{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:40:20Z","timestamp":1790419220161,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2004,11,16]],"date-time":"2004-11-16T00:00:00Z","timestamp":1100563200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1007\/s00198-004-1801-4","type":"journal-article","created":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T17:35:32Z","timestamp":1100540132000},"page":"928-936","source":"Crossref","is-referenced-by-count":124,"title":["Decreased bone mineral density and content in neurofibromatosis type 1: Lowest local values are located in the load-carrying parts of the body"],"prefix":"10.1007","volume":"16","author":[{"given":"T.","family":"Kuorilehto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"P\u00f6yh\u00f6nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bloigu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Heikkinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"V\u00e4\u00e4n\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Peltonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,11,16]]},"reference":[{"key":"1801_CR1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/jama.1997.03550010065042","volume":"278","author":"Gutmann","year":"1997","unstructured":"Gutmann DH, Aylsworth A, Carey JC, Korf B, Marks J, Pyeritz RE, Rubenstein A, Viskochil D (1997) The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA 278:51\u201357","journal-title":"JAMA"},{"key":"1801_CR2","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1177\/088307380201700802","volume":"17","author":"Friedman","year":"2002","unstructured":"Friedman JM (2002) Neurofibromatosis 1: clinical manifestations and diagnostic criteria. J Child Neurol 17:548\u2013554","journal-title":"J Child Neurol"},{"key":"1801_CR3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/01241398-198601000-00015","volume":"6","author":"Crawford","year":"1986","unstructured":"Crawford AH Jr, Bagamery N (1986) Osseous manifestations of neurofibromatosis in childhood. J Pediatr Orthop 6:72\u201388","journal-title":"J Pediatr Orthop"},{"key":"1801_CR4","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s002340000455","volume":"43","author":"Jacquemin","year":"2001","unstructured":"Jacquemin C, Mullaney P, Bosley TM (2001) Abnormal development of the lesser wing of the sphenoid with microphthalmos and microcephaly. Neuroradiology 43:178\u201382","journal-title":"Neuroradiology"},{"key":"1801_CR5","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/(SICI)1096-8628(19970516)70:2<138::AID-AJMG7>3.0.CO;2-U","volume":"70","author":"Friedman","year":"1997","unstructured":"Friedman JM, Birch PH (1997) Type 1 neurofibromatosis: a descriptive analysis of the disorder in 1,728 patients. Am J Med Genet 70:138\u2013143","journal-title":"Am J Med Genet"},{"key":"1801_CR6","unstructured":"Huson SM (1994) Neurofibromatoses 1: a pathogenetic and clinical overview. In: Huson SM, Hughes RAC (eds) The neurofibromatoses: a pathogenetic and clinical overview 7. Chapman & Hall Medical, London, pp 160\u2013203"},{"key":"1801_CR7","doi-asserted-by":"crossref","first-page":"E43","DOI":"10.1136\/jmg.37.12.e43","volume":"37","author":"Poyhonen","year":"2000","unstructured":"Poyhonen M (2000) A clinical assessment of neurofibromatosis type 1 (NF1) and segmental NF in northern Finland. J Med Genet 37:E43","journal-title":"J Med Genet"},{"key":"1801_CR8","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1097\/00007632-199712010-00014","volume":"22","author":"Kim","year":"1997","unstructured":"Kim HW, Weinstein SL (1997) Spine update. The management of scoliosis in neurofibromatosis. Spine 22:2770\u20132776","journal-title":"Spine"},{"key":"1801_CR9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/01202412-200001000-00003","volume":"9","author":"Hefti","year":"2000","unstructured":"Hefti F, Bollini G, Dungl P, Fixsen J, Grill F, Ippolito E, Romanus B, Tudisco C, Wientroub S (2000) Congenital pseudarthrosis of the tibia: history, etiology, classification, and epidemiologic data. J Pediatr Orthop B 9:11\u201315","journal-title":"J Pediatr Orthop B"},{"key":"1801_CR10","doi-asserted-by":"crossref","first-page":"9658","DOI":"10.1073\/pnas.88.21.9658","volume":"88","author":"Gutmann","year":"1991","unstructured":"Gutmann DH, Wood DL, Collins FS (1991) Identification of the neurofibromatosis type 1 gene product. Proc Natl Acad Sci U S A 88:9658\u20139662","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1801_CR11","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0888-7543(91)90017-9","volume":"11","author":"Marchuk","year":"1991","unstructured":"Marchuk DA, Saulino AM, Tavakkol R, Swaroop M, Wallace MR, Andersen LB, Mitchell AL, Gutmann DH, Boguski M, Collins FS (1991) cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product. Genomics 11:931\u2013940","journal-title":"Genomics"},{"key":"1801_CR12","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0896-6273(92)90270-N","volume":"8","author":"Daston","year":"1992","unstructured":"Daston MM, Scrable H, Nordlund M, Sturbaum AK, Nissen LM, Ratner N (1992) The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes. Neuron 8:415\u2013428","journal-title":"Neuron"},{"key":"1801_CR13","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1006\/dbio.1994.1052","volume":"161","author":"Huynh","year":"1994","unstructured":"Huynh DP, Nechiporuk T, Pulst SM (1994) Differential expression and tissue distribution of type I and type II neurofibromins during mouse fetal development. Dev Biol 161:538\u2013551","journal-title":"Dev Biol"},{"key":"1801_CR14","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1359\/JBMR.040130","volume":"19","author":"Kuorilehto","year":"2004","unstructured":"Kuorilehto T, Nissinen M, Koivunen J, Benson MD, Peltonen J (2004) NF1 tumor suppressor protein and mRNA in skeletal tissues of developing and adult normal mouse and NF1-deficient embryos. J Bone Miner Res 19:983\u2013989","journal-title":"J Bone Miner Res"},{"key":"1801_CR15","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s001980170032","volume":"12","author":"Illes","year":"2001","unstructured":"Illes T, Halmai V, de Jonge T, Dubousset J (2001) Decreased bone mineral density in neurofibromatosis-1 patients with spinal deformities. Osteoporos Int 12:823\u2013827","journal-title":"Osteoporos Int"},{"key":"1801_CR16","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1001\/jama.288.15.1889","volume":"288","author":"Cummings","year":"2002","unstructured":"Cummings SR, Bates D, Black DM (2002) Clinical use of bone densitometry: scientific review. JAMA 288:1889\u20131897","journal-title":"JAMA"},{"key":"1801_CR17","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650090802","volume":"9","author":"Kanis","year":"1994","unstructured":"Kanis JA, Melton LJ 3rd, Christiansen C, Johnston CC, Khaltaev N (1994) The diagnosis of osteoporosis. J Bone Miner Res 9:1137\u20131141","journal-title":"J Bone Miner Res"},{"key":"1801_CR18","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1136\/jmg.37.8.632","volume":"37","author":"Poyhonen","year":"2000","unstructured":"Poyhonen M, Kytola S, Leisti J (2000) Epidemiology of neurofibromatosis type 1 (NF1) in northern Finland. J Med Genet 37:632\u2013636","journal-title":"J Med Genet"},{"key":"1801_CR19","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1001\/jama.279.6.440","volume":"279","author":"Kujala","year":"1998","unstructured":"Kujala UM, Kaprio J, Sarna S, Koskenvuo M (1998) Relationship of leisure-time physical activity and mortality: the Finnish twin cohort. JAMA 279:440\u2013444","journal-title":"JAMA"},{"key":"1801_CR20","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s001980070020","volume":"11","author":"Heaney","year":"2000","unstructured":"Heaney RP, Abrams S, Dawson-Hughes B, Looker A, Marcus R, Matkovic V, Weaver C (2000) Peak bone mass. Osteoporos Int 11:985\u20131009","journal-title":"Osteoporos Int"},{"key":"1801_CR21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s007740300003","volume":"21","author":"Douchi","year":"2003","unstructured":"Douchi T, Kuwahata R, Matsuo T, Uto H, Oki T, Nagata Y (2003) Relative contribution of lean and fat mass component to bone mineral density in males. J Bone Miner Metab 21:17\u201321","journal-title":"J Bone Miner Metab"},{"key":"1801_CR22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jpeds.2003.08.054","volume":"144","author":"Gafni","year":"2004","unstructured":"Gafni RI, Baron J (2004) Overdiagnosis of osteoporosis in children due to misinterpretation of dual-energy X-ray absorptiometry (DEXA). J Pediatr 144:253\u2013257","journal-title":"J Pediatr"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-004-1801-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-004-1801-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-004-1801-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T15:03:52Z","timestamp":1558623832000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-004-1801-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,16]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["1801"],"URL":"https:\/\/doi.org\/10.1007\/s00198-004-1801-4","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,16]]}}}