{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T03:04:29Z","timestamp":1770779069975,"version":"3.50.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T00:00:00Z","timestamp":1163462400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2007,2,28]]},"DOI":"10.1007\/s00198-006-0251-6","type":"journal-article","created":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T18:09:35Z","timestamp":1163441375000},"page":"445-451","source":"Crossref","is-referenced-by-count":28,"title":["Adult-type hypolactasia and calcium availability: decreased calcium intake or impaired calcium absorption?"],"prefix":"10.1007","volume":"18","author":[{"given":"B. M.","family":"Obermayer-Pietsch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gugatschka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Reitter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Plank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Strele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Walter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bonelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Goessler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Dobnig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"H\u00f6genauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Renner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fahrleitner-Pammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,11,14]]},"reference":[{"key":"251_CR1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/00365529409091740","volume":"202","author":"T Sahi","year":"1994","unstructured":"Sahi T (1994) Genetics and epidemiology of adult-type hypolactasia. Scand J Gastroenterol 202:7\u201320","journal-title":"Scand J Gastroenterol"},{"issue":"2","key":"251_CR2","doi-asserted-by":"crossref","first-page":"198S","DOI":"10.1080\/07315724.2001.10719032","volume":"20","author":"KA Jackson","year":"2001","unstructured":"Jackson KA, Savaiano DA (2001) Lactose maldigestion, calcium intake and osteoporosis in African-, Asian- and Hispanic-Americans. J Am Coll Nutr 20(2):198S\u2013270S","journal-title":"J Am Coll Nutr"},{"issue":"8","key":"251_CR3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1056\/NEJM196702232760805","volume":"276","author":"SJ Birge Jr","year":"1967","unstructured":"Birge SJ Jr, Keutmann HT, Cuatrecasas P, Whedon GD (1967) Osteoporosis, intestinal lactase deficiency and low dietary calcium intake. N Engl J Med 276(8):445\u2013448","journal-title":"N Engl J Med"},{"issue":"12","key":"251_CR4","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/jbmr.5650061214","volume":"6","author":"CW Slemenda","year":"1991","unstructured":"Slemenda CW, Christian JC, Hui S, Fitzgerald J, Johnston CC Jr (1991) No evidence for an effect of lactase deficiency on bone mass in pre- or postmenopausal women. J Bone Miner Res 6(12):1367\u20131371","journal-title":"J Bone Miner Res"},{"issue":"6","key":"251_CR5","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S8756-3282(97)00172-5","volume":"21","author":"R Honkanen","year":"1997","unstructured":"Honkanen R, Kroger H, Alhava E, Turpeinen P, Tuppurainen M, Saarikoski S (1997) Lactose intolerance associated with fractures of weight-bearing bones in Finnish women aged 38\u201357\u00a0years. Bone 21(6):473\u2013477","journal-title":"Bone"},{"key":"251_CR6","unstructured":"National Institutes of Health Consensus Statement (1994) Optimal calcium intake. Bethesda, MD: National Institutes of Health 94:6\u20138; 12:1\u201331"},{"key":"251_CR7","doi-asserted-by":"crossref","first-page":"83S","DOI":"10.1080\/07315724.2000.10718088","volume":"19","author":"RP Heaney","year":"2000","unstructured":"Heaney RP (2000) Calcium, dairy products and osteoporosis. J Am Coll Nutr 19:83S\u201399S","journal-title":"J Am Coll Nutr"},{"issue":"1","key":"251_CR8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1359\/jbmr.0301207","volume":"19","author":"BM Obermayer-Pietsch","year":"2004","unstructured":"Obermayer-Pietsch BM, Bonelli CM, Walter DE, Kuhn R, Fahrleitner-Pammer A, Berghold A, Goessler W, Stepan V, Dobnig H, Leb G, Renner W (2004) Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures. J Bone Miner Res 19(1):42\u201347","journal-title":"J Bone Miner Res"},{"issue":"2","key":"251_CR9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/ng826","volume":"30","author":"NS Enattah","year":"2002","unstructured":"Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Jarvela I (2002) Identification of a variant associated with adult-type hypolactasia. Nat Genet 30(2):233\u2013237","journal-title":"Nat Genet"},{"issue":"5","key":"251_CR10","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/gut.52.5.647","volume":"52","author":"M Kuokkanen","year":"2003","unstructured":"Kuokkanen M, Enattah NS, Oksanen A, Savilahti E, Orpana A, Jarvela I (2003) Transcriptional regulation of thelactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia. Gut 52(5):647\u2013652","journal-title":"Gut"},{"issue":"3","key":"251_CR11","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/00042737-200503000-00018","volume":"17","author":"C H\u00f6genauer","year":"2005","unstructured":"H\u00f6genauer C, Hammer HF, Mellitzer K, Renner W, Krejs GJK, Toplak H (2005) Evaluation of a new DNA test compared with the lactose hydrogen breath test for the diagnosis of lactase non-persistence. Eur J Gastroenterol Hepatol 17(3):371\u2013376","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"6","key":"251_CR12","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1172\/JCI114927","volume":"86","author":"HF Hammer","year":"1990","unstructured":"Hammer HF, Fine KD, Santa Ana CA, Porter JL, Schiller LR, Fordtran JS (1990) Carbohydrate malabsorption. Its measurement and its contribution to diarrhea. J Clin Invest 86(6):1936\u20131944","journal-title":"J Clin Invest"},{"issue":"10","key":"251_CR13","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1359\/JBMR.040802","volume":"19","author":"BM Obermayer-Pietsch","year":"2004","unstructured":"Obermayer-Pietsch BM, Bonelli CM, Walter DE, Kuhn R, Fahrleitner-Pammer A, Berghold A, Goessler W, Stepan V, Dobnig H, Leb G, Renner W (2004) Genetic components of lactose intolerance and community frequency. J Bone Miner Res 19(10):1747","journal-title":"J Bone Miner Res"},{"issue":"953","key":"251_CR14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1136\/pgmj.2004.025551","volume":"81","author":"SB Matthews","year":"2005","unstructured":"Matthews SB, Waud JP, Roberts AG, Campbell AK (2005) Systemic lactose intolerance: a new perspective of an old problem. Postgrad Med J 81(953):167\u2013173","journal-title":"Postgrad Med J"},{"issue":"6","key":"251_CR15","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/jn\/110.6.1101","volume":"10","author":"G Schaafsma","year":"1980","unstructured":"Schaafsma G, Visser R (1980) Nutritional interrelationships between calcium, phosphorus and lactose in rats. J Nutr 10(6):1101\u20131111","journal-title":"J Nutr"},{"issue":"4","key":"251_CR16","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/ajcn\/71.4.931","volume":"71","author":"A Zittermann","year":"2000","unstructured":"Zittermann A, Bock P, Drummer C, Scheld K, Heer M, Stehle P (2000) Lactose does not enhance calcium bioavailability in lactose-tolerant, healthy adults. Am J Clin Nutr 71(4):931\u2013936","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"251_CR17","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/clinchem\/40.2.257","volume":"40","author":"AJ Sips","year":"1994","unstructured":"Sips AJ, Netelenbos JC, Barto R, Lips P, van der Vijgh WJ (1994) One-hour test for estimating intestinal absorption of calcium by using stable strontium as a marker. Clin Chem 40(2):257\u2013259","journal-title":"Clin Chem"},{"issue":"3","key":"251_CR18","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1042\/cs0870363","volume":"87","author":"A Blumsohn","year":"1994","unstructured":"Blumsohn A, Morris B, Eastell R (1994) Stable strontium absorption as a measure of intestinal calcium absorption: comparison with the double-radiotracer calcium absorption test. Clin Sci (Lond) 87(3):363\u2013368","journal-title":"Clin Sci (Lond)"},{"issue":"5","key":"251_CR19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF02556611","volume":"38","author":"IR Reid","year":"1986","unstructured":"Reid IR, Pybus J, Lim TM, Hannon S, Ibbertson HK (1986) The assessment of intestinal calcium absorption using stable strontium. Calcif Tissue Int 38(5):303\u2013305","journal-title":"Calcif Tissue Int"},{"issue":"9","key":"251_CR20","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1210\/jc.2005-0636","volume":"90","author":"MJ Barger-Lux","year":"2005","unstructured":"Barger-Lux MJ, Heaney RP (2005) Calcium absorptive efficiency is positively related to body size. J Clin Endocrinol Metab 90(9):5118\u20135120","journal-title":"J Clin Endocrinol Metab"},{"key":"251_CR21","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0016-5085(83)90194-4","volume":"84","author":"B Cochet","year":"1983","unstructured":"Cochet B, Jung A, Griessen M, Bartholdi P, Schaller P, Donath A (1983) Effects of lactose on intestinal calcium absorption in normal and lactase-deficient subjects. Gastroenterology 84:935\u2013940","journal-title":"Gastroenterology"},{"issue":"4","key":"251_CR22","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/ajcn\/80.4.998","volume":"80","author":"BE Nordin","year":"2004","unstructured":"Nordin BE, Need AG, Morris HA, O\u2019Loughlin PD, Horowith M (2004) Effect of age on calcium absorption in postmenopausal women. Am J Clin Nutr 80(4):998\u20131002","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"251_CR23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/jbmr.5650040404","volume":"4","author":"RP Heaney","year":"1989","unstructured":"Heaney RP, Recker RR, Stegman MR, Moy AJ (1989) Calcium absorption in women: relationships to calcium intake, estrogen status, and age. J Bone Miner Res 4(4):469\u2013475","journal-title":"J Bone Miner Res"},{"issue":"11","key":"251_CR24","doi-asserted-by":"crossref","first-page":"4914","DOI":"10.1210\/jc.2002-020727","volume":"87","author":"JC Gallagher","year":"2002","unstructured":"Gallagher JC, RApuri PB, Haynatzki G, Detter JR (2002) Effect of discontinuation of estrogen, calcitriol, and the combination of both on bone density and bone markers. J Clin Endocrinol Metab 87(11):4914\u20134923","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"251_CR25","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1093\/jn\/133.3.852S","volume":"133","author":"B Dawson-Hughes","year":"2003","unstructured":"Dawson-Hughes B (2003) Interaction of dietary calcium and protein in bone health in humans. J Nutr 133(3):852\u2013854","journal-title":"J Nutr"},{"issue":"2","key":"251_CR26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1359\/jbmr.1999.14.2.215","volume":"14","author":"EA Krall","year":"1999","unstructured":"Krall EA, Dawson-Hughes B (1999) Smoking increases bone loss and decreases intestinal calcium absorption. J Bone Miner Res 14(2):215\u2013220","journal-title":"J Bone Miner Res"},{"issue":"12","key":"251_CR27","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1080\/003655201317097119","volume":"36","author":"M Stefano Di","year":"2001","unstructured":"Di Stefano M, Veneto G, Malservisi S, Strocchi A, Corazza GR (2001) Lactose malabsorption and intolerance in the elderly. Scand J Gastroenterol 36(12):1274\u20131278","journal-title":"Scand J Gastroenterol"},{"issue":"2","key":"251_CR28","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/ageing\/28.2.175","volume":"28","author":"A Goulding","year":"1999","unstructured":"Goulding A, Taylor RW, Keil D, Gold E, Lewis-Barned NJ, Williams SM (1999) Lactose malabsorption and rate of bone loss in older women. Age Ageing 28(2):175\u2013180","journal-title":"Age Ageing"},{"issue":"1","key":"251_CR29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1532-5415.2005.53014.x","volume":"53","author":"NS Enattah","year":"2005","unstructured":"Enattah NS, Sulkava R, Halonen P, Kontula K, Jarvela I (2005) Genetic variant of lactase-persistent C\/T-13910 is associated with bone fractures in very old age. J Am Geriatr Soc 53(1):79\u201382","journal-title":"J Am Geriatr Soc"},{"issue":"S1","key":"251_CR30","first-page":"128","volume":"74","author":"BM Obermayer-Pietsch","year":"2004","unstructured":"Obermayer-Pietsch BM, Bonelli CM, Walter DE, Kuhn R, Fahrleitner-Pammer A, Berghold A, Goessler W, Stepan V, Dobnig H, Leb G, Renner W (2004) Genetic disposition for adult lactose intolerance and relation to bone properties and fractures during lifetime. Calcif Tissue Int 74(S1):128","journal-title":"Calcif Tissue Int"},{"issue":"6","key":"251_CR31","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s00223-004-0029-9","volume":"75","author":"N Enattah","year":"2004","unstructured":"Enattah N, Valimaki VV, Valimaki MJ, Loyttyniemi E, Sahi T, Jarvela I (2004) Mlecularly defined lactose malabsorption, peak bone mass and bone turnover rate in young finnish men. Calcif Tissue Int 75(6):488\u2013493","journal-title":"Calcif Tissue Int"},{"issue":"10","key":"251_CR32","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/sj.ejcn.1602219","volume":"9","author":"N Enattah","year":"2005","unstructured":"Enattah N, Pekkarinen T, Valimaki MJ, Loyttyniemi E, Jarvela I (2005) Genetically defined adult-type hypolactasia and self-reported lactose intolerance as risk factors of osteoporosis in Finnish postmenopausal women. Eur J Clin Nutr 9(10):1105\u20131111","journal-title":"Eur J Clin Nutr"},{"issue":"1","key":"251_CR33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3148\/66.1.2005.25","volume":"6","author":"MR French","year":"2005","unstructured":"French MR, Moore K, Vernace-Inserra F, Hawker GA (2005) Factors that influence adherence to calcium recommendations. Can J Diet Pract Res 6(1):25\u201329","journal-title":"Can J Diet Pract Res"},{"issue":"12","key":"251_CR34","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/qjmed\/hci140","volume":"98","author":"M Gugatschka","year":"2005","unstructured":"Gugatschka M, Dobnig H, Fahrleitner-Pammer A, Pietschmann P, Kudlacek S, Strele A, Obermayer-Pietsch B (2005) Molecularly-defined lactose malabsorption, milk consumption and anthropometric differences in adult males. QJM 98(12):857\u2013863","journal-title":"QJM"},{"issue":"7","key":"251_CR35","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00198-004-1755-6","volume":"16","author":"JA Kanis","year":"2005","unstructured":"Kanis JA, Johansson H, Oden A, De Laet C, Johnell O, Eisman JA, McCloskey E, Mellstrom D, Pols H, Reeve J, Silman A, Tenenhouse A (2005) A meta-analysis of milk intake and fracture risk: low utility for case finding. Osteoporosis Int 16(7):799\u2013804","journal-title":"Osteoporosis Int"},{"issue":"9","key":"251_CR36","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1210\/jc.2004-0924","volume":"90","author":"D Teegarden","year":"2005","unstructured":"Teegarden D, Legowski P, Gunther CW, McCabe GP, Peacock M, Lyle RM (2005) Dietary calcium intake protects women consuming oral contraceptives from spine and hip bone loss. J Clin Endocrinol Metab 90(9):5127\u20135133","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"251_CR37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0002-8223(96)00074-0","volume":"96","author":"SR Hertzler","year":"1996","unstructured":"Hertzler SR, Huynh BC, Savaiano DA (1996) How much lactose is low lactose? J Am Diet Assoc 96(3):243\u2013246","journal-title":"J Am Diet Assoc"},{"issue":"7","key":"251_CR38","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1080\/00365520510015764","volume":"40","author":"P Ridefelt","year":"2005","unstructured":"Ridefelt P, Hakansson LD (2005) Lactose intolerance: lactose tolerance test versus genotyping. Scand J Gastroenterol 40(7):822\u2013826","journal-title":"Scand J Gastroenterol"},{"issue":"9319","key":"251_CR39","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","volume":"359","author":"SR Cummings","year":"2002","unstructured":"Cummings SR, Melton LJ III (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359(9319):1761\u20131767","journal-title":"Lancet"},{"issue":"5","key":"251_CR40","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1054\/mehy.1999.0992","volume":"54","author":"S Seely","year":"2000","unstructured":"Seely S (2000) Possible connection between milk and coronary heart disease: the calcium hypothesis. Med Hypotheses 54(5):701\u2013703","journal-title":"Med Hypotheses"},{"issue":"5","key":"251_CR41","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/gut.2004.055939","volume":"54","author":"H Rasinpera","year":"2005","unstructured":"Rasinpera H, Forsblom C, Enattah NS, Halonen P, Salo K, Victorzon M, Mecklin JP, Jarvinen H, Enholm S, Sellick G, Alazzouzi H, Houlston R, Robinson J, Groop PH, Tomlinson I, Schwartz S Jr, Aaltonen LA, Jarvela I, FinnDiane Study Group (2005) The C\/C-13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population. Gut 54(5):643\u2013647","journal-title":"Gut"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-006-0251-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-006-0251-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-006-0251-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:11:45Z","timestamp":1587255105000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-006-0251-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,14]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,2,28]]}},"alternative-id":["251"],"URL":"https:\/\/doi.org\/10.1007\/s00198-006-0251-6","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,14]]}}}