{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:41:25Z","timestamp":1788968485037,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s00198-016-3496-8","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T10:16:31Z","timestamp":1453716991000},"page":"2335-2344","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Xanthotoxin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis"],"prefix":"10.1007","volume":"27","author":[{"given":"C.","family":"Dou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,25]]},"reference":[{"issue":"9319","key":"3496_CR1","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","volume":"359","author":"SR Cummings","year":"2002","unstructured":"Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359(9319):1761\u20131767. doi: 10.1016\/S0140-6736(02)08657-9","journal-title":"Lancet"},{"issue":"2 Suppl 1","key":"3496_CR2","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1016\/j.bone.2005.11.024","volume":"38","author":"JY Reginster","year":"2006","unstructured":"Reginster JY, Burlet N (2006) Osteoporosis: a still increasing prevalence. Bone 38(2 Suppl 1):S4\u2013S9. doi: 10.1016\/j.bone.2005.11.024","journal-title":"Bone"},{"issue":"9","key":"3496_CR3","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1002\/jbmr.5650070902","volume":"7","author":"LJ Melton 3rd","year":"1992","unstructured":"Melton LJ 3rd, Chrischilles EA, Cooper C, Lane AW, Riggs BL (1992) Perspective. How many women have osteoporosis? J Bone Miner Res 7(9):1005\u20131010. doi: 10.1002\/jbmr.5650070902","journal-title":"J Bone Miner Res"},{"issue":"2","key":"3496_CR4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","volume":"93","author":"DL Lacey","year":"1998","unstructured":"Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93(2):165\u2013176","journal-title":"Cell"},{"issue":"3","key":"3496_CR5","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1172\/JCI114485","volume":"85","author":"IR Garrett","year":"1990","unstructured":"Garrett IR, Boyce BF, Oreffo RO, Bonewald L, Poser J, Mundy GR (1990) Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 85(3):632\u2013639. doi: 10.1172\/JCI114485","journal-title":"J Clin Invest"},{"issue":"2","key":"3496_CR6","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.yexcr.2004.07.035","volume":"301","author":"H Ha","year":"2004","unstructured":"Ha H, Kwak HB, Lee SW, Jin HM, Kim HM, Kim HH, Lee ZH (2004) Reactive oxygen species mediate RANK signaling in osteoclasts. Exp Cell Res 301(2):119\u2013127. doi: 10.1016\/j.yexcr.2004.07.035","journal-title":"Exp Cell Res"},{"issue":"3","key":"3496_CR7","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1182\/blood-2004-09-3662","volume":"106","author":"NK Lee","year":"2005","unstructured":"Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N, Lee SY (2005) A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood 106(3):852\u2013859. doi: 10.1182\/blood-2004-09-3662","journal-title":"Blood"},{"issue":"11","key":"3496_CR8","doi-asserted-by":"crossref","first-page":"6427","DOI":"10.4049\/jimmunol.169.11.6427","volume":"169","author":"NY Bhatt","year":"2002","unstructured":"Bhatt NY, Kelley TW, Khramtsov VV, Wang Y, Lam GK, Clanton TL, Marsh CB (2002) Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves phosphatidylinositol 3-kinase and reactive oxygen species in human monocytes. J Immunol 169(11):6427\u20136434","journal-title":"J Immunol"},{"issue":"6","key":"3496_CR9","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1172\/JCI18859","volume":"112","author":"JM Lean","year":"2003","unstructured":"Lean JM, Davies JT, Fuller K, Jagger CJ, Kirstein B, Partington GA, Urry ZL, Chambers TJ (2003) A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest 112(6):915\u2013923. doi: 10.1172\/JCI18859","journal-title":"J Clin Invest"},{"issue":"3","key":"3496_CR10","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1210\/er.2009-0024","volume":"31","author":"SC Manolagas","year":"2010","unstructured":"Manolagas SC (2010) From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev 31(3):266\u2013300. doi: 10.1210\/er.2009-0024","journal-title":"Endocr Rev"},{"issue":"12","key":"3496_CR11","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1038\/nm1515","volume":"12","author":"K Sato","year":"2006","unstructured":"Sato K, Suematsu A, Nakashima T, Takemoto-Kimura S, Aoki K, Morishita Y, Asahara H, Ohya K, Yamaguchi A, Takai T, Kodama T, Chatila TA, Bito H, Takayanagi H (2006) Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med 12(12):1410\u20131416. doi: 10.1038\/nm1515","journal-title":"Nat Med"},{"issue":"3","key":"3496_CR12","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nm.1910","volume":"15","author":"KA Ishii","year":"2009","unstructured":"Ishii KA, Fumoto T, Iwai K, Takeshita S, Ito M, Shimohata N, Aburatani H, Taketani S, Lelliott CJ, Vidal-Puig A, Ikeda K (2009) Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat Med 15(3):259\u2013266. doi: 10.1038\/nm.1910","journal-title":"Nat Med"},{"issue":"5","key":"3496_CR13","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.bbamcr.2010.11.002","volume":"1813","author":"SY Hwang","year":"2011","unstructured":"Hwang SY, Putney JW Jr (2011) Calcium signaling in osteoclasts. Biochim Biophys Acta 1813(5):979\u2013983. doi: 10.1016\/j.bbamcr.2010.11.002","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"3496_CR14","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1007\/s10439-014-0984-x","volume":"42","author":"P Li","year":"2014","unstructured":"Li P, Liu C, Hu M, Long M, Zhang D, Huo B (2014) Fluid flow-induced calcium response in osteoclasts: signaling pathways. Ann Biomed Eng 42(6):1250\u20131260. doi: 10.1007\/s10439-014-0984-x","journal-title":"Ann Biomed Eng"},{"issue":"5","key":"3496_CR15","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1055\/s-2006-958144","volume":"61","author":"M Purohit","year":"1995","unstructured":"Purohit M, Pande D, Datta A, Srivastava PS (1995) Enhanced xanthotoxin content in regenerating cultures of Ammi majus and micropropagation. Planta Med 61(5):481\u2013482. doi: 10.1055\/s-2006-958144","journal-title":"Planta Med"},{"issue":"6","key":"3496_CR16","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/j.1600-0781.2011.00615.x","volume":"27","author":"AH Ehsani","year":"2011","unstructured":"Ehsani AH, Ghaninejad H, Kiani A, Daneshpazhooh M, Hosseini SH, Noormohammadpoor P (2011) Comparison of topical 8-methoxypsoralen and narrowband ultraviolet B with narrowband ultraviolet B alone in treatment-resistant sites in plaque-type psoriasis: a placebo-controlled study. Photodermatol Photoimmunol Photomed 27(6):294\u2013296. doi: 10.1111\/j.1600-0781.2011.00615.x","journal-title":"Photodermatol Photoimmunol Photomed"},{"issue":"4","key":"3496_CR17","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2165\/00003495-199856040-00015","volume":"56","author":"W McNeely","year":"1998","unstructured":"McNeely W, Goa KL (1998) 5-Methoxypsoralen. A review of its effects in psoriasis and vitiligo. Drugs 56(4):667\u2013690","journal-title":"Drugs"},{"issue":"5","key":"3496_CR18","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0889-8588(18)30062-5","volume":"9","author":"HW Lim","year":"1995","unstructured":"Lim HW, Edelson RL (1995) Photopheresis for the treatment of cutaneous T-cell lymphoma. Hematol Oncol Clin North Am 9(5):1117\u20131126","journal-title":"Hematol Oncol Clin North Am"},{"key":"3496_CR19","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1749-6632.1991.tb33453.x","volume":"636","author":"SE Malawista","year":"1991","unstructured":"Malawista SE, Trock D, Edelson RL (1991) Photopheresis for rheumatoid arthritis. Ann N Y Acad Sci 636:217\u2013226","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"3496_CR20","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11418-013-0774-z","volume":"68","author":"M Sumiyoshi","year":"2014","unstructured":"Sumiyoshi M, Sakanaka M, Taniguchi M, Baba K, Kimura Y (2014) Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation. J Nat Med 68(1):83\u201394. doi: 10.1007\/s11418-013-0774-z","journal-title":"J Nat Med"},{"issue":"1","key":"3496_CR21","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jphotobiol.2006.04.002","volume":"85","author":"J Bartosova","year":"2006","unstructured":"Bartosova J, Kuzelova K, Pluskalova M, Marinov I, Halada P, Gasova Z (2006) UVA-activated 8-methoxypsoralen (PUVA) causes G2\/M cell cycle arrest in Karpas 299 T-lymphoma cells. J Photochem Photobiol B 85(1):39\u201348. doi: 10.1016\/j.jphotobiol.2006.04.002","journal-title":"J Photochem Photobiol B"},{"issue":"8","key":"3496_CR22","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0024-3205(99)00642-6","volume":"66","author":"TB Ng","year":"2000","unstructured":"Ng TB, Liu F, Wang ZT (2000) Antioxidative activity of natural products from plants. Life Sci 66(8):709\u2013723","journal-title":"Life Sci"},{"issue":"6","key":"3496_CR23","first-page":"995","volume":"27","author":"A Potapenko","year":"1982","unstructured":"Potapenko A, Moshnin MV, Abyev GA, Gerashchenko PG, Belikov NG (1982) Effect of antioxidants on photoaddition of 8-methoxypsoralen to thymine, double-helix DNA and photosensitized inactivation of Escherichia coli. Biofizika 27(6):995\u2013999","journal-title":"Biofizika"},{"issue":"4","key":"3496_CR24","first-page":"348","volume":"38","author":"XQ Zhang","year":"2009","unstructured":"Zhang XQ, Zheng M, Mou KH, Feng J (2009) Effects of 8-methoxypsoralen on intracellular [Ca(2+)]i and cytoskeleton actin organization in human melanocytes in vitro. Zhejiang Da Xue Xue Bao Yi Xue Ban 38(4):348\u2013351","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"issue":"11","key":"3496_CR25","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1016\/j.bbagrm.2014.08.002","volume":"1839","author":"C Dou","year":"2014","unstructured":"Dou C, Zhang C, Kang F, Yang X, Jiang H, Bai Y, Xiang J, Xu J, Dong S (2014) MiR-7b directly targets DC-STAMP causing suppression of NFATc1 and c-Fos signaling during osteoclast fusion and differentiation. Biochim Biophys Acta 1839(11):1084\u20131096. doi: 10.1016\/j.bbagrm.2014.08.002","journal-title":"Biochim Biophys Acta"},{"key":"3496_CR26","doi-asserted-by":"crossref","unstructured":"Dou C, Li J, Kang F, Cao Z, Yang X, Jiang H, Yang B, Xiang J, Xu J, Dong S (2014) Dual Effect of Cyanidin on RANKL-Induced differentiation and fusion of osteoclasts. Journal of cellular physiology. doi:10.1002\/jcp.24916","DOI":"10.1002\/jcp.24916"},{"issue":"3","key":"3496_CR27","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1085\/jgp.103.3.365","volume":"103","author":"RE Dolmetsch","year":"1994","unstructured":"Dolmetsch RE, Lewis RS (1994) Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes. J Gen Physiol 103(3):365\u2013388","journal-title":"J Gen Physiol"},{"issue":"11","key":"3496_CR28","doi-asserted-by":"publisher","first-page":"5057","DOI":"10.1172\/JCI71882","volume":"124","author":"S Li","year":"2014","unstructured":"Li S, Miller CH, Giannopoulou E, Hu X, Ivashkiv LB, Zhao B (2014) RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis. J Clin Invest 124(11):5057\u20135073. doi: 10.1172\/JCI71882","journal-title":"J Clin Invest"},{"issue":"11","key":"3496_CR29","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1515\/CCLM.2008.302","volume":"46","author":"G Banfi","year":"2008","unstructured":"Banfi G, Iorio EL, Corsi MM (2008) Oxidative stress, free radicals and bone remodeling. Clin Chem Lab Med 46(11):1550\u20131555. doi: 10.1515\/CCLM.2008.302","journal-title":"Clin Chem Lab Med"},{"issue":"2","key":"3496_CR30","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1096\/fasebj.11.2.9039953","volume":"11","author":"HM Lander","year":"1997","unstructured":"Lander HM (1997) An essential role for free radicals and derived species in signal transduction. FASEB J 11(2):118\u2013124","journal-title":"FASEB J"},{"key":"3496_CR31","doi-asserted-by":"publisher","first-page":"3773","DOI":"10.1038\/ncomms4773","volume":"5","author":"SM Bartell","year":"2014","unstructured":"Bartell SM, Kim HN, Ambrogini E, Han L, Iyer S, Serra Ucer S, Rabinovitch P, Jilka RL, Weinstein RS, Zhao H, O'Brien CA, Manolagas SC, Almeida M (2014) FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun 5:3773. doi: 10.1038\/ncomms4773","journal-title":"Nat Commun"},{"key":"3496_CR32","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/978-94-007-2888-2_41","volume":"740","author":"H Kajiya","year":"2012","unstructured":"Kajiya H (2012) Calcium signaling in osteoclast differentiation and bone resorption. Adv Exp Med Biol 740:917\u2013932. doi: 10.1007\/978-94-007-2888-2_41","journal-title":"Adv Exp Med Biol"},{"issue":"9773","key":"3496_CR33","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","volume":"377","author":"TD Rachner","year":"2011","unstructured":"Rachner TD, Khosla S, Hofbauer LC (2011) Osteoporosis: now and the future. Lancet 377(9773):1276\u20131287. doi: 10.1016\/S0140-6736(10)62349-5","journal-title":"Lancet"},{"issue":"11","key":"3496_CR34","doi-asserted-by":"publisher","first-page":"4731","DOI":"10.1172\/JCI67603","volume":"123","author":"C Goettsch","year":"2013","unstructured":"Goettsch C, Babelova A, Trummer O, Erben RG, Rauner M, Rammelt S, Weissmann N, Weinberger V, Benkhoff S, Kampschulte M, Obermayer-Pietsch B, Hofbauer LC, Brandes RP, Schroder K (2013) NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis. J Clin Invest 123(11):4731\u20134738. doi: 10.1172\/JCI67603","journal-title":"J Clin Invest"},{"issue":"Suppl 1","key":"3496_CR35","first-page":"17","volume":"16","author":"BQ Jiang","year":"2007","unstructured":"Jiang BQ, Zhong PH, Cheng XB, Yang XL, Yang J, Cao YF (2007) Investigation of health and nutrition status of middle-aged and old residents in the urban district of Chongqing. Asia Pac J Clin Nutr 16(Suppl 1):17\u201321","journal-title":"Asia Pac J Clin Nutr"},{"issue":"10","key":"3496_CR36","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1007\/s00198-009-0925-y","volume":"20","author":"Y Wang","year":"2009","unstructured":"Wang Y, Tao Y, Hyman ME, Li J, Chen Y (2009) Osteoporosis in China. Osteoporos Int 20(10):1651\u20131662. doi: 10.1007\/s00198-009-0925-y","journal-title":"Osteoporos Int"},{"issue":"2","key":"3496_CR37","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.bbrc.2012.01.005","volume":"418","author":"HJ Moon","year":"2012","unstructured":"Moon HJ, Ko WK, Han SW, Kim DS, Hwang YS, Park HK, Kwon IK (2012) Antioxidants, like coenzyme Q10, selenite, and curcumin, inhibited osteoclast differentiation by suppressing reactive oxygen species generation. Biochem Biophys Res Commun 418(2):247\u2013253. doi: 10.1016\/j.bbrc.2012.01.005","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-016-3496-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-016-3496-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-016-3496-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-016-3496-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T20:18:13Z","timestamp":1567541893000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-016-3496-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,25]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["3496"],"URL":"https:\/\/doi.org\/10.1007\/s00198-016-3496-8","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,25]]}}}