{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T15:09:28Z","timestamp":1782313768649,"version":"3.54.5"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002352","name":"Ain Shams University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002352","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urogynecol J"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and Hypothesis<\/jats:title>\n                    <jats:p>The aim of this study was to assess the effectiveness of a single session of submucosal intravesical injections of autologous platelet-rich plasma in the treatment of IC\/PBS resistant to conventional methods of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a prospective one-arm clinical trial that was conducted from April 2021 to April 2023 on 30 patients ranging from 30 to 50\u00a0years old with Interstitial Cystitis\/Painful Bladder Syndrome symptoms (IC\/PBS) not relieved by medical treatment. They were assessed by the O'Leary-Sant Interstitial Cystitis Symptom Index and problem indexes (ICSI) (ICPI). They received a single session of 20 submucosal injections of PRP and were assessed after 1, 3, and 6\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four patients declined to show in the follow-up visits (13.3%) due to personal reasons and were excluded from the final analysis due to incomplete outcome data. Out of 26 patients, 16 patients (61.54%) were considered to have successful results, while treatment failed in 10 patients (38.46%). There was a highly statistically significant decrease in ICPI, ICSI, pain VAS score, frequency, nocturia, and functional bladder capacity (FBC) with a\n                      <jats:italic>p<\/jats:italic>\n                      value of\u2009&lt;\u20090.001. Hematuria was observed in three patients (11.5%), while urinary tract infection (UTI) was detected in four patients (15.4%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A single session of submucosal intravesical injections of platelet-rich plasma (PRP) presents a promising therapeutic option for patients with IC\/PBS. The constrains of this research encompass the absence of a placebo arm, further randomized controlled trials are needed to prove its efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00192-025-06324-6","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T12:10:19Z","timestamp":1759925419000},"page":"655-662","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and Safety of Submucosal Intravesical Injection of Platelet-Rich Plasma in the Treatment of Interstitial Cystitis\/Painful Bladder Syndrome"],"prefix":"10.1007","volume":"37","author":[{"given":"M Sherif","family":"Mourad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Tawfick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Kotb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail Mahdy","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Salim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4226-4587","authenticated-orcid":false,"given":"Younan R.","family":"Samir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"6324_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11884-019-00569-w","volume":"15","author":"Y Akiyama","year":"2020","unstructured":"Akiyama Y. Update on the pathophysiology of interstitial cystitis\/bladder pain syndrome. Curr Bladder Dysfunct Rep. 2020;15:1\u20138. https:\/\/doi.org\/10.1007\/s11884-019-00569-w.","journal-title":"Curr Bladder Dysfunct Rep"},{"issue":"5","key":"6324_CR2","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1016\/j.juro.2015.01.086","volume":"193","author":"PM Hanno","year":"2015","unstructured":"Hanno PM, Erickson D, Moldwin R, Faraday MM. Diagnosis and treatment of interstitial cystitis\/bladder pain syndrome: AUA guideline amendment. J Urol. 2015;193(5):1545\u201353.","journal-title":"J Urol"},{"key":"6324_CR3","doi-asserted-by":"crossref","unstructured":"Mellado BH, Pilger TL, Poli-Neto OB, Rosa e Silva JC, Nogueira AA, Candido dos Reis FJ. Current usage of qualitative research in female pelvic pain: a systematic review. 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