{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:24:02Z","timestamp":1773087842924,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T00:00:00Z","timestamp":1467936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T00:00:00Z","timestamp":1467936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR060829"],"award-info":[{"award-number":["R01 AR060829"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 RR-025758"],"award-info":[{"award-number":["UL1 RR-025758"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K23 HD060066"],"award-info":[{"award-number":["K23 HD060066"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012299","name":"Brown Alpert Medical School Department of Orthopaedics","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012299","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006823","name":"Boston Children\u2019s Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s00198-016-3685-5","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T15:26:44Z","timestamp":1467991604000},"page":"3549-3558","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Skeletal outcomes by peripheral quantitative computed tomography and dual-energy X-ray absorptiometry in adolescent girls with anorexia nervosa"],"prefix":"10.1007","volume":"27","author":[{"given":"A. D.","family":"DiVasta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. A.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"O\u2019Donnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. B.","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,7,8]]},"reference":[{"issue":"4","key":"3685_CR1","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1007\/s11920-012-0282-y","volume":"14","author":"FRE Smink","year":"2012","unstructured":"Smink FRE, van Hoeken D, Hoek HW (2012) Epidemiology of eating disorders: incidence, prevalence and mortality rates. Curr Psychiatry Rep 14(4):406\u2013414","journal-title":"Curr Psychiatry Rep"},{"key":"3685_CR2","doi-asserted-by":"crossref","unstructured":"Donaldson A, Gordon CM (2015) Skeletal consequences of eating disorders. Metabolism. In press","DOI":"10.1016\/j.metabol.2015.06.007"},{"issue":"1","key":"3685_CR3","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1067\/mpd.2002.125003","volume":"141","author":"CM Gordon","year":"2002","unstructured":"Gordon CM, Goodman E, Emans SJ, et al. (2002) Physiologic regulators of bone turnover in young women with anorexia nervosa. J Pediatr 141(1):64\u201370","journal-title":"J Pediatr"},{"issue":"9","key":"3685_CR4","doi-asserted-by":"publisher","first-page":"4177","DOI":"10.1210\/jc.2001-011889","volume":"87","author":"LA Soyka","year":"2002","unstructured":"Soyka LA, Misra M, Frenchman A, et al. (2002) Abnormal bone mineral accrual in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab 87(9):4177\u20134185","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"3685_CR5","first-page":"898","volume":"80","author":"A Klibanski","year":"1995","unstructured":"Klibanski A, Biller BM, Schoenfeld DA, Herzog DB, Saxe VC (1995) The effects of estrogen administration on trabecular bone loss in young women with anorexia nervosa. J Clin Endocrinol Metab 80(3):898\u2013904","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"3685_CR6","first-page":"4489","volume":"84","author":"LA Soyka","year":"1999","unstructured":"Soyka LA, Grinspoon S, Levitsky LL, Herzog DB, Klibanski A (1999) The effects of anorexia nervosa on bone metabolism in female adolescents. J Clin Endocrinol Metab 84(12):4489\u20134496","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"3685_CR7","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1542\/peds.2004-0540","volume":"114","author":"M Misra","year":"2004","unstructured":"Misra M, Aggarwal A, Miller KK, et al. (2004) Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls. Pediatrics 114(6):1574\u20131583","journal-title":"Pediatrics"},{"issue":"2","key":"3685_CR8","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s007870200011","volume":"11","author":"G Jagielska","year":"2002","unstructured":"Jagielska G, Wolanczyk T, Komender J, Tomaszewicz-Libudzic C, Przedlacki J, Ostrowski K (2002) Bone mineral density in adolescent girls with anorexia nervosa--a cross-sectional study. Eur Child Adolesc Psychiatry 11(2):57\u201362","journal-title":"Eur Child Adolesc Psychiatry"},{"issue":"3","key":"3685_CR9","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1210\/jcem-68-3-548","volume":"68","author":"BM Biller","year":"1989","unstructured":"Biller BM, Saxe V, Herzog DB, Rosenthal DI, Holzman S, Klibanski A (1989) Mechanisms of osteoporosis in adult and adolescent women with anorexia nervosa. J Clin Endocrinol Metab 68(3):548\u2013554","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"3685_CR10","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1203\/00006450-200204000-00016","volume":"51","author":"L Audi","year":"2002","unstructured":"Audi L, Vargas DM, Gussinye M, Yeste D, Marti G, Carrascosa A (2002) Clinical and biochemical determinants of bone metabolism and bone mass in adolescent female patients with anorexia nervosa. Pediatr Res 51(4):497\u2013504","journal-title":"Pediatr Res"},{"issue":"3","key":"3685_CR11","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/eat.1081","volume":"30","author":"JM Turner","year":"2001","unstructured":"Turner JM, Bulsara MK, McDermott BM, Byrne GC, Prince RL, Forbes DA (2001) Predictors of low bone density in young adolescent females with anorexia nervosa and other dieting disorders. Int J Eat Disord 30(3):245\u2013251","journal-title":"Int J Eat Disord"},{"issue":"9","key":"3685_CR12","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1001\/jama.1991.03460090081037","volume":"265","author":"NA Rigotti","year":"1991","unstructured":"Rigotti NA, Neer RM, Skates SJ, Herzog DB, Nussbaum SR (1991) The clinical course of osteoporosis in anorexia nervosa. A longitudinal study of cortical bone mass. JAMA 265(9):1133\u20131138","journal-title":"JAMA"},{"issue":"7","key":"3685_CR13","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s00198-007-0325-0","volume":"18","author":"D Liu","year":"2007","unstructured":"Liu D, Manske SL, Kontulainen SA, et al. (2007) Tibial geometry is associated with failure load ex vivo: a MRI, pQCT and DXA study. Osteoporos Int 18(7):991\u2013997","journal-title":"Osteoporos Int"},{"key":"3685_CR14","unstructured":"DiVasta AD, Beck TJ, Petit MA, Feldman HA, Leboff MS, Gordon CM (2006) Bone strength in adolescents with anorexia nervosa: a hip structural analysis study. Osteoporos Int"},{"issue":"1","key":"3685_CR15","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/jbmr.2005","volume":"29","author":"AD DiVasta","year":"2014","unstructured":"DiVasta AD, Feldman HA, Beck TJ, LeBoff MS, Gordon CM (2014) Does hormone replacement normalize bone geometry in adolescents with anorexia nervosa? J Bone Miner Res 29(1):151\u2013157","journal-title":"J Bone Miner Res"},{"issue":"5","key":"3685_CR16","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1210\/jc.2012-4153","volume":"98","author":"AT Faje","year":"2013","unstructured":"Faje AT, Karim L, Taylor A, et al. (2013) Adolescent girls with anorexia nervosa have impaired cortical and trabecular microarchitecture and lower estimated bone strength at the distal radius. J Clin Endocrinol Metab 98(5):1923\u20131929","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"3685_CR17","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1359\/jbmr.081101","volume":"24","author":"RJ Wetzsteon","year":"2009","unstructured":"Wetzsteon RJ, Shults J, Zemel BS, et al. (2009) Divergent effects of glucocorticoids on cortical and trabecular compartment BMD in childhood nephrotic syndrome. J Bone Miner Res 24(3):503\u2013513","journal-title":"J Bone Miner Res"},{"issue":"1","key":"3685_CR18","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1111\/ajt.12524","volume":"14","author":"A Tsampalieros","year":"2014","unstructured":"Tsampalieros A, Griffin L, Terpstra AM, et al. (2014) Changes in DXA and quantitative CT measures of musculoskeletal outcomes following pediatric renal transplantation. Am J Transplant 14(1):124\u2013132","journal-title":"Am J Transplant"},{"issue":"2","key":"3685_CR19","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s00198-008-0646-7","volume":"20","author":"O Louis","year":"2009","unstructured":"Louis O, Clerinx P, Gies I, De Wachter E, De Schepper J (2009) Well-nourished cystic fibrosis patients have normal mineral density, but reduced cortical thickness at the forearm. Osteoporos Int 20(2):309\u2013314","journal-title":"Osteoporos Int"},{"issue":"9","key":"3685_CR20","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1002\/jbmr.2512","volume":"30","author":"S Mostoufi-Moab","year":"2015","unstructured":"Mostoufi-Moab S, Magland J, Isaacoff EJ, et al. (2015) Adverse fat depots and marrow adiposity are associated with skeletal deficits and insulin resistance in long-term survivors of pediatric hematopoietic stem cell transplantation. J Bone Miner Res 30(9):1657\u20131666","journal-title":"J Bone Miner Res"},{"issue":"11","key":"3685_CR21","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1002\/acr.22328","volume":"66","author":"JF Baker","year":"2014","unstructured":"Baker JF, Von Feldt J, Mostoufi-Moab S, et al. (2014) Deficits in muscle mass, muscle density, and modified associations with fat in rheumatoid arthritis. Arthritis Care Res (Hoboken) 66(11):1612\u20131618","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"5","key":"3685_CR22","doi-asserted-by":"publisher","first-page":"3128","DOI":"10.1210\/jc.2005-0162","volume":"90","author":"MF Holick","year":"2005","unstructured":"Holick MF (2005) 25-OH-vitamin D assays. J Clin Endocrinol Metab 90(5):3128\u20133129","journal-title":"J Clin Endocrinol Metab"},{"key":"3685_CR23","first-page":"73","volume-title":"Diabetes mellitus: diagnosis and treatment","author":"GJ Hamwi","year":"1964","unstructured":"Hamwi GJ (1964) Therapy: changing dietary concepts. In: Danowski TS (ed) Diabetes mellitus: diagnosis and treatment. American Diabetes Association, New York, pp. 73\u201378"},{"key":"3685_CR24","volume-title":"Physical status: the use and interpretation of anthropometry","author":"Organization WH","year":"1995","unstructured":"Organization WH (1995) Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee, Geneva"},{"issue":"1","key":"3685_CR25","first-page":"45","volume":"44","author":"TJ Cole","year":"1990","unstructured":"Cole TJ (1990) The LMS method for constructing normalized growth standards. Eur J Clin Nutr 44(1):45\u201360","journal-title":"Eur J Clin Nutr"},{"issue":"10","key":"3685_CR26","doi-asserted-by":"publisher","first-page":"3160","DOI":"10.1210\/jc.2011-1111","volume":"96","author":"BS Zemel","year":"2011","unstructured":"Zemel BS, Kalkwarf HJ, Gilsanz V, et al. (2011) Revised reference curves for bone mineral content and areal bone mineral density according to age and sex for black and non-black children: results of the bone mineral density in childhood study. J Clin Endocrinol Metab 96(10):3160\u20133169","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"3685_CR27","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1210\/jc.2009-1913","volume":"95","author":"MB Leonard","year":"2010","unstructured":"Leonard MB, Elmi A, Mostoufi-Moab S, et al. (2010) Effects of sex, race, and puberty on cortical bone and the functional muscle bone unit in children, adolescents, and young adults. J Clin Endocrinol Metab 95(4):1681\u20131689","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"3685_CR28","doi-asserted-by":"publisher","first-page":"2630","DOI":"10.1210\/jc.2014-4152","volume":"100","author":"LM Griffin","year":"2015","unstructured":"Griffin LM, Thayu M, Baldassano RN, et al. (2015) Improvements in bone density and structure during anti-TNF-\u03b1 therapy in pediatric Crohn\u2019s disease. J Clin Endocrinol Metab 100(7):2630\u20132639","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"3685_CR29","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1037\/1082-989X.12.4.399","volume":"12","author":"GY Zou","year":"2007","unstructured":"Zou GY (2007) Toward using confidence intervals to compare correlations. Psychol Methods 12(4):399\u2013413","journal-title":"Psychol Methods"},{"issue":"7","key":"3685_CR30","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1007\/s00467-012-2116-x","volume":"27","author":"LM Griffin","year":"2012","unstructured":"Griffin LM, Kalkwarf HJ, Zemel BS, et al. (2012) Assessment of dual-energy X-ray absorptiometry measures of bone health in pediatric chronic kidney disease. Pediatr Nephrol 27(7):1139\u20131148","journal-title":"Pediatr Nephrol"},{"issue":"5","key":"3685_CR31","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1210\/jc.2008-1654","volume":"94","author":"AD DiVasta","year":"2009","unstructured":"DiVasta AD, Feldman HA, Quach AE, Balestrino M, Gordon CM (2009) The effect of bed rest on bone turnover in young women hospitalized for anorexia nervosa: a pilot study. J Clin Endocrinol Metab 94(5):1650\u20131655","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"3685_CR32","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1002\/jbmr.1785","volume":"28","author":"A Tsampalieros","year":"2013","unstructured":"Tsampalieros A, Gupta P, Denburg MR, et al. (2013) Glucocorticoid effects on changes in bone mineral density and cortical structure in childhood nephrotic syndrome. J Bone Miner Res 28(3):480\u2013488","journal-title":"J Bone Miner Res"},{"issue":"12","key":"3685_CR33","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1007\/s00198-005-1992-3","volume":"16","author":"AL Boskey","year":"2005","unstructured":"Boskey AL, DiCarlo E, Paschalis E, West P, Mendelsohn R (2005) Comparison of mineral quality and quantity in iliac crest biopsies from high- and low-turnover osteoporosis: an FT-IR microspectroscopic investigation. Osteoporos Int 16(12):2031\u20132038","journal-title":"Osteoporos Int"},{"issue":"1","key":"3685_CR34","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.semarthrit.2006.04.002","volume":"36","author":"KS Davison","year":"2006","unstructured":"Davison KS, Siminoski K, Adachi JD, et al. (2006) Bone strength: the whole is greater than the sum of its parts. Semin Arthritis Rheum 36(1):22\u201331","journal-title":"Semin Arthritis Rheum"},{"issue":"8","key":"3685_CR35","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1359\/JBMR.050326","volume":"20","author":"SM Tommasini","year":"2005","unstructured":"Tommasini SM, Nasser P, Schaffler MB, Jepsen KJ (2005) Relationship between bone morphology and bone quality in male tibias: implications for stress fracture risk. J Bone Miner Res 20(8):1372\u20131380","journal-title":"J Bone Miner Res"},{"issue":"7","key":"3685_CR36","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s00198-004-1759-2","volume":"16","author":"G Milos","year":"2005","unstructured":"Milos G, Spindler A, Ruegsegger P, et al. (2005) Cortical and trabecular bone density and structure in anorexia nervosa. Osteoporos Int 16(7):783\u2013790","journal-title":"Osteoporos Int"},{"issue":"11","key":"3685_CR37","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1007\/s00467-007-0490-6","volume":"22","author":"MB Leonard","year":"2007","unstructured":"Leonard MB (2007) A structural approach to the assessment of fracture risk in children and adolescents with chronic kidney disease. Pediatr Nephrol 22(11):1815\u20131824","journal-title":"Pediatr Nephrol"},{"issue":"11","key":"3685_CR38","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1359\/jbmr.2000.15.11.2259","volume":"15","author":"E Seeman","year":"2000","unstructured":"Seeman E, Karlsson MK, Duan Y (2000) On exposure to anorexia nervosa, the temporal variation in axial and appendicular skeletal development predisposes to site-specific deficits in bone size and density: a cross-sectional study. J Bone Miner Res 15(11):2259\u20132265","journal-title":"J Bone Miner Res"},{"issue":"11","key":"3685_CR39","doi-asserted-by":"publisher","first-page":"4935","DOI":"10.1210\/jc.2002-020545","volume":"87","author":"CM Gordon","year":"2002","unstructured":"Gordon CM, Grace E, Emans SJ, et al. (2002) Effects of oral dehydroepiandrosterone on bone density in young women with anorexia nervosa: a randomized trial. J Clin Endocrinol Metab 87(11):4935\u20134941","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"3685_CR40","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.metabol.2011.11.016","volume":"61","author":"AD Divasta","year":"2012","unstructured":"Divasta AD, HA F, Giancaterino C, CJ R, MS L, CM G (2012) The effect of gonadal and adrenal steroid therapy on skeletal health in adolescents and young women with anorexia nervosa. Metabolism 61(7):1010\u20131020","journal-title":"Metabolism"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-016-3685-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-016-3685-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-016-3685-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T07:36:19Z","timestamp":1589441779000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-016-3685-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,8]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["3685"],"URL":"https:\/\/doi.org\/10.1007\/s00198-016-3685-5","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,8]]},"assertion":[{"value":"8 March 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The local institutional review boards approved the study protocol. Written informed consent was obtained from study patients or their parent\/guardian. Minor subjects also provided assent for participation.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}