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Owing to complications such as dyspareunia, mesh exposure, erosion and vaginal discharge, transvaginal mesh was removed from the market. Regenerative treatments such as transvaginal platelet-rich plasma (PRP) and fractional CO<jats:sub>2<\/jats:sub> laser therapy may offer relief from mesh complications.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>From 2013 to 2024, women with mesh complications, including dyspareunia, vaginal discharge and\/or vaginal mesh exposure (&lt; 2 cm) awaiting surgery, were enrolled in this prospective study. Wilcoxon signed-rank test was used to assess IQR changes in Australian Pelvic Floor Questionnaire (APFQ) and Pelvic Organ Prolapse Quantification symptom severity, whereas a general linear model analysed outcome differences at baseline, 3\u20136 months and &gt; 9 months. The primary aim was to assess the proportion of patients who avoided surgical intervention after PRP and CO<jats:sub>2<\/jats:sub> laser treatment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A cohort of 47 women were eligible. The average age and body mass index were 64 years and 27.94 kg\/m<jats:sup>2<\/jats:sup> respectively. Thirty-nine received PRP and CO<jats:sub>2<\/jats:sub> laser combined, whereas 8 underwent CO<jats:sub>2<\/jats:sub> laser alone. Overall, 40 women (85.0%) avoided surgery over an average 12-month follow-up. APFQ scores improved significantly from baseline to &gt; 9 months (<jats:italic>p<\/jats:italic> = 0.02). Treatments also improved bladder, bowel, prolapse and sexual function (<jats:italic>p<\/jats:italic> &lt; 0.001) between 3\u20139 months. Vaginal laxity and prolapse sensation improved at 9 months (<jats:italic>p<\/jats:italic> = 0.04, <jats:italic>p<\/jats:italic> = 0.005).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Platelet-rich plasma and CO<jats:sub>2<\/jats:sub> laser treatments allowed most women to avoid surgery, improving bladder, bowel, sexual function and vaginal atrophy. These alternatives may expand treatment options for mesh complications.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00192-025-06123-z","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T07:44:46Z","timestamp":1743839086000},"page":"903-912","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Platelet-Rich Plasma and Fractional CO2 Laser Therapy to Reduce Surgical Intervention for Symptomatic Vaginal Mesh-Related Complications"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3570-2499","authenticated-orcid":false,"given":"Nadia","family":"Willison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"McPhail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvis","family":"Seman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahshid","family":"Taheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouria","family":"Aryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Abbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanaka","family":"Dune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Behnia-Willison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"issue":"4","key":"6123_CR1","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1097\/01.AOG.0000255977.91296.5d","volume":"109","author":"CS Bradley","year":"2007","unstructured":"Bradley CS, Zimmerman MB, Qi Y, Nygaard IE. 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