{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:13:27Z","timestamp":1784693607163,"version":"3.55.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1007\/s00198-014-2684-7","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T22:31:06Z","timestamp":1395700266000},"page":"1937-1944","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["External auditory canal and middle ear cholesteatoma and osteonecrosis in bisphosphonate-treated osteoporosis patients: a Danish national register-based cohort study and literature review"],"prefix":"10.1007","volume":"25","author":[{"given":"A.-L.","family":"Thorsteinsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vestergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Eiken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,25]]},"reference":[{"key":"2684_CR1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1001\/jama.2009.50","volume":"301","author":"D Bliuc","year":"2009","unstructured":"Bliuc D, Nguyen ND, Milch VE, Nguyen TV, Eisman JA, Center JR (2009) Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA 301:513\u2013521","journal-title":"JAMA"},{"key":"2684_CR2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.amjmed.2012.06.023","volume":"126","author":"M McClung","year":"2013","unstructured":"McClung M, Harris ST, Miller PD, Bauer DC, Davison KS, Dian L, Hanley DA, Kendler DL, Yuen CK, Lewiecki EM (2013) Bisphosphonate therapy for osteoporosis: benefits, risks, and drug holiday. Am J Med 126:13\u201320","journal-title":"Am J Med"},{"key":"2684_CR3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bone.2011.04.022","volume":"49","author":"RG Russell","year":"2011","unstructured":"Russell RG (2011) Bisphosphonates: the first 40\u00a0years. Bone 49:2\u201319","journal-title":"Bone"},{"key":"2684_CR4","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bone.2013.09.023","volume":"58","author":"EF Eriksen","year":"2014","unstructured":"Eriksen EF, Diez-Perez A, Boonen S (2014) Update on long-term treatment with bisphosphonates for postmenopausal osteoporosis: a systematic review. Bone 58:126\u2013135","journal-title":"Bone"},{"key":"2684_CR5","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1210\/jc.2012-1027","volume":"97","author":"S Khosla","year":"2012","unstructured":"Khosla S, Bilezikian JP, Dempster DW, Lewiecki EM, Miller PD, Neer RM, Recker RR, Shane E, Shoback D, Potts JT (2012) Benefits and risks of bisphosphonate therapy for osteoporosis. J Clin Endocrinol Metab 97:2272\u20132282","journal-title":"J Clin Endocrinol Metab"},{"key":"2684_CR6","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.rdc.2012.09.001","volume":"38","author":"C Orozco","year":"2012","unstructured":"Orozco C, Maalouf NM (2012) Safety of bisphosphonates. Rheum Dis Clin N Am 38:681\u2013705","journal-title":"Rheum Dis Clin N Am"},{"key":"2684_CR7","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.joms.2011.02.093","volume":"70","author":"P Vestergaard","year":"2012","unstructured":"Vestergaard P, Schwartz K, Rejnmark L, Mosekilde L, Pinholt EM (2012) Oral bisphosphonate use increases the risk for inflammatory jaw disease: a cohort study. J Oral Maxillofac Surg 70:821\u2013829","journal-title":"J Oral Maxillofac Surg"},{"key":"2684_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jbmr.1998","volume":"29","author":"E Shane","year":"2014","unstructured":"Shane E, Burr D, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster DW, Ebeling PR, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O\u2019Keefe R, Papapoulos S, Howe TS, van der Meulen MC, Weinstein RS, Whyte MP (2014) Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the american society for bone and mineral research. J Bone Miner Res 29:1\u201323","journal-title":"J Bone Miner Res"},{"key":"2684_CR9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/MAO.0b013e31827ca34d","volume":"34","author":"R Salzman","year":"2013","unstructured":"Salzman R, Hoza J, Perina V, Starek I (2013) Osteonecrosis of the external auditory canal associated with oral bisphosphonate therapy: case report and literature review. Otol Neurotol 34:209\u2013213","journal-title":"Otol Neurotol"},{"issue":"Suppl 2","key":"2684_CR10","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1017\/S002221511300100X","volume":"127","author":"N Wickham","year":"2013","unstructured":"Wickham N, Crawford A, Carney AS, Goss AN (2013) Bisphosphonate-associated osteonecrosis of the external auditory canal. J Laryngol Otol 127(Suppl 2):S51\u2013S53","journal-title":"J Laryngol Otol"},{"key":"2684_CR11","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1365-2141.2005.05833.x","volume":"132","author":"MN Polizzotto","year":"2006","unstructured":"Polizzotto MN, Cousins V, Schwarer AP (2006) Bisphosphonate-associated osteonecrosis of the auditory canal. Br J Haematol 132:114","journal-title":"Br J Haematol"},{"key":"2684_CR12","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s00405-011-1496-z","volume":"268","author":"K Froelich","year":"2011","unstructured":"Froelich K, Radeloff A, Kohler C, Mlynski R, Muller J, Hagen R, Kleinsasser NH (2011) Bisphosphonate-induced osteonecrosis of the external ear canal: a retrospective study. Eur Arch Otorhinolaryngol 268:1219\u20131225","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2684_CR13","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s00106-012-2554-6","volume":"60","author":"F Bast","year":"2012","unstructured":"Bast F, Fuss H, Schrom T (2012) Bilateral bisphosphonate-associated osteonecrosis of the external ear canal : a rare case. HNO 60:1127\u20131129","journal-title":"HNO"},{"key":"2684_CR14","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/B978-1-4377-1738-9.00103-1","volume-title":"Kelley\u2019s textbook of rheumatology","author":"C Chang","year":"2013","unstructured":"Chang C, Greenspan A, Gershwin E (2013) Osteonecrosis. In: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O\u2019Dell JR, Kelley WN (eds) Kelley\u2019s textbook of rheumatology. Elsevier\/Saunders, Philadelphia, pp 1692\u20131711"},{"key":"2684_CR15","first-page":"1605","volume-title":"Goldman\u2019s Cecil medicine","author":"L Goldman","year":"2012","unstructured":"Goldman L, Schafer AI (2012) Osteonecrosis, osteosclerosis\/hyperostosis, and other disorders of bone. In: Cecil RL, Goldman L, Schafer AI (eds) Goldman\u2019s Cecil medicine. Elsevier\/Saunders, Philadelphia, pp 1605\u20131610"},{"key":"2684_CR16","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1365-2273.2004.00898.x","volume":"29","author":"RA Persaud","year":"2004","unstructured":"Persaud RA, Hajioff D, Thevasagayam MS, Wareing MJ, Wright A (2004) Keratosis obturans and external ear canal cholesteatoma: how and why we should distinguish between these conditions. Clin Otolaryngol Allied Sci 29:577\u2013581","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"2684_CR17","first-page":"1963","volume-title":"Cummings otolaryngology: head & neck surgery","author":"PW Flint","year":"2010","unstructured":"Flint PW et al (2010) Chronic otitis media, mastoiditis, and petrositis. In: Flint PW et al (eds) Cummings otolaryngology: head & neck surgery. Mosby Elsevier, Philadelphia, pp 1963\u20131978"},{"key":"2684_CR18","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1359\/jbmr.0707onj","volume":"22","author":"S Khosla","year":"2007","unstructured":"Khosla S, Burr D, Cauley J, Dempster DW, Ebeling PR, Felsenberg D, Gagel RF, Gilsanz V, Guise T, Koka S, McCauley LK, McGowan J, McKee MD, Mohla S, Pendrys DG, Raisz LG, Ruggiero SL, Shafer DM, Shum L, Silverman SL, Van Poznak CH, Watts N, Woo SB, Shane E, American Society for Bone and Mineral Research (2007) Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 22:1479\u20131491","journal-title":"J Bone Miner Res"},{"key":"2684_CR19","unstructured":"Statistics Denmark (2013) Population and population projections. http:\/\/www.dst.dk\/en\/Statistik\/emner\/befolkning-og-befolkningsfremskrivning.aspx . Accessed Oct 2013"},{"key":"2684_CR20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373\u2013383","journal-title":"J Chronic Dis"},{"key":"2684_CR21","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bone.2008.09.012","volume":"44","author":"IR Reid","year":"2009","unstructured":"Reid IR (2009) Osteonecrosis of the jaw: who gets it, and why? Bone 44:4\u201310","journal-title":"Bone"},{"key":"2684_CR22","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1742-7843.2008.00374.x","volume":"104","author":"T Oizumi","year":"2009","unstructured":"Oizumi T, Yamaguchi K, Funayama H, Kuroishi T, Kawamura H, Sugawara S, Endo Y (2009) Necrotic actions of nitrogen-containing bisphosphonates and their inhibition by clodronate, a non-nitrogen-containing bisphosphonate in mice: potential for utilization of clodronate as a combination drug with a nitrogen-containing bisphosphonate. Basic Clin Pharmacol Toxicol 104:384\u2013392","journal-title":"Basic Clin Pharmacol Toxicol"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-014-2684-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-014-2684-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-014-2684-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T11:15:10Z","timestamp":1558610110000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-014-2684-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,25]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["2684"],"URL":"https:\/\/doi.org\/10.1007\/s00198-014-2684-7","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,25]]}}}