{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:35:33Z","timestamp":1773182133126,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T00:00:00Z","timestamp":1493856000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Svenska L\u00e4kares\u00e4llskapet (SE)"},{"name":"\u00d6sterg\u00f6tland County Council"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s00198-017-4058-4","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T06:41:42Z","timestamp":1493880102000},"page":"2439-2444","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Undisturbed local bone formation capacity in patients with atypical femoral fractures: a case series"],"prefix":"10.1007","volume":"28","author":[{"given":"H. P.","family":"B\u00f6gl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Aspenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Schilcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"4058_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jbmr.1998","volume":"29","author":"E Shane","year":"2014","unstructured":"Shane E, Burr D, Abrahamsen B et al (2014) Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 29:1\u201323","journal-title":"J Bone Miner Res"},{"key":"4058_CR2","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1002\/jbmr.253","volume":"25","author":"E Shane","year":"2010","unstructured":"Shane E, Burr D, Ebeling PR et al (2010) Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 25:2267\u20132294","journal-title":"J Bone Miner Res"},{"key":"4058_CR3","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1056\/NEJMe1003064","volume":"362","author":"E Shane","year":"2010","unstructured":"Shane E (2010) Evolving data about subtrochanteric fractures and bisphosphonates. N Engl J Med 362:1825\u20131827","journal-title":"N Engl J Med"},{"key":"4058_CR4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3109\/17453674.2015.1004149","volume":"86","author":"J Schilcher","year":"2015","unstructured":"Schilcher J, Koeppen V, Aspenberg P, Michaelsson K (2015) Risk of atypical femoral fracture during and after bisphosphonate use. Acta Orthop 86:100\u2013107","journal-title":"Acta Orthop"},{"key":"4058_CR5","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1056\/NEJMoa1010650","volume":"364","author":"J Schilcher","year":"2011","unstructured":"Schilcher J, Michaelsson K, Aspenberg P (2011) Bisphosphonate use and atypical fractures of the femoral shaft. N Engl J Med 364:1728\u20131737","journal-title":"N Engl J Med"},{"key":"4058_CR6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3109\/17453670903139914","volume":"80","author":"J Schilcher","year":"2009","unstructured":"Schilcher J, Aspenberg P (2009) Incidence of stress fractures of the femoral shaft in women treated with bisphosphonate. Acta Orthop 80:413\u2013415","journal-title":"Acta Orthop"},{"key":"4058_CR7","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1002\/jbmr.1719","volume":"27","author":"RM Dell","year":"2012","unstructured":"Dell RM, Adams AL, Greene DF, Funahashi TT, Silverman SL, Eisemon EO, Zhou H, Burchette RJ, Ott SM (2012) Incidence of atypical nontraumatic diaphyseal fractures of the femur. J Bone Miner Res 27:2544\u20132550","journal-title":"J Bone Miner Res"},{"key":"4058_CR8","first-page":"930","volume":"172","author":"RP Meier","year":"2012","unstructured":"Meier RP, Perneger TV, Stern R, Rizzoli R, Peter RE (2012) Increasing occurrence of atypical femoral fractures associated with bisphosphonate use. Arch Intern Med 172:930\u2013936","journal-title":"Arch Intern Med"},{"key":"4058_CR9","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1056\/NEJMc0910389","volume":"362","author":"CM Girgis","year":"2010","unstructured":"Girgis CM, Sher D, Seibel MJ (2010) Atypical femoral fractures and bisphosphonate use. N Engl J Med 362:1848\u20131849","journal-title":"N Engl J Med"},{"key":"4058_CR10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/BOT.0b013e31827240ae","volume":"27","author":"KA Egol","year":"2013","unstructured":"Egol KA, Park JH, Prensky C, Rosenberg ZS, Peck V, Tejwani NC (2013) Surgical treatment improves clinical and functional outcomes for patients who sustain incomplete bisphosphonate-related femur fractures. J Orthop Trauma 27:331\u2013335","journal-title":"J Orthop Trauma"},{"key":"4058_CR11","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3109\/17453674.2014.916488","volume":"85","author":"J Schilcher","year":"2014","unstructured":"Schilcher J, Sandberg O, Isaksson H, Aspenberg P (2014) Histology of 8 atypical femoral fractures: remodeling but no healing. Acta Orthop 85:280\u2013286","journal-title":"Acta Orthop"},{"key":"4058_CR12","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1210\/jc.2004-0952","volume":"90","author":"CV Odvina","year":"2005","unstructured":"Odvina CV, Zerwekh JE, Rao DS, Maalouf N, Gottschalk FA, Pak CY (2005) Severely suppressed bone turnover: a potential complication of alendronate therapy. J Clin Endocrinol Metab 90:1294\u20131301","journal-title":"J Clin Endocrinol Metab"},{"key":"4058_CR13","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.2106\/JBJS.N.00075","volume":"96","author":"JE Hagen","year":"2014","unstructured":"Hagen JE, Miller AN, Ott SM, Gardner M, Morshed S, Jeray K, Alton TB, Ren D, Abblitt WP, Krieg JC (2014) Association of atypical femoral fractures with bisphosphonate use by patients with varus hip geometry. J Bone Joint Surg Am 96:1905\u20131909","journal-title":"J Bone Joint Surg Am"},{"key":"4058_CR14","doi-asserted-by":"crossref","unstructured":"Chen LP, Chang TK, Huang TY, Kwok TG, Lu YC (2014) The correlation between lateral bowing angle of the femur and the location of atypical femur fractures. Calcif Tissue Int","DOI":"10.1007\/s00223-014-9887-y"},{"key":"4058_CR15","doi-asserted-by":"crossref","unstructured":"Morin S, Godbout BW, Belzile MEL, Michou L, Ste-Marie L-G, Karaplis ACDGJA, Brown JP (2013) Femur geometrical parameters in the pathogenesis of atypical femur fractures. Bone Abstracts.\u00a0Elsevier,\u00a0Amsterdam","DOI":"10.1530\/boneabs.01.OC1.6"},{"key":"4058_CR16","volume-title":"Potential pathogenic mechanism for stress fractures of the bowed femoral shaft in the elderly: mechanical analysis by the CT-based finite element method","author":"Y Oh","year":"2014","unstructured":"Oh Y, Wakabayashi Y, Kurosa Y, Fujita K, Okawa A (2014) Potential pathogenic mechanism for stress fractures of the bowed femoral shaft in the elderly: mechanical analysis by the CT-based finite element method. Injury"},{"key":"4058_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bone.2014.02.006","volume":"63","author":"DP Taormina","year":"2014","unstructured":"Taormina DP, Marcano AI, Karia R, Egol KA, Tejwani NC (2014) Symptomatic atypical femoral fractures are related to underlying hip geometry. Bone 63:1\u20136","journal-title":"Bone"},{"key":"4058_CR18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00402-012-1558-8","volume":"134","author":"S Larsson","year":"2014","unstructured":"Larsson S, Fazzalari NL (2014) Anti-osteoporosis therapy and fracture healing. Arch Orthop Trauma Surg 134:291\u2013297","journal-title":"Arch Orthop Trauma Surg"},{"key":"4058_CR19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bone.2016.04.020","volume":"88","author":"A Gustafsson","year":"2016","unstructured":"Gustafsson A, Schilcher J, Grassi L, Aspenberg P, Isaksson H (2016) Strains caused by daily loading might be responsible for delayed healing of an incomplete atypical femoral fracture. Bone 88:125\u2013130","journal-title":"Bone"},{"key":"4058_CR20","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bone.2014.10.010","volume":"71","author":"DB Burr","year":"2015","unstructured":"Burr DB, Liu Z, Allen MR (2015) Duration-dependent effects of clinically relevant oral alendronate doses on cortical bone toughness in beagle dogs. Bone 71:58\u201362","journal-title":"Bone"},{"key":"4058_CR21","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/jbmr.560","volume":"27","author":"E Donnelly","year":"2012","unstructured":"Donnelly E, Meredith DS, Nguyen JT, Gladnick BP, Rebolledo BJ, Shaffer AD, Lorich DG, Lane JM, Boskey AL (2012) Reduced cortical bone compositional heterogeneity with bisphosphonate treatment in postmenopausal women with intertrochanteric and subtrochanteric fractures. J Bone Miner Res 27:672\u2013678","journal-title":"J Bone Miner Res"},{"key":"4058_CR22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bone.2016.07.015","volume":"91","author":"A Demirtas","year":"2016","unstructured":"Demirtas A, Curran E, Ural A (2016) Assessment of the effect of reduced compositional heterogeneity on fracture resistance of human cortical bone using finite element modeling. Bone 91:92\u2013101","journal-title":"Bone"},{"key":"4058_CR23","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bone.2014.04.012","volume":"64","author":"K Iwata","year":"2014","unstructured":"Iwata K, Mashiba T, Hitora T, Yamagami Y, Yamamoto T (2014) A large amount of microdamages in the cortical bone around fracture site in a patient of atypical femoral fracture after long-term bisphosphonate therapy. Bone 64:183\u2013186","journal-title":"Bone"},{"key":"4058_CR24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bone.2013.01.016","volume":"54","author":"Y Yamagami","year":"2013","unstructured":"Yamagami Y, Mashiba T, Iwata K, Tanaka M, Nozaki K, Yamamoto T (2013) Effects of minodronic acid and alendronate on bone remodeling, microdamage accumulation, degree of mineralization and bone mechanical properties in ovariectomized cynomolgus monkeys. Bone 54:1\u20137","journal-title":"Bone"},{"key":"4058_CR25","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1007\/s11999-013-2963-1","volume":"472","author":"KA Egol","year":"2014","unstructured":"Egol KA, Park JH, Rosenberg ZS, Peck V, Tejwani NC (2014) Healing delayed but generally reliable after bisphosphonate-associated complete femur fractures treated with IM nails. Clin Orthop Relat Res 472:2728\u20132734","journal-title":"Clin Orthop Relat Res"},{"key":"4058_CR26","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1007\/s11999-012-2412-6","volume":"470","author":"ML Prasarn","year":"2012","unstructured":"Prasarn ML, Ahn J, Helfet DL, Lane JM, Lorich DG (2012) Bisphosphonate-associated femur fractures have high complication rates with operative fixation. Clin Orthop Relat Res 470:2295\u20132301","journal-title":"Clin Orthop Relat Res"},{"key":"4058_CR27","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1302\/0301-620X.92B5.22941","volume":"92","author":"S Das De","year":"2010","unstructured":"Das De S, Setiobudi T, Shen L, Das De S (2010) A rational approach to management of alendronate-related subtrochanteric fractures. J Bone Joint Surg Br 92:679\u2013686","journal-title":"J Bone Joint Surg Br"},{"key":"4058_CR28","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1302\/0301-620X.96B5.32887","volume":"96-B","author":"BJ Teo","year":"2014","unstructured":"Teo BJ, Koh JS, Goh SK, Png MA, Chua DT, Howe TS (2014) Post-operative outcomes of atypical femoral subtrochanteric fracture in patients on bisphosphonate therapy. The bone & joint journal 96-B:658\u2013664","journal-title":"The bone & joint journal"},{"key":"4058_CR29","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bone.2012.10.016","volume":"52","author":"J Schilcher","year":"2013","unstructured":"Schilcher J, Koeppen V, Ranstam J, Skripitz R, Michaelsson K, Aspenberg P (2013) Atypical femoral fractures are a separate entity, characterized by highly specific radiographic features. A comparison of 59 cases and 218 controls. Bone 52:389\u2013392","journal-title":"Bone"},{"key":"4058_CR30","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.orthres.2005.03.004","volume":"23","author":"N Amanat","year":"2005","unstructured":"Amanat N, Brown R, Bilston LE, Little DG (2005) A single systemic dose of pamidronate improves bone mineral content and accelerates restoration of strength in a rat model of fracture repair. J Orthop Res 23:1029\u20131034","journal-title":"J Orthop Res"},{"key":"4058_CR31","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.bone.2015.09.018","volume":"81","author":"Y Hao","year":"2015","unstructured":"Hao Y, Wang X, Wang L, Lu Y, Mao Z, Ge S, Dai K (2015) Zoledronic acid suppresses callus remodeling but enhances callus strength in an osteoporotic rat model of fracture healing. Bone 81:702\u2013711","journal-title":"Bone"},{"key":"4058_CR32","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1359\/jbmr.1999.14.6.969","volume":"14","author":"J Li","year":"1999","unstructured":"Li J, Mori S, Kaji Y, Mashiba T, Kawanishi J, Norimatsu H (1999) Effect of bisphosphonate (incadronate) on fracture healing of long bones in rats. J Bone Miner Res 14:969\u2013979","journal-title":"J Bone Miner Res"},{"key":"4058_CR33","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.2106\/JBJS.K.01434","volume":"94","author":"HS Gong","year":"2012","unstructured":"Gong HS, Song CH, Lee YH, Rhee SH, Lee HJ, Baek GH (2012) Early initiation of bisphosphonate does not affect healing and outcomes of volar plate fixation of osteoporotic distal radial fractures. J Bone Joint Surg Am 94:1729\u20131736","journal-title":"J Bone Joint Surg Am"},{"key":"4058_CR34","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4055\/cios.2016.8.4.437","volume":"8","author":"JB Seo","year":"2016","unstructured":"Seo JB, Yoo JS, Ryu JW, Yu KW (2016) Influence of early bisphosphonate administration for fracture healing in patients with osteoporotic proximal humerus fractures. Clin Orthop Surg 8:437\u2013443","journal-title":"Clin Orthop Surg"},{"key":"4058_CR35","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1302\/0301-620X.94B7.29079","volume":"94","author":"TY Kim","year":"2012","unstructured":"Kim TY, Ha YC, Kang BJ, Lee YK, Koo KH (2012) Does early administration of bisphosphonate affect fracture healing in patients with intertrochanteric fractures? J Bone Joint Surg Br 94:956\u2013960","journal-title":"J Bone Joint Surg Br"},{"key":"4058_CR36","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1302\/0301-620X.95B11.31652","volume":"95-B","author":"S Uchiyama","year":"2013","unstructured":"Uchiyama S, Itsubo T, Nakamura K, Fujinaga Y, Sato N, Imaeda T, Kadoya M, Kato H (2013) Effect of early administration of alendronate after surgery for distal radial fragility fracture on radiological fracture healing time. The bone & joint journal 95-B:1544\u20131550","journal-title":"The bone & joint journal"},{"key":"4058_CR37","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.2106\/JBJS.16.01009","volume":"98","author":"EJ Harvey","year":"2016","unstructured":"Harvey EJ (2016) Bisphosphonates are not always helpful: commentary on an article by Hae-Seong Lim, MD, et al.: \"Factors associated with increased healing time in complete femoral fractures after long-term bisphosphonate therapy\". J Bone Joint Surg Am 98:e107","journal-title":"J Bone Joint Surg Am"},{"key":"4058_CR38","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1007\/s11999-010-1583-2","volume":"468","author":"YC Ha","year":"2010","unstructured":"Ha YC, Cho MR, Park KH, Kim SY, Koo KH (2010) Is surgery necessary for femoral insufficiency fractures after long-term bisphosphonate therapy? Clin Orthop Relat Res 468:3393\u20133398","journal-title":"Clin Orthop Relat Res"},{"key":"4058_CR39","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/BOT.0b013e3181b6499b","volume":"24","author":"JS Koh","year":"2010","unstructured":"Koh JS, Goh SK, Png MA, Kwek EB, Howe TS (2010) Femoral cortical stress lesions in long-term bisphosphonate therapy: a herald of impending fracture? J Orthop Trauma 24:75\u201381","journal-title":"J Orthop Trauma"},{"key":"4058_CR40","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1302\/0301-620X.84B8.13752","volume":"84","author":"SM Perren","year":"2002","unstructured":"Perren SM (2002) Evolution of the internal fixation of long bone fractures. The scientific basis of biological internal fixation: choosing a new balance between stability and biology. J Bone Joint Surg Br 84:1093\u20131110","journal-title":"J Bone Joint Surg Br"},{"key":"4058_CR41","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1002\/jor.21464","volume":"29","author":"LJ Kidd","year":"2011","unstructured":"Kidd LJ, Cowling NR, Wu AC, Kelly WL, Forwood MR (2011) Bisphosphonate treatment delays stress fracture remodeling in the rat ulna. J Orthop Res 29:1827\u20131833","journal-title":"J Orthop Res"},{"key":"4058_CR42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/8756-3282(93)90235-3","volume":"14","author":"S Mori","year":"1993","unstructured":"Mori S, Burr DB (1993) Increased intracortical remodeling following fatigue damage. Bone 14:103\u2013109","journal-title":"Bone"},{"key":"4058_CR43","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/2151458514522058","volume":"5","author":"C Fang","year":"2014","unstructured":"Fang C, Chau JY, Woo SB, Lau TW, Kwan K, Leung F (2014) Propagation of bisphosphonate-related femoral stress fractures despite femoral nailing: a cautionary tale from 2 cases. Geriatric orthopaedic surgery & rehabilitation 5:14\u201317","journal-title":"Geriatric orthopaedic surgery & rehabilitation"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-017-4058-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-017-4058-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-017-4058-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T03:34:18Z","timestamp":1569209658000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-017-4058-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,4]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["4058"],"URL":"https:\/\/doi.org\/10.1007\/s00198-017-4058-4","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,4]]}}}