{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:23:41Z","timestamp":1764689021087},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s00198-015-3108-z","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T11:29:56Z","timestamp":1427282996000},"page":"2291-2298","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Hyponatremia and osteoporosis: reappraisal of a novel association"],"prefix":"10.1007","volume":"26","author":[{"given":"F.","family":"Afshinnia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Sundaram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Ackermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. K.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,3,26]]},"reference":[{"issue":"21","key":"3108_CR1","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1056\/NEJM200005253422107","volume":"342","author":"HJ Adrogue","year":"2000","unstructured":"Adrogue HJ, Madias NE (2000) Hyponatremia. N Engl J Med 342(21):1581\u20131589. doi: 10.1056\/NEJM200005253422107","journal-title":"N Engl J Med"},{"issue":"7 Suppl 1","key":"3108_CR2","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.amjmed.2006.05.005","volume":"119","author":"A Upadhyay","year":"2006","unstructured":"Upadhyay A, Jaber BL, Madias NE (2006) Incidence and prevalence of hyponatremia. Am J Med 119(7 Suppl 1):S30\u201335. doi: 10.1016\/j.amjmed.2006.05.005","journal-title":"Am J Med"},{"issue":"10","key":"3108_CR3","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1111\/jgs.12468","volume":"61","author":"R Gunathilake","year":"2013","unstructured":"Gunathilake R, Oldmeadow C, McEvoy M, Kelly B, Inder K, Schofield P, Attia J (2013) Mild hyponatremia is associated with impaired cognition and falls in community-dwelling older persons. J Am Geriatr Soc 61(10):1838\u20131839. doi: 10.1111\/jgs.12468","journal-title":"J Am Geriatr Soc"},{"issue":"5","key":"3108_CR4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3949\/ccjm.74.5.377","volume":"74","author":"P Widdess-Walsh","year":"2007","unstructured":"Widdess-Walsh P, Sabharwal V, Demirjian S, DeGeorgia M (2007) Neurologic effects of hyponatremia and its treatment. Cleve Clin J Med 74(5):377\u2013383","journal-title":"Cleve Clin J Med"},{"issue":"3","key":"3108_CR5","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1001\/archinternmed.2009.513","volume":"170","author":"R Wald","year":"2010","unstructured":"Wald R, Jaber BL, Price LL, Upadhyay A, Madias NE (2010) Impact of hospital-associated hyponatremia on selected outcomes. Arch Intern Med 170(3):294\u2013302. doi: 10.1001\/archinternmed.2009.513","journal-title":"Arch Intern Med"},{"issue":"9","key":"3108_CR6","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.amjmed.2009.01.027","volume":"122","author":"SS Waikar","year":"2009","unstructured":"Waikar SS, Mount DB, Curhan GC (2009) Mortality after hospitalization with mild, moderate, and severe hyponatremia. Am J Med 122(9):857\u2013865. doi: 10.1016\/j.amjmed.2009.01.027","journal-title":"Am J Med"},{"issue":"6","key":"3108_CR7","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1185\/03007990802081675","volume":"24","author":"MD Zilberberg","year":"2008","unstructured":"Zilberberg MD, Exuzides A, Spalding J, Foreman A, Jones AG, Colby C, Shorr AF (2008) Epidemiology, clinical and economic outcomes of admission hyponatremia among hospitalized patients. Curr Med Res Opin 24(6):1601\u20131608. doi: 10.1185\/03007990802081675","journal-title":"Curr Med Res Opin"},{"issue":"2","key":"3108_CR8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1365-2265.2006.02583.x","volume":"65","author":"G Gill","year":"2006","unstructured":"Gill G, Huda B, Boyd A, Skagen K, Wile D, Watson I, van Heyningen C (2006) Characteristics and mortality of severe hyponatraemia\u2014a hospital-based study. Clin Endocrinol 65(2):246\u2013249. doi: 10.1111\/j.1365-2265.2006.02583.x","journal-title":"Clin Endocrinol"},{"issue":"8","key":"3108_CR9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/qjmed\/hcl071","volume":"99","author":"JA Clayton","year":"2006","unstructured":"Clayton JA, Le Jeune IR, Hall IP (2006) Severe hyponatraemia in medical in-patients: aetiology, assessment and outcome. QJM: Monthly J Assoc Phys 99(8):505\u2013511. doi: 10.1093\/qjmed\/hcl071","journal-title":"QJM: Monthly J Assoc Phys"},{"issue":"6","key":"3108_CR10","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/BF02596422","volume":"1","author":"WM Tierney","year":"1986","unstructured":"Tierney WM, Martin DK, Greenlee MC, Zerbe RL, McDonald CJ (1986) The prognosis of hyponatremia at hospital admission. J Gen Intern Med 1(6):380\u2013385","journal-title":"J Gen Intern Med"},{"issue":"2","key":"3108_CR11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.7326\/0003-4819-102-2-164","volume":"102","author":"RJ Anderson","year":"1985","unstructured":"Anderson RJ, Chung HM, Kluge R, Schrier RW (1985) Hyponatremia: a prospective analysis of its epidemiology and the pathogenetic role of vasopressin. Ann Intern Med 102(2):164\u2013168","journal-title":"Ann Intern Med"},{"issue":"12","key":"3108_CR12","doi-asserted-by":"crossref","first-page":"10864","DOI":"10.1074\/jbc.M110.155002","volume":"286","author":"J Barsony","year":"2011","unstructured":"Barsony J, Sugimura Y, Verbalis JG (2011) Osteoclast response to low extracellular sodium and the mechanism of hyponatremia-induced bone loss. J Biol Chem 286(12):10864\u201310875. doi: 10.1074\/jbc.M110.155002","journal-title":"J Biol Chem"},{"issue":"3","key":"3108_CR13","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1359\/jbmr.090827","volume":"25","author":"JG Verbalis","year":"2010","unstructured":"Verbalis JG, Barsony J, Sugimura Y, Tian Y, Adams DJ, Carter EA, Resnick HE (2010) Hyponatremia-induced osteoporosis. J Bone Mineral Res: Off J Am Soc Bone Mineral Res 25(3):554\u2013563. doi: 10.1359\/jbmr.090827","journal-title":"J Bone Mineral Res: Off J Am Soc Bone Mineral Res"},{"issue":"8","key":"3108_CR14","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/jbmr.380","volume":"26","author":"EJ Hoorn","year":"2011","unstructured":"Hoorn EJ, Rivadeneira F, van Meurs JB, Ziere G, Stricker BH, Hofman A, Pols HA, Zietse R, Uitterlinden AG, Zillikens MC (2011) Mild hyponatremia as a risk factor for fractures: the Rotterdam study. J Bone Mineral Res: Off J Am Soc Bone Mineral Res 26(8):1822\u20131828. doi: 10.1002\/jbmr.380","journal-title":"J Bone Mineral Res: Off J Am Soc Bone Mineral Res"},{"issue":"2","key":"3108_CR15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2215\/CJN.06120809","volume":"5","author":"S Kinsella","year":"2010","unstructured":"Kinsella S, Moran S, Sullivan MO, Molloy MG, Eustace JA (2010) Hyponatremia independent of osteoporosis is associated with fracture occurrence. Clin J Am Soc Nephrol: CJASN 5(2):275\u2013280. doi: 10.2215\/CJN.06120809","journal-title":"Clin J Am Soc Nephrol: CJASN"},{"issue":"9","key":"3108_CR16","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","volume":"150","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J, Ckd EPI (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150(9):604\u2013612","journal-title":"Ann Intern Med"},{"key":"3108_CR17","unstructured":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group (1994). World Health Organization technical report series 843:1\u2013129"},{"issue":"10","key":"3108_CR18","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1093\/ndt\/gfs412","volume":"27","author":"JC Ayus","year":"2012","unstructured":"Ayus JC, Negri AL, Kalantar-Zadeh K, Moritz ML (2012) Is chronic hyponatremia a novel risk factor for hip fracture in the elderly? Nephrol, Dialysis, Transplant: Off Publication of the European Dialysis and Transplant Assoc - Eur Renal Assoc 27(10):3725\u20133731. doi: 10.1093\/ndt\/gfs412","journal-title":"Nephrol, Dialysis, Transplant: Off Publication of the European Dialysis and Transplant Assoc - Eur Renal Assoc"},{"issue":"3","key":"3108_CR19","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s11255-009-9585-2","volume":"41","author":"HS Sandhu","year":"2009","unstructured":"Sandhu HS, Gilles E, DeVita MV, Panagopoulos G, Michelis MF (2009) Hyponatremia associated with large-bone fracture in elderly patients. Int Urol Nephrol 41(3):733\u2013737. doi: 10.1007\/s11255-009-9585-2","journal-title":"Int Urol Nephrol"},{"issue":"7","key":"3108_CR20","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/qjmed\/hcn061","volume":"101","author":"F Gankam Kengne","year":"2008","unstructured":"Gankam Kengne F, Andres C, Sattar L, Melot C, Decaux G (2008) Mild hyponatremia and risk of fracture in the ambulatory elderly. QJM: Monthly J Assoc Phys 101(7):583\u2013588. doi: 10.1093\/qjmed\/hcn061","journal-title":"QJM: Monthly J Assoc Phys"},{"issue":"11","key":"3108_CR21","first-page":"522","volume":"42","author":"CJ Zaino","year":"2013","unstructured":"Zaino CJ, Maheshwari AV, Goldfarb DS (2013) Impact of mild chronic hyponatremia on falls, fractures, osteoporosis, and death. Am J Orthop 42(11):522\u2013527","journal-title":"Am J Orthop"},{"issue":"3","key":"3108_CR22","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/JCP.0b013e318218f446","volume":"31","author":"S Bun","year":"2011","unstructured":"Bun S, Serby MJ, Friedmann P (2011) Psychotropic medication use, hyponatremia, and falls in an inpatient population: a retrospective study. J Clin Psychopharmacol 31(3):395\u2013397. doi: 10.1097\/JCP.0b013e318218f446","journal-title":"J Clin Psychopharmacol"},{"issue":"1","key":"3108_CR23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.amjmed.2005.09.026","volume":"119","author":"B Renneboog","year":"2006","unstructured":"Renneboog B, Musch W, Vandemergel X, Manto MU, Decaux G (2006) Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med 119(1):71. doi: 10.1016\/j.amjmed.2005.09.026 , e71-78","journal-title":"Am J Med"},{"issue":"4\u20135","key":"3108_CR24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF03324927","volume":"21","author":"N Yilmaz","year":"2009","unstructured":"Yilmaz N, Eren E (2009) Homocysteine oxidative stress and relation to bone mineral density in post-menopausal osteoporosis. Aging Clin Exp Res 21(4\u20135):353\u2013357","journal-title":"Aging Clin Exp Res"},{"issue":"5","key":"3108_CR25","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.freeradbiomed.2009.05.031","volume":"47","author":"B Ostman","year":"2009","unstructured":"Ostman B, Michaelsson K, Helmersson J, Byberg L, Gedeborg R, Melhus H, Basu S (2009) Oxidative stress and bone mineral density in elderly men: antioxidant activity of alpha-tocopherol. Free Radic Biol Med 47(5):668\u2013673. doi: 10.1016\/j.freeradbiomed.2009.05.031","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"3108_CR26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/bbrc.2001.5747","volume":"288","author":"S Basu","year":"2001","unstructured":"Basu S, Michaelsson K, Olofsson H, Johansson S, Melhus H (2001) Association between oxidative stress and bone mineral density. Biochem Biophys Res Commun 288(1):275\u2013279. doi: 10.1006\/bbrc.2001.5747","journal-title":"Biochem Biophys Res Commun"},{"issue":"46","key":"3108_CR27","doi-asserted-by":"crossref","first-page":"18644","DOI":"10.1073\/pnas.1318257110","volume":"110","author":"R Tamma","year":"2013","unstructured":"Tamma R, Sun L, Cuscito C, Lu P, Corcelli M, Li J, Colaianni G, Moonga SS, Di Benedetto A, Grano M, Colucci S, Yuen T, New MI, Zallone A, Zaidi M (2013) Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia. Proc Natl Acad Sci U S A 110(46):18644\u201318649. doi: 10.1073\/pnas.1318257110","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"3108_CR28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrendo.2011.173","volume":"8","author":"EJ Hoorn","year":"2012","unstructured":"Hoorn EJ, Liamis G, Zietse R, Zillikens MC (2012) Hyponatremia and bone: an emerging relationship. Nat Rev Endocrinol 8(1):33\u201339. doi: 10.1038\/nrendo.2011.173","journal-title":"Nat Rev Endocrinol"},{"issue":"39","key":"3108_CR29","doi-asserted-by":"crossref","first-page":"13192","DOI":"10.1523\/JNEUROSCI.3315-10.2010","volume":"30","author":"AS Tseng","year":"2010","unstructured":"Tseng AS, Beane WS, Lemire JM, Masi A, Levin M (2010) Induction of vertebrate regeneration by a transient sodium current. J Neurosci Off J Soc Neurosci 30(39):13192\u201313200. doi: 10.1523\/JNEUROSCI. 3315-10.2010","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"8","key":"3108_CR30","doi-asserted-by":"crossref","first-page":"637","DOI":"10.2174\/1381612013397799","volume":"7","author":"SV Komarova","year":"2001","unstructured":"Komarova SV, Dixon SJ, Sims SM (2001) Osteoclast ion channels: potential targets for antiresorptive drugs. Curr Pharm Des 7(8):637\u2013654","journal-title":"Curr Pharm Des"},{"key":"3108_CR31","unstructured":"WHO Scientific Group on the Prevention and Management of Osteoporosis. Prevention and management of osteoporosis: report of a WHO scientific group (2003). World Health Organ Tech Rep Ser"},{"issue":"1","key":"3108_CR32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.maturitas.2013.02.007","volume":"75","author":"S Arampatzis","year":"2013","unstructured":"Arampatzis S, Gaetcke LM, Funk GC, Schwarz C, Mohaupt M, Zimmermann H, Exadaktylos AK, Lindner G (2013) Diuretic-induced hyponatremia and osteoporotic fractures in patients admitted to the emergency department. Maturitas 75(1):81\u201386. doi: 10.1016\/j.maturitas.2013.02.007","journal-title":"Maturitas"},{"issue":"2","key":"3108_CR33","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ecl.2013.02.005","volume":"42","author":"LE Cowen","year":"2013","unstructured":"Cowen LE, Hodak SP, Verbalis JG (2013) Age-associated abnormalities of water homeostasis. Endocrinol Metab Clin N Am 42(2):349\u2013370. doi: 10.1016\/j.ecl.2013.02.005","journal-title":"Endocrinol Metab Clin N Am"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-015-3108-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-015-3108-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-015-3108-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T11:15:22Z","timestamp":1558610122000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-015-3108-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,26]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["3108"],"URL":"https:\/\/doi.org\/10.1007\/s00198-015-3108-z","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,26]]}}}