{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T09:45:00Z","timestamp":1781343900724,"version":"3.54.1"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T00:00:00Z","timestamp":1307664000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1007\/s00198-011-1676-0","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T04:56:13Z","timestamp":1307681773000},"page":"17-38","source":"Crossref","is-referenced-by-count":108,"title":["Calcitonin for treating acute and chronic pain of recent and remote osteoporotic vertebral compression fractures: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"23","author":[{"given":"J. A.","family":"Knopp-Sihota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. V.","family":"Newburn-Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Homik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. G.","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Voaklander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,6,10]]},"reference":[{"issue":"3","key":"1676_CR1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00042192-200310030-00010","volume":"10","author":"J Lorrain","year":"2003","unstructured":"Lorrain J, Paiement G, Chevrier N, Lalumiere G, Laflamme GH, Caron P, Fillion A (2003) Population demographics and socioeconomic impact of osteoporotic fractures in Canada. Menopause 10(3):228\u2013234","journal-title":"Menopause"},{"issue":"9319","key":"1676_CR2","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","volume":"359","author":"SR Cummings","year":"2002","unstructured":"Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359(9319):1761\u20131767","journal-title":"Lancet"},{"issue":"5","key":"1676_CR3","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.beem.2008.06.001","volume":"22","author":"C Holroyd","year":"2008","unstructured":"Holroyd C, Cooper C, Dennison E (2008) Epidemiology of osteoporosis. Best Pract Res Clin Endocrinol Metab 22(5):671\u2013685","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"3","key":"1676_CR4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1359\/jbmr.061113","volume":"22","author":"R Burge","year":"2007","unstructured":"Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A (2007) Incidence and economic burden of osteoporosis-related fractures in the United States, 2005\u20132025. J Bone Miner Res 22(3):465\u2013475","journal-title":"J Bone Miner Res"},{"issue":"5","key":"1676_CR5","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.spinee.2006.04.013","volume":"6","author":"DH Kim","year":"2006","unstructured":"Kim DH, Vaccaro AR (2006) Osteoporotic compression fractures of the spine: current options and considerations for treatment. Spine J 6(5):479\u2013487","journal-title":"Spine J"},{"issue":"10","key":"1676_CR6","doi-asserted-by":"crossref","first-page":"793","DOI":"10.7326\/0003-4819-128-10-199805150-00001","volume":"128","author":"MC Nevitt","year":"1998","unstructured":"Nevitt MC, Ettinger B, Black DM, Stone K, Jamal SA, Ensrud K, Segal M, Genant HK, Cummings SR (1998) The association of radiographically detected vertebral fractures with back pain and function: a prospective study. Ann Int Med 128(10):793\u2013800","journal-title":"Ann Int Med"},{"issue":"Suppl 2","key":"1676_CR7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF02207237","volume":"8","author":"GP Lyritis","year":"1989","unstructured":"Lyritis GP, Mayasis B, Tsakalakos N, Lambropoulos A, Gazi S, Karachalios T, Tsekoura M, Yiatzides A (1989) The natural history of the osteoporotic vertebral fracture. Clin Rheumatol 8(Suppl 2):66\u201369","journal-title":"Clin Rheumatol"},{"issue":"9","key":"1676_CR8","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1007\/s00198-004-1615-4","volume":"15","author":"TW O\u2019Neill","year":"2004","unstructured":"O\u2019Neill TW, Cockerill W, Matthis C, Raspe HH, Lunt M, Cooper C, Banzer D, Cannata JB, Naves M, Felsch B, Felsenberg D, Janott J, Johnell O, Kanis JA, Kragl G, Lopes Vaz A, Lyritis G, Masaryk P, Poor G, Reid DM, Reisinger W, Scheidt-Nave C, Stepan JJ, Todd CJ, Woolf AD, Reeve J, Silman AJ (2004) Back pain, disability, and radiographic vertebral fracture in European women: a prospective study. Osteoporos Int 15(9):760\u2013765","journal-title":"Osteoporos Int"},{"issue":"2","key":"1676_CR9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/jbmr.5650070214","volume":"7","author":"C Cooper","year":"1992","unstructured":"Cooper C, Atkinson EJ, O\u2019Fallon WM, Melton LJ 3rd (1992) Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985\u20131989. J Bone Miner Res 7(2):221\u2013227","journal-title":"J Bone Miner Res"},{"issue":"7","key":"1676_CR10","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s00198-007-0530-x","volume":"19","author":"RM Francis","year":"2008","unstructured":"Francis RM, Aspray TJ, Hide G, Sutcliffe AM, Wilkinson P (2008) Back pain in osteoporotic vertebral fractures. Osteoporos Int 19(7):895\u2013903","journal-title":"Osteoporos Int"},{"issue":"5","key":"1676_CR11","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00198-008-0743-7","volume":"20","author":"A Papaioannou","year":"2009","unstructured":"Papaioannou A, Kennedy CC, Ioannidis G, Sawka A, Hopman WM, Pickard L, Brown JP, Josse RG, Kaiser S, Anastassiades T, Goltzman D, Papadimitropoulos M, Tenenhouse A, Prior JC, Olszynski WP, Adachi JD (2009) The impact of incident fractures on health-related quality of life: 5\u00a0years of data from the Canadian Multicentre Osteoporosis Study. Osteoporos Int 20(5):703\u2013714","journal-title":"Osteoporos Int"},{"issue":"6","key":"1676_CR12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2165\/00002018-200932060-00003","volume":"32","author":"JB Barber","year":"2009","unstructured":"Barber JB, Gibson SJ (2009) Treatment of chronic non-malignant pain in the elderly: safety considerations. Drug Saf 32(6):457\u2013474","journal-title":"Drug Saf"},{"issue":"5","key":"1676_CR13","doi-asserted-by":"crossref","first-page":"378","DOI":"10.2165\/00002512-199608050-00006","volume":"8","author":"GL Plosker","year":"1996","unstructured":"Plosker GL, McTavish D (1996) Intranasal salcatonin (salmon calcitonin). A review of its pharmacological properties and role in the management of postmenopausal osteoporosis. Drugs Aging 8(5):378\u2013400","journal-title":"Drugs Aging"},{"key":"1676_CR14","first-page":"2160","volume":"44","author":"WP Maksymowych","year":"1998","unstructured":"Maksymowych WP (1998) Managing acute osteoporotic vertebral fractures with calcitonin. Can Fam Physician 44:2160\u20132166","journal-title":"Can Fam Physician"},{"issue":"7","key":"1676_CR15","first-page":"962","volume":"155","author":"K Siminoski","year":"1996","unstructured":"Siminoski K, Josse RG, Bowyer M (1996) Calcitonin in the treatment of osteoporosis. CMAJ 155(7):962\u2013965","journal-title":"CMAJ"},{"issue":"1","key":"1676_CR16","first-page":"12","volume":"12","author":"M Abellan Perez","year":"1995","unstructured":"Abellan Perez M, Bayina Garcia FJ, Calabozo M, Carpintero Benitez P, Figueroa Pedrosa M, Fernandez Crisostomo MC, Garcia Lopez A, Garcia Perez S, Mesa Ramos M, Paulino Tevar J, Rodriguez Perez M, Salazar Vallina JM, Valenzuela Castano A, Povedano Gomez J, Sanchez Trenado A (1995) Multicentric comparative study of synthetic salmon calcitonin nasally administered in the treatment of established postmenopausic osteoporosis. An Med Interna 12(1):12\u201316","journal-title":"An Med Interna"},{"issue":"1","key":"1676_CR17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF02555897","volume":"49","author":"S Ljunghall","year":"1991","unstructured":"Ljunghall S, Gardsell P, Johnell O, Larsson K, Lindh E, Obrant K, Sernbo I (1991) Synthetic human calcitonin in postmenopausal osteoporosis: a placebo-controlled, double-blind study. Calcif Tissue Int 49(1):17\u201319","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"1676_CR18","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00198-007-0490-1","volume":"19","author":"CH Chesnut 3rd","year":"2008","unstructured":"Chesnut CH 3rd, Azria M, Silverman S, Engelhardt M, Olson M, Mindeholm L (2008) Salmon calcitonin: a review of current and future therapeutic indications. Osteoporos Int 19(4):479\u2013491","journal-title":"Osteoporos Int"},{"issue":"Suppl 5","key":"1676_CR19","doi-asserted-by":"crossref","first-page":"80S","DOI":"10.1016\/S8756-3282(02)00701-9","volume":"30","author":"M Azria","year":"2002","unstructured":"Azria M (2002) Possible mechanisms of the analgesic action of calcitonin. Bone 30(Suppl 5):80S\u201383S","journal-title":"Bone"},{"issue":"1","key":"1676_CR20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s10067-006-0228-z","volume":"26","author":"D Ofluoglu","year":"2007","unstructured":"Ofluoglu D, Akyuz G, Unay O, Kayhan O (2007) The effect of calcitonin on beta-endorphin levels in postmenopausal osteoporotic patients with back pain. Clin Rheumatol 26(1):44\u201349","journal-title":"Clin Rheumatol"},{"issue":"10","key":"1676_CR21","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s00198-004-1798-8","volume":"16","author":"JA Knopp","year":"2005","unstructured":"Knopp JA, Diner BM, Blitz M, Lyritis GP, Rowe BH (2005) Calcitonin for treating acute pain of osteoporotic vertebral compression fractures: a systematic review of randomized, controlled trials. Osteoporos Int 16(10):1281\u20131290","journal-title":"Osteoporos Int"},{"key":"1676_CR22","unstructured":"Higgins J, Green S (eds) (2009) Cochrane handbook for systematic reviews of interventions version 5.0.2 (updated September 2009)"},{"key":"1676_CR23","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","volume":"339","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 339:b2535","journal-title":"BMJ"},{"key":"1676_CR24","doi-asserted-by":"crossref","unstructured":"Higgens JPT, Deeks JJ (2008) Chapter 7: selecting studies and collecting data. In: Higgins J, Green S (eds) Cochrane handbook for systematic reviews of interventions version 501. The Cochrane Collaboration","DOI":"10.1002\/9780470712184.ch7"},{"key":"1676_CR25","doi-asserted-by":"crossref","unstructured":"Higgens JPT, Altman DG (2008) Chapter 8: assessing risk of bias in included studies. In: Higgins J, Green S (eds) Cochrane handbook for systematic reviews of interventions version 501. The Cochrane Collaboration","DOI":"10.1002\/9780470712184.ch8"},{"key":"1676_CR26","doi-asserted-by":"crossref","unstructured":"Deeks JJ, Higgins JPT, Altman DG (2008) Chapter 9: analysing data and undertaking meta-analysis. In: Higgins J, Green S (eds) Cochrane handbook for systematic reviews of interventions version 501. The Cochrane Collaboration","DOI":"10.1002\/9780470712184.ch9"},{"key":"1676_CR27","doi-asserted-by":"crossref","unstructured":"Sch\u00fcnemann HJ, Oxman AD, Vist GE, Higgins JPT, Deeks JJ, Glasziou P, Guyatt GH (2008) Chapter 12: interpreting results and drawing conclusions. In: Higgins J, Green S (eds) Cochrane handbook for systematic reviews of interventions version 501. The Cochrane Collaboration","DOI":"10.1002\/9780470712184.ch12"},{"issue":"7109","key":"1676_CR28","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629\u2013634","journal-title":"BMJ"},{"key":"1676_CR29","unstructured":"Review Manager (RevMan) program. 5.0 (2008) The Nordic Cochrane Centre, Copenhagen. The Cochrane Collaboration"},{"issue":"2","key":"1676_CR30","first-page":"87","volume":"23","author":"D Aloysio De","year":"1996","unstructured":"De Aloysio D, Pansini F, Campobasso C, Zanotti L, Abbruzzese AD, Mauloni M, Bottiglioni F (1996) Effects of cyclic therapy with intranasal carbocalcitonin in healthy spontaneous postmenopausal women. Clin Exp Obstet Gynecol 23(2):87\u201393","journal-title":"Clin Exp Obstet Gynecol"},{"issue":"8","key":"1676_CR31","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1742-1241.2001.tb11111.x","volume":"55","author":"N Dursun","year":"2001","unstructured":"Dursun N, Dursun E, Yalcin S (2001) Comparison of alendronate, calcitonin and calcium treatments in postmenopausal osteoporosis. Int J Clin Pract 55(8):505\u2013509","journal-title":"Int J Clin Pract"},{"issue":"3","key":"1676_CR32","first-page":"79","volume":"27","author":"TS Fidelis","year":"1987","unstructured":"Fidelis TS, Latorre LC, Resende C, Zerbini CA (1987) Effect of the combined therapy in the treatment of osteoporosis: observations on the use of salmon calcitonin. Rev Bras Reumatol 27(3):79\u201386","journal-title":"Rev Bras Reumatol"},{"issue":"5","key":"1676_CR33","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0011-393X(95)85012-0","volume":"56","author":"R Foti","year":"1995","unstructured":"Foti R, Martorana U, Broggini M (1995) Long-term tolerability of nasal spray formulation of salmon calcitonin. Curr Ther Res 56(5):429\u2013435","journal-title":"Curr Ther Res"},{"issue":"2","key":"1676_CR34","first-page":"119","volume":"118","author":"S Gnudi","year":"1986","unstructured":"Gnudi S, Maggi G, Figus E, Rimondi E, Olmi R, Vellani G, Busacchi CA (1986) Efficacy of calcitonin in the symptomatic control of chronic backache due to senile osteoporosis. Clin Ter 118(2):119\u2013124","journal-title":"Clin Ter"},{"issue":"1","key":"1676_CR35","first-page":"3","volume":"2","author":"C Hernandez-Cassis","year":"1985","unstructured":"Hernandez-Cassis C, Cure-Cure C, Hernandez-Cassis S, Latorre A, Cure J, Crespo S, Perez O, Arevalo O (1985) Uso de la calitonina en el tratamiento multifactorial de la osteoporosis. Salud Uninorte 2(1):3\u201312","journal-title":"Salud Uninorte"},{"issue":"3","key":"1676_CR36","first-page":"101","volume":"86","author":"GC Isaia","year":"1995","unstructured":"Isaia GC, Di Stefano M, Sciolla A, Mussetta M, Vassellatti D (1995) Synthetic salmon calcitonin suppositories for the short-term treatment of involutive osteoporosis. Minerva Med 86(3):101\u2013104","journal-title":"Minerva Med"},{"issue":"3","key":"1676_CR37","first-page":"168","volume":"15","author":"S Konno","year":"2005","unstructured":"Konno S, Kikuchi S (2005) Therapeutic effects of calcitonin on back pain in the patients with osteoporosis. Clin Calcium 15(3):168\u2013173","journal-title":"Clin Calcium"},{"issue":"7","key":"1676_CR38","first-page":"358","volume":"31","author":"A Tolino","year":"1993","unstructured":"Tolino A, Romano L, Ronsini S, Riccio S, Montemagno U (1993) Treatment of postmenopausal osteoporosis with salmon calcitonin nasal spray: evaluation by bone mineral content and biochemical patterns. Int J Clin Pharmacol Ther Toxicol 31(7):358\u2013360","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"issue":"2","key":"1676_CR39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00774-004-0556-5","volume":"23","author":"K Yoh","year":"2005","unstructured":"Yoh K, Tanaka K, Ishikawa A, Ishibashi T, Uchino Y, Sato Y, Tobinaga M, Hasegawa N, Kamae S, Yoshizawa M (2005) Health-related quality of life (HRQOL) in Japanese osteoporotic patients and its improvement by elcatonin treatment. J Bone Miner Metab 23(2):167\u2013173","journal-title":"J Bone Miner Metab"},{"issue":"Suppl 1","key":"1676_CR40","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF02500571","volume":"6","author":"G Dilsen","year":"1996","unstructured":"Dilsen G, Sindel D, An C (1996) Effect of nasal calcitonin on pain in osteoporotic patients with vertebral fractures. Osteoporos Int 6(Suppl 1):259","journal-title":"Osteoporos Int"},{"key":"1676_CR41","first-page":"38","volume":"121","author":"M Kopaliani","year":"2005","unstructured":"Kopaliani M (2005) Effectiveness of intranasal salmon calcitonin treatment in postmenopausal osteoporosis. Georgian Med News 121:38\u201342","journal-title":"Georgian Med News"},{"key":"1676_CR42","first-page":"211","volume":"22","author":"H Orimo","year":"1994","unstructured":"Orimo H, Fujita T, Yoshikawa S, Inoue T, Morita R (1994) Clinical study of SMC-20-051 nasal spray in pain due to osteoporosis. Clin Eval 22:211\u2013231","journal-title":"Clin Eval"},{"key":"1676_CR43","first-page":"233","volume":"22","author":"H Orimo","year":"1994","unstructured":"Orimo H, Fujita T, Yoshikawa S, Inoue T, Morita R (1994) Clinical study of SMC-20-051 nasal spray in pain due to osteoporosis. Clin Eval 22:233\u2013258","journal-title":"Clin Eval"},{"issue":"31\u201332","key":"1676_CR44","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1055\/s-2008-1065138","volume":"115","author":"JD Ringe","year":"1990","unstructured":"Ringe JD (1990) Treatment of primary osteoporosis with calcium and salmon calcitonin. Dtsch Med Wochenschr 115(31\u201332):1176\u20131182","journal-title":"Dtsch Med Wochenschr"},{"issue":"1","key":"1676_CR45","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF00297289","volume":"50","author":"J Szucs","year":"1992","unstructured":"Szucs J, Horvath C, Kollin E, Szathmari M, Hollo I (1992) Three-year calcitonin combination therapy for postmenopausal osteoporosis with crush fractures of the spine. Calcif Tissue Int 50(1):7\u201310","journal-title":"Calcif Tissue Int"},{"key":"1676_CR46","unstructured":"Vinceneux P, Pouchot J (1989) Analgesic effect of salmon calcitonin in crush vertebral fractures: double blind versus placebo study in 58 patients. Colombes, France"},{"issue":"13","key":"1676_CR47","first-page":"6831","volume":"20","author":"M Watanabe","year":"1986","unstructured":"Watanabe M (1986) Clinical efficacy of YM-11221 (synthetic salmon calcitonin) for back or low back pain in osteoporosis: a double blind dose finding study. Clin Rep 20(13):6831\u20136844","journal-title":"Clin Rep"},{"issue":"27","key":"1676_CR48","doi-asserted-by":"crossref","first-page":"156","DOI":"10.2307\/20066001","volume":"9","author":"J Zhong","year":"2005","unstructured":"Zhong J, Zhou YR, Lui SQ (2005) Interventional effects of salmon calcitonin on the bone metabolism, fracture healing and low back pain elderly patients with osteoporotic vertebral fracture. Chin J Rehab 9(27):156\u2013157","journal-title":"Chin J Rehab"},{"issue":"1","key":"1676_CR49","first-page":"17","volume":"14","author":"G Bertolini","year":"1982","unstructured":"Bertolini G, Naliato P, Cruciatti A, Geatti O, Perraro F (1982) Treatment of senile and postmenopausal osteoporosis with synthetic calcitonin. Med Geriatr 14(1):17\u201331","journal-title":"Med Geriatr"},{"issue":"4","key":"1676_CR50","first-page":"206","volume":"13","author":"A Covarrubias Cobos","year":"1986","unstructured":"Covarrubias Cobos A, Javier Escalante F (1986) Clinical experience in the treatment of osteoporosis with synthetic salmon calcitocine. Invest Med Int 13(4):206\u2013212","journal-title":"Invest Med Int"},{"issue":"3","key":"1676_CR51","first-page":"177","volume":"107","author":"MA Pascalis De","year":"1983","unstructured":"De Pascalis MA, Fletzer DA, Spirito A (1983) Clinico-statistical study in patients with an arthrosis\u2013osteoporosis picture in its painful stage treated with synthetic salmon calcitonin. Clin Ter 107(3):177\u2013184","journal-title":"Clin Ter"},{"issue":"1","key":"1676_CR52","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00310172","volume":"55","author":"JP Devogelaer","year":"1994","unstructured":"Devogelaer JP, Azria M, Attinger M, Abbiati G, Castiglioni C, Nagant de Deuxchaisnes C (1994) Comparison of the acute biological action of injectable salmon calcitonin and an injectable and oral calcitonin analogue. Calcif Tissue Int 55(1):71\u201373","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"1676_CR53","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0011-393X(05)80652-6","volume":"54","author":"S Gonnelli","year":"1993","unstructured":"Gonnelli S, Agnusdei D, Camporeale A, Palmieri R, Gennari C (1993) Effect of rectal salmon calcitonin treatment on bone mass and bone turnover in patients with established postmenopausal osteoporosis: a 1-year crossover study. Curr Ther Res Clin Exp 54(4):458\u2013465","journal-title":"Curr Ther Res Clin Exp"},{"issue":"9","key":"1676_CR54","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0011-393X(05)80278-4","volume":"55","author":"M Mannarini","year":"1994","unstructured":"Mannarini M, Fincato G, Galimberti S, Maderna M, Greco F (1994) Analgesic effect of salmon calcitonin suppositories in patients with bone pain. Curr Ther Res 55(9):1079\u20131083","journal-title":"Curr Ther Res"},{"issue":"3","key":"1676_CR55","first-page":"189","volume":"13","author":"O Alcala","year":"1986","unstructured":"Alcala O (1986) An evaluation of therapeutic efficiency of synthetic salmon calcitonine in osteoporosis. Invest Med Int 13(3):189\u2013192","journal-title":"Invest Med Int"},{"issue":"1","key":"1676_CR56","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s002239900284","volume":"61","author":"B Combe","year":"1997","unstructured":"Combe B, Cohen C, Aubin F (1997) Equivalence of nasal spray and subcutaneous formulations of salmon calcitonin. Calcif Tissue Int 61(1):10\u201315","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"1676_CR57","first-page":"83","volume":"28","author":"P Kapuscinski","year":"1996","unstructured":"Kapuscinski P, Talalaj M, Borowicz J, Marcinowska-Suchowierska E, Brzozowski R (1996) An analgesic effect of synthetic human calcitonin in patients with primary osteoporosis. Mater Med Pol 28(3):83\u201386","journal-title":"Mater Med Pol"},{"issue":"5","key":"1676_CR58","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s10067-005-0159-0","volume":"25","author":"M Laroche","year":"2006","unstructured":"Laroche M, Cantogrel S, Jamard B, Constantin A, Zabraniecki L, Cantagrel A, Mazieres B (2006) Comparison of the analgesic efficacy of pamidronate and synthetic human calcitonin in osteoporotic vertebral fractures: a double-blind controlled study. Clin Rheumatol 25(5):683\u2013686","journal-title":"Clin Rheumatol"},{"issue":"2","key":"1676_CR59","first-page":"73","volume":"14","author":"R Lauro","year":"1993","unstructured":"Lauro R, Palmieri G (1993) Effect of s-calcitonin on pain related to recent osteoporotic vertebral fractures: a single-blind controlled clinical study against ipriflavone. Acta Toxicologica et Therapeutica 14(2):73\u201383","journal-title":"Acta Toxicologica et Therapeutica"},{"issue":"6","key":"1676_CR60","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/030006058501300602","volume":"13","author":"V Maresca","year":"1985","unstructured":"Maresca V (1985) Human calcitonin in the management of osteoporosis: a multicentre study. J Int Med Res 13(6):311\u2013316","journal-title":"J Int Med Res"},{"issue":"2","key":"1676_CR61","first-page":"58","volume":"5","author":"F Cisneros Dreinhoffer","year":"1991","unstructured":"Cisneros Dreinhoffer F, Mendez Huerta JV (1991) [Vertebral body compression fractures in the elderly female. A combination of conservative arthotic treatment and calcitonin-calcium administration]. Rev Mex Ortop Traumatol 5(2):58\u201361","journal-title":"Rev Mex Ortop Traumatol"},{"issue":"2","key":"1676_CR62","first-page":"23","volume":"8","author":"L Kelly Mexia","year":"1988","unstructured":"Kelly Mexia L, Gonzalez Ibanez J (1988) Effectiveness of synthetic salmon calcitonin in the osteoporosis of the spine. Compend Invest Clin Latinoam 8(2):23\u201331","journal-title":"Compend Invest Clin Latinoam"},{"issue":"1","key":"1676_CR63","first-page":"51","volume":"8","author":"JA Yabur","year":"1989","unstructured":"Yabur JA (1989) Postmenopausal osteoporosis: long time therapy with calcitonin and calcium. Arch Venez Farmacol Ter 8(1):51\u201355","journal-title":"Arch Venez Farmacol Ter"},{"issue":"Suppl 2","key":"1676_CR64","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1007\/BF02561370","volume":"49","author":"C Gennari","year":"1991","unstructured":"Gennari C, Agnusdei D, Camporeale A (1991) Use of calcitonin in the treatment of bone pain associated with osteoporosis. Calcif Tissue Int 49(Suppl 2):S9\u2013S13","journal-title":"Calcif Tissue Int"},{"issue":"Suppl 5","key":"1676_CR65","doi-asserted-by":"crossref","first-page":"71S","DOI":"10.1016\/S8756-3282(02)00714-7","volume":"30","author":"GP Lyritis","year":"2002","unstructured":"Lyritis GP, Trovas G (2002) Analgesic effects of calcitonin. Bone 30(Suppl 5):71S\u201374S","journal-title":"Bone"},{"issue":"32","key":"1676_CR66","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.2174\/1381612033453622","volume":"9","author":"NM Mehta","year":"2003","unstructured":"Mehta NM, Malootian A, Gilligan JP (2003) Calcitonin for osteoporosis and bone pain. Curr Pharm Des 9(32):2659\u20132676","journal-title":"Curr Pharm Des"},{"key":"1676_CR67","first-page":"930","volume-title":"Osteoporosis 1987\/International Symposium on Osteoporosis","author":"G Attali","year":"1987","unstructured":"Attali G, Levernieux L, Caulin F (1987) Recent crush fracture syndrome. Effect of salmon calcitonin. Results of three double blind studies and one open study. In: Christiansen C, Johanson JS, Riis BJ (eds) Osteoporosis 1987\/International Symposium on Osteoporosis. Osteopress, Copenhagen, pp 930\u2013932"},{"issue":"7","key":"1676_CR68","first-page":"215","volume":"38","author":"Ph Bordier","year":"1986","unstructured":"Bordier Ph, Julien D, Caulin F (1986) Effects of a calcitonin treatment on bone pain and resorption parameters due to recent vertebral compression fracture. Results of a double blind and opened study. Rhumatologie 38(7):215\u2013221","journal-title":"Rhumatologie"},{"issue":"1","key":"1676_CR69","first-page":"93","volume":"35","author":"SF Rifat","year":"1992","unstructured":"Rifat SF, Kiningham RB, Peggs JF (1992) Calcitonin in the treatment of osteoporotic bone pain. J Fam Pract 35(1):93\u201396","journal-title":"J Fam Pract"},{"issue":"4","key":"1676_CR70","first-page":"297","volume":"62","author":"MF Medeiros Magliano","year":"1988","unstructured":"Medeiros Magliano MF, Monteiro Zilenovski A (1988) Treatment of senile osteoporosis with salmon calcitonin: results of a multicentric short-term study; evaluation of epidemiologic data. Arq Bras Med 62(4):297\u2013308","journal-title":"Arq Bras Med"},{"issue":"11","key":"1676_CR71","first-page":"1039","volume":"115","author":"R Arinoviche","year":"1987","unstructured":"Arinoviche R, Arriagada M, Jacobelli S, Massardo L, Rivero S, Aris H, Valenzuela M, Rojas C, Carvallo A, Gatica H et al (1987) Calcitonin in acute pain due to vertebral fracture in osteoporosis. Cooperative study. Rev Med Chil 115(11):1039\u20131043","journal-title":"Rev Med Chil"},{"key":"1676_CR72","first-page":"171","volume-title":"5th International Congress on Calciotropic Hormones and Calcium Metabolism","author":"J Levernieux","year":"1985","unstructured":"Levernieux J, Bordier P, Julien D, Caulin F (1985) The effect of calcitonin on bone pain and acute resorption related to recent osteoporotic fractures. Result of a double blind and open study. In: Cecchettin M, Segre G (eds) 5th International Congress on Calciotropic Hormones and Calcium Metabolism. Elsevier Science Publishers (Biomedical Division), Venice, pp 171\u2013178"},{"issue":"4","key":"1676_CR73","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/00002508-199912000-00004","volume":"15","author":"GP Lyritis","year":"1999","unstructured":"Lyritis GP, Ioannidis GV, Karachalios T, Roidis N, Kataxaki E, Papaioannou N, Kaloudis J, Galanos A (1999) Analgesic effect of salmon calcitonin suppositories in patients with acute pain due to recent osteoporotic vertebral crush fractures: a prospective double-blind, randomized, placebo-controlled clinical study. Clin J Pain 15(4):284\u2013289","journal-title":"Clin J Pain"},{"issue":"275","key":"1676_CR74","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/17453674.1997.11744761","volume":"68","author":"GP Lyritis","year":"1997","unstructured":"Lyritis GP, Paspati I, Karachalios T, Ioakimidis D, Skarantavos G, Lyritis PG (1997) Pain relief from nasal salmon calcitonin in osteoporotic vertebral crush fractures. A double blind, placebo-controlled clinical study. Acta Orthop Scand 68(275):112\u2013114","journal-title":"Acta Orthop Scand"},{"issue":"6","key":"1676_CR75","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/BF02555844","volume":"49","author":"GP Lyritis","year":"1991","unstructured":"Lyritis GP, Tsakalakos N, Magiasis B, Karachalios T, Yiatzides A, Tsekoura M (1991) Analgesic effect of salmon calcitonin in osteoporotic vertebral fractures: a double-blind placebo-controlled clinical study. Calcif Tissue Int 49(6):369\u2013372","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"1676_CR76","first-page":"205","volume":"11","author":"KK Pun","year":"1989","unstructured":"Pun KK, Chan LW (1989) Analgesic effect of intranasal salmon calcitonin in the treatment of osteoporotic vertebral fractures. Clin Ther 11(2):205\u2013209","journal-title":"Clin Ther"},{"issue":"3","key":"1676_CR77","first-page":"369","volume":"50","author":"V Consoli","year":"1991","unstructured":"Consoli V, Alfieri P, Giuntini C, Mancia M, Avaldi F, Soncini R (1991) A double blind placebo-controlled trial of the efficacy and tolerability of intranasal elcatonin administered to patients suffering from senile and postmenopausal osteoporosis. Curr Ther Res 50(3):369\u2013378","journal-title":"Curr Ther Res"},{"issue":"3","key":"1676_CR78","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s00586-005-0916-4","volume":"15","author":"G Papadokostakis","year":"2006","unstructured":"Papadokostakis G, Damilakis J, Mantzouranis E, Katonis P, Hadjipavlou A (2006) The effectiveness of calcitonin on chronic back pain and daily activities in postmenopausal women with osteoporosis. Eur Spine J 15(3):356\u2013362","journal-title":"Eur Spine J"},{"issue":"1","key":"1676_CR79","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/09513599909167526","volume":"13","author":"P Peichl","year":"1999","unstructured":"Peichl P, Rintelen B, Kumpan W, Broll H (1999) Increase of axial and appendicular trabecular and cortical bone density in established osteoporosis with intermittent nasal salmon calcitonin therapy. Gynecol Endocrinol 13(1):7\u201314","journal-title":"Gynecol Endocrinol"},{"issue":"6","key":"1676_CR80","first-page":"459","volume":"6","author":"AE Pontiroli","year":"1994","unstructured":"Pontiroli AE, Pajetta E, Scaglia L, Rubinacci A, Resmini G, Arrigoni M, Pozza G (1994) Analgesic effect of intranasal and intramuscular salmon calcitonin in post-menopausal osteoporosis: a double-blind, double-placebo study. Aging (Milano) 6(6):459\u2013463","journal-title":"Aging (Milano)"},{"issue":"3","key":"1676_CR81","first-page":"81","volume":"26","author":"VL Szejnfeld","year":"1991","unstructured":"Szejnfeld VL, Ferraz MB, Sato EI, Atra E (1991) Analgesic effect of salmon calcitonin in patients with osteoporosis: randomized double blind method. Rev Bras Ortop 26(3):81\u201385","journal-title":"Rev Bras Ortop"},{"issue":"4","key":"1676_CR82","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","volume":"50","author":"CB Begg","year":"1994","unstructured":"Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50(4):1088\u20131101","journal-title":"Biometrics"},{"issue":"6","key":"1676_CR83","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1213\/00000539-199912000-00038","volume":"89","author":"PS Myles","year":"1999","unstructured":"Myles PS, Troedel S, Boquest M, Reeves M (1999) The pain visual analog scale: is it linear or nonlinear? Anesth Analg 89(6):1517\u20131520","journal-title":"Anesth Analg"},{"issue":"4","key":"1676_CR84","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0196-0644(96)70238-X","volume":"27","author":"KH Todd","year":"1996","unstructured":"Todd KH, Funk KG, Funk JP, Bonacci R (1996) Clinical significance of reported changes in pain severity. Ann Emerg Med 27(4):485\u2013489","journal-title":"Ann Emerg Med"},{"issue":"2","key":"1676_CR85","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1210\/jcem-72-2-344","volume":"72","author":"K Overgaard","year":"1991","unstructured":"Overgaard K, Agnusdei D, Hansen MA, Maioli E, Christiansen C, Gennari C (1991) Dose\u2013response bioactivity and bioavailability of salmon calcitonin in premenopausal and postmenopausal women. J Clin Endocrinol Metab 72(2):344\u2013349","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"1676_CR86","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1056\/NEJM199708213370806","volume":"337","author":"J LeLorier","year":"1997","unstructured":"LeLorier J, Gregoire G, Benhaddad A, Lapierre J, Derderian F (1997) Discrepancies between meta-analyses and subsequent large randomized, controlled trials. N Engl J Med 337(8):536\u2013542","journal-title":"N Engl J Med"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-011-1676-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-011-1676-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-011-1676-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T12:20:59Z","timestamp":1712492459000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-011-1676-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,10]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["1676"],"URL":"https:\/\/doi.org\/10.1007\/s00198-011-1676-0","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,10]]}}}