{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:12:12Z","timestamp":1791263532644,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T00:00:00Z","timestamp":1393286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1007\/s00198-014-2650-4","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T11:34:28Z","timestamp":1393241668000},"page":"1595-1606","source":"Crossref","is-referenced-by-count":31,"title":["Accuracy of trabecular structure by HR-pQCT compared to gold standard \u03bcCT in the radius and tibia of patients with osteoporosis and long-term bisphosphonate therapy"],"prefix":"10.1007","volume":"25","author":[{"given":"M.","family":"Krause","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Museyko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Breer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wulff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Duckstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vettorazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Glueer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"P\u00fcschel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Engelke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Amling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,25]]},"reference":[{"issue":"12","key":"2650_CR1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1056\/NEJM199503233321202","volume":"332","author":"SR Cummings","year":"1995","unstructured":"Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley J, Black D, Vogt TM (1995) Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 332(12):767\u2013773. doi: 10.1056\/NEJM199503233321202","journal-title":"N Engl J Med"},{"issue":"Suppl 3","key":"2650_CR2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2106\/00004623-200300003-00003","volume":"85-A","author":"GA Rodan","year":"2003","unstructured":"Rodan GA, Reszka AA (2003) Osteoporosis and bisphosphonates. J Bone Jt Surg Am 85-A (Suppl 3):8\u201312","journal-title":"J Bone Jt Surg Am"},{"key":"2650_CR3","doi-asserted-by":"crossref","unstructured":"Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis (1993) Am J Med 94(6):646\u201350","DOI":"10.1016\/0002-9343(93)90218-E"},{"issue":"Suppl 3","key":"2650_CR4","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1007\/s00198-002-1345-4","volume":"14","author":"P Ammann","year":"2003","unstructured":"Ammann P, Rizzoli R (2003) Bone strength and its determinants. Osteoporos Int 14(Suppl 3):S13\u201318. doi: 10.1007\/s00198-002-1345-4","journal-title":"Osteoporos Int"},{"issue":"1","key":"2650_CR5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bone.2003.10.001","volume":"34","author":"SC Schuit","year":"2004","unstructured":"Schuit SC, van der Klift M, Weel AE, de Laet CE, Burger H, Seeman E, Hofman A, Uitterlinden AG, van Leeuwen JP, Pols HA (2004) Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone 34(1):195\u2013202","journal-title":"Bone"},{"issue":"3","key":"2650_CR6","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1359\/jbmr.071108","volume":"23","author":"S Boutroy","year":"2008","unstructured":"Boutroy S, Van Rietbergen B, Sornay-Rendu E, Munoz F, Bouxsein ML, Delmas PD (2008) Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women. J Bone Miner Res 23(3):392\u2013399. doi: 10.1359\/jbmr.071108","journal-title":"J Bone Miner Res"},{"issue":"5","key":"2650_CR7","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1007\/s00198-012-2160-1","volume":"24","author":"KK Nishiyama","year":"2013","unstructured":"Nishiyama KK, Macdonald HM, Hanley DA, Boyd SK (2013) Women with previous fragility fractures can be classified based on bone microarchitecture and finite element analysis measured with HR-pQCT. Osteoporos Int 24(5):1733\u20131740. doi: 10.1007\/s00198-012-2160-1","journal-title":"Osteoporos Int"},{"issue":"3","key":"2650_CR8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1359\/jbmr.061206","volume":"22","author":"E Sornay-Rendu","year":"2007","unstructured":"Sornay-Rendu E, Boutroy S, Munoz F, Delmas PD (2007) Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study. J Bone Miner Res 22(3):425\u2013433. doi: 10.1359\/jbmr.061206","journal-title":"J Bone Miner Res"},{"issue":"6","key":"2650_CR9","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.medengphy.2007.11.003","volume":"30","author":"JA MacNeil","year":"2008","unstructured":"MacNeil JA, Boyd SK (2008) Improved reproducibility of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys 30(6):792\u2013799. doi: 10.1016\/j.medengphy.2007.11.003","journal-title":"Med Eng Phys"},{"issue":"10","key":"2650_CR10","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1007\/s10439-007-9344-4","volume":"35","author":"AJ Burghardt","year":"2007","unstructured":"Burghardt AJ, Kazakia GJ, Majumdar S (2007) A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone. Ann Biomed Eng 35(10):1678\u20131686. doi: 10.1007\/s10439-007-9344-4","journal-title":"Ann Biomed Eng"},{"issue":"4","key":"2650_CR11","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1359\/jbmr.090822","volume":"25","author":"XS Liu","year":"2010","unstructured":"Liu XS, Zhang XH, Sekhon KK, Adams MF, McMahon DJ, Bilezikian JP, Shane E, Guo XE (2010) High-resolution peripheral quantitative computed tomography can assess microstructural and mechanical properties of human distal tibial bone. J Bone Miner Res 25(4):746\u2013756. doi: 10.1359\/jbmr.090822","journal-title":"J Bone Miner Res"},{"issue":"3","key":"2650_CR12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.bone.2009.05.023","volume":"45","author":"K Sekhon","year":"2009","unstructured":"Sekhon K, Kazakia GJ, Burghardt AJ, Hermannsson B, Majumdar S (2009) Accuracy of volumetric bone mineral density measurement in high-resolution peripheral quantitative computed tomography. Bone 45(3):473\u2013479. doi: 10.1016\/j.bone.2009.05.023","journal-title":"Bone"},{"issue":"5","key":"2650_CR13","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S8756-3282(00)00376-8","volume":"27","author":"GY Boivin","year":"2000","unstructured":"Boivin GY, Chavassieux PM, Santora AC, Yates J, Meunier PJ (2000) Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women. Bone 27(5):687\u2013694","journal-title":"Bone"},{"issue":"6","key":"2650_CR14","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.bone.2009.08.002","volume":"45","author":"B Busse","year":"2009","unstructured":"Busse B, Hahn M, Soltau M, Zustin J, Puschel K, Duda GN, Amling M (2009) Increased calcium content and inhomogeneity of mineralization render bone toughness in osteoporosis: mineralization, morphology and biomechanics of human single trabeculae. Bone 45(6):1034\u20131043. doi: 10.1016\/j.bone.2009.08.002","journal-title":"Bone"},{"key":"2650_CR15","unstructured":"Ibanez L, Schroeder W, Ng L, Cates J (2005) The ITK Software Guide."},{"issue":"7","key":"2650_CR16","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1007\/s10439-010-9981-x","volume":"38","author":"O Museyko","year":"2010","unstructured":"Museyko O, Eisa F, Hess A, Schett G, Kalender WA, Engelke K (2010) Binary segmentation masks can improve intrasubject registration accuracy of bone structures in CT images. Ann Biomed Eng 38(7):2464\u20132472. doi: 10.1007\/s10439-010-9981-x","journal-title":"Ann Biomed Eng"},{"issue":"1","key":"2650_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01600238","volume":"418","author":"M Hahn","year":"1991","unstructured":"Hahn M, Vogel M, Delling G (1991) Undecalcified preparation of bone tissue: report of technical experience and development of new methods. Virchows Arch A, Pathological Anat histopathol 418(1):1\u20137","journal-title":"Virchows Arch A, Pathological Anat histopathol"},{"issue":"7","key":"2650_CR18","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1007\/s00264-011-1464-7","volume":"36","author":"M Krause","year":"2012","unstructured":"Krause M, Breer S, Hahn M, Ruther W, Morlock MM, Amling M, Zustin J (2012) Cementation and interface analysis of early failure cases after hip-resurfacing arthroplasty. Int Orthop 36(7):1333\u20131340. doi: 10.1007\/s00264-011-1464-7","journal-title":"Int Orthop"},{"key":"2650_CR19","doi-asserted-by":"crossref","unstructured":"Krause M, Rupprecht M, Mumme M, Puschel K, Amling M, Barvencik F (2013) Bone Microarchitecture of the Talus Changes With Aging. Clin Orthop Relat Res. doi: 10.1007\/s11999-013-3195-0","DOI":"10.1007\/s11999-013-3195-0"},{"issue":"1","key":"2650_CR20","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","volume":"28","author":"DW Dempster","year":"2013","unstructured":"Dempster DW, Compston JE, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR, Parfitt AM (2013) Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 28(1):2\u201317. doi: 10.1002\/jbmr.1805","journal-title":"J Bone Miner Res"},{"issue":"10","key":"2650_CR21","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.medengphy.2006.11.002","volume":"29","author":"JA MacNeil","year":"2007","unstructured":"MacNeil JA, Boyd SK (2007) Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys 29(10):1096\u20131105. doi: 10.1016\/J.Medengphy.2006.11.002","journal-title":"Med Eng Phys"},{"key":"2650_CR22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1365-2818.1997.1340694.x","volume":"185","author":"T Hildebrand","year":"1997","unstructured":"Hildebrand T, Ruegsegger P (1997) A new method for the model-independent assessment of thickness in three-dimensional images. J Microsc-Oxford 185:67\u201375","journal-title":"J Microsc-Oxford"},{"issue":"4","key":"2650_CR23","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1172\/JCI111096","volume":"72","author":"AM Parfitt","year":"1983","unstructured":"Parfitt AM, Mathews CH, Villanueva AR, Kleerekoper M, Frame B, Rao DS (1983) Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest 72(4):1396\u20131409. doi: 10.1172\/JCI111096","journal-title":"J Clin Invest"},{"issue":"2","key":"2650_CR24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00223-008-9158-x","volume":"83","author":"AJ Burghardt","year":"2008","unstructured":"Burghardt AJ, Kazakia GJ, Laib A, Majumdar S (2008) Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomography. Calcif Tissue Int 83(2):129\u2013138. doi: 10.1007\/s00223-008-9158-x","journal-title":"Calcif Tissue Int"},{"issue":"7","key":"2650_CR25","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1080\/02841850410008171","volume":"45","author":"L Mulder","year":"2004","unstructured":"Mulder L, Koolstra JH, Van Eijden TM (2004) Accuracy of microCT in the quantitative determination of the degree and distribution of mineralization in developing bone. Acta Radiol 45(7):769\u2013777","journal-title":"Acta Radiol"},{"issue":"8982","key":"2650_CR26","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0140-6736(95)91748-9","volume":"346","author":"JM Bland","year":"1995","unstructured":"Bland JM, Altman DG (1995) Comparing methods of measurement: why plotting difference against standard method is misleading. Lancet 346(8982):1085\u20131087","journal-title":"Lancet"},{"issue":"1","key":"2650_CR27","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/ALN.0b013e31823d7784","volume":"116","author":"JM Bland","year":"2012","unstructured":"Bland JM, Altman DG (2012) Agreed statistics: measurement method comparison. Anesthesiology 116(1):182\u2013185. doi: 10.1097\/ALN.0b013e31823d7784","journal-title":"Anesthesiology"},{"issue":"2","key":"2650_CR28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1191\/096228099673819272","volume":"8","author":"JM Bland","year":"1999","unstructured":"Bland JM, Altman DG (1999) Measuring agreement in method comparison studies. Stat Methods Med Res 8(2):135\u2013160","journal-title":"Stat Methods Med Res"},{"issue":"2","key":"2650_CR29","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1359\/jbmr.090728","volume":"25","author":"M Priemel","year":"2010","unstructured":"Priemel M, von Domarus C, Klatte TO, Kessler S, Schlie J, Meier S, Proksch N, Pastor F, Netter C, Streichert T, Puschel K, Amling M (2010) Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res 25(2):305\u2013312. doi: 10.1359\/jbmr.090728","journal-title":"J Bone Miner Res"},{"issue":"10","key":"2650_CR30","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1007\/s00198-013-2374-x","volume":"24","author":"A Bernhard","year":"2013","unstructured":"Bernhard A, Milovanovic P, Zimmermann EA, Hahn M, Djonic D, Krause M, Breer S, Puschel K, Djuric M, Amling M, Busse B (2013) Micro-morphological properties of osteons reveal changes in cortical bone stability during aging, osteoporosis, and bisphosphonate treatment in women. Osteoporos Int 24(10):2671\u20132680. doi: 10.1007\/s00198-013-2374-x","journal-title":"Osteoporos Int"},{"issue":"1","key":"2650_CR31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1359\/jbmr.090702","volume":"25","author":"P Roschger","year":"2010","unstructured":"Roschger P, Lombardi A, Misof BM, Maier G, Fratzl-Zelman N, Fratzl P, Klaushofer K (2010) Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: qBEI and sSAXS data from the fracture intervention trial long-term extension (FLEX). J Bone Miner Res 25(1):48\u201355. doi: 10.1359\/jbmr.090702","journal-title":"J Bone Miner Res"},{"issue":"9727","key":"2650_CR32","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/S0140-6736(10)60320-0","volume":"375","author":"RM Zebaze","year":"2010","unstructured":"Zebaze RM, Ghasem-Zadeh A, Bohte A, Iuliano-Burns S, Mirams M, Price RI, Mackie EJ, Seeman E (2010) Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study. Lancet 375(9727):1729\u20131736. doi: 10.1016\/S0140-6736(10)60320-0","journal-title":"Lancet"},{"issue":"1","key":"2650_CR33","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bone.2007.02.029","volume":"41","author":"JA MacNeil","year":"2007","unstructured":"MacNeil JA, Boyd SK (2007) Load distribution and the predictive power of morphological indices in the distal radius and tibia by high resolution peripheral quantitative computed tomography. Bone 41(1):129\u2013137. doi: 10.1016\/j.bone.2007.02.029","journal-title":"Bone"},{"issue":"1","key":"2650_CR34","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S8756-3282(98)00159-8","volume":"24","author":"A Laib","year":"1999","unstructured":"Laib A, Ruegsegger P (1999) Calibration of trabecular bone structure measurements of in vivo three-dimensional peripheral quantitative computed tomography with 28-microm-resolution microcomputed tomography. Bone 24(1):35\u201339","journal-title":"Bone"},{"issue":"2","key":"2650_CR35","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.bone.2007.04.179","volume":"41","author":"RK Fuchs","year":"2007","unstructured":"Fuchs RK, Shea M, Durski SL, Winters-Stone KM, Widrick J, Snow CM (2007) Individual and combined effects of exercise and alendronate on bone mass and strength in ovariectomized rats. Bone 41(2):290\u2013296. doi: 10.1016\/j.bone.2007.04.179","journal-title":"Bone"},{"issue":"1","key":"2650_CR36","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1359\/jbmr.090713","volume":"25","author":"MR Allen","year":"2010","unstructured":"Allen MR, Kubek DJ, Burr DB (2010) Cancer treatment dosing regimens of zoledronic acid result in near-complete suppression of mandible intracortical bone remodeling in beagle dogs. J Bone Miner Res 25(1):98\u2013105. doi: 10.1359\/jbmr.090713","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2650_CR37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S8756-3282(02)00923-7","volume":"32","author":"SY Smith","year":"2003","unstructured":"Smith SY, Recker RR, Hannan M, Muller R, Bauss F (2003) Intermittent intravenous administration of the bisphosphonate ibandronate prevents bone loss and maintains bone strength and quality in ovariectomized cynomolgus monkeys. Bone 32(1):45\u201355","journal-title":"Bone"},{"issue":"1","key":"2650_CR38","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bone.2011.10.003","volume":"50","author":"JB Pialat","year":"2012","unstructured":"Pialat JB, Burghardt AJ, Sode M, Link TM, Majumdar S (2012) Visual grading of motion induced image degradation in high resolution peripheral computed tomography: impact of image quality on measures of bone density and micro-architecture. Bone 50(1):111\u2013118. doi: 10.1016\/j.bone.2011.10.003","journal-title":"Bone"},{"issue":"1","key":"2650_CR39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1359\/jbmr.090711","volume":"25","author":"B Borah","year":"2010","unstructured":"Borah B, Dufresne T, Nurre J, Phipps R, Chmielewski P, Wagner L, Lundy M, Bouxsein M, Zebaze R, Seeman E (2010) Risedronate reduces intracortical porosity in women with osteoporosis. J Bone Miner Res 25(1):41\u201347. doi: 10.1359\/jbmr.090711","journal-title":"J Bone Miner Res"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-014-2650-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-014-2650-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-014-2650-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T14:26:22Z","timestamp":1716560782000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-014-2650-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,25]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["2650"],"URL":"https:\/\/doi.org\/10.1007\/s00198-014-2650-4","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,25]]}}}