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A literature search was conducted using online databases Embase, Medline, and PubMed. Quality of articles was assessed, and articles were divided into groups to reduce heterogeneity for meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of eight studies were selected for analysis. The mean bladder wall thickness in those \u201cwith detrusor overactivity\u201d was found to be 5.234+\/\u22121.424 and those \u201cwithout detrusor overactivity\u201d 4.356+\/\u22121.124. Those \u201cwith detrusor overactivity\u201d were found to have a mean increased bladder wall thickness of 0.879+\/\u22120.958 (95% CI 0.143 to 1.615) when compared to those \u201cwithout detrusor overactivity\u201d. Meta-analysis was performed with six of the eight studies to reduce heterogeneity of data. We found no overall effect and no significant difference in measurements taken in those \u201cwith detrusor overactivity\u201d and those \u201cwithout detrusor overactivity\u201d. Tests of heterogeneity demonstrate a moderate level of heterogeneity I\n                      <jats:sup>2<\/jats:sup>\n                      = 61.4% and T\n                      <jats:sup>2<\/jats:sup>\n                      = 0.049. A summary receiver operator characteristic curve was used to demonstrate overall performance of ultrasound measurement of bladder wall thickness as an alternative diagnostic test of urodynamic detrusor overactivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Meta-analysis has demonstrated that measurement of bladder wall thickness using ultrasound cannot be used to diagnose detrusor overactivity and can therefore not replace urodynamics in the investigation of women with lower urinary tract symptoms. The results of this meta-analysis must be viewed with the understanding that studies included showed significant heterogeneity despite efforts to reduce large variation in data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00192-026-06634-3","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T11:44:10Z","timestamp":1776167050000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Systematic Review and Meta-Analysis of Bladder Wall Thickness for the Diagnosis of Detrusor Overactivity in Women"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-656X","authenticated-orcid":false,"given":"Bernadette","family":"Lemmon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mittal","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruwan","family":"Fernando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Digesu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alka","family":"Bhide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vik","family":"Khullar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"6634_CR1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.euros.2022.08.013","volume":"44","author":"NS Bodmer","year":"2022","unstructured":"Bodmer NS, Wirth C, Birkh\u00e4user V, Sartori AM, Leitner L, Averbeck MA, et al. 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