{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:33:24Z","timestamp":1761863604957},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1007\/s00198-016-3770-9","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T19:11:05Z","timestamp":1475089865000},"page":"577-584","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Higher serum sclerostin levels and insufficiency of vitamin D are strongly associated with vertebral fractures in hemodialysis patients: a case control study"],"prefix":"10.1007","volume":"28","author":[{"given":"M.","family":"Atteritano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Di Mauro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Canale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Bruzzese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"Ricciardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Cernaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lacquaniti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Buemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,9,28]]},"reference":[{"key":"3770_CR1","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1007\/s00198-012-2133-4","volume":"24","author":"A Trombetti","year":"2013","unstructured":"Trombetti A, Stoermann C, Chevalley T, Van Rietbergen B, Herrmann FR, Martin PY, Rizzoli R (2013) Alterations of bone microstructure and strength in end-stage renal failure. Osteoporos Int 24:1721\u20131732","journal-title":"Osteoporos Int"},{"key":"3770_CR2","first-page":"77","volume":"23","author":"AE Grzegorzewska","year":"2007","unstructured":"Grzegorzewska AE, Mlot M (2007) Influence of age and sex on bone mineral density in dialysis patients. Adv Perit Dial 23:77\u201381","journal-title":"Adv Perit Dial"},{"key":"3770_CR3","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1053\/j.ajkd.2007.08.019","volume":"51","author":"AC Dooly","year":"2008","unstructured":"Dooly AC, Weiss NS, Kestenbaum B (2008) Increased risk of hip fracture among men with CKD. Am J Kidney Dis 51:38\u201344","journal-title":"Am J Kidney Dis"},{"key":"3770_CR4","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1046\/j.1523-1755.2000.00178.x","volume":"58","author":"AM Alem","year":"2000","unstructured":"Alem AM, Sherrard DJ, Gillen DL, Weiss NS, Beresford SA, Heckbert SR et al (2000) Increased risk of hip fracture among patients with end-stage renal disease. Kidney Int 58:396\u2013399","journal-title":"Kidney Int"},{"issue":"7","key":"3770_CR5","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1038\/sj.ki.5001754","volume":"70","author":"M Jadoul","year":"2006","unstructured":"Jadoul M, Albert JM, Akiba T, Akizawa T, Arab L, Bragg-Gresham JL et al (2006) Incidence and risk factors for hip or other bone fractures among hemodialysis patients in the dialysis outcomes and practice patterns study. Kidney Int 70(7):1358\u20131366","journal-title":"Kidney Int"},{"issue":"1","key":"3770_CR6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00223-013-9722-x","volume":"93","author":"M Fusaro","year":"2013","unstructured":"Fusaro M, Tripepi G, Noale M, Vajente N, Plebani M, Zaninotto M et al (2013) High prevalence of vertebral fractures assessed by quantitative morphometry in hemodialysis patients, strongly associated with vascular calcifications. Calcif Tissue Int 93(1):39\u201334","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"3770_CR7","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s00223-009-9278-y","volume":"85","author":"Y Maeno","year":"2009","unstructured":"Maeno Y, Inaba M, Okuno S, Kohno K, Maekawa K, Yamakawa T et al (2009) Significant association of fracture of the lumbar spine with mortality in female hemodialysis patients: a prospective observational study. Calcif Tissue Int 85(4):310\u2013316","journal-title":"Calcif Tissue Int"},{"key":"3770_CR8","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1093\/ndt\/gfn466","volume":"24","author":"M Rodriguez-Garcia","year":"2009","unstructured":"Rodriguez-Garcia M, Gomez-Alonso C, Naves-Diaz M, Diaz-Lopez JB, Diaz-Corte C, Cannata-Andia JB (2009) Asturias study group vascular calcifications, vertebral fractures and mortality in haemodialysis patients. Nephrol Dial Transplant 24:239\u2013246","journal-title":"Nephrol Dial Transplant"},{"key":"3770_CR9","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1111\/j.1523-1755.2000.00394.x","volume":"58","author":"CO Stehman-Breen","year":"2000","unstructured":"Stehman-Breen CO, Sherrad DJ, Alem AM, Gillen DL, Heckbert SR, Wong CS et al (2000) Risk factors for hip fracture among patients with end-stage renal disease. Kidney Int 58:2200\u20132205","journal-title":"Kidney Int"},{"key":"3770_CR10","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1093\/ndt\/gfr317","volume":"27","author":"S Iimori","year":"2012","unstructured":"Iimori S, Mori Y, Akita W, Kuyama T, Takada S, Asai T et al (2012) Diagnostic usefulness of bone mineral density and biochemical markers of bone turn-over in predicting fracture in CKD stage 5D patients: a single-center cohort study. Nephrol Dial Transplant 27:345\u2013351","journal-title":"Nephrol Dial Transplant"},{"key":"3770_CR11","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0070-2153(06)76004-5","volume":"76","author":"R Baron","year":"2006","unstructured":"Baron R, Rawadi G, Roman-Roman S (2006) Wnt signaling: a key regulator of bone mass. Curr Top Dev Biol 76:103\u2013127","journal-title":"Curr Top Dev Biol"},{"key":"3770_CR12","doi-asserted-by":"publisher","first-page":"19883","DOI":"10.1074\/jbc.M413274200","volume":"280","author":"X Li","year":"2005","unstructured":"Li X, Zhang Y, Kang H, Liu W, Liu P, Zhang J et al (2005) Sclerostin binds to LRP5\/6 and antagonizes canonical Wnt signaling. J Biol Chem 280:19883\u201319887","journal-title":"J Biol Chem"},{"key":"3770_CR13","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1096\/fj.05-4221fje","volume":"19","author":"KE Poole","year":"2005","unstructured":"Poole KE, van Bezooijen RL, Loveridge N, Hamersma H, Papapoulos SE, L\u00f6wik CW, Reeve J (2005) Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation. FASEB J 19:1842\u20131844","journal-title":"FASEB J"},{"issue":"6","key":"3770_CR14","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1210\/jc.2011-3419","volume":"97","author":"A Arasu","year":"2012","unstructured":"Arasu A, Cawthon PM, Lui LY, Do TP, Arora PS, Cauley JA et al (2012) Study of osteoporotic fractures research group serum sclerostin and risk of hip fracture in older Caucasian women. J Clin Endocrinol Metab 97(6):2027\u20132032","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"3770_CR15","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1007\/s00198-015-3127-9","volume":"26","author":"S Pelletier","year":"2015","unstructured":"Pelletier S, Confavreux CB, Haesebaert J, Guebre-Egziabher F, Bacchetta J, Carlier MC et al (2015) Serum sclerostin: the missing link in the bone-vessel cross-talk in hemodialysis patients? Osteoporos Int 26(8):2165\u20132174","journal-title":"Osteoporos Int"},{"key":"3770_CR16","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","volume":"8","author":"HK Genant","year":"1993","unstructured":"Genant HK, CY W, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8:1137\u20131148","journal-title":"J Bone Miner Res"},{"key":"3770_CR17","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0021-9150(97)00106-8","volume":"132","author":"L Kauppila","year":"1997","unstructured":"Kauppila L, Polak J, Cupples L, Hannan M, Kiel D, Wilson P (1997) New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study. Atherosclerosis 132:245\u2013250","journal-title":"Atherosclerosis"},{"key":"3770_CR18","doi-asserted-by":"publisher","unstructured":"Fishbane S, Hazzan AD, Jhaveri KD, Ma L, Lacson E Jr (2016) Bone parameters and risk of hip and femur fractures in patients on hemodialysis. Clin J Am Soc Nephrol 29:09280915","DOI":"10.2215\/CJN.09280915"},{"issue":"1","key":"3770_CR19","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/ndt\/gft352","volume":"29","author":"J Wagner","year":"2014","unstructured":"Wagner J, Jhaveri KD, Rosen L, Sunday S, Mathew AT, Fishbane S (2014) Increased bone fractures among elderly United States hemodialysis patients. Nephrol Dial Transplant 29(1):146\u2013151","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"3770_CR20","doi-asserted-by":"publisher","first-page":"248","DOI":"10.2174\/15701611113119990146","volume":"13","author":"M Fusaro","year":"2015","unstructured":"Fusaro M, Tripepi G, Noale M, Plebani M, Zaninotto M, Piccoli A et al (2015) Vertebral fractures and vascular calcifications study group. Prevalence of vertebral fractures, vascular calcifications, and mortality in warfarin treated hemodialysis patients. Curr Vasc Pharmacol 13(2):248\u2013258","journal-title":"Curr Vasc Pharmacol"},{"issue":"11","key":"3770_CR21","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1002\/jbmr.1677","volume":"27","author":"M Fusaro","year":"2012","unstructured":"Fusaro M, Noale M, Viola V, Galli F, Tripepi G, Vajente N et al (2012) Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study. J Bone Miner Res 27(11):2271\u20132278","journal-title":"J Bone Miner Res"},{"key":"3770_CR22","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1002\/jbmr.5650100304","volume":"10","author":"DC Bauer","year":"1995","unstructured":"Bauer DC, Gl\u00fcer CC, Genant HK, Stone K (1995) Quantitative ultrasound and vertebral fracture in postmenopausal women. J Bone Miner Res 10:353\u2013358","journal-title":"J Bone Miner Res"},{"key":"3770_CR23","first-page":"629","volume":"157","author":"DC Bauer","year":"1997","unstructured":"Bauer DC, Gl\u00fcer CC, Cauley JA, Vogt TM, Ensrud KE, Genant HK, Black DM (1997) Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women. A prospective study Study of Osteoporotic Fractures Research Group Arch Intern Med 157:629\u2013634","journal-title":"A prospective study Study of Osteoporotic Fractures Research Group Arch Intern Med"},{"key":"3770_CR24","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s00198-006-0317-5","volume":"18","author":"DC Bauer","year":"2007","unstructured":"Bauer DC, Ewing SK, Cauley JA, Ensrud KE, Cummings SR, Orwoll ES (2007) Quantitative ultrasound predicts hip and non-spine fracture in men: the MrOS study. Osteoporos Int 18:771\u2013777","journal-title":"Osteoporos Int"},{"issue":"2","key":"3770_CR25","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s11255-010-9723-x","volume":"43","author":"C Ambrus","year":"2011","unstructured":"Ambrus C, Almasi C, Berta K, Deak G, Marton A, Molnar MZ et al (2011) Vitamin D insufficiency and bone fractures in patients on maintenance hemodialysis. Int Urol Nephrol 43(2):475\u2013482","journal-title":"Int Urol Nephrol"},{"issue":"6","key":"3770_CR26","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/ki.2008.264","volume":"74","author":"TL Nickolas","year":"2008","unstructured":"Nickolas TL, Leonard MB, Shane E (2008) Chronic kidney disease and bone fracture: a growing concern. Kidney Int 74(6):721\u2013731","journal-title":"Kidney Int"},{"key":"3770_CR27","first-page":"12","volume":"24","author":"A El Maghraoui","year":"2012","unstructured":"El Maghraoui A, Ouzzif Z, Mounach A, Rezqi A, Achemlal L, Bezza A et al (2012) Hypovitaminosis D and prevalent asymptomatic vertebral fractures in Moroccan postmenopausal women. BMC Womens Health 24:12\u201311","journal-title":"BMC Womens Health"},{"key":"3770_CR28","doi-asserted-by":"publisher","first-page":"819","DOI":"10.2215\/CJN.07670712","volume":"8","author":"S Pelletier","year":"2013","unstructured":"Pelletier S, Dubourg L, Carlier MC, Hadj-Aissa A, Fouque D (2013) The relation between renalvfunction and serum sclerostin in adult patients with CKD. Clin J Am Soc Nephrol 8:819\u2013823","journal-title":"Clin J Am Soc Nephrol"},{"key":"3770_CR29","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1007\/s00198-010-1525-6","volume":"23","author":"SA Polyzos","year":"2012","unstructured":"Polyzos SA, Anastasilakis AD, Bratengeier C, Woloszczuk W, Papatheodorou A, Terpos E (2012) Serum sclerostin levels positively correlate with lumbar spinal bone mineral density in postmenopausal women\u2014the six-month effect of risedronate and teriparatide. Osteoporos Int 23:1171\u20131176","journal-title":"Osteoporos Int"},{"key":"3770_CR30","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1210\/jc.2011-2152","volume":"97","author":"K Amrein","year":"2012","unstructured":"Amrein K, Amrein S, Drexler C et al (2012) Sclerostin and its association with physical activity, age, gender, body composition, and bone mineral content in healthy adults. J Clin Endocrinol Metab 97:148\u2013154","journal-title":"J Clin Endocrinol Metab"},{"key":"3770_CR31","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/jbmr.217","volume":"26","author":"UI Modder","year":"2011","unstructured":"Modder UI, Hoey KA, Amin S et al (2011) Relation of age, gender, and bone mass to rcirculating sclerostin levels in women and men. J Bone Miner Res 26:373\u2013379","journal-title":"J Bone Miner Res"},{"key":"3770_CR32","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1210\/jc.2011-3419","volume":"97","author":"A Arasu","year":"2012","unstructured":"Arasu A, Cawthon PM, Cummings SR et al (2012) Serum sclerostin and risk of hip fracture in older Caucasian women. J Clin Endocrinol Metab 97:2027\u20132032","journal-title":"J Clin Endocrinol Metab"},{"key":"3770_CR33","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1002\/jbmr.1718","volume":"27","author":"MS Ardawi","year":"2012","unstructured":"Ardawi MS, Rouzi AA, Al-Sibiani SA, Al-Senani NS, Qari MH, Mousa SA (2012) High serum sclerostin predicts the occurrence of osteoporotic fractures in postmenopausal women: the Center of Excellence for osteoporosis research study. J Bone Miner Res 27:2592\u20132602","journal-title":"J Bone Miner Res"},{"issue":"2","key":"3770_CR34","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00198-012-1978-x","volume":"24","author":"P Garnero","year":"2013","unstructured":"Garnero P, Sornay-Rendu E, Munoz F, Borel O, Chapurlat RD (2013) Association of serum sclerostin with bone mineral density, bone turnover, steroid and parathyroid hormones, and fracture risk in postmenopausal women: the OFELY study. Osteoporos Int 24(2):489\u2013494","journal-title":"Osteoporos Int"},{"key":"3770_CR35","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/jbmr.1823","volume":"28","author":"P Szulc","year":"2013","unstructured":"Szulc P, Bertholon C, Borel O, Marchand F, Chapurlat R (2013) Lower fracture risk in older men with higher sclerostin concentration: a prospective analysis from the MINOS study. J Bone Miner Res 28:855\u2013864","journal-title":"J Bone Miner Res"},{"issue":"4","key":"3770_CR36","doi-asserted-by":"publisher","first-page":"877","DOI":"10.2215\/CJN.06550810","volume":"6","author":"D Cejka","year":"2011","unstructured":"Cejka D, Herberth J, Branscum AJ, Fardo DW, Monier-Faugere MC, Diarra D et al (2011) Sclerostin and Dickkopf-1 in renal osteodystrophy. Clin J Am Soc Nephrol 6(4):877\u2013882","journal-title":"Clin J Am Soc Nephrol"},{"issue":"8","key":"3770_CR37","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1002\/jbmr.1630","volume":"27","author":"YL Sabbagh","year":"2012","unstructured":"Sabbagh YL, Graciolli FG, O\u2019Brien S, Tang W, dos Reis LM, Ryan S, Phillips L, Boulanger J, Song W, Bracken C, Liu S, Ledbetter S, Dechow P, Canziani ME, Carvalho AB, Jorgetti V, Moyses RM (2012) Schiavi SC (2012) repression of osteocyte Wnt\/\u03b2-catenin signaling is an early event in the progression of renal osteodystrophy. J Bone Miner Res 27(8):1757\u20131772","journal-title":"J Bone Miner Res"},{"key":"3770_CR38","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.2337\/dc12-1691","volume":"36","author":"S Morales-Santana","year":"2013","unstructured":"Morales-Santana S, Garcia-Fontana B, Garcia-Martin A, Rozas-Moreno P, Garcia-Salcedo JA, Reyes-Garcia R, Munoz-Torres M (2013) Atherosclerotic disease in type 2 diabetes is associated with an increase in sclerostin levels. Diabetes Care 36:1667\u20131674","journal-title":"Diabetes Care"},{"issue":"23","key":"3770_CR39","doi-asserted-by":"publisher","first-page":"6267","DOI":"10.1093\/emboj\/cdg599","volume":"22","author":"DG Winkler","year":"2003","unstructured":"Winkler DG, Sutherland MK, Geoghegan JC, Yu C, Hayes T, Skonier JE, Shpektor D et al (2003) Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO J 22(23):6267\u20136276","journal-title":"EMBO J"},{"key":"3770_CR40","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.bone.2013.05.010","volume":"56","author":"G Hampson","year":"2013","unstructured":"Hampson G, Edwards S, Conroy S, Blake GM, Fogelman I, Frost ML (2013) The relationship between inhibitors of the Wnt signalling pathway (Dickkopf-1(DKK1) and sclerostin), bone mineral density, vascular calcification and arterial stiffness in postmenopausal women. Bone 56:42\u201347","journal-title":"Bone"},{"issue":"5","key":"3770_CR41","doi-asserted-by":"publisher","first-page":"e19595","DOI":"10.1371\/journal.pone.0019595","volume":"6","author":"D Zhu","year":"2011","unstructured":"Zhu D, Mackenzie NC, Mill\u00e1n JL, Farquharson C, MacRae VE (2011) The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells. PLoS One 6(5):e19595","journal-title":"PLoS One"},{"issue":"2","key":"3770_CR42","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/ki.2015.156","volume":"88","author":"P Evenepoel","year":"2015","unstructured":"Evenepoel P, D\u2019Haese P, Brandenburg V (2015) Sclerostin and DKK1: new players in renal bone and vascular disease. Kidney Int 88(2):235\u2013240 Review","journal-title":"Kidney Int"},{"key":"3770_CR43","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.cca.2014.08.034","volume":"438","author":"S Evrard","year":"2015","unstructured":"Evrard S, Delanaye P, Kamel S, Cristol JP, Cavalier E (2015) SFBC\/SN joined working group on vascular calcifications. Vascular calcification: from pathophysiology to biomarkers. Clin Chim Acta 438:401\u2013414","journal-title":"Clin Chim Acta"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-016-3770-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-016-3770-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-016-3770-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T02:46:39Z","timestamp":1568429199000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-016-3770-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,28]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["3770"],"URL":"https:\/\/doi.org\/10.1007\/s00198-016-3770-9","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,28]]}}}