{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:59:10Z","timestamp":1793642350002,"version":"4.5.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L232076"],"award-info":[{"award-number":["L232076"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Technology R&D Program of China","award":["2023YFC2411204"],"award-info":[{"award-number":["2023YFC2411204"]}]},{"name":"National Key Technology R&D Program of China","award":["2023YFC2411202"],"award-info":[{"award-number":["2023YFC2411202"]}]},{"name":"National Key Technology R&D Program of China","award":["2023YFC2411203"],"award-info":[{"award-number":["2023YFC2411203"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471661"],"award-info":[{"award-number":["82471661"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171615"],"award-info":[{"award-number":["82171615"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Peking University People\u2019s Hospital Research and Development Fund","award":["RDGS2022-12"],"award-info":[{"award-number":["RDGS2022-12"]}],"id":[{"id":"https:\/\/ror.org\/035adwg89","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urogynecol J"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s00192-025-06117-x","type":"journal-article","created":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T19:12:25Z","timestamp":1742670745000},"page":"881-893","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Recombinant Humanized Collagen: A Promising Treatment for Pelvic Organ Prolapse via Enhanced Fibroblast Function and Angiogenesis"],"prefix":"10.1007","volume":"36","author":[{"given":"Yue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7060-7030","authenticated-orcid":false,"given":"Xiuli","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"issue":"1","key":"6117_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00192-009-0976-9","volume":"21","author":"BT Haylen","year":"2010","unstructured":"Haylen BT, de Ridder D, Freeman RM, Swift SE, Berghmans B, Lee J, Monga A, Petri E, Rizk DE, Sand PK, Schaer GN. An International Urogynecological Association (IUGA)\/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Int Urogynecol J. 2010;21(1):5\u201326. https:\/\/doi.org\/10.1007\/s00192-009-0976-9","journal-title":"Int Urogynecol J"},{"issue":"1","key":"6117_CR2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1590\/S1677-5538","volume":"46","author":"AY Weintraub","year":"2020","unstructured":"Weintraub AY, Glinter H, Marcus-Braun N. Narrative review of the epidemiology, diagnosis and pathophysiology of pelvic organ prolapse. Int Braz J Urol. 2020;46(1):5\u201314. https:\/\/doi.org\/10.1590\/S1677-5538","journal-title":"Int Braz J Urol"},{"issue":"8","key":"6117_CR3","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1111\/1471-0528","volume":"128","author":"H Pang","year":"2021","unstructured":"Pang H, Zhang L, Han S, Li Z, Gong J, Liu Q, Liu X, Wang J, Xia Z, Lang J, Xu T, Zhu L. A nationwide population-based survey on the prevalence and risk factors of symptomatic pelvic organ prolapse in adult women in China - a pelvic organ prolapse quantification system-based study. BJOG. 2021;128(8):1313\u201323. https:\/\/doi.org\/10.1111\/1471-0528","journal-title":"BJOG"},{"issue":"7","key":"6117_CR4","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1001\/jama.2023","volume":"330","author":"DD Rahn","year":"2023","unstructured":"Rahn DD, Richter HE, Sung VW, Pruszynski JE, Hynan LS. Perioperative vaginal estrogen as adjunct to native tissue vaginal apical prolapse repair: a randomized clinical trial. JAMA. 2023;330(7):615\u201325. https:\/\/doi.org\/10.1001\/jama.2023","journal-title":"JAMA"},{"issue":"3","key":"6117_CR5","doi-asserted-by":"publisher","first-page":"CD012079","DOI":"10.1002\/14651858","volume":"3","author":"E Yeung","year":"2024","unstructured":"Yeung E, Baessler K, Christmann-Schmid C, Haya N, Chen Z, Wallace SA, Mowat A, Maher C. Transvaginal mesh or grafts or native tissue repair for vaginal prolapse. Cochrane Database Syst Rev. 2024;3(3):CD012079. https:\/\/doi.org\/10.1002\/14651858","journal-title":"Cochrane Database Syst Rev."},{"key":"6117_CR6","doi-asserted-by":"crossref","unstructured":"DeLancey JOL. Biomechanics of living organs, biomechanics of the female reproductive system: breast and pelvic organs. Academic Press; 2023. pp. 3\u201326.","DOI":"10.1016\/B978-0-12-823403-7.00012-9"},{"issue":"1","key":"6117_CR7","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1186\/s13287-021-02488-2","volume":"12","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Ma Y, Chen J, Wang M, Cao Y, Li L, Yang H, Liu X, Li Y, Zhu L. Mesenchymal stem cell transplantation for vaginal repair in an ovariectomized rhesus macaque model. Stem Cell Res Ther. 2021;12(1):406. https:\/\/doi.org\/10.1186\/s13287-021-02488-2","journal-title":"Stem Cell Res Ther"},{"issue":"5","key":"6117_CR8","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.3390\/pharmaceutics15051443","volume":"15","author":"N Zhou","year":"2023","unstructured":"Zhou N, Liu YD, Zhang Y, Gu TW, Peng LH. Pharmacological functions, synthesis, and delivery progress for collagen as biodrug and biomaterial. Pharmaceutics. 2023;15(5):1443. https:\/\/doi.org\/10.3390\/pharmaceutics15051443","journal-title":"Pharmaceutics"},{"issue":"4","key":"6117_CR9","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3390\/bioengineering7040155","volume":"7","author":"A Fertala","year":"2020","unstructured":"Fertala A. Three decades of research on recombinant collagens: reinventing the wheel or developing new biomedical products? Bioengineering (Basel). 2020;7(4):155. https:\/\/doi.org\/10.3390\/bioengineering7040155","journal-title":"Bioengineering (Basel)"},{"issue":"12","key":"6117_CR10","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.bioactmat.2021.10.031","volume":"29","author":"W Liu","year":"2021","unstructured":"Liu W, Lin H, Zhao P, Xing L, Li J, Wang Z, Ju S, Shi X, Liu Y, Deng G, Gao G, Sun L, Zhang X. A regulatory perspective on recombinant collagen-based medical devices. Bioact Mater. 2021;29(12):198\u2013202. https:\/\/doi.org\/10.1016\/j.bioactmat.2021.10.031","journal-title":"Bioact Mater"},{"issue":"27","key":"6117_CR11","doi-asserted-by":"publisher","first-page":"6346","DOI":"10.1039\/d3tb00438d","volume":"11","author":"Z Dong","year":"2023","unstructured":"Dong Z, Liu Q, Han X, Zhang X, Wang X, Hu C, Li X, Liang J, Chen Y, Fan Y. Electrospun nanofibrous membranes of recombinant human collagen type III promote cutaneous wound healing. J Mater Chem B. 2023;11(27):6346\u201360. https:\/\/doi.org\/10.1039\/d3tb00438d","journal-title":"J Mater Chem B"},{"key":"6117_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121849","volume":"290","author":"C Hu","year":"2022","unstructured":"Hu C, Liu W, Long L, Wang Z, Zhang W, He S, Lu L, Fan H, Yang L, Wang Y. Regeneration of infarcted hearts by myocardial infarction-responsive injectable hydrogels with combined anti-apoptosis, anti-inflammatory and pro-angiogenesis properties. Biomaterials. 2022;290: 121849. https:\/\/doi.org\/10.1016\/j.biomaterials.2022.121849","journal-title":"Biomaterials"},{"issue":"6","key":"6117_CR13","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.3390\/pharmaceutics15061658","volume":"15","author":"K Malhotra","year":"2023","unstructured":"Malhotra K, Buznyk O, Islam MM, Edin E, Basu S, Groleau M, D\u00e9gu\u00e9 DS, Fagerholm P, Fois A, Lesage S, Jangamreddy JR, \u0160imoli\u016bnas E, Liszka A, Patra HK, Griffith M. Phosphorylcholine and KR12-containing corneal implants in HSV-1-infected rabbit corneas. Pharmaceutics. 2023;15(6):1658. https:\/\/doi.org\/10.3390\/pharmaceutics15061658","journal-title":"Pharmaceutics"},{"issue":"707","key":"6117_CR14","doi-asserted-by":"publisher","first-page":"eabj3138","DOI":"10.1126\/scitranslmed.abj3138","volume":"15","author":"P Duran","year":"2023","unstructured":"Duran P, BoscoloSesillo F, Cook M, Burnett L, Menefee SA, Do E, French S, Zazueta-Damian G, Dzieciatkowska M, Saviola AJ, Shah MM, Sanvictores C, Osborn KG, Hansen KC, Shtrahman M, Christman KL, Alperin M. Proregenerative extracellular matrix hydrogel mitigates pathological alterations of pelvic skeletal muscles after birth injury. Sci Transl Med. 2023;15(707):eabj3138. https:\/\/doi.org\/10.1126\/scitranslmed.abj3138","journal-title":"Sci Transl Med."},{"issue":"24","key":"6117_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100910","volume":"18","author":"X Wu","year":"2023","unstructured":"Wu X, Zhang F, Mao X, Xu F, Ding X, Sun X, Wang J. The mechanism of adipose mesenchymal stem cells to stabilize the immune microenvironment of pelvic floor injury by regulating pyroptosis and promoting tissue repair. Mater Today Bio. 2023;18(24):100910. https:\/\/doi.org\/10.1016\/j.mtbio.2023.100910","journal-title":"Mater Today Bio"},{"issue":"11","key":"6117_CR16","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1007\/s00192-024-05943-9","volume":"35","author":"Q Wang","year":"2024","unstructured":"Wang Q, Wu X, Wang S, Xie B, Sun X, Wang J. Mechanical stress-oxidative stress axis: biological basis in the vaginal wall and pelvic floor muscles of rats with simulated birth injury. Int Urogynecol J. 2024;35(11):2141\u201352. https:\/\/doi.org\/10.1007\/s00192-024-05943-9","journal-title":"Int Urogynecol J"},{"issue":"4","key":"6117_CR17","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s00192-008-0737-1","volume":"20","author":"MH Kerkhof","year":"2009","unstructured":"Kerkhof MH, Hendriks L, Br\u00f6lmann HA. Changes in connective tissue in patients with pelvic organ prolapse\u2013a review of the current literature. Int Urogynecol J Pelvic Floor Dysfunct. 2009;20(4):461\u201374. https:\/\/doi.org\/10.1007\/s00192-008-0737-1","journal-title":"Int Urogynecol J Pelvic Floor Dysfunct"},{"issue":"20","key":"6117_CR18","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1016\/j.scib.2023.09.003","volume":"68","author":"Y Li","year":"2023","unstructured":"Li Y, Liu J, Zhang Y, Mao M, Wang H, Ma Y, Chen Z, Zhang Y, Liao C, Chang X, Gao Q, Guo J, Ye Y, Ai F, Liu X, Zhao X, Tian W, Yang H, Ji W, Tan T, Zhu L. A comprehensive evaluation of spontaneous pelvic organ prolapse in rhesus macaques as an ideal model for the study of human pelvic organ prolapse. Sci Bull (Beijing). 2023;68(20):2434\u201347. https:\/\/doi.org\/10.1016\/j.scib.2023.09.003","journal-title":"Sci Bull (Beijing)"},{"issue":"2","key":"6117_CR19","doi-asserted-by":"publisher","first-page":"111","DOI":"10.2174\/1574888X14666191104151928","volume":"15","author":"LVK Reddy","year":"2020","unstructured":"Reddy LVK, Murugan D, Mullick M, Begum Moghal ET, Sen D. Recent approaches for angiogenesis in search of successful tissue engineering and regeneration. Curr Stem Cell Res Ther. 2020;15(2):111\u201334. https:\/\/doi.org\/10.2174\/1574888X14666191104151928","journal-title":"Curr Stem Cell Res Ther"},{"issue":"1","key":"6117_CR20","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41467-020-20358-y","volume":"12","author":"Y Li","year":"2021","unstructured":"Li Y, Zhang QY, Sun BF, Ma Y, Zhang Y, Wang M, Ma C, Shi H, Sun Z, Chen J, Yang YG, Zhu L. Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse. Nat Commun. 2021;12(1):87. https:\/\/doi.org\/10.1038\/s41467-020-20358-y","journal-title":"Nat Commun"},{"issue":"9","key":"6117_CR21","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.3390\/biomedicines10092307","volume":"10","author":"IN Amirrah","year":"2022","unstructured":"Amirrah IN, Lokanathan Y, Zulkiflee I, Wee MFMR, Motta A, Fauzi MB. A comprehensive review on collagen type I development of biomaterials for tissue engineering: from biosynthesis to bioscaffold. Biomedicines. 2022;10(9):2307. https:\/\/doi.org\/10.3390\/biomedicines10092307","journal-title":"Biomedicines"},{"issue":"1","key":"6117_CR22","doi-asserted-by":"publisher","first-page":"5","DOI":"10.26502\/fccm.92920302","volume":"7","author":"D Singh","year":"2023","unstructured":"Singh D, Rai V, Agrawal DK. Regulation of collagen I and collagen III in tissue injury and regeneration. Cardiol Cardiovasc Med. 2023;7(1):5\u201316. https:\/\/doi.org\/10.26502\/fccm.92920302","journal-title":"Cardiol Cardiovasc Med"},{"key":"6117_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111846","volume":"121","author":"Y Yang","year":"2021","unstructured":"Yang Y, Campbell Ritchie A, Everitt NM. Recombinant human collagen\/chitosan-based soft hydrogels as biomaterials for soft tissue engineering. Mater Sci Eng C Mater Biol Appl. 2021;121: 111846. https:\/\/doi.org\/10.1016\/j.msec.2020.111846","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"issue":"2","key":"6117_CR24","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","volume":"186","author":"C L\u00f3pez-Ot\u00edn","year":"2023","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: an expanding universe. Cell. 2023;186(2):243\u201378. https:\/\/doi.org\/10.1016\/j.cell.2022.11.001","journal-title":"Cell"},{"issue":"11","key":"6117_CR25","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1016\/j.stemcr.2022.09.005","volume":"17","author":"O Ben Menachem-Zidon","year":"2022","unstructured":"Ben Menachem-Zidon O, Gropp M, Reubinoff B, Shveiky D. Mesenchymal stem cell transplantation improves biomechanical properties of vaginal tissue following full-thickness incision in aged rats. Stem Cell Reports. 2022;17(11):2565\u201378. https:\/\/doi.org\/10.1016\/j.stemcr.2022.09.005","journal-title":"Stem Cell Reports"},{"issue":"11","key":"6117_CR26","doi-asserted-by":"publisher","first-page":"5714","DOI":"10.3390\/ijms25115714","volume":"25","author":"O Ben Menachem-Zidon","year":"2024","unstructured":"Ben Menachem-Zidon O, Reubinoff B, Shveiky D. Transplantation of mesenchymal stem cells derived from old rats improves healing and biomechanical properties of vaginal tissue following surgical incision in aged rats. Int J Mol Sci. 2024;25(11):5714. https:\/\/doi.org\/10.3390\/ijms25115714","journal-title":"Int J Mol Sci"}],"container-title":["International Urogynecology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00192-025-06117-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00192-025-06117-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00192-025-06117-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T08:54:12Z","timestamp":1746780852000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00192-025-06117-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["6117"],"URL":"https:\/\/doi.org\/10.1007\/s00192-025-06117-x","relation":{},"ISSN":["0937-3462","1433-3023"],"issn-type":[{"value":"0937-3462","type":"print"},{"value":"1433-3023","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]},"assertion":[{"value":"7 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Review Committee of Peking University People\u2019s Hospital (PKUPH) (Approval No.2021PHB137-001), and all tissue samples were obtained from Peking University People\u2019s\u00a0Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}}]}}