{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:41:40Z","timestamp":1791092500566,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,3,27]],"date-time":"2010-03-27T00:00:00Z","timestamp":1269648000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1007\/s00198-010-1219-0","type":"journal-article","created":{"date-parts":[[2010,3,26]],"date-time":"2010-03-26T12:43:16Z","timestamp":1269607396000},"page":"167-177","source":"Crossref","is-referenced-by-count":51,"title":["Structural parameters of normal and osteoporotic human trabecular bone are affected differently by microCT image resolution"],"prefix":"10.1007","volume":"22","author":[{"given":"H.","family":"Isaksson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"T\u00f6yr\u00e4s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hakulinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Aula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Tamminen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Julkunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kr\u00f6ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Jurvelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,27]]},"reference":[{"issue":"Suppl 2","key":"1219_CR1","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1007\/PL00004156","volume":"9","author":"C Cooper","year":"1999","unstructured":"Cooper C (1999) Epidemiology of osteoporosis. Osteoporos Int 9(Suppl 2):S2\u2013S8","journal-title":"Osteoporos Int"},{"key":"1219_CR2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s001980050094","volume":"8","author":"JE Compston","year":"1998","unstructured":"Compston JE, Papapoulos SE, Blanchard F (1998) Report on osteoporosis in the European Community: current status and recommendations for the future. Working Party from European Union Member States. Osteoporos Int 8:531\u2013534","journal-title":"Osteoporos Int"},{"key":"1219_CR3","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/jbmr.5650081010","volume":"8","author":"LJ Melton 3rd","year":"1993","unstructured":"Melton LJ 3rd, Atkinson EJ, O'Fallon WM, Wahner HW, Riggs BL (1993) Long-term fracture prediction by bone mineral assessed at different skeletal sites. J Bone Miner Res 8:1227\u20131233","journal-title":"J Bone Miner Res"},{"key":"1219_CR4","first-page":"201","volume":"2","author":"DB Burr","year":"2002","unstructured":"Burr DB (2002) Bone material properties and mineral matrix contributions to fracture risk or age in women and men. J Musculoskelet Neuronal Interact 2:201\u2013204","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"1219_CR5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.bone.2003.12.022","volume":"34","author":"PD Delmas","year":"2004","unstructured":"Delmas PD, Seeman E (2004) Changes in bone mineral density explain little of the reduction in vertebral or nonvertebral fracture risk with anti-resorptive therapy. Bone 34:599\u2013604","journal-title":"Bone"},{"key":"1219_CR6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/17453670610045623","volume":"77","author":"J Astrand","year":"2006","unstructured":"Astrand J, Thorngren KG, Tagil M (2006) One fracture is enough! Experience with a prospective and consecutive osteoporosis screening program with 239 fracture patients. Acta Orthop 77:3\u20138","journal-title":"Acta Orthop"},{"key":"1219_CR7","volume-title":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis","author":"World Health Organization Group","year":"1994","unstructured":"World Health Organization Group (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. World Health Organization, Geneva"},{"key":"1219_CR8","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1007\/s00198-006-0135-9","volume":"17","author":"JA Pasco","year":"2006","unstructured":"Pasco JA, Seeman E, Henry MJ, Merriman EN, Nicholson GC, Kotowicz MA (2006) The population burden of fractures originates in women with osteopenia, not osteoporosis. Osteoporos Int 17:1404\u20131409","journal-title":"Osteoporos Int"},{"key":"1219_CR9","first-page":"715","volume-title":"Cecil essentials of medicine","author":"S Greenspan","year":"2004","unstructured":"Greenspan S (2004) Osteoporosis. In: Andreoli TE (ed) Cecil essentials of medicine. W.B. Saunders, Philadelphia, pp 715\u2013722"},{"key":"1219_CR10","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1359\/jbmr.090317","volume":"24","author":"AJ Fields","year":"2009","unstructured":"Fields AJ, Eswaran SK, Jekir MG, Keaveny TM (2009) Role of trabecular microarchitecture in whole-vertebral body biomechanical behavior. J Bone Miner Res 24:1523\u20131530","journal-title":"J Bone Miner Res"},{"key":"1219_CR11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF03350919","volume":"27","author":"L Dalle Carbonare","year":"2004","unstructured":"Dalle Carbonare L, Giannini S (2004) Bone microarchitecture as an important determinant of bone strength. J Endocrinol Invest 27:99\u2013105","journal-title":"J Endocrinol Invest"},{"key":"1219_CR12","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s001980200027","volume":"13","author":"DC Newitt","year":"2002","unstructured":"Newitt DC, Majumdar S, van Rietbergen B, von Ingersleben G, Harris ST, Genant HK, Chesnut C, Garnero P, MacDonald B (2002) In vivo assessment of architecture and micro-finite element analysis derived indices of mechanical properties of trabecular bone in the radius. Osteoporos Int 13:6\u201317","journal-title":"Osteoporos Int"},{"key":"1219_CR13","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.bone.2006.04.017","volume":"39","author":"SK Boyd","year":"2006","unstructured":"Boyd SK, Davison P, Muller R, Gasser JA (2006) Monitoring individual morphological changes over time in ovariectomized rats by in vivo micro-computed tomography. Bone 39:854\u2013862","journal-title":"Bone"},{"key":"1219_CR14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s11914-006-0004-7","volume":"4","author":"J Carballido-Gamio","year":"2006","unstructured":"Carballido-Gamio J, Majumdar S (2006) Clinical utility of microarchitecture measurements of trabecular bone. Curr Osteoporos Rep 4:64\u201370","journal-title":"Curr Osteoporos Rep"},{"key":"1219_CR15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF02509542","volume":"58","author":"P Ruegsegger","year":"1996","unstructured":"Ruegsegger P, Koller B, Muller R (1996) A microtomographic system for the nondestructive evaluation of bone architecture. Calcif Tissue Int 58:24\u201329","journal-title":"Calcif Tissue Int"},{"key":"1219_CR16","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s00198-008-0581-7","volume":"19","author":"GM Campbell","year":"2008","unstructured":"Campbell GM, Buie HR, Boyd SK (2008) Signs of irreversible architectural changes occur early in the development of experimental osteoporosis as assessed by in vivo micro-CT. Osteoporos Int 19:1409\u20131419","journal-title":"Osteoporos Int"},{"key":"1219_CR17","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/BF03026331","volume":"23","author":"JA Gasser","year":"2005","unstructured":"Gasser JA, Ingold P, Grosios K, Laib A, Hammerle S, Koller B (2005) Noninvasive monitoring of changes in structural cancellous bone parameters with a novel prototype micro-CT. J Bone Miner Metab 23:90\u201396, Suppl","journal-title":"J Bone Miner Metab"},{"key":"1219_CR18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2818.2005.01469.x","volume":"218","author":"JS Thomsen","year":"2005","unstructured":"Thomsen JS, Laib A, Koller B, Prohaska S, Mosekilde L, Gowin W (2005) Stereological measures of trabecular bone structure: comparison of 3D micro computed tomography with 2D histological sections in human proximal tibial bone biopsies. J Microsc 218:171\u2013179","journal-title":"J Microsc"},{"key":"1219_CR19","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1359\/JBMR.050205","volume":"20","author":"D Chappard","year":"2005","unstructured":"Chappard D, Retailleau-Gaborit N, Legrand E, Basle MF, Audran M (2005) Comparison insight bone measurements by histomorphometry and microCT. J Bone Miner Res 20:1177\u20131184","journal-title":"J Bone Miner Res"},{"key":"1219_CR20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bone.2007.03.019","volume":"41","author":"MP Akhter","year":"2007","unstructured":"Akhter MP, Lappe JM, Davies KM, Recker RR (2007) Transmenopausal changes in the trabecular bone structure. Bone 41:111\u2013116","journal-title":"Bone"},{"key":"1219_CR21","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s00223-007-9084-3","volume":"82","author":"JE Brouwers","year":"2008","unstructured":"Brouwers JE, Lambers FM, Gasser JA, van Rietbergen B, Huiskes R (2008) Bone degeneration and recovery after early and late bisphosphonate treatment of ovariectomized wistar rats assessed by in vivo micro-computed tomography. Calcif Tissue Int 82:202\u2013211","journal-title":"Calcif Tissue Int"},{"key":"1219_CR22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S8756-3282(98)00031-3","volume":"22","author":"M Kothari","year":"1998","unstructured":"Kothari M, Keaveny TM, Lin JC, Newitt DC, Genant HK, Majumdar S (1998) Impact of spatial resolution on the prediction of trabecular architecture parameters. Bone 22:437\u2013443","journal-title":"Bone"},{"key":"1219_CR23","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3233\/THC-1996-4112","volume":"4","author":"R Muller","year":"1996","unstructured":"Muller R, Koller B, Hildebrand T, Laib A, Gianolini S, Ruegsegger P (1996) Resolution dependency of microstructural properties of cancellous bone based on three-dimensional mu-tomography. Technol Health Care 4:113\u2013119","journal-title":"Technol Health Care"},{"key":"1219_CR24","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.bone.2007.12.004","volume":"42","author":"M Sode","year":"2008","unstructured":"Sode M, Burghardt AJ, Nissenson RA, Majumdar S (2008) Resolution dependence of the non-metric trabecular structure indices. Bone 42:728\u2013736","journal-title":"Bone"},{"key":"1219_CR25","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.bone.2004.09.007","volume":"35","author":"DG Kim","year":"2004","unstructured":"Kim DG, Christopherson GT, Dong XN, Fyhrie DP, Yeni YN (2004) The effect of microcomputed tomography scanning and reconstruction voxel size on the accuracy of stereological measurements in human cancellous bone. Bone 35:1375\u20131382","journal-title":"Bone"},{"key":"1219_CR26","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1359\/JBMR.040705","volume":"19","author":"JH Waarsing","year":"2004","unstructured":"Waarsing JH, Day JS, Weinans H (2004) An improved segmentation method for in vivo microCT imaging. J Bone Miner Res 19:1640\u20131650","journal-title":"J Bone Miner Res"},{"key":"1219_CR27","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1359\/jbmr.071116","volume":"23","author":"GJ Kazakia","year":"2008","unstructured":"Kazakia GJ, Hyun B, Burghardt AJ, Krug R, Newitt DC, de Papp AE, Link TM, Majumdar S (2008) In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging. J Bone Miner Res 23:463\u2013474","journal-title":"J Bone Miner Res"},{"key":"1219_CR28","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1210\/jc.2005-1258","volume":"90","author":"S Boutroy","year":"2005","unstructured":"Boutroy S, Bouxsein ML, Munoz F, Delmas PD (2005) In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab 90:6508\u20136515","journal-title":"J Clin Endocrinol Metab"},{"key":"1219_CR29","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.bone.2008.10.045","volume":"44","author":"TL Mueller","year":"2009","unstructured":"Mueller TL, Stauber M, Kohler T, Eckstein F, Muller R, van Lenthe GH (2009) Non-invasive bone competence analysis by high-resolution pQCT: an in vitro reproducibility study on structural and mechanical properties at the human radius. Bone 44:364\u2013371","journal-title":"Bone"},{"key":"1219_CR30","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1359\/jbmr.071108","volume":"23","author":"S Boutroy","year":"2008","unstructured":"Boutroy S, Van Rietbergen B, Sornay-Rendu E, Munoz F, Bouxsein ML, Delmas PD (2008) Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women. J Bone Miner Res 23:392\u2013399","journal-title":"J Bone Miner Res"},{"key":"1219_CR31","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s00223-008-9181-y","volume":"83","author":"G Diederichs","year":"2008","unstructured":"Diederichs G, Link T, Marie K, Huber M, Rogalla P, Burghardt A, Majumdar S, Issever A (2008) Feasibility of measuring trabecular bone structure of the proximal femur using 64-slice multidetector computed tomography in a clinical setting. Calcif Tissue Int 83:332\u2013341","journal-title":"Calcif Tissue Int"},{"key":"1219_CR32","doi-asserted-by":"crossref","unstructured":"Tamminen I, Aula A, Isaksson H, Jurvelin JS, Kr\u00f6ger H (2009) Reproducibility and agreement of microCT and histomorphometry depends on the metabolic status of human trabecular bone. Transactions of 55th annual meeting of the Orthopaedic Research Society, Las Vegas, Nevada, USA","DOI":"10.1016\/j.bone.2009.03.246"},{"key":"1219_CR33","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1088\/0031-9155\/51\/6\/019","volume":"51","author":"MA Hakulinen","year":"2006","unstructured":"Hakulinen MA, Day JS, Toyras J, Weinans H, Jurvelin JS (2006) Ultrasonic characterization of human trabecular bone microstructure. Phys Med Biol 51:1633\u20131648","journal-title":"Phys Med Biol"},{"key":"1219_CR34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/01495739708936692","volume":"1","author":"T Hildebrand","year":"1997","unstructured":"Hildebrand T, Ruegsegger P (1997) Quantification of bone microarchitecture with the structure model index. Comput Methods Biomech Biomed Engin 1:15\u201323","journal-title":"Comput Methods Biomech Biomed Engin"},{"key":"1219_CR35","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0021-9290(96)00177-7","volume":"30","author":"A Odgaard","year":"1997","unstructured":"Odgaard A, Kabel J, van Rietbergen B, Dalstra M, Huiskes R (1997) Fabric and elastic principal directions of cancellous bone are closely related. J Biomech 30:487\u2013495","journal-title":"J Biomech"},{"key":"1219_CR36","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","volume":"1","author":"JM Bland","year":"1986","unstructured":"Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1:307\u2013310","journal-title":"Lancet"},{"key":"1219_CR37","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s00774-008-0856-2","volume":"26","author":"C Chappard","year":"2008","unstructured":"Chappard C, Marchadier A, Benhamou L (2008) Interindividual and intraspecimen variability of 3-D bone microarchitectural parameters in iliac crest biopsies imaged by conventional micro-computed tomography. J Bone Miner Metab 26:506\u2013513","journal-title":"J Bone Miner Metab"},{"key":"1219_CR38","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1359\/jbmr.070301","volume":"22","author":"F Eckstein","year":"2007","unstructured":"Eckstein F, Matsuura M, Kuhn V, Priemel M, Muller R, Link TM, Lochmuller EM (2007) Sex differences of human trabecular bone microstructure in aging are site-dependent. J Bone Miner Res 22:817\u2013824","journal-title":"J Bone Miner Res"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-010-1219-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-010-1219-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-010-1219-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T13:34:58Z","timestamp":1558964098000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-010-1219-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,27]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["1219"],"URL":"https:\/\/doi.org\/10.1007\/s00198-010-1219-0","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,27]]}}}