{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:46:21Z","timestamp":1761518781258},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2005,3,22]],"date-time":"2005-03-22T00:00:00Z","timestamp":1111449600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1007\/s00198-005-1865-9","type":"journal-article","created":{"date-parts":[[2005,3,21]],"date-time":"2005-03-21T12:03:03Z","timestamp":1111406583000},"page":"1519-1524","source":"Crossref","is-referenced-by-count":64,"title":["The influence of Lys3Asn polymorphism in the osteoprotegerin gene on bone mineral density in Chinese postmenopausal women"],"prefix":"10.1007","volume":"16","author":[{"given":"Hong-yan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-ju","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian-zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-hao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man-yin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. G.","family":"Uitterlinden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-lun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,3,22]]},"reference":[{"key":"1865_CR1","doi-asserted-by":"crossref","unstructured":"Giguere Y, Rousseau F (2000) The genetics of osteoporosis: \u201ccomplexities and difficulties.\u201d Clin Genet 57:161\u2013169","DOI":"10.1034\/j.1399-0004.2000.570301.x"},{"key":"1865_CR2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/367284a0","volume":"367","author":"Morrison","year":"1994","unstructured":"Morrison NA, Qi JC, Tokita A, et al (1994) Prediction of bone density from vitamin D receptor alleles. Nature 367:284\u2013287","journal-title":"Nature"},{"key":"1865_CR3","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/jbmr.5650110908","volume":"11","author":"Uitterlinden","year":"1996","unstructured":"Uitterlinden AG, Pols HAP, Burger H, et al (1996) A large-scale population-based study of the association of vitamin D receptor gene polymorphisms with bone mineral density. J Bone Miner Res 11:1242\u20131248","journal-title":"J Bone Miner Res"},{"key":"1865_CR4","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/jbmr.5650110304","volume":"11","author":"Kobayashi","year":"1996","unstructured":"Kobayashi S, Inoue S, Hosoi T, et al (1996) Association of bone mineral density with polymorphism of the estrogen receptor gene. J Bone Miner Res 11:306\u2013311","journal-title":"J Bone Miner Res"},{"key":"1865_CR5","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/hmg\/ddg176","volume":"12","author":"van","year":"2003","unstructured":"van Meurs JB, Schuit SC, Weel AE, et al (2003) Association of 5\u2019 estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk. Hum Mol Genet 12:1745\u20131754","journal-title":"Hum Mol Genet"},{"key":"1865_CR6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/ng1096-203","volume":"14","author":"Grant","year":"1996","unstructured":"Grant SFA, Reid DM, Blake G, et al (1996) Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I\u03b11 gene. Nat Genet 14:203\u2013205","journal-title":"Nat Genet"},{"key":"1865_CR7","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1056\/NEJM199804093381502","volume":"338","author":"Uitterlinden","year":"1998","unstructured":"Uitterlinden AG, Burger H, Huang Q, et al (1998) Relation of alleles of the collagen type I\u03b11 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. N Engl J Med 338:1016\u20131021","journal-title":"N Engl J Med"},{"key":"1865_CR8","first-page":"115","volume":"21","author":"Manolagas","year":"2000","unstructured":"Manolagas SC (2000) Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev 21:115\u2013137","journal-title":"Endocr Rev"},{"key":"1865_CR9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","volume":"93","author":"Lacey","year":"1998","unstructured":"Lacey DL, Timms E, Tan H-L, et al (1998) Osteoprotegerin (OPG) ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165\u2013176","journal-title":"Cell"},{"key":"1865_CR10","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/36593","volume":"390","author":"Anderson","year":"1997","unstructured":"Anderson MA, Maraskovsky E, Billingsley WL, et al (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390:175\u2013179","journal-title":"Nature"},{"key":"1865_CR11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","volume":"89","author":"Simonet","year":"1997","unstructured":"Simonet WS, Lacey DL, Dunstan CR, et al (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89:309\u2013319","journal-title":"Cell"},{"key":"1865_CR12","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1101\/gad.12.9.1260","volume":"12","author":"Bucay","year":"1998","unstructured":"Bucay N, Sarosi I, Dunstan CR, et al (1998) Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 12:1260\u20131268","journal-title":"Genes Dev"},{"key":"1865_CR13","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1006\/bbrc.1998.8697","volume":"247","author":"Mizuno","year":"1998","unstructured":"Mizuno A, Amizuka N, Irie K, et al (1998) Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor\/osteoprotegerin. Biochem Biophys Res Commun 247:610\u2013615","journal-title":"Biochem Biophys Res Commun"},{"key":"1865_CR14","unstructured":"Geneva:WHO (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO study group. WHO Technical Report Series, no. 843"},{"key":"1865_CR15","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1046\/j.1432-1327.1998.2540685.x","volume":"254","author":"Morinaga","year":"1998","unstructured":"Morinaga T, Nakagawa N, Yasuda H, et al (1998) Cloning and characterization of the gene encoding human osteoprotegerin\/osteoclastogenesis-inhibitory factor. Eur J Biochem 254:685\u2013691","journal-title":"Eur J Biochem"},{"key":"1865_CR16","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1359\/jbmr.2002.17.7.1245","volume":"17","author":"Langdahl","year":"2002","unstructured":"Langdahl B, Carstens M, Stenkjaer L, et al (2002) Polymorphisms in the osteoprotegerin gene are associated with osteoporotic fractures. J Bone Miner Res 17:1245\u20131255","journal-title":"J Bone Miner Res"},{"key":"1865_CR17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s100380200058","volume":"47","author":"Ohmori","year":"2002","unstructured":"Ohmori H, Makita Y, Funamizu M, et al (2002) Linkage and association analyses of the osteoprotegerin gene locus with human osteoporosis. J Hum Genet 47:400\u2013406","journal-title":"J Hum Genet"},{"key":"1865_CR18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00223-001-2081-z","volume":"71","author":"Wynne","year":"2002","unstructured":"Wynne F, Drummond F, O\u2019Sullivan K, et al (2002) Investigation of the genetic influence of the OPG, VDR(Fok1), and COLIA1 Sp1 polymorphisms on BMD in the Irish population. Calcif Tissue Int 71:26\u201335","journal-title":"Calcif Tissue Int"},{"key":"1865_CR19","doi-asserted-by":"crossref","first-page":"35749","DOI":"10.1074\/jbc.274.50.35749","volume":"274","author":"Nakajima","year":"1999","unstructured":"Nakajima T, Cheng T, Rohrwasser A, et al (1999) Functional analysis of a mutation occurring between the two in-frame AUG codons of human angiotensinogen. J Biol Chem 274:35749\u201335755","journal-title":"J Biol Chem"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-005-1865-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-005-1865-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-005-1865-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T03:51:08Z","timestamp":1706068268000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-005-1865-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,22]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["1865"],"URL":"https:\/\/doi.org\/10.1007\/s00198-005-1865-9","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,22]]}}}