{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:15:44Z","timestamp":1784265344243,"version":"3.55.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,4,17]],"date-time":"2009-04-17T00:00:00Z","timestamp":1239926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1007\/s00198-009-0931-0","type":"journal-article","created":{"date-parts":[[2009,4,16]],"date-time":"2009-04-16T08:08:48Z","timestamp":1239869328000},"page":"109-118","source":"Crossref","is-referenced-by-count":70,"title":["Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study"],"prefix":"10.1007","volume":"21","author":[{"given":"J.","family":"Velasco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"Zarrabeitia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Perez-Castrillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. D.","family":"Perez-Aguilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. I.","family":"Perez-Nu\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Sa\u00f1udo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hernandez-Elena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gonzalez-Macias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Riancho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,4,17]]},"reference":[{"key":"931_CR1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/art.23159","volume":"58","author":"C Sanchez","year":"2008","unstructured":"Sanchez C, Deberg MA, Bellahcene A et al (2008) Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone. Arthritis Rheum 58:442\u2013455","journal-title":"Arthritis Rheum"},{"key":"931_CR2","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/BF03327364","volume":"15","author":"J Dequeker","year":"2003","unstructured":"Dequeker J, Aerssens J, Luyten FP (2003) Osteoarthritis and osteoporosis: clinical and research evidence of inverse relationship. Aging Clin Exp Res 15:426\u2013439","journal-title":"Aging Clin Exp Res"},{"key":"931_CR3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1086\/338450","volume":"70","author":"RD Little","year":"2002","unstructured":"Little RD, Carulli JP, Del Mastro RG et al (2002) A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet 70:11\u201319","journal-title":"Am J Hum Genet"},{"key":"931_CR4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nm0207-133","volume":"13","author":"SR Goldring","year":"2007","unstructured":"Goldring SR, Goldring MB (2007) Eating bone or adding it: the Wnt pathway decides. Nat Med 13:133\u2013134","journal-title":"Nat Med"},{"key":"931_CR5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11914-007-0006-0","volume":"5","author":"R Baron","year":"2007","unstructured":"Baron R, Rawadi G (2007) Wnt signaling and the regulation of bone mass. Curr Osteoporos Rep 5:73\u201380","journal-title":"Curr Osteoporos Rep"},{"key":"931_CR6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0002-9440(10)62957-4","volume":"167","author":"Y Nakamura","year":"2005","unstructured":"Nakamura Y, Nawata M, Wakitani S (2005) Expression profiles and functional analyses of Wnt-related genes in human joint disorders. Am J Pathol 167:97\u2013105","journal-title":"Am J Pathol"},{"key":"931_CR7","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1002\/art.23139","volume":"56","author":"M Corr","year":"2007","unstructured":"Corr M, Lane NE (2007) FRZB: a bone and joint connection. Arthritis Rheum 56:3881\u20133883","journal-title":"Arthritis Rheum"},{"key":"931_CR8","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/labinvest.3700747","volume":"88","author":"T Yuasa","year":"2008","unstructured":"Yuasa T, Otani T, Koike T et al (2008) Wnt\/beta-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration. Lab Invest 88:264\u2013274","journal-title":"Lab Invest"},{"key":"931_CR9","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.bbrc.2006.05.075","volume":"345","author":"K Imai","year":"2006","unstructured":"Imai K, Morikawa M, D'Armiento J et al (2006) Differential expression of WNTs and FRPs in the synovium of rheumatoid arthritis and osteoarthritis. Biochem Biophys Res Commun 345:1615\u20131620","journal-title":"Biochem Biophys Res Commun"},{"key":"931_CR10","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1002\/art.23137","volume":"56","author":"RJ Lories","year":"2007","unstructured":"Lories RJ, Peeters J, Bakker A et al (2007) Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum 56:4095\u20134103","journal-title":"Arthritis Rheum"},{"key":"931_CR11","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/art.21673","volume":"54","author":"NE Lane","year":"2006","unstructured":"Lane NE, Lian K, Nevitt MC et al (2006) Frizzled-related protein variants are risk factors for hip osteoarthritis. Arthritis Rheum 54:1246\u20131254","journal-title":"Arthritis Rheum"},{"key":"931_CR12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00774-007-0757-9","volume":"25","author":"T Urano","year":"2007","unstructured":"Urano T, Narusawa K, Shiraki M et al (2007) Association of a single nucleotide polymorphism in the WISP1 gene with spinal osteoarthritis in postmenopausal Japanese women. J Bone Miner Metab 25:253\u2013258","journal-title":"J Bone Miner Metab"},{"key":"931_CR13","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/art.20993","volume":"52","author":"JL Min","year":"2005","unstructured":"Min JL, Meulenbelt I, Riyazi N et al (2005) Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. Arthritis Rheum 52:1077\u20131080","journal-title":"Arthritis Rheum"},{"key":"931_CR14","doi-asserted-by":"crossref","first-page":"9757","DOI":"10.1073\/pnas.0403456101","volume":"101","author":"J Loughlin","year":"2004","unstructured":"Loughlin J, Dowling B, Chapman K et al (2004) Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci USA 101:9757\u20139762","journal-title":"Proc Natl Acad Sci USA"},{"key":"931_CR15","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.joca.2005.01.008","volume":"13","author":"AJ Smith","year":"2005","unstructured":"Smith AJ, Gidley J, Sandy JR et al (2005) Haplotypes of the low-density lipoprotein receptor-related protein 5 (LRP5) gene: are they a risk factor in osteoarthritis? Osteoarthritis Cartilage 13:608\u2013613","journal-title":"Osteoarthritis Cartilage"},{"key":"931_CR16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/rheumatology\/kei148","volume":"45","author":"RJ Lories","year":"2006","unstructured":"Lories RJ, Boonen S, Peeters J et al (2006) Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosis. Rheumatology (Oxford) 45:113\u2013114","journal-title":"Rheumatology (Oxford)"},{"key":"931_CR17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3109\/17453679908997826","volume":"70","author":"KB Jonsson","year":"1999","unstructured":"Jonsson KB, Frost A, Nilsson O et al (1999) Three isolation techniques for primary culture of human osteoblast-like cells: a comparison. Acta Orthop Scand 70:365\u2013373","journal-title":"Acta Orthop Scand"},{"key":"931_CR18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"JC Barrett","year":"2005","unstructured":"Barrett JC, Fry B, Maller J et al (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263\u2013265","journal-title":"Bioinformatics"},{"key":"931_CR19","doi-asserted-by":"crossref","first-page":"W621","DOI":"10.1093\/nar\/gkl071","volume":"34","author":"L Conde","year":"2006","unstructured":"Conde L, Vaquerizas JM, Dopazo H et al (2006) PupaSuite: finding functional single nucleotide polymorphisms for large-scale genotyping purposes. Nucleic Acids Res 34:W621\u2013W625","journal-title":"Nucleic Acids Res"},{"key":"931_CR20","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2105-6-86","volume":"6","author":"P Trivedi","year":"2005","unstructured":"Trivedi P, Edwards JW, Wang J et al (2005) HDBStat!: a platform-independent software suite for statistical analysis of high dimensional biology data. BMC Bioinformatics 6:86","journal-title":"BMC Bioinformatics"},{"key":"931_CR21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","volume":"125","author":"Y Benjamini","year":"2001","unstructured":"Benjamini Y, Drai D, Elmer G et al (2001) Controlling the false discovery rate in behavior genetics research. Behav Brain Res 125:279\u2013284","journal-title":"Behav Brain Res"},{"key":"931_CR22","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1534\/genetics.104.036699","volume":"171","author":"Y Benjamini","year":"2005","unstructured":"Benjamini Y, Yekutieli D (2005) Quantitative trait loci analysis using the false discovery rate. Genetics 171:783\u2013790","journal-title":"Genetics"},{"key":"931_CR23","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1002\/art.23500","volume":"58","author":"JL Hernandez","year":"2008","unstructured":"Hernandez JL, Garc\u00e9s CM, Sumillera M et al (2008) Aromatase expression in osteoarthritic and osteoporotic bone. Arthritis Rheum 58:1696\u20131700","journal-title":"Arthritis Rheum"},{"key":"931_CR24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","volume":"39","author":"F Faul","year":"2007","unstructured":"Faul F, Erdfelder E, Lang AG et al (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39:175\u2013191","journal-title":"Behav Res Methods"},{"key":"931_CR25","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1086\/383251","volume":"74","author":"DR Nyholt","year":"2004","unstructured":"Nyholt DR (2004) A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 74:765\u2013769","journal-title":"Am J Hum Genet"},{"key":"931_CR26","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.bone.2008.12.006","volume":"44","author":"FP Luyten","year":"2009","unstructured":"Luyten FP, Tylzanowski P, Lories RJ (2009) Wnt signaling and osteoarthritis. Bone 44:522\u2013527","journal-title":"Bone"},{"key":"931_CR27","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1186\/ar2301","volume":"9","author":"B Hopwood","year":"2007","unstructured":"Hopwood B, Tsykin A, Findlay DM et al (2007) Microarray gene expression profiling of human osteoarthritic bone suggests altered bone remodelling, WNT and TGF beta\/BMP signalling. Arthritis Res Ther 9:R100","journal-title":"Arthritis Res Ther"},{"key":"931_CR28","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1002\/art.22867","volume":"56","author":"NE Lane","year":"2007","unstructured":"Lane NE, Nevitt MC, Lui LY et al (2007) Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women. Arthritis Rheum 56:3319\u20133325","journal-title":"Arthritis Rheum"},{"key":"931_CR29","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/art.24247","volume":"60","author":"AB Blom","year":"2009","unstructured":"Blom AB, Brockbank SM, van Lent PL et al (2009) Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1. Arthritis Rheum 60:501\u2013512","journal-title":"Arthritis Rheum"},{"key":"931_CR30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1359\/jbmr.081115","volume":"24","author":"H Kawaguchi","year":"2009","unstructured":"Kawaguchi H (2009) Regulation of osteoarthritis development by Wnt-beta-catenin signaling through the endochondral ossification process. J Bone Miner Res 24:8\u201311","journal-title":"J Bone Miner Res"},{"key":"931_CR31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1359\/jbmr.080901","volume":"24","author":"M Zhu","year":"2009","unstructured":"Zhu M, Tang D, Wu Q et al (2009) Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice. J Bone Miner Res 24:12\u201321","journal-title":"J Bone Miner Res"},{"key":"931_CR32","doi-asserted-by":"crossref","first-page":"21657","DOI":"10.1074\/jbc.M200139200","volume":"277","author":"JY Leung","year":"2002","unstructured":"Leung JY, Kolligs FT, Wu R et al (2002) Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling. J Biol Chem 277:21657\u201321665","journal-title":"J Biol Chem"},{"key":"931_CR33","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.bone.2007.12.224","volume":"42","author":"LF Bonewald","year":"2008","unstructured":"Bonewald LF, Johnson ML (2008) Osteocytes, mechanosensing and Wnt signaling. Bone 42:606\u2013615","journal-title":"Bone"},{"key":"931_CR34","doi-asserted-by":"crossref","first-page":"31720","DOI":"10.1074\/jbc.M602308200","volume":"281","author":"JA Robinson","year":"2006","unstructured":"Robinson JA, Chatterjee-Kishore M, Yaworsky PJ et al (2006) Wnt\/beta-catenin signaling is a normal physiological response to mechanical loading in bone. J Biol Chem 281:31720\u201331728","journal-title":"J Biol Chem"},{"key":"931_CR35","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.bone.2005.05.001","volume":"37","author":"AP Bergink","year":"2005","unstructured":"Bergink AP, Uitterlinden AG, van Leeuwen JP et al (2005) Bone mineral density and vertebral fracture history are associated with incident and progressive radiographic knee osteoarthritis in elderly men and women: the Rotterdam Study. Bone 37:446\u2013456","journal-title":"Bone"},{"key":"931_CR36","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0092-8674(01)00571-2","volume":"107","author":"Y Gong","year":"2001","unstructured":"Gong Y, Slee RB, Fukai N et al (2001) LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107:513\u2013523","journal-title":"Cell"},{"key":"931_CR37","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.tig.2006.10.001","volume":"22","author":"R Amerongen van","year":"2006","unstructured":"van Amerongen R, Berns A (2006) Knockout mouse models to study Wnt signal transduction. Trends Genet 22:678\u2013689","journal-title":"Trends Genet"},{"key":"931_CR38","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cellsig.2005.12.008","volume":"18","author":"HY Wang","year":"2006","unstructured":"Wang HY, Liu T, Malbon CC (2006) Structure-function analysis of Frizzleds. Cell Signal 18:934\u2013941","journal-title":"Cell Signal"},{"key":"931_CR39","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.bbrc.2008.01.088","volume":"368","author":"KS Carmon","year":"2008","unstructured":"Carmon KS, Loose DS (2008) Wnt7a interaction with Fzd5 and detection of signaling activation using a split eGFP. Biochem Biophys Res Commun 368:285\u2013291","journal-title":"Biochem Biophys Res Commun"},{"key":"931_CR40","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bbrc.2007.12.128","volume":"367","author":"SW Cho","year":"2008","unstructured":"Cho SW, Her SJ, Sun HJ et al (2008) Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts. Biochem Biophys Res Commun 367:399\u2013405","journal-title":"Biochem Biophys Res Commun"},{"key":"931_CR41","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1242\/jcs.00623","volume":"116","author":"Y Kawano","year":"2003","unstructured":"Kawano Y, Kypta R (2003) Secreted antagonists of the Wnt signalling pathway. J Cell Sci 116:2627\u20132634","journal-title":"J Cell Sci"},{"key":"931_CR42","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cellsig.2007.11.005","volume":"20","author":"YN Lee","year":"2008","unstructured":"Lee YN, Gao Y, Wang HY (2008) Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. Cell Signal 20:443\u2013452","journal-title":"Cell Signal"},{"key":"931_CR43","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1242\/jcs.03363","volume":"120","author":"S Hoppler","year":"2007","unstructured":"Hoppler S, Kavanagh CL (2007) Wnt signalling: variety at the core. J Cell Sci 120:385\u2013393","journal-title":"J Cell Sci"},{"key":"931_CR44","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1038\/sj.emboj.7601667","volume":"26","author":"J Li","year":"2007","unstructured":"Li J, Sutter C, Parker DS et al (2007) CBP\/p300 are bimodal regulators of Wnt signaling. EMBO J 26:2284\u20132294","journal-title":"EMBO J"},{"key":"931_CR45","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1002\/art.23444","volume":"58","author":"F Dell'accio","year":"2008","unstructured":"Dell'accio F, De Bari C, Eltawil NM et al (2008) Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis. Arthritis Rheum 58:1410\u20131421","journal-title":"Arthritis Rheum"},{"key":"931_CR46","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1158\/0008-5472.CAN-07-5172","volume":"68","author":"JB Tuynman","year":"2008","unstructured":"Tuynman JB, Vermeulen L, Boon EM et al (2008) Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer. Cancer Res 68:1213\u20131220","journal-title":"Cancer Res"},{"key":"931_CR47","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.1038\/sj.onc.1209658","volume":"25","author":"CL Bos","year":"2006","unstructured":"Bos CL, Kodach LL, van den Brink GR et al (2006) Effect of aspirin on the Wnt\/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene 25:6447\u20136456","journal-title":"Oncogene"},{"key":"931_CR48","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.joca.2008.02.007","volume":"16","author":"JM Kerkhof","year":"2008","unstructured":"Kerkhof JM, Uitterlinden AG, Valdes AM et al (2008) Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts. Osteoarthritis Cartilage 16:1141\u20131149","journal-title":"Osteoarthritis Cartilage"},{"key":"931_CR49","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1002\/art.21300","volume":"52","author":"HI Roach","year":"2005","unstructured":"Roach HI, Yamada N, Cheung KS et al (2005) Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. Arthritis Rheum 52:3110\u20133124","journal-title":"Arthritis Rheum"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-009-0931-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-009-0931-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-009-0931-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T19:01:04Z","timestamp":1558638064000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-009-0931-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,17]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["931"],"URL":"https:\/\/doi.org\/10.1007\/s00198-009-0931-0","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,17]]}}}