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A total of 65 patients who underwent RASC and 71 who underwent the Uphold\u2122 procedure completed the 15-dimensional (15D) and the EuroQol five-dimensional three-level (EQ-5D-3L) instruments measuring health-related quality of life (HR-QoL). All patients had symptomatic and anatomical apical prolapse (POP-Q C\u2009\u2265\u2009stage II) with or without other vaginal wall defects. Changes in HR-QoL instruments were calculated and compared with minimal important change (MIC) thresholds and QALYs gained were estimated for each intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 15D and EQ-5D-3L mean index scores were improved from preoperatively to 1 year after RASC ([0.88\u2009\u00b1\u20090.10 to 0.90\u2009\u00b1\u20090.01] and [0.85\u2009\u00b1\u20090.1 to 0.90\u2009\u00b1\u20090.1]) and after Uphold\u2122= ([0.87\u2009\u00b1\u20090.1 to 0.89\u2009\u00b1\u20090.1] and [0.86\u2009\u00b1\u20090.1 to 0.93\u2009\u00b1\u20090.1],\n                      <jats:italic>p<\/jats:italic>\n                      0.024 to\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) with no significant difference between cohorts. Prolapse-related 15D profile index measures, including discomfort, sexual activity, and distress were significantly improved after RASC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039 to\u2009&lt;\u20090.001), whereas excretion, discomfort, and sexual activity were significantly improved after the Uphold\u2122 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009 to\u2009&lt;\u20090.001). The improvement in 15D scores from baseline to 1-year follow-up of\u2009+\u20090.026 for RASC and\u2009+\u20090.025 for Uphold\u2122 exceeded the MIC, indicating meaningful improvements in patient quality of life. The overall 1-year QALY gain was estimated to be 0.90\u2009\u00b1\u20090.1 in the RASC and 0.88\u2009\u00b1\u20090.1 in the Uphold\u2122 cohorts (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with no significant difference between the two interventions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.514).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The RASC and Uphold\u2122 are both meaningful surgical treatments for prolapse, with significant improvement in the HR-QoL and the 1-year QALY gain and with no significant difference between the two surgeries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00192-025-06242-7","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T10:18:43Z","timestamp":1755080323000},"page":"161-173","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality-Adjusted Life-Years Outcome 1 Year After Surgery by Robotics-Assisted Sacral Hystero-Colpopexy Versus Vaginal Mesh for Pelvic Organ Prolapse Repair"],"prefix":"10.1007","volume":"37","author":[{"given":"Georgios","family":"Poutakidis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk","family":"Geale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2420-5580","authenticated-orcid":false,"given":"Edward","family":"Morcos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"issue":"7","key":"6242_CR1","volume":"7","author":"C Maher","year":"2023","unstructured":"Maher C, Yeung E, Haya N, Christmann-Schmid C, Mowat A, Chen Z, Baessler K. 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