{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:23:59Z","timestamp":1773296639869,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T00:00:00Z","timestamp":1353024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1007\/s00198-012-2217-1","type":"journal-article","created":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T13:19:31Z","timestamp":1352985571000},"page":"1677-1682","source":"Crossref","is-referenced-by-count":19,"title":["Chlamydia pneumoniae and osteoporosis-associated bone loss: a new risk factor?"],"prefix":"10.1007","volume":"24","author":[{"given":"M.","family":"Di Pietro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Schiavoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Sessa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Pallotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Costanzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Sessa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,11,16]]},"reference":[{"key":"2217_CR1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","volume":"377","author":"TD Rachner","year":"2011","unstructured":"Rachner TD, Khosla S, Hofbauer LC (2011) Osteoporosis: now and the future. Lancet 377:1276\u20131287","journal-title":"Lancet"},{"key":"2217_CR2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00228-011-0999-2","volume":"67","author":"L Brewer","year":"2011","unstructured":"Brewer L, Williams D, Moore A (2011) Current and future treatment options in osteoporosis. Eur J Clin Pharmacol 67:321\u2013331","journal-title":"Eur J Clin Pharmacol"},{"key":"2217_CR3","doi-asserted-by":"crossref","first-page":"e18748","DOI":"10.1371\/journal.pone.0018748","volume":"6","author":"T Claro","year":"2011","unstructured":"Claro T, Widaa A, O\u2019Seaghdha M, Miajlovic H, Foster TJ, O\u2019Brien FJ, Kerrigan SW (2011) Staphylococcus aureus protein A binds to osteoblasts and triggers signals that weaken bone in osteomyelitis. PLoS One 6:e18748","journal-title":"PLoS One"},{"key":"2217_CR4","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1902\/jop.2010.100250","volume":"82","author":"H Schreiner","year":"2011","unstructured":"Schreiner H, Markowitz K, Miryalkar M, Moore D, Diehl S, Fine DH (2011) Aggregatibacter actinomycetemcomitans-induced bone loss and antibody response in three rat strains. J Periodontol 82:142\u2013150","journal-title":"J Periodontol"},{"key":"2217_CR5","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1128\/IAI.01259-08","volume":"77","author":"MV Delpino","year":"2009","unstructured":"Delpino MV, Fossati CA, Baldi PC (2009) Proinflammatory response of human osteoblastic cell lines and osteoblast-monocyte interaction upon infection with Brucella spp. Infect Immun 77:984\u2013995","journal-title":"Infect Immun"},{"key":"2217_CR6","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1902\/jop.2008.080183","volume":"79","author":"D Graves","year":"2008","unstructured":"Graves D (2008) Cytokines that promote periodontal tissue destruction. J Periodontol 79:1585\u20131591","journal-title":"J Periodontol"},{"key":"2217_CR7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1385\/IR:30:3:291","volume":"30","author":"I Marriott","year":"2004","unstructured":"Marriott I (2004) Osteoblast responses to bacterial pathogens: a previously unappreciated role for bone-forming cells in host defense and disease progression. Immunol Res 30:291\u2013308","journal-title":"Immunol Res"},{"key":"2217_CR8","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.micinf.2008.06.010","volume":"10","author":"L Bailey","year":"2008","unstructured":"Bailey L, Engstr\u00f6m P, Nordstr\u00f6m A, Bergstr\u00f6m S, Waldenstr\u00f6m A, Nordstr\u00f6m P (2008) Chlamydia pneumoniae infection results in generalized bone loss in mice. Microbes Infect 10:1175\u20131181","journal-title":"Microbes Infect"},{"key":"2217_CR9","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.cyto.2011.06.027","volume":"56","author":"A Rizzo","year":"2011","unstructured":"Rizzo A, Di Domenico M, Carratelli CR, Mazzola N, Paolillo R (2011) Induction of proinflammatory cytokines in human osteoblastic cells by Chlamydia pneumoniae. Cytokine 56:450\u2013457","journal-title":"Cytokine"},{"key":"2217_CR10","first-page":"277","volume":"26","author":"M Pietro Di","year":"2012","unstructured":"Di Pietro M, Tramonti A, De Santis F, De Biase D, Schiavoni G, Sessa R (2012) Analysis of gene expression in penicillin G induced persistence of Chlamydia pneumoniae. J Biological Regulators & Homeostatic Agents 26:277\u2013284","journal-title":"J Biological Regulators & Homeostatic Agents"},{"key":"2217_CR11","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.imbio.2010.05.021","volume":"215","author":"R Bellmann-Weiler","year":"2010","unstructured":"Bellmann-Weiler R, Martinz V, Kurz K, Engl S, Feistritzer C, Fuchs D, Rupp J, Paldanius M, Weiss G (2010) Divergent modulation of Chlamydia pneumoniae infection cycle in human monocytic and endothelial cells by iron, tryptophan availability and interferon gamma. Immunobiology 215:842\u2013848","journal-title":"Immunobiology"},{"key":"2217_CR12","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1160\/TH11-06-0392","volume":"106","author":"ME Rosenfeld","year":"2011","unstructured":"Rosenfeld ME, Campbell LA (2011) Pathogens and atherosclerosis: update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis. Thromb Haemost 106:858\u2013867","journal-title":"Thromb Haemost"},{"key":"2217_CR13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/039463200902200102","volume":"22","author":"R Sessa","year":"2009","unstructured":"Sessa R, Nicoletti M, Di Pietro M, Schiavoni G, Santino I, Zagaglia C, Del Piano M, Cipriani P (2009) Chlamydia pneumoniae and atherosclerosis: current state and future prospectives. Int J Immunopathol Pharmacol 22:9\u201314","journal-title":"Int J Immunopathol Pharmacol"},{"key":"2217_CR14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrrheum.2011.173","volume":"8","author":"E Gracey","year":"2011","unstructured":"Gracey E, Inman RD (2011) Chlamydia-induced ReA: immune imbalances and persistent pathogens. Nat Rev Rheumatol 8:55\u201359","journal-title":"Nat Rev Rheumatol"},{"key":"2217_CR15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/ar382","volume":"4","author":"C Villareal","year":"2002","unstructured":"Villareal C, Whittum-Hudson JA, Hudson AP (2002) Persistent Chlamydiae and chronic arthritis. Arthritis Res 4:5\u20139","journal-title":"Arthritis Res"},{"key":"2217_CR16","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/1521-4141(200002)30:2<541::AID-IMMU541>3.0.CO;2-X","volume":"30","author":"MG Netea","year":"2000","unstructured":"Netea MG, Selzmann CH, Kullberg BJ (2000) Acellular components of Chlamydia pneumoniae stimulate cytokine production in human blood mononuclear cells. Eur J Immunol 30:541\u2013549","journal-title":"Eur J Immunol"},{"key":"2217_CR17","first-page":"160","volume":"50","author":"R Takano","year":"2005","unstructured":"Takano R, Yamaguchi H, Sugimoto S, Nakamura S, Friedman H, Yamamoto Y (2005) Cytokine response of lymphocytes persistently infected with Chlamydia pneumoniae. Curr Microbiol 50:160\u2013166","journal-title":"Curr Microbiol"},{"key":"2217_CR18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9440(10)65266-2","volume":"154","author":"KD Merkel","year":"1999","unstructured":"Merkel KD, Erdmann JM, McHugh KP, Abu-Amer Y, Ross FP, Teitelbaum SL (1999) Tumor necrosis factor-\u03b1 mediates orthopedic implant osteolysis. Am J Pathol 154:203\u2013210","journal-title":"Am J Pathol"},{"key":"2217_CR19","first-page":"1","volume":"843","author":"WHO Study Group","year":"1994","unstructured":"WHO Study Group (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group World Health Organ Tech Rep Ser 843:1\u2013129","journal-title":"Report of a WHO Study Group World Health Organ Tech Rep Ser"},{"key":"2217_CR20","doi-asserted-by":"crossref","first-page":"e224","DOI":"10.1016\/j.atherosclerosis.2007.04.052","volume":"195","author":"R Sessa","year":"2007","unstructured":"Sessa R, Di Pietro M, Schiavoni G, Petrucca A, Cipriani P, Zagaglia C, Nicoletti M, Santino I, del Piano M (2007) Measurement of Chlamydia pneumoniae bacterial load in peripheral blood mononuclear cells may be helpful to assess the state of chlamydial infection in patients with carotid atherosclerotic disease. Atherosclerosis 195:e224\u2013e230","journal-title":"Atherosclerosis"},{"key":"2217_CR21","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1183\/09031936.04.00093304","volume":"23","author":"J Gieffers","year":"2004","unstructured":"Gieffers J, van Zandbergen G, Rupp J, Sayk F, Kr\u00fcger S, Ehlers S, Solbach W, Maass M (2004) Phagocytes transmit Chlamydia pneumoniae from the lungs to the vasculature. Eur Respir J 23:506\u2013510","journal-title":"Eur Respir J"},{"key":"2217_CR22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/mpat.2000.0360","volume":"29","author":"HC G\u00e9rard","year":"2000","unstructured":"G\u00e9rard HC, Schumacher HR, El-Gabalawy H, Goldbach-Mansky R, Hudson AP (2000) Chlamydia pneumoniae present in the human synovium are viable and metabolically active. Microb Pathog 29:17\u201324","journal-title":"Microb Pathog"},{"key":"2217_CR23","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1002\/art.24431","volume":"60","author":"JD Carter","year":"2009","unstructured":"Carter JD, G\u00e9rard HC, Espinoza LR, Ricca LR, Valeriano J, Snelgrove J, Oszust C, Vasey FB, Hudson AP (2009) Chlamydiae as etiologic agents in chronic undifferentiated spondylarthritis. Arthritis Rheum 60:1311\u20131316","journal-title":"Arthritis Rheum"},{"key":"2217_CR24","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s11914-011-0078-8","volume":"9","author":"A Teti","year":"2011","unstructured":"Teti A (2011) Bone development: overview of bone cells and signaling. Curr Osteoporos Rep 9:264\u2013273","journal-title":"Curr Osteoporos Rep"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-012-2217-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-012-2217-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-012-2217-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T15:08:51Z","timestamp":1558624131000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-012-2217-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,16]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["2217"],"URL":"https:\/\/doi.org\/10.1007\/s00198-012-2217-1","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,16]]}}}