{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:59:46Z","timestamp":1792897186208,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,5,30]],"date-time":"2009-05-30T00:00:00Z","timestamp":1243641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1007\/s00198-009-0973-3","type":"journal-article","created":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T16:49:33Z","timestamp":1243615773000},"page":"527-533","source":"Crossref","is-referenced-by-count":36,"title":["Osteonecrosis of the jaw induced by oral administration of bisphosphonates in Asian population: five cases"],"prefix":"10.1007","volume":"21","author":[{"given":"W.","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.-K.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-Y.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-M.","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. J.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,5,30]]},"reference":[{"key":"973_CR1","doi-asserted-by":"crossref","first-page":"6258s","DOI":"10.1158\/1078-0432.CCR-06-0840","volume":"12","author":"JJ Body","year":"2006","unstructured":"Body JJ (2006) Breast cancer: bisphosphonate therapy for metastatic bone disease. Clin Cancer Res 12:6258s\u20136263s","journal-title":"Clin Cancer Res"},{"issue":"Suppl 1","key":"973_CR2","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.3816\/CBC.2007.s.002","volume":"7","author":"A Lipton","year":"2007","unstructured":"Lipton A (2007) Efficacy and safety of intravenous bisphosphonates in patients with bone metastases caused by metastatic breast cancer. Clin Breast Cancer 7(Suppl 1):S14\u2013S20","journal-title":"Clin Breast Cancer"},{"key":"973_CR3","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1080\/02841860701233435","volume":"46","author":"S Wu","year":"2007","unstructured":"Wu S, Dahut WL, Gulley JL (2007) The use of bisphosphonates in cancer patients. Acta Oncol 46:581\u2013591","journal-title":"Acta Oncol"},{"key":"973_CR4","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00198-004-1675-5","volume":"15","author":"V Elliot-Gibson","year":"2004","unstructured":"Elliot-Gibson V, Bogoch ER, Jamal SA, Beaton DE (2004) Practice patterns in the diagnosis and treatment of osteoporosis after a fragility fracture: a systematic review. Osteoporos Int 15:767\u2013778","journal-title":"Osteoporos Int"},{"key":"973_CR5","doi-asserted-by":"crossref","unstructured":"Wells G, Cranney A, Peterson J, Boucher M, Shea B, Robinson V, Coyle D, Tugwell P (2008) Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst Rev CD004523","DOI":"10.1002\/14651858.CD004523.pub3"},{"key":"973_CR6","first-page":"5","volume":"28","author":"RE Marx","year":"2008","unstructured":"Marx RE (2008) Bisphosphonate-induced osteonecrosis of the jaws: a challenge, a responsibility, and an opportunity. Int J Periodontics Restor Dent 28:5\u20136","journal-title":"Int J Periodontics Restor Dent"},{"key":"973_CR7","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/ncponc1000","volume":"4","author":"F Bertoldo","year":"2007","unstructured":"Bertoldo F, Santini D, Lo Cascio V (2007) Bisphosphonates and osteomyelitis of the jaw: a pathogenic puzzle. Nat Clin Pract Oncol 4:711\u2013721","journal-title":"Nat Clin Pract Oncol"},{"key":"973_CR8","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1177\/154405910708601101","volume":"86","author":"SL Ruggiero","year":"2007","unstructured":"Ruggiero SL, Drew SJ (2007) Osteonecrosis of the jaws and bisphosphonate therapy. J Dent Res 86:1013\u20131021","journal-title":"J Dent Res"},{"key":"973_CR9","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.14219\/jada.archive.2006.0355","volume":"137","author":"American Dental Association Council on Scientific Affairs","year":"2006","unstructured":"American Dental Association Council on Scientific Affairs (2006) Dental management of patients receiving oral bisphosphonate therapy: expert panel recommendations. J Am Dent Assoc 137:1144\u20131150","journal-title":"J Am Dent Assoc"},{"key":"973_CR10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.tripleo.2006.06.004","volume":"102","author":"SL Ruggiero","year":"2006","unstructured":"Ruggiero SL, Fantasia J, Carlson E (2006) Bisphosphonate-related osteonecrosis of the jaw: background and guidelines for diagnosis, staging and management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:433\u2013441","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"973_CR11","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.joms.2006.11.003","volume":"65","author":"AAOMS","year":"2007","unstructured":"AAOMS (2007) American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg 65:369\u2013376","journal-title":"J Oral Maxillofac Surg"},{"key":"973_CR12","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.coms.2007.07.003","volume":"19","author":"Y Sawatari","year":"2007","unstructured":"Sawatari Y, Marx RE (2007) Bisphosphonates and bisphosphonate induced osteonecrosis. Oral Maxillofac Surg Clin North Am 19:487\u2013498 v-vi","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"973_CR13","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.clinthera.2007.08.008","volume":"29","author":"M Pazianas","year":"2007","unstructured":"Pazianas M, Miller P, Blumentals WA, Bernal M, Kothawala P (2007) A review of the literature on osteonecrosis of the jaw in patients with osteoporosis treated with oral bisphosphonates: prevalence, risk factors, and clinical characteristics. Clin Ther 29:1548\u20131558","journal-title":"Clin Ther"},{"key":"973_CR14","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","volume":"63","author":"RE Marx","year":"2005","unstructured":"Marx RE, Sawatari Y, Fortin M, Broumand V (2005) Bisphosphonate-induced exposed bone (osteonecrosis\/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg 63:1567\u20131575","journal-title":"J Oral Maxillofac Surg"},{"key":"973_CR15","doi-asserted-by":"crossref","first-page":"vi168","DOI":"10.1093\/annonc\/mdm250","volume":"18","author":"G Campisi","year":"2007","unstructured":"Campisi G, Di Fede O, Musciotto A, Lo Casto A, Lo Muzio L, Fulfaro F, Badalamenti G, Russo A, Gebbia N (2007) Bisphosphonate-related osteonecrosis of the jaw (BRONJ): run dental management designs and issues in diagnosis. Ann Oncol 18:vi168\u2013vi172","journal-title":"Ann Oncol"},{"key":"973_CR16","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.bone.2008.01.003","volume":"42","author":"R Rizzoli","year":"2008","unstructured":"Rizzoli R, Burlet N, Cahall D, Delmas PD, Eriksen EF, Felsenberg D, Grbic J, Jontell M, Landesberg R, Laslop A, Wollenhaupt M, Papapoulos S, Sezer O, Sprafka M, Reginster JY (2008) Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis. Bone 42:841\u2013847","journal-title":"Bone"},{"key":"973_CR17","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.tripleo.2007.08.040","volume":"105","author":"A Bedogni","year":"2008","unstructured":"Bedogni A, Blandamura S, Lokmic Z, Palumbo C, Ragazzo M, Ferrari F, Tregnaghi A, Pietrogrande F, Procopio O, Saia G, Ferretti M, Bedogni G, Chiarini L, Ferronato G, Ninfo V, Lo Russo L, Lo Muzio L, Nocini PF (2008) Bisphosphonate-associated jawbone osteonecrosis: a correlation between imaging techniques and histopathology. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:358\u2013364","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"973_CR18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tripleo.2007.01.040","volume":"104","author":"SD Bianchi","year":"2007","unstructured":"Bianchi SD, Scoletta M, Cassione FB, Migliaretti G, Mozzati M (2007) Computerized tomographic findings in bisphosphonate-associated osteonecrosis of the jaw in patients with cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:249\u2013258","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"973_CR19","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.tripleo.2006.09.022","volume":"103","author":"R Diego","year":"2007","unstructured":"Diego R, D'Orto O, Pagani D, Agazzi A, Marzano U, Derada Troletti G, Fontanella W, Pignataro L (2007) Bisphosphonate-associated osteonecrosis of the jaws: a therapeutic dilemma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:e1\u2013e5","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"973_CR20","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.ijom.2006.02.022","volume":"35","author":"I Dimitrakopoulos","year":"2006","unstructured":"Dimitrakopoulos I, Magopoulos C, Karakasis D (2006) Bisphosphonate-induced avascular osteonecrosis of the jaws: a clinical report of 11 cases. Int J Oral Maxillofac Surg 35:588\u2013593","journal-title":"Int J Oral Maxillofac Surg"},{"key":"973_CR21","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","volume":"61","author":"RE Marx","year":"2003","unstructured":"Marx RE (2003) Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 61:1115\u20131117","journal-title":"J Oral Maxillofac Surg"},{"key":"973_CR22","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.joms.2007.08.003","volume":"65","author":"RE Marx","year":"2007","unstructured":"Marx RE, Cillo JE Jr, Ulloa JJ (2007) Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment. J Oral Maxillofac Surg 65:2397\u20132410","journal-title":"J Oral Maxillofac Surg"},{"key":"973_CR23","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.joms.2004.02.004","volume":"62","author":"SL Ruggiero","year":"2004","unstructured":"Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL (2004) Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg 62:527\u2013534","journal-title":"J Oral Maxillofac Surg"},{"key":"973_CR24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF03324753","volume":"20","author":"F Bertoldo","year":"2008","unstructured":"Bertoldo F (2008) Bisphosphonates and osteonecrosis of the mandible\/maxilla in osteoporosis: no reason to panic. Aging Clin Exp Res 20:87\u201390","journal-title":"Aging Clin Exp Res"},{"key":"973_CR25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.14219\/jada.archive.2008.0016","volume":"139","author":"VM Cartsos","year":"2008","unstructured":"Cartsos VM, Zhu S, Zavras AI (2008) Bisphosphonate use and the risk of adverse jaw outcomes: a medical claims study of 714, 217 people. J Am Dent Assoc 139:23\u201330","journal-title":"J Am Dent Assoc"},{"key":"973_CR26","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00198-007-0502-1","volume":"19","author":"M Pazianas","year":"2008","unstructured":"Pazianas M, Blumentals WA, Miller PD (2008) Lack of association between oral bisphosphonates and osteonecrosis using jaw surgery as a surrogate marker. Osteoporos Int 19:773\u2013779","journal-title":"Osteoporos Int"},{"key":"973_CR27","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1210\/jcem.87.6.8575","volume":"87","author":"NH Bell","year":"2002","unstructured":"Bell NH, Bilezikian JP, Bone HG 3rd, Kaur A, Maragoto A, Santora AC (2002) Alendronate increases bone mass and reduces bone markers in postmenopausal African-American women. J Clin Endocrinol Metab 87:2792\u20132797","journal-title":"J Clin Endocrinol Metab"},{"key":"973_CR28","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1345\/aph.1E580","volume":"39","author":"AY Ho","year":"2005","unstructured":"Ho AY, Kung AW (2005) Efficacy and tolerability of alendronate once weekly in Asian postmenopausal osteoporotic women. Ann Pharmacother 39:1428\u20131433","journal-title":"Ann Pharmacother"},{"key":"973_CR29","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s0022330001142","volume":"67","author":"AW Kung","year":"2000","unstructured":"Kung AW, Yeung SS, Chu LW (2000) The efficacy and tolerability of alendronate in postmenopausal osteoporotic Chinese women: a randomized placebo-controlled study. Calcif Tissue Int 67:286\u2013290","journal-title":"Calcif Tissue Int"},{"key":"973_CR30","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.bone.2004.10.014","volume":"36","author":"JY Leung","year":"2005","unstructured":"Leung JY, Ho AY, Ip TP, Lee G, Kung AW (2005) The efficacy and tolerability of risedronate on bone mineral density and bone turnover markers in osteoporotic Chinese women: a randomized placebo-controlled study. Bone 36:358\u2013364","journal-title":"Bone"},{"key":"973_CR31","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00774-006-0735-7","volume":"25","author":"EG Pasion","year":"2007","unstructured":"Pasion EG, Sivananthan SK, Kung AW, Chen SH, Chen YJ, Mirasol R, Tay BK, Shah GA, Khan MA, Tam F, Hall BJ, Thiebaud D (2007) Comparison of raloxifene and bisphosphonates based on adherence and treatment satisfaction in postmenopausal Asian women. J Bone Miner Metab 25:105\u2013113","journal-title":"J Bone Miner Metab"},{"key":"973_CR32","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.metabol.2006.01.008","volume":"55","author":"LN Tseng","year":"2006","unstructured":"Tseng LN, Sheu WH, Ho ES, Lan HH, Hu CC, Kao CH (2006) Effects of alendronate combined with hormone replacement therapy on osteoporotic postmenopausal Chinese women. Metabolism 55:741\u2013747","journal-title":"Metabolism"},{"key":"973_CR33","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s001980050171","volume":"9","author":"RD Wasnich","year":"1999","unstructured":"Wasnich RD, Ross PD, Thompson DE, Cizza G, Yates AJ (1999) Skeletal benefits of two years of alendronate treatment are similar for early postmenopausal Asian and Caucasian women. Osteoporos Int 9:455\u2013460","journal-title":"Osteoporos Int"},{"key":"973_CR34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/01.mlg.0000187398.51857.3c","volume":"116","author":"MC Farrugia","year":"2006","unstructured":"Farrugia MC, Summerlin DJ, Krowiak E, Huntley T, Freeman S, Borrowdale R, Tomich C (2006) Osteonecrosis of the mandible or maxilla associated with the use of new generation bisphosphonates. Laryngoscope 116:115\u2013120","journal-title":"Laryngoscope"},{"key":"973_CR35","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.14219\/jada.archive.2007.0346","volume":"138","author":"L Levin","year":"2007","unstructured":"Levin L, Laviv A, Schwartz-Arad D (2007) Denture-related osteonecrosis of the maxilla associated with oral bisphosphonate treatment. J Am Dent Assoc 138:1218\u20131220","journal-title":"J Am Dent Assoc"},{"key":"973_CR36","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/bdj.2007.636","volume":"203","author":"NJ Malden","year":"2007","unstructured":"Malden NJ, Pai AY (2007) Oral bisphosphonate associated osteonecrosis of the jaws: three case reports. Br Dent J 203:93\u201397","journal-title":"Br Dent J"},{"key":"973_CR37","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.14219\/jada.archive.2006.0350","volume":"137","author":"JB Nase","year":"2006","unstructured":"Nase JB, Suzuki JB (2006) Osteonecrosis of the jaw and oral bisphosphonate treatment. J Am Dent Assoc 137:1115\u20131119 quiz 1169-1170","journal-title":"J Am Dent Assoc"},{"key":"973_CR38","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s00198-007-0384-2","volume":"18","author":"N Yarom","year":"2007","unstructured":"Yarom N, Yahalom R, Shoshani Y, Hamed W, Regev E, Elad S (2007) Osteonecrosis of the jaw induced by orally administered bisphosphonates: incidence, clinical features, predisposing factors and treatment outcome. Osteoporos Int 18:1363\u20131370","journal-title":"Osteoporos Int"},{"key":"973_CR39","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1359\/jbmr.0707onj","volume":"22","author":"S Khosla","year":"2007","unstructured":"Khosla S, Burr D, Cauley J, Dempster DW, Ebeling PR, Felsenberg D, Gagel RF, Gilsanz V, Guise T, Koka S, McCauley LK, McGowan J, McKee MD, Mohla S, Pendrys DG, Raisz LG, Ruggiero SL, Shafer DM, Shum L, Silverman SL, Van Poznak CH, Watts N, Woo SB, Shane E (2007) Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 22:1479\u20131491","journal-title":"J Bone Miner Res"},{"key":"973_CR40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.joms.2007.09.019","volume":"66","author":"BT Grant","year":"2008","unstructured":"Grant BT, Amenedo C, Freeman K, Kraut RA (2008) Outcomes of placing dental implants in patients taking oral bisphosphonates: a review of 115 cases. J Oral Maxillofac Surg 66:223\u2013230","journal-title":"J Oral Maxillofac Surg"},{"key":"973_CR41","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.joms.2007.12.040","volume":"66","author":"BM Bell","year":"2008","unstructured":"Bell BM, Bell RE (2008) Oral bisphosphonates and dental implants: a retrospective study. J Oral Maxillofac Surg 66:1022\u20131024","journal-title":"J Oral Maxillofac Surg"},{"key":"973_CR42","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1902\/jop.2007.060239","volume":"78","author":"HL Wang","year":"2007","unstructured":"Wang HL, Weber D, McCauley LK (2007) Effect of long-term oral bisphosphonates on implant wound healing: literature review and a case report. J Periodontol 78:584\u2013594","journal-title":"J Periodontol"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-009-0973-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-009-0973-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-009-0973-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T19:01:05Z","timestamp":1558638065000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-009-0973-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,30]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["973"],"URL":"https:\/\/doi.org\/10.1007\/s00198-009-0973-3","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,30]]}}}