{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:20:28Z","timestamp":1791811228811,"version":"4.3.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T00:00:00Z","timestamp":1400630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1007\/s00198-014-2745-y","type":"journal-article","created":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T08:16:19Z","timestamp":1400573779000},"page":"2189-2198","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Early-stage chronic kidney disease, insulin resistance, and osteoporosis as risk factors of sarcopenia in aged population: The Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV), 2008\u20132009"],"prefix":"10.1007","volume":"25","author":[{"given":"J. E.","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-h.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. R.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.-K.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,5,21]]},"reference":[{"issue":"4","key":"2745_CR1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","volume":"39","author":"AJ Cruz-Jentoft","year":"2010","unstructured":"Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F et al (2010) Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 39(4):412\u2013423","journal-title":"Age Ageing"},{"issue":"2","key":"2745_CR2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.clnu.2009.12.004","volume":"29","author":"M Muscaritoli","year":"2010","unstructured":"Muscaritoli M, Anker SD, Argiles J, Aversa Z, Bauer JM, Biolo G et al (2010) Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) \u201ccachexia-anorexia in chronic wasting diseases\u201d and \u201cnutrition in geriatrics\u201d. Clin Nutr 29(2):154\u2013159","journal-title":"Clin Nutr"},{"issue":"8","key":"2745_CR3","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/oxfordjournals.aje.a009520","volume":"147","author":"RN Baumgartner","year":"1998","unstructured":"Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR et al (1998) Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147(8):755\u2013763","journal-title":"Am J Epidemiol"},{"issue":"12","key":"2745_CR4","doi-asserted-by":"crossref","first-page":"M772","DOI":"10.1093\/gerona\/57.12.M772","volume":"57","author":"M Iannuzzi-Sucich","year":"2002","unstructured":"Iannuzzi-Sucich M, Prestwood KM, Kenny AM (2002) Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci 57(12):M772\u2013M777","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"3","key":"2745_CR5","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.archger.2012.12.009","volume":"56","author":"SH Kim","year":"2013","unstructured":"Kim SH, Kim TH, Hwang HJ (2013) The relationship of physical activity (PA) and walking with sarcopenia in Korean males aged 60\u00a0years and older using the Fourth Korean National Health and Nutrition Examination Survey (KNHANES IV-2, 3), 2008\u20132009. Arch Gerontol Geriatr 56(3):472\u2013477","journal-title":"Arch Gerontol Geriatr"},{"issue":"5","key":"2745_CR6","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s00198-012-2236-y","volume":"24","author":"A Mithal","year":"2013","unstructured":"Mithal A, Bonjour JP, Boonen S, Burckhardt P, Degens H, El Hajj FG et al (2013) Impact of nutrition on muscle mass, strength, and performance in older adults. Osteoporos Int 24(5):1555\u20131566","journal-title":"Osteoporos Int"},{"issue":"5","key":"2745_CR7","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF03654825","volume":"24","author":"E Jo","year":"2012","unstructured":"Jo E, Lee SR, Park BS, Kim JS (2012) Potential mechanisms underlying the role of chronic inflammation in age-related muscle wasting. Aging Clin Exp Res 24(5):412\u2013422","journal-title":"Aging Clin Exp Res"},{"issue":"6","key":"2745_CR8","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/01.bor.0000245722.10136.6d","volume":"18","author":"SM Roth","year":"2006","unstructured":"Roth SM, Metter EJ, Ling S, Ferrucci L (2006) Inflammatory factors in age-related muscle wasting. Curr Opin Rheumatol 18(6):625\u2013630","journal-title":"Curr Opin Rheumatol"},{"issue":"10","key":"2745_CR9","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1210\/jc.2011-1602","volume":"96","author":"MK Kim","year":"2011","unstructured":"Kim MK, Baek KH, Song KH, Il Kang M, Park CY, Lee WY et al (2011) Vitamin D deficiency is associated with sarcopenia in older Koreans, regardless of obesity: the Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) 2009. J Clin Endocrinol Metab 96(10):3250\u20133256","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2745_CR10","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/ajcn\/80.2.496","volume":"80","author":"P Szulc","year":"2004","unstructured":"Szulc P, Duboeuf F, Marchand F, Delmas PD (2004) Hormonal and lifestyle determinants of appendicular skeletal muscle mass in men: the MINOS study. Am J Clin Nutr 80(2):496\u2013503","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"2745_CR11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.5114\/aoms.2013.33356","volume":"9","author":"MS Anker","year":"2013","unstructured":"Anker MS, von Haehling S, Springer J, Banach M, Anker SD (2013) Highlights of mechanistic and therapeutic cachexia and sarcopenia research 2010 to 2012 and their relevance for cardiology. Arch Med Sci 9(1):166\u2013171","journal-title":"Arch Med Sci"},{"key":"2745_CR12","author":"C Cetin","year":"2013","unstructured":"Cetin C, Ucar A, Bas F, Poyrazoglu S, Bundak R, Saka N et al (2013) Are metabolic syndrome antecedents in prepubertal children associated with being born idiopathic large for gestational age? Pediatr Diabetes. doi: 10.1111\/pedi.12041","journal-title":"Pediatr Diabetes"},{"issue":"9","key":"2745_CR13","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/dme.12201","volume":"30","author":"CH Kim","year":"2013","unstructured":"Kim CH, Kim HK, Kim EH, Bae SJ, Park JY (2013) Relative contributions of insulin resistance and beta-cell dysfunction to the development of Type 2 diabetes in Koreans. Diabet Med 30(9):1075\u20131079","journal-title":"Diabet Med"},{"issue":"8","key":"2745_CR14","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1532-5415.2007.01259.x","volume":"55","author":"PM Cawthon","year":"2007","unstructured":"Cawthon PM, Marshall LM, Michael Y, Dam TT, Ensrud KE, Barrett-Connor E et al (2007) Frailty in older men: prevalence, progression, and relationship with mortality. J Am Geriatr Soc 55(8):1216\u20131223","journal-title":"J Am Geriatr Soc"},{"issue":"5","key":"2745_CR15","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.clnu.2012.02.007","volume":"31","author":"F Landi","year":"2012","unstructured":"Landi F, Liperoti R, Russo A, Giovannini S, Tosato M, Capoluongo E et al (2012) Sarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study. Clin Nutr 31(5):652\u2013658","journal-title":"Clin Nutr"},{"issue":"7","key":"2745_CR16","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF02982704","volume":"12","author":"Y Rolland","year":"2008","unstructured":"Rolland Y, Czerwinski S, Abellan Van Kan G, Morley JE, Cesari M, Onder G et al (2008) Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives. J Nutr Health Aging 12(7):433\u2013450","journal-title":"J Nutr Health Aging"},{"issue":"4","key":"2745_CR17","doi-asserted-by":"crossref","first-page":"736","DOI":"10.2337\/dc08-1781","volume":"32","author":"JI Barzilay","year":"2009","unstructured":"Barzilay JI, Cotsonis GA, Walston J, Schwartz AV, Satterfield S, Miljkovic I et al (2009) Insulin resistance is associated with decreased quadriceps muscle strength in nondiabetic adults aged >or=70 years. Diabetes Care 32(4):736\u2013738","journal-title":"Diabetes Care"},{"issue":"7","key":"2745_CR18","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/j.1532-5415.2011.03472.x","volume":"59","author":"CG Lee","year":"2011","unstructured":"Lee CG, Boyko EJ, Strotmeyer ES, Lewis CE, Cawthon PM, Hoffman AR et al (2011) Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus. J Am Geriatr Soc 59(7):1217\u20131224","journal-title":"J Am Geriatr Soc"},{"issue":"11","key":"2745_CR19","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.2337\/dc09-0264","volume":"32","author":"SW Park","year":"2009","unstructured":"Park SW, Goodpaster BH, Lee JS, Kuller LH, Boudreau R, de Rekeneire N et al (2009) Excessive loss of skeletal muscle mass in older adults with type 2 diabetes. Diabetes Care 32(11):1993\u20131997","journal-title":"Diabetes Care"},{"issue":"1","key":"2745_CR20","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/gerona\/glr022","volume":"67","author":"RR Kalyani","year":"2012","unstructured":"Kalyani RR, Metter EJ, Ramachandran R, Chia CW, Saudek CD, Ferrucci L (2012) Glucose and insulin measurements from the oral glucose tolerance test and relationship to muscle mass. J Gerontol A Biol Sci Med Sci 67(1):74\u201381","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"9","key":"2745_CR21","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1210\/jc.2011-0435","volume":"96","author":"P Srikanthan","year":"2011","unstructured":"Srikanthan P, Karlamangla AS (2011) Relative muscle mass is inversely associated with insulin resistance and prediabetes. Findings from the third National Health and Nutrition Examination Survey. J Clin Endocrinol Metab 96(9):2898\u20132903","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2745_CR22","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1210\/en.2006-0251","volume":"147","author":"X Wang","year":"2006","unstructured":"Wang X, Hu Z, Hu J, Du J, Mitch WE (2006) Insulin resistance accelerates muscle protein degradation: activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology 147(9):4160\u20134168","journal-title":"Endocrinology"},{"issue":"11","key":"2745_CR23","doi-asserted-by":"crossref","first-page":"5384","DOI":"10.1210\/en.2008-0132","volume":"149","author":"J Hu","year":"2008","unstructured":"Hu J, Klein JD, Du J, Wang XH (2008) Cardiac muscle protein catabolism in diabetes mellitus: activation of the ubiquitin-proteasome system by insulin deficiency. Endocrinology 149(11):5384\u20135390","journal-title":"Endocrinology"},{"issue":"1","key":"2745_CR24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s13539-011-0051-5","volume":"3","author":"MA Honors","year":"2012","unstructured":"Honors MA, Kinzig KP (2012) The role of insulin resistance in the development of muscle wasting during cancer cachexia. J Cachexia Sarcopenia Muscle 3(1):5\u201311","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"2745_CR25","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1055\/s-2003-39072","volume":"35","author":"T Kino","year":"2003","unstructured":"Kino T, Mirani M, Alesci S, Chrousos GP (2003) AIDS-related lipodystrophy\/insulin resistance syndrome. Horm Metab Res 35(3):129\u2013136","journal-title":"Horm Metab Res"},{"issue":"7 Suppl 4","key":"2745_CR26","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1097\/00005344-200000004-00002","volume":"35","author":"AJ Coats","year":"2000","unstructured":"Coats AJ, Anker SD (2000) Insulin resistance in chronic heart failure. J Cardiovasc Pharmacol 35(7 Suppl 4):S9\u2013S14","journal-title":"J Cardiovasc Pharmacol"},{"issue":"1","key":"2745_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI113033","volume":"80","author":"RA Gelfand","year":"1987","unstructured":"Gelfand RA, Barrett EJ (1987) Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man. J Clin Invest 80(1):1\u20136","journal-title":"J Clin Invest"},{"issue":"25","key":"2745_CR28","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1056\/NEJM199612193352507","volume":"335","author":"WE Mitch","year":"1996","unstructured":"Mitch WE, Goldberg AL (1996) Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway. N Engl J Med 335(25):1897\u20131905","journal-title":"N Engl J Med"},{"issue":"7","key":"2745_CR29","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1681\/ASN.2006010083","volume":"17","author":"SH Lecker","year":"2006","unstructured":"Lecker SH, Goldberg AL, Mitch WE (2006) Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol 17(7):1807\u20131819","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"2745_CR30","doi-asserted-by":"crossref","first-page":"1128S","DOI":"10.3945\/ajcn.2010.28608B","volume":"91","author":"BT Workeneh","year":"2010","unstructured":"Workeneh BT, Mitch WE (2010) Review of muscle wasting associated with chronic kidney disease. Am J Clin Nutr 91(4):1128S\u20131132S","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"2745_CR31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000101827","volume":"27","author":"RN Foley","year":"2007","unstructured":"Foley RN, Wang C, Ishani A, Collins AJ, Murray AM (2007) Kidney function and sarcopenia in the United States general population: NHANES III. Am J Nephrol 27(3):279\u2013286","journal-title":"Am J Nephrol"},{"issue":"4","key":"2745_CR32","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1172\/JCI0216494","volume":"110","author":"WE Mitch","year":"2002","unstructured":"Mitch WE (2002) Malnutrition: a frequent misdiagnosis for hemodialysis patients. J Clin Invest 110(4):437\u2013439","journal-title":"J Clin Invest"},{"key":"2745_CR33","doi-asserted-by":"crossref","unstructured":"Wang XH, Mitch WE (2013) Muscle wasting from kidney failure-a model for catabolic conditions. Int J Biochem Cell Biol 45(10):2230\u20132238","DOI":"10.1016\/j.biocel.2013.06.027"},{"key":"2745_CR34","unstructured":"2013. A shared pleiotropy of bone and muscle mass: muscle mass is more strongly associated with bone mass than with fat mass or deterioration of glucose metabolism in the elderly: Hearing before the Seoul International Congress of Endocrinology and Metabolism (SICEM), Bone III Sess. (4 May, 2013)"},{"issue":"5","key":"2745_CR35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/BF02982665","volume":"12","author":"Y Rolland","year":"2008","unstructured":"Rolland Y, Abellan van Kan G, Benetos A, Blain H, Bonnefoy M, Chassagne P et al (2008) Frailty, osteoporosis and hip fracture: causes, consequences and therapeutic perspectives. J Nutr Health Aging 12(5):335\u2013346","journal-title":"J Nutr Health Aging"},{"issue":"10 Suppl","key":"2745_CR36","first-page":"66","volume":"28","author":"G Crepaldi","year":"2005","unstructured":"Crepaldi G, Maggi S (2005) Sarcopenia and osteoporosis: a hazardous duet. J Endocrinol Invest 28(10 Suppl):66\u201368","journal-title":"J Endocrinol Invest"},{"issue":"5","key":"2745_CR37","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.bone.2010.01.382","volume":"46","author":"D Karasik","year":"2010","unstructured":"Karasik D, Kiel DP (2010) Evidence for pleiotropic factors in genetics of the musculoskeletal system. Bone 46(5):1226\u20131237","journal-title":"Bone"},{"key":"2745_CR38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jamda.2011.01.003","volume":"12","author":"RA Fielding","year":"2011","unstructured":"Fielding RA, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB et al (2011) Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International Working Group on Sarcopenia. J Am Med Dir Assoc 12:249\u2013256","journal-title":"J Am Med Dir Assoc"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-014-2745-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-014-2745-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-014-2745-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T20:02:09Z","timestamp":1716753729000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-014-2745-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,21]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["2745"],"URL":"https:\/\/doi.org\/10.1007\/s00198-014-2745-y","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,21]]}}}