{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:23:33Z","timestamp":1761128613527},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2007,7,10]],"date-time":"2007-07-10T00:00:00Z","timestamp":1184025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2007,10,17]]},"DOI":"10.1007\/s00198-007-0401-5","type":"journal-article","created":{"date-parts":[[2007,7,16]],"date-time":"2007-07-16T20:24:08Z","timestamp":1184617448000},"page":"1683-1692","source":"Crossref","is-referenced-by-count":9,"title":["Family-based association study of ROR2 polymorphisms with an array of radiographic hand bone strength phenotypes"],"prefix":"10.1007","volume":"18","author":[{"given":"S.","family":"Ermakov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Malkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Keter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Kobyliansky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Livshits","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,7,10]]},"reference":[{"key":"401_CR1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ajog.2005.08.047","volume":"194","author":"NE Lane","year":"2006","unstructured":"Lane NE (2006) Epidemiology, etiology, and diagnosis of osteoporosis. Am J Obstet Gynecol 194:3\u201311","journal-title":"Am J Obstet Gynecol"},{"key":"401_CR2","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1210\/edrv.20.6.0384","volume":"20","author":"JA Eisman","year":"1999","unstructured":"Eisman JA (1999) Genetics of osteoporosis. Endocr Rev 20:788\u2013804","journal-title":"Endocr Rev"},{"key":"401_CR3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1210\/edrv.23.3.0464","volume":"23","author":"M Peacock","year":"2002","unstructured":"Peacock M, Turner CH, Econs MJ et al (2002) Genetics of osteoporosis. Endocr Rev 23:303\u2013326","journal-title":"Endocr Rev"},{"key":"401_CR4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.mad.2004.08.020","volume":"126","author":"G Livshits","year":"2005","unstructured":"Livshits G (2005) Genetic epidemiology of skeletal system aging in apparently healthy human population. Mech Ageing Dev 126:269\u2013279","journal-title":"Mech Ageing Dev"},{"key":"401_CR5","first-page":"16","volume":"6","author":"AG Uitterlinden","year":"2006","unstructured":"Uitterlinden AG, van Meurs JB, Rivadeneira F et al (2006) Identifying genetic risk factors for osteoporosis. J Musculoskelet Neuronal Interact 6:16\u201326","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"401_CR6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/73488","volume":"24","author":"TM DeChiara","year":"2000","unstructured":"DeChiara TM, Kimble RB, Poueymirou WT et al (2000) Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development. Nat Genet 24:271\u2013274","journal-title":"Nat Genet"},{"key":"401_CR7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1210\/me.2004-0153","volume":"19","author":"J Billiard","year":"2005","unstructured":"Billiard J, Way DS, Seestaller-Wehr LM et al (2005) The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells. Mol Endocrinol 19:90\u2013101","journal-title":"Mol Endocrinol"},{"key":"401_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/humu.10233","volume":"22","author":"AR Afzal","year":"2003","unstructured":"Afzal AR, Jeffery S (2003) One gene, two phenotypes: ROR2 mutations in autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B. Hum Mutat 22:1\u201311","journal-title":"Hum Mutat"},{"key":"401_CR9","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1136\/jmg.39.5.305","volume":"39","author":"MA Patton","year":"2002","unstructured":"Patton MA, Afzal AR (2002) Robinow syndrome. J Med Genet 39:305\u2013310","journal-title":"J Med Genet"},{"key":"401_CR10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1046\/j.1365-2443.2000.00300.x","volume":"5","author":"S Takeuchi","year":"2000","unstructured":"Takeuchi S, Takeda K, Oishi I et al (2000) Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes Cells 5:71\u201378","journal-title":"Genes Cells"},{"key":"401_CR11","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1086\/303084","volume":"67","author":"GC Schwabe","year":"2000","unstructured":"Schwabe GC, Tinschert S, Buschow C et al (2000) Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B. Am J Hum Genet 67:822\u2013831","journal-title":"Am J Hum Genet"},{"key":"401_CR12","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1046\/j.1529-8817.2003.00117.x","volume":"68","author":"YZ Liu","year":"2004","unstructured":"Liu YZ, Xu FH, Shen H et al (2004) Genetic dissection of human stature in a large sample of multiplex pedigrees. Ann Hum Genet 68:472\u2013488","journal-title":"Ann Hum Genet"},{"key":"401_CR13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00439-006-0136-y","volume":"119","author":"YZ Liu","year":"2006","unstructured":"Liu YZ, Xiao P, Guo YF et al (2006) Genetic linkage of human height is confirmed to 9q22 and Xq24. Hum Genet 119:295\u2013304","journal-title":"Hum Genet"},{"key":"401_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1359\/jbmr.2002.17.1.152","volume":"17","author":"G Livshits","year":"2002","unstructured":"Livshits G, Karasik D, Kobyliansky E (2002) Complex segregation analysis of the radiographic phalanges bone mineral density and their age related changes. J Bone Miner Res 17:1\u201310","journal-title":"J Bone Miner Res"},{"key":"401_CR15","doi-asserted-by":"crossref","unstructured":"Malkin I, Bigman G, Matias R et al (2006) Age-related changes of bone strength phenotypes: observational follow-up study of hand bone mineral density. Osteoporos Int 12; Epub ahead of print","DOI":"10.1007\/s00198-006-0233-8"},{"key":"401_CR16","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s001980050031","volume":"7","author":"ML Bouxsein","year":"1997","unstructured":"Bouxsein ML, Michaeli DA, Plass DB et al (1997) Precision and accuracy of computed digital absorptiometry for assessment of bone density of the hand. Osteoporos Int 7:444\u2013449","journal-title":"Osteoporos Int"},{"key":"401_CR17","unstructured":"Malkin I, Ginsburg E (2003) Program package for Mendelian analysis of pedigree data (MAN, Version 6). Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University; Technical Report"},{"key":"401_CR18","volume-title":"The genetic basis of evolutionary change","author":"R Lewontin","year":"1974","unstructured":"Lewontin R (1974) The genetic basis of evolutionary change. Columbia University Press, New York"},{"key":"401_CR19","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s001980070037","volume":"11","author":"LJ Melton 3rd","year":"2000","unstructured":"Melton LJ 3rd, Khosla S, Achenbach SJ et al (2000) Effects of body size and skeletal site on the estimated prevalence of osteoporosis in women and men. Osteoporos Int 11:977\u2013983","journal-title":"Osteoporos Int"},{"key":"401_CR20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000076635","volume":"61","author":"E Schoenau","year":"2004","unstructured":"Schoenau E, Saggese G, Peter F et al (2004) From bone biology to bone analysis. Horm Res 61:257\u2013269","journal-title":"Horm Res"},{"key":"401_CR21","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1080\/03014460110075729","volume":"29","author":"I Malkin","year":"2002","unstructured":"Malkin I, Karasik D, Livshits G et al (2002) Modeling of age related bone loss using cross-sectional data. Ann Hum Biol 29:256\u2013270","journal-title":"Ann Hum Biol"},{"key":"401_CR22","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/sj.ijo.0800511","volume":"21","author":"T Rice","year":"1997","unstructured":"Rice T, Despr\u00e9s JP, Daw EW et al (1997) Familial resemblance for abdominal visceral fat: the HERITAGE family study. Int J Obes Relat Metab Disord 21:1024\u20131031","journal-title":"Int J Obes Relat Metab Disord"},{"key":"401_CR23","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/sj.ejhg.5200625","volume":"9","author":"S Horvath","year":"2001","unstructured":"Horvath S, Xu X, Laird NM (2001) The family based association test method: strategies for studying general genotype-phenotype associations. Eur J Hum Genet 9:301\u2013306","journal-title":"Eur J Hum Genet"},{"key":"401_CR24","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/gepi.10180","volume":"23","author":"I Malkin","year":"2002","unstructured":"Malkin I, Ginsburg E, Elston RC (2002) Increase in power of transmission disequilibrium tests for quantitative traits. Genet Epidemiol 23:234\u2013244","journal-title":"Genet Epidemiol"},{"key":"401_CR25","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1086\/302698","volume":"66","author":"GR Abecasis","year":"2000","unstructured":"Abecasis GR, Cardon LR, Cookson WS (2000) A general test of association for quantitative traits in nuclear families. Am J Hum Genet 66:279\u2013292","journal-title":"Am J Hum Genet"},{"key":"401_CR26","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.bone.2004.09.002","volume":"36","author":"I Malkin","year":"2005","unstructured":"Malkin I, Dahm S, Suk A et al (2005) Association of ANKH gene polymorphisms with radiographic hand bone size and geometry in a Chuvasha population. Bone 36:365\u2013373","journal-title":"Bone"},{"key":"401_CR27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s00439-006-0173-6","volume":"120","author":"I Malkin","year":"2006","unstructured":"Malkin I, Ermakov S, Kobyliansky E et al (2006) Strong association between polymorphisms in ANKH locus and skeletal size traits. Hum Genet 120:42\u201351","journal-title":"Hum Genet"},{"key":"401_CR28","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1214\/aos\/1013699998","volume":"29","author":"Y Benjamini","year":"2001","unstructured":"Benjamini Y, Yekutieli D (2001) The control of the false discovery rate in multiple testing under dependency. Ann Stat 29:1165\u20131188","journal-title":"Ann Stat"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-007-0401-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-007-0401-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-007-0401-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T15:00:50Z","timestamp":1558623650000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-007-0401-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,10]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,10,17]]}},"alternative-id":["401"],"URL":"https:\/\/doi.org\/10.1007\/s00198-007-0401-5","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,10]]}}}