundation during the conduct of the study. Mentula has received research grants from the Finnish Cultural Foundation during the conduct of the study. Mikkola has received personal lecture fees from Astellas, Contura, and Mylan.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}