{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:09:34Z","timestamp":1772579374446,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2012,2,8]],"date-time":"2012-02-08T00:00:00Z","timestamp":1328659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1007\/s00198-011-1876-7","type":"journal-article","created":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T14:05:20Z","timestamp":1328623520000},"page":"2507-2515","source":"Crossref","is-referenced-by-count":49,"title":["A pragmatic randomised controlled trial of the effectiveness and cost-effectiveness of screening older women for the prevention of fractures: rationale, design and methods for the SCOOP study"],"prefix":"10.1007","volume":"23","author":[{"given":"L.","family":"Shepstone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fordham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lenaghan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Gittoes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Heawood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. J.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"O\u2019Neill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Torgerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Holland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Howe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Kanis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"McCloskey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,2,8]]},"reference":[{"key":"1876_CR1","unstructured":"Osteoporosis Prevention, Diagnosis, and Therapy. NIH Consensus Statement 2000 March 27\u201329;17: 1\u201345"},{"key":"1876_CR2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s001980050281","volume":"11","author":"JA Kanis","year":"2000","unstructured":"Kanis JA, Gl\u00fcer CC (2000) An update on the diagnosis and assessment of osteoporosis with densitometry. Osteoporos Int 11:192\u2013202","journal-title":"Osteoporos Int"},{"key":"1876_CR3","volume-title":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis","author":"World Health Organisation","year":"1994","unstructured":"World Health Organisation (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. WHO Technical Report Series, Geneva"},{"issue":"12","key":"1876_CR4","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","volume":"17","author":"O Johnell","year":"2006","unstructured":"Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17(12):1726\u20131733","journal-title":"Osteoporos Int"},{"key":"1876_CR5","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1001\/archinte.1991.00400100100017","volume":"151","author":"EA Chrischilles","year":"1991","unstructured":"Chrischilles EA, Butler CD, Davis CS, Wallace RB (1991) A model of lifetime osteoporosis impact. Arch Intern Med 151:2026\u20132032","journal-title":"Arch Intern Med"},{"key":"1876_CR6","volume-title":"Clinical guidelines for the prevention and treatment of osteoporosis","author":"Royal College of Physicians","year":"1999","unstructured":"Royal College of Physicians (1999) Clinical guidelines for the prevention and treatment of osteoporosis. RCP, London"},{"issue":"S4","key":"1876_CR7","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1007\/PL00020934","volume":"8","author":"DM Eddy","year":"1998","unstructured":"Eddy DM, Johnston CC Jr, Cummings SR et al (1998) Osteoporosis: review of the evidence for prevention, diagnosis, and treatment and cost-effectiveness analysis. Status report. Osteoporos Int 8(S4):S1\u2013S82","journal-title":"Osteoporos Int"},{"key":"1876_CR8","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","volume":"359","author":"SR Cummings","year":"2002","unstructured":"Cummings SR, Melton LJ III, Osteoporosis I (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359:1761\u20131767","journal-title":"Lancet"},{"key":"1876_CR9","volume-title":"The effective management of osteoporosis","author":"DJ Torgerson","year":"2001","unstructured":"Torgerson DJ, Iglesias CP, Reid D (2001) The economics of fracture prevention. In: Barlow DH, Francis RM, Miles A (eds) The effective management of osteoporosis. Aesculapius Medical Press, London"},{"key":"1876_CR10","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1056\/NEJM199212033272305","volume":"327","author":"MC Chapuy","year":"1992","unstructured":"Chapuy MC, Arlot ME, Duboeuf F et al (1992) Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med 327:1637\u20131642","journal-title":"N Engl J Med"},{"key":"1876_CR11","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1056\/NEJM199709043371003","volume":"337","author":"B Dawson-Hughes","year":"1997","unstructured":"Dawson-Hughes B, Harris SS, Krall EA et al (1997) Effect of calcium and vitamin D supplementation on bone density in men and women 65\u00a0years of age or older. N Engl J Med 337:670\u2013676","journal-title":"N Engl J Med"},{"key":"1876_CR12","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1359\/jbmr.060101","volume":"21","author":"C Roux","year":"2006","unstructured":"Roux C, Reginster J-Y, Fechtenbaum J, Kolta S, Sawicki A, Tulassay Z, Luisetto G, Padrino J-M, Doyle D, Prince R, Fardellone P, Sorensen OH, Meunier PJ (2006) Vertebral fracture risk reduction with strontium ranelate in women with postmenopausal osteoporosis is independent of baseline risk factors. J Bone Miner Res 21:536\u2013542","journal-title":"J Bone Miner Res"},{"key":"1876_CR13","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","volume":"288","author":"Writing Group for the Women\u2019s Health Initiative","year":"2002","unstructured":"Writing Group for the Women\u2019s Health Initiative (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the Women\u2019s Health Initiative RCT. JAMA 288:321\u2013333","journal-title":"JAMA"},{"key":"1876_CR14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1056\/NEJM200102013440503","volume":"344","author":"M McClung","year":"2001","unstructured":"McClung M, Geusens P, Miller P et al (2001) Effect of risedronate on the risk of hip fracture in elderly women. N Engl J Med 344:333\u2013340","journal-title":"N Engl J Med"},{"key":"1876_CR15","first-page":"1426","volume":"166","author":"AB Hodsman","year":"2002","unstructured":"Hodsman AB, Hanley DA, Josse R (2002) Do bisphosphonates reduce the risk of osteoporotic fractures? An evaluation of the evidence to date. CMAJ 166:1426\u20131430","journal-title":"CMAJ"},{"issue":"29","key":"1876_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta6290","volume":"6","author":"JA Kanis","year":"2002","unstructured":"Kanis JA, Brazier JE, Stevenson M, Calvert NW, Jones LM (2002) Treatment of established osteoporosis: a systematic review and cost-utility analysis. Health Technol Assess 6(29):1\u2013146","journal-title":"Health Technol Assess"},{"key":"1876_CR17","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1136\/bmj.312.7041.1254","volume":"312","author":"D Marshall","year":"1996","unstructured":"Marshall D, Johnell O, Wedel H (1996) Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 312:1254\u20131259","journal-title":"BMJ"},{"key":"1876_CR18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bone.2003.10.001","volume":"34","author":"SCE Schuit","year":"2004","unstructured":"Schuit SCE, van der Klift M, Weel AEA et al (2004) Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone 34:195\u2013202","journal-title":"Bone"},{"key":"1876_CR19","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1210\/jc.2004-1568","volume":"90","author":"SA Wainwright","year":"2005","unstructured":"Wainwright SA, Marshall LM, Ensrud KE et al (2005) Hip fracture in women without osteoporosis. J Clin Endocrinol Metab 90:2787\u20132793","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"1876_CR20","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00198-004-1780-5","volume":"16","author":"JA Kanis","year":"2005","unstructured":"Kanis JA, Borgstrom F, De Laet C et al (2005) Assessment of fracture risk. Osteoporos Int 16(6):581\u2013589","journal-title":"Osteoporos Int"},{"key":"1876_CR21","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00198-007-0343-y","volume":"18","author":"JA Kanis","year":"2007","unstructured":"Kanis JA, Oden A, Johnell O et al (2007) The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int 18:1033\u20131046","journal-title":"Osteoporos Int"},{"key":"1876_CR22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s198-002-8343-6","volume":"13","author":"CW McGrother","year":"2002","unstructured":"McGrother CW, Donaldson MMK, Clayton D, Abrams KR, Clarke M (2002) Evaluation of a hip fracture risk score for assessing elderly women: the Melton osteoporotic fracture study. Osteoporos Int 13:89\u201396","journal-title":"Osteoporos Int"},{"key":"1876_CR23","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s001980170072","volume":"12","author":"DM Black","year":"2001","unstructured":"Black DM, Steinbuch M, Palermo L et al (2001) An assessment tool for predicting fracture risk in postmenopausal women. Osteoporos Int 12:519\u2013528","journal-title":"Osteoporos Int"},{"key":"1876_CR24","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S8756-3282(02)00848-7","volume":"31","author":"TP Staa van","year":"2002","unstructured":"van Staa TP, Leufkens HGM, Cooper C (2002) Utility of medical and drug history in fracture risk prediction among men and women. Bone 31:508\u2013514","journal-title":"Bone"},{"key":"1876_CR25","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s001980050105","volume":"8","author":"A Oden","year":"1998","unstructured":"Oden A, Dawson A, Dere W et al (1998) Lifetime risk of hip fracture is underestimated. Osteoporos Int 8:599\u2013603","journal-title":"Osteoporos Int"},{"key":"1876_CR26","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1359\/jbmr.2004.19.6.906","volume":"19","author":"H Johansson","year":"2004","unstructured":"Johansson H, Oden A, Johnell O et al (2004) Optimisation of BMD measurements to identify high risk groups for treatment\u2014a test analysis. J Bone Miner Res 19:906\u2013913","journal-title":"J Bone Miner Res"},{"key":"1876_CR27","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S8756-3282(00)00381-1","volume":"27","author":"JA Kanis","year":"2000","unstructured":"Kanis JA, Johnell O, Oden A et al (2000) Risk of hip fracture according to the World Health Organization criteria for osteopenia and osteoporosis. Bone 27:585\u2013590","journal-title":"Bone"},{"key":"1876_CR28","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00198-007-0543-5","volume":"19","author":"JA Kanis","year":"2008","unstructured":"Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E (2008) FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int 19:385\u2013397","journal-title":"Osteoporos Int"},{"key":"1876_CR29","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S8756-3282(03)00200-X","volume":"33","author":"JA Kanis","year":"2003","unstructured":"Kanis JA, Johnell O, Black DM, Downs RW Jr, Sarkar S, Fuerst T, Secrest RJ, Pavo I (2003) Effect of raloxifene on the risk of new vertebral fracture in postmenopausal women with osteopenia or osteoporosis: a reanalysis of the Multiple Outcomes of Raloxifene Evaluation trial. Bone 33:293\u2013300","journal-title":"Bone"},{"issue":"5","key":"1876_CR30","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00198-004-1698-y","volume":"16","author":"JA Kanis","year":"2005","unstructured":"Kanis JA, Barton IP, Johnell O (2005) Risedronate decreases fracture risk in patients selected solely on the basis of prior vertebral fracture. Osteoporos Int 16(5):475\u2013482","journal-title":"Osteoporos Int"},{"issue":"3","key":"1876_CR31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.4065\/80.3.343","volume":"80","author":"SA Quandt","year":"2005","unstructured":"Quandt SA, Thompson DE, Schneider DL, Nevitt MC, Black DM (2005) Effect of alendronate on vertebral fracture risk in women with bone mineral density T scores of \u22121.6 to \u22122.5 at the femoral neck: the Fracture Intervention Trial. Mayo Clin Proc 80(3):343\u2013349","journal-title":"Mayo Clin Proc"},{"issue":"5","key":"1876_CR32","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1359\/jbmr.040116","volume":"19","author":"E McCloskey","year":"2004","unstructured":"McCloskey E, Selby P, Davies M et al (2004) Clodronate reduces vertebral fracture risk in women with postmenopausal or secondary osteoporosis: results of a double-blind, placebo-controlled 3-year study. J Bone Miner Res 19(5):728\u2013736","journal-title":"J Bone Miner Res"},{"key":"1876_CR33","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00198-008-0786-9","volume":"20","author":"EV McCloskey","year":"2009","unstructured":"McCloskey EV, Johansson H, Oden A, Vasireddy S, Kayan K, Pande K, Jalava T, Kanis JA (2009) Ten-year fracture probability identifies women who will benefit from clodronate therapy\u2014additional results from a double blind, placebo controlled randomised study. Osteoporos Int 20:811\u2013818","journal-title":"Osteoporos Int"},{"key":"1876_CR34","first-page":"49","volume":"44","author":"JA Kanis","year":"2009","unstructured":"Kanis JA, Johansson H, Oden A, McCloskey EV (2009) Bazedoxifene reduces vertebral and clinical fractures in postmenopausal women at high risk assessed with FRAX\u00ae. Bone 44:49\u201354","journal-title":"Bone"},{"key":"1876_CR35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.maturitas.2008.11.022","volume":"62","author":"J Compston","year":"2009","unstructured":"Compston J, Cooper A, Cooper C, Francis R, Kanis JA, Marsh D, McCloskey EV, Reid DM, Selby P, Wilkins M (2009) On behalf of the National Osteoporosis Guideline Group (NOGG) Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50\u00a0years in the UK. Maturitas 62:105\u2013108","journal-title":"Maturitas"},{"key":"1876_CR36","volume-title":"Principles and practices of screening for disease","author":"JMG Wilson","year":"1968","unstructured":"Wilson JMG, Jungner G (1968) Principles and practices of screening for disease. World Health Organisation, Geneva"},{"key":"1876_CR37","first-page":"260","volume":"17","author":"AZ Croix La","year":"2002","unstructured":"La Croix AZ, Buist DSM, Brenneman SK et al (2002) Evaluation of three population-based strategies for fracture prevention: results of the OPRA trial. J Bone Miner Res 17:260","journal-title":"J Bone Miner Res"},{"key":"1876_CR38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0028-2243(94)02002-V","volume":"59","author":"DJ Torgerson","year":"1995","unstructured":"Torgerson DJ, Donaldson C, Russell IT et al (1995) Hormone replacement therapy: compliance and cost after screening for osteoporosis. Eur J Obstet Gynaecol 59:57\u201360","journal-title":"Eur J Obstet Gynaecol"},{"key":"1876_CR39","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00223-004-0101-5","volume":"76","author":"RJ Barr","year":"2005","unstructured":"Barr RJ, Stewart A, Torgerson DJ et al (2005) Screening elderly women for risk of future fractures\u2014participation rates and impact on incidence of falls and fractures. Calcif Tissue Int 76:243\u2013248","journal-title":"Calcif Tissue Int"},{"key":"1876_CR40","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bone.2004.08.018","volume":"36","author":"JA Kanis","year":"2005","unstructured":"Kanis JA, Borgstrom F, Zethraeus N et al (2005) Intervention thresholds for osteoporosis in the UK. Bone 36:22\u201332","journal-title":"Bone"},{"key":"1876_CR41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/sim.4780110205","volume":"11","author":"E Lakatos","year":"1992","unstructured":"Lakatos E, Lan K (1992) A comparison of sample size methods for the logrank statistic. Stat Med 11:179\u2013191","journal-title":"Stat Med"},{"key":"1876_CR42","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S8756-3282(01)00614-7","volume":"29","author":"TP Staa van","year":"2001","unstructured":"van Staa TP, Dennison EM, Leufkens HGM et al (2001) Epidemiology of fractures in England and Wales. Bone 29:517\u2013522","journal-title":"Bone"},{"key":"1876_CR43","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1136\/bmj.322.7282.355","volume":"322","author":"DJ Torgerson","year":"2001","unstructured":"Torgerson DJ (2001) Contamination in trials: is cluster randomization the answer? BMJ 322:355\u2013357","journal-title":"BMJ"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-011-1876-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-011-1876-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-011-1876-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T15:08:43Z","timestamp":1558624123000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-011-1876-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,8]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["1876"],"URL":"https:\/\/doi.org\/10.1007\/s00198-011-1876-7","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,8]]}}}