{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:20:44Z","timestamp":1789395644487,"version":"build-2803163510"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the National Key Technology R&D Program of China","award":["2023YFC2411203"],"award-info":[{"award-number":["2023YFC2411203"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82471661"],"award-info":[{"award-number":["82471661"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82501961"],"award-info":[{"award-number":["82501961"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Being High-Level innovation and Entrepreneurship Talent Support Program","award":["20250012"],"award-info":[{"award-number":["20250012"]}]},{"name":"the Beijing Natural Science Foundation","award":["L232076"],"award-info":[{"award-number":["L232076"]}]},{"name":"S&T Program of Hebei","award":["252W7707D"],"award-info":[{"award-number":["252W7707D"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urogynecol J"],"DOI":"10.1007\/s00192-026-06878-z","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:49:17Z","timestamp":1789393757000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thrombospondin-1 as a Mechanosensitive Matrix Protein Driving Fibroblast Senescence: A Novel Pathogenic Target for Pelvic Organ Prolapse"],"prefix":"10.1007","author":[{"given":"Yaqin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7060-7030","authenticated-orcid":false,"given":"Xiuli","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"issue":"23","key":"6878_CR1","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1001\/jama.2022.22385","volume":"328","author":"LR van der Vaart","year":"2022","unstructured":"van der Vaart LR, Vollebregt A, Milani AL, Lagro-Janssen AL, Duijnhoven RG, Roovers JWR, et al. Effect of pessary vs surgery on patient-reported improvement in patients with symptomatic pelvic organ prolapse: a randomized clinical trial. JAMA. 2022;328(23):2312\u201323.","journal-title":"JAMA"},{"issue":"5","key":"6878_CR2","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s00192-025-06049-6","volume":"36","author":"P Li","year":"2025","unstructured":"Li P, Ma H, Zhang J, Zhang Q. Global trends in prevalence and future projections of pelvic organ prolapse: a 30-year epidemiological study. Int Urogynecol J. 2025;36(5):991\u20131002.","journal-title":"Int Urogynecol J"},{"issue":"7","key":"6878_CR3","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1001\/jama.2023.13140","volume":"330","author":"RA Enklaar","year":"2023","unstructured":"Enklaar RA, Schulten SFM, van Eijndhoven HWF, Weemhoff M, van Leijsen SAL, van der Weide MC, et al. Manchester procedure vs sacrospinous hysteropexy for treatment of uterine descent: a randomized clinical trial. JAMA. 2023;330(7):626\u201335.","journal-title":"JAMA"},{"issue":"5","key":"6878_CR4","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.ajog.2023.11.1247","volume":"230","author":"JO DeLancey","year":"2024","unstructured":"DeLancey JO, Mastrovito S, Masteling M, Horner W, Ashton-Miller JA, Chen L. A unified pelvic floor conceptual model for studying morphological changes with prolapse, age, and parity. Am J Obstet Gynecol. 2024;230(5):476-84 e2.","journal-title":"Am J Obstet Gynecol"},{"issue":"9566","key":"6878_CR5","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/S0140-6736(07)60462-0","volume":"369","author":"JE Jelovsek","year":"2007","unstructured":"Jelovsek JE, Maher C, Barber MD. Pelvic organ prolapse. Lancet. 2007;369(9566):1027\u201338.","journal-title":"Lancet"},{"issue":"1","key":"6878_CR6","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/s41420-023-01482-2","volume":"9","author":"Y He","year":"2023","unstructured":"He Y, Huang G, Hong S, Zuo X, Zhao Z, Hong L. Ferrostatin-1 alleviates the damage of C2C12 myoblast and mouse pelvic floor muscle induced by mechanical trauma. Cell Death Discov. 2023;9(1):232.","journal-title":"Cell Death Discov"},{"issue":"5","key":"6878_CR7","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1002\/nau.25455","volume":"43","author":"X Wang","year":"2024","unstructured":"Wang X, Zhang W, Zhou Y, Li Y, Xu X, Xue J, et al. SIRT1 as a potential therapeutic target in pelvic organ prolapse due to protective effects against oxidative stress and cellular senescence in human uterosacral ligament fibroblasts. Neurourol Urodyn. 2024;43(5):1217\u201329.","journal-title":"Neurourol Urodyn"},{"issue":"2","key":"6878_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2024.114139","volume":"440","author":"J Zhu","year":"2024","unstructured":"Zhu J, Xu HN, Lin T, Xia ZJ. Silencing of cysteine and serine rich nuclear protein 1 inhibits apoptosis, senescence and collagen degradation in human-derived vaginal fibroblasts in response to oxidative stress or DNA damage. Exp Cell Res. 2024;440(2):114139.","journal-title":"Exp Cell Res"},{"issue":"3","key":"6878_CR9","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.3892\/mmr.2020.11339","volume":"22","author":"L Huang","year":"2020","unstructured":"Huang L, Zhao Z, Wen J, Ling W, Miao Y, Wu J. Cellular senescence: a pathogenic mechanism of pelvic organ prolapse (review). Mol Med Rep. 2020;22(3):2155\u201362.","journal-title":"Mol Med Rep"},{"issue":"18","key":"6878_CR10","doi-asserted-by":"publisher","first-page":"9896","DOI":"10.1073\/pnas.1919702117","volume":"117","author":"Y Yamashiro","year":"2020","unstructured":"Yamashiro Y, Thang BQ, Ramirez K, Shin SJ, Kohata T, Ohata S, et al. Matrix mechanotransduction mediated by thrombospondin-1\/integrin\/YAP in the vascular remodeling. Proc Natl Acad Sci U S A. 2020;117(18):9896\u2013905.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"6878_CR11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41413-025-00493-2","volume":"14","author":"MK Hunter","year":"2026","unstructured":"Hunter MK, Korlakunta S, Vishlaghi N, Mittal M, Cragg K, Juan C, et al. Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization. Bone Res. 2026;14(1):10.","journal-title":"Bone Res"},{"issue":"13","key":"6878_CR12","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1161\/CIRCULATIONAHA.116.026361","volume":"136","author":"CW Kim","year":"2017","unstructured":"Kim CW, Pokutta-Paskaleva A, Kumar S, Timmins LH, Morris AD, Kang DW, et al. Disturbed flow promotes arterial stiffening through thrombospondin-1. Circulation. 2017;136(13):1217\u201332.","journal-title":"Circulation"},{"key":"6878_CR13","doi-asserted-by":"crossref","unstructured":"Ramalingam P, Gutkin MC, Poulos MG, Winiarski A, Smith A, Carter C, et al. Suppression of thrombospondin-1-mediated inflammaging prolongs hematopoietic health span. Sci Immunol. 2025;10(103):eads1556.","DOI":"10.1126\/sciimmunol.ads1556"},{"key":"6878_CR14","doi-asserted-by":"publisher","DOI":"10.1172\/jci184158","author":"L Xu","year":"2025","unstructured":"Xu L, Li T, Cao Y, He Y, Shao Z, Liu S, et al. PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice. J Clin Invest. 2025. https:\/\/doi.org\/10.1172\/jci184158.","journal-title":"J Clin Invest"},{"key":"6878_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100910","volume":"24","author":"X Wu","year":"2024","unstructured":"Wu X, Zhang F, Mao X, Xu F, Ding X, Sun X, et al. The mechanism of adipose mesenchymal stem cells to stabilize the immune microenvironment of pelvic floor injury by regulating pyroptosis and promoting tissue repair. Mater Today Bio. 2024;24:100910.","journal-title":"Mater Today Bio"},{"issue":"11","key":"6878_CR16","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1007\/s00192-024-05943-9","volume":"35","author":"Q Wang","year":"2024","unstructured":"Wang Q, Wu X, Wang S, Xie B, Sun X, Wang J. Mechanical stress-oxidative stress axis: biological basis in the vaginal wall and pelvic floor muscles of rats with simulated birth injury. Int Urogynecol J. 2024;35(11):2141\u201352.","journal-title":"Int Urogynecol J"},{"issue":"47","key":"6878_CR17","doi-asserted-by":"publisher","first-page":"e13314","DOI":"10.1002\/advs.202513314","volume":"12","author":"SE Schneider","year":"2025","unstructured":"Schneider SE, Scott AK, Gallagher KM, Miller EY, Ghosh S, Neu CP. Mechanical stress triggers premature senescence in cardiac fibroblasts. Adv Sci (Weinh). 2025;12(47):e13314.","journal-title":"Adv Sci (Weinh)"},{"issue":"6","key":"6878_CR18","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1515\/mr-2024-0034","volume":"4","author":"J Chansaenroj","year":"2024","unstructured":"Chansaenroj J, Suwittayarak R, Egusa H, Samaranayake LP, Osathanon T. Mechanical force modulates inflammation and immunomodulation in periodontal ligament cells. Med Rev. 2024;4(6):544\u20138.","journal-title":"Med Rev"},{"issue":"23","key":"6878_CR19","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1001\/jama.2018.18315","volume":"320","author":"JL Blomquist","year":"2018","unstructured":"Blomquist JL, Munoz A, Carroll M, Handa VL. Association of delivery mode with pelvic floor disorders after childbirth. JAMA. 2018;320(23):2438\u201347.","journal-title":"JAMA"},{"issue":"22","key":"6878_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300086","volume":"12","author":"B Miller","year":"2023","unstructured":"Miller B, Wolfe W, Gentry JL, Grewal MG, Highley CB, De Vita R, et al. Supramolecular fibrous hydrogel augmentation of uterosacral ligament suspension for treatment of pelvic organ prolapse. Adv Healthc Mater. 2023;12(22):e2300086.","journal-title":"Adv Healthc Mater"},{"issue":"1","key":"6878_CR21","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41467-020-20358-y","volume":"12","author":"Y Li","year":"2021","unstructured":"Li Y, Zhang QY, Sun BF, Ma Y, Zhang Y, Wang M, et al. Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse. Nat Commun. 2021;12(1):87.","journal-title":"Nat Commun"},{"key":"6878_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2021.101660","volume":"73","author":"J Feng","year":"2021","unstructured":"Feng J, Li Y, Jin X, Gong R, Xia Z. ATF3 regulates oxidative stress and extracellular matrix degradation via p38\/Nrf2 signaling pathway in pelvic organ prolapse. Tissue Cell. 2021;73:101660.","journal-title":"Tissue Cell"},{"issue":"5","key":"6878_CR23","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1007\/s00192-022-05378-0","volume":"34","author":"C Wu","year":"2023","unstructured":"Wu C, Zhou Z, Yang Y, Li H, Guo Y, Tong X. Bioinformatically deciphering immune cell infiltration and signature genes in pelvic organ prolapse. Int Urogynecol J. 2023;34(5):1091\u2013101.","journal-title":"Int Urogynecol J"},{"issue":"5","key":"6878_CR24","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/SPV.0000000000001131","volume":"28","author":"ME Florian-Rodriguez","year":"2022","unstructured":"Florian-Rodriguez ME, Hare AM, Gaddam NG, Shi H, Keller P, Word RA. Induction of cellular senescence in rat vaginal fibroblasts and treatment with senolytics: an in vitro model for the study of pelvic organ prolapse. Female Pelvic Med Reconstr Surg. 2022;28(5):341\u20135.","journal-title":"Female Pelvic Med Reconstr Surg"},{"key":"6878_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2021.101652","volume":"73","author":"AM Hare","year":"2021","unstructured":"Hare AM, Gaddam NG, Shi H, Acevedo JF, Word RA, Florian-Rodriguez ME. Impact of vaginal distention on cell senescence in an animal model of pelvic organ prolapse. Tissue Cell. 2021;73:101652.","journal-title":"Tissue Cell"},{"issue":"1","key":"6878_CR26","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1038\/s41467-023-36824-2","volume":"14","author":"AF Vom Stein","year":"2023","unstructured":"Vom Stein AF, Rebollido-Rios R, Lukas A, Koch M, von Lom A, Reinartz S, et al. LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1. Nat Commun. 2023;14(1):1330.","journal-title":"Nat Commun"},{"key":"6878_CR27","doi-asserted-by":"crossref","unstructured":"Vanhoutte D, Schips TG, Vo A, Grimes KM, Baldwin TA, Brody MJ, et al. Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy. Nat Commun. 2021;12(1):3928.","DOI":"10.1038\/s41467-021-24215-4"},{"issue":"12","key":"6878_CR28","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1016\/j.stem.2022.10.009","volume":"29","author":"E Porpiglia","year":"2022","unstructured":"Porpiglia E, Mai T, Kraft P, Holbrook CA, de Morree A, Gonzalez VD, et al. Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration. Cell Stem Cell. 2022;29(12):1653-68 e8.","journal-title":"Cell Stem Cell"},{"key":"6878_CR29","doi-asserted-by":"publisher","first-page":"112111","DOI":"10.1016\/j.mce.2023.112111","volume":"580","author":"Y Lv","year":"2024","unstructured":"Lv Y, Huang Y, Fan H, Zhao Y, Ma L, Lan Y, et al. 17beta-Estradiol inhibits hydrogen peroxide-induced senescence and apoptosis in human umbilical vein endothelial cells by regulating the THBS1\/TGF-beta\/Smad axis. Mol Cell Endocrinol. 2024;580:112111.","journal-title":"Mol Cell Endocrinol"},{"key":"6878_CR30","doi-asserted-by":"crossref","unstructured":"Gong J, Li X, Chen Y, Wei X, Bai L, Zhu H, et al. Construction of a postpartum pelvic floor rehabilitation exercise programme based on the Delphi method. Gynecol Obstet Clin Med. 2025;5:e000044.","DOI":"10.1136\/gocm-2024-000044"},{"key":"6878_CR31","doi-asserted-by":"crossref","unstructured":"Luo C, Wei D, Chen Y, Mei L, Niu X. Laparoscopic lateral suspension (Dubuisson) in the treatment of pelvic organ prolapse. Gynecol Obstet Clin Med. 2024;4:e000010.","DOI":"10.1136\/gocm-2024-000010"}],"container-title":["International Urogynecology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00192-026-06878-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00192-026-06878-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00192-026-06878-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:49:22Z","timestamp":1789393762000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00192-026-06878-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":31,"alternative-id":["6878"],"URL":"https:\/\/doi.org\/10.1007\/s00192-026-06878-z","relation":{},"ISSN":["0937-3462","1433-3023"],"issn-type":[{"value":"0937-3462","type":"print"},{"value":"1433-3023","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]},"assertion":[{"value":"23 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Ethics Review Committee of PKUPH (Approval No. 2021PHB137-001), and all tissue samples were obtained from the PKUPH Biobank.","order":1,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","label":"Conflicts of Interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}