{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:09:58Z","timestamp":1788318598795,"version":"build-2803163510"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T00:00:00Z","timestamp":1521849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["School Primary care research 256"],"award-info":[{"award-number":["School Primary care research 256"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1007\/s00198-018-4491-z","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T11:40:08Z","timestamp":1521891608000},"page":"1659-1664","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Risk of fragility fracture among patients with late-onset psoriasis: a UK population-based study"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-2986","authenticated-orcid":false,"given":"Z.","family":"Paskins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Whittle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Abdul Sultan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Blagojevic-Bucknall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Helliwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Packham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Roddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Mallen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,24]]},"reference":[{"key":"4491_CR1","first-page":"1354","volume":"35","author":"Y Alamanos","year":"2008","unstructured":"Alamanos Y, Voulgari PV, Drosos AA (2008) Incidence and prevalence of psoriatic arthritis: a systematic review. J Rheumatol 35:1354\u20131358","journal-title":"J Rheumatol"},{"key":"4491_CR2","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.jaad.2008.01.006","volume":"58","author":"AB Kimball","year":"2008","unstructured":"Kimball AB, Gladman D, Gelfand JM, Gordon K, Horn EJ, Korman NJ, Korver G, Krueger GG, Strober BE, Lebwohl MG (2008) National Psoriasis Foundation clinical consensus on psoriasis co-morbidities and recommendations for screening. J Am Acad Dermatol 58:1031\u20131042","journal-title":"J Am Acad Dermatol"},{"key":"4491_CR3","doi-asserted-by":"publisher","first-page":"3104","DOI":"10.1002\/art.22117","volume":"54","author":"T Staa Van","year":"2006","unstructured":"Van Staa T, Geusens P, Bijlsma J, Leufkens H, Cooper C (2006) Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis. Arthritis Rheumatism 54:3104\u20133112","journal-title":"Arthritis Rheumatism"},{"key":"4491_CR4","doi-asserted-by":"publisher","first-page":"S147","DOI":"10.1301\/nr.2007.dec.S147-S151","volume":"65","author":"GR Mundy","year":"2007","unstructured":"Mundy GR (2007) Osteoporosis and inflammation. Nutr Rev 65:S147\u2013S151","journal-title":"Nutr Rev"},{"key":"4491_CR5","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1136\/ard.52.8.582","volume":"52","author":"SJ Preston","year":"1993","unstructured":"Preston SJ, Diamond T, Scott A, Laurent MR (1993) Methotrexate osteopathy in rheumatic disease. Ann Rheum Dis 52:582\u2013585","journal-title":"Ann Rheum Dis"},{"key":"4491_CR6","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1038\/jid.2008.432","volume":"129","author":"J Dreiher","year":"2009","unstructured":"Dreiher J, Weitzman D, Cohen AD (2009) Psoriasis and osteoporosis: a sex-specific association? J Invest Dermatol 129:1643\u20131649","journal-title":"J Invest Dermatol"},{"key":"4491_CR7","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1111\/bjd.15123","volume":"176","author":"E Modalsli","year":"2017","unstructured":"Modalsli E, \u00c5svold B, Romundstad P, Langhammer A, Hoff M, Forsmo S, Naldi L, Saunes M (2017) Psoriasis, fracture risk and bone mineral density: the HUNT Study, Norway. Br J Dermatol 176:1162\u20131169","journal-title":"Br J Dermatol"},{"key":"4491_CR8","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1136\/annrheumdis-2016-210441","volume":"76","author":"A Ogdie","year":"2017","unstructured":"Ogdie A, Harter L, Shin D, Baker J, Takeshita J, Choi HK, Love TJ, Gelfand JM (2017) The risk of fracture among patients with psoriatic arthritis and psoriasis: a population-based study. Ann Rheum Dis 76:882\u2013885","journal-title":"Ann Rheum Dis"},{"key":"4491_CR9","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1111\/bjd.15021","volume":"176","author":"D Springate","year":"2017","unstructured":"Springate D, Parisi R, Kontopantelis E, Reeves D, Griffiths C, Ashcroft D (2017) Incidence, prevalence and mortality of patients with psoriasis: a UK population-based cohort study. Br J Dermatol 176:650\u2013658","journal-title":"Br J Dermatol"},{"key":"4491_CR10","doi-asserted-by":"crossref","unstructured":"Henseler T, Christophers E Psoriasis of early and late onset: characterization of two types of psoriasis vulgaris. J Am Acad Dermatol 13:450\u2013456, 1985","DOI":"10.1016\/S0190-9622(85)70188-0"},{"key":"4491_CR11","unstructured":"National Institute for Health and Care Excellence (2012) Psoriasis: assessment and management"},{"key":"4491_CR12","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1136\/annrheumdis-2015-208337","volume":"75","author":"L Gossec","year":"2016","unstructured":"Gossec L, Smolen JS, Ramiro S, de Wit M, Cutolo M, Dougados M, Emery P, Landewe R, Oliver S, Aletaha D, Betteridge N, Braun J, Burmester G, Canete JD, Damjanov N, FitzGerald O, Haglund E, Helliwell P, Kvien TK, Lories R, Luger T, Maccarone M, Marzo-Ortega H, McGonagle D, McInnes IB, Olivieri I, Pavelka K, Schett G, Sieper J, van den Bosch F, Veale DJ, Wollenhaupt J, Zink A, van der Heijde D (2016) European League Against Rheumatism (EULAR) recommendations for the management of psoriatic arthritis with pharmacological therapies: 2015 update. Ann Rheum Dis 75:499\u2013510","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"4491_CR13","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s00223-006-0060-0","volume":"79","author":"P Vestergaard","year":"2006","unstructured":"Vestergaard P, Rejnmark L, Mosekilde L (2006) Methotrexate, azathioprine, cyclosporine, and risk of fracture. Calcif Tissue Int 79(2):69\u201375","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"4491_CR14","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1093\/ije\/dyv098","volume":"44","author":"E Herrett","year":"2015","unstructured":"Herrett E, Gallagher AM, Bhaskaran K, Forbes H, Mathur R, van Staa T, Smeeth L (2015) Data Resource Profile: Clinical Practice Research Datalink (CPRD). Int J Epidemiol 44(3):827\u2013836","journal-title":"Int J Epidemiol"},{"key":"4491_CR15","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1001\/archderm.143.12.1559","volume":"143","author":"C Huerta","year":"2007","unstructured":"Huerta C, Rivero E, Rodriguez LA (2007) Incidence and risk factors for psoriasis in the general population. Arch Dermatol 143:1559\u20131565","journal-title":"Arch Dermatol"},{"key":"4491_CR16","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s00198-007-0543-5","volume":"19","author":"J Kanis","year":"2008","unstructured":"Kanis J, Johnell O, Od\u00e9n A, Johansson H, McCloskey E (2008) FRAX\u2122 and the assessment of fracture probability in men and women from the UK. Osteoporosis Int 19:385\u2013397","journal-title":"Osteoporosis Int"},{"key":"4491_CR17","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1159\/000265557","volume":"220","author":"S Gerdes","year":"2010","unstructured":"Gerdes S, Zahl VA, Weichenthal M, Mrowietz U (2010) Smoking and alcohol intake in severely affected patients with psoriasis in Germany. Dermatology 220:38\u201343","journal-title":"Dermatology"},{"key":"4491_CR18","doi-asserted-by":"publisher","first-page":"e0169952","DOI":"10.1371\/journal.pone.0169952","volume":"12","author":"X Xu","year":"2017","unstructured":"Xu X, Su L, Gao Y, Ding Y (2017) The prevalence of nonalcoholic fatty liver disease and related metabolic comorbidities was associated with age at onset of moderate to severe plaque psoriasis: a cross-sectional study. PLoS One 12:e0169952","journal-title":"PLoS One"},{"key":"4491_CR19","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1046\/j.0022-202x.2001.01642.x","volume":"118","author":"K Reich","year":"2002","unstructured":"Reich K, M\u00f6ssner R, Neumann C, K\u00f6nig IR, Westphal G, Ziegler A (2002) Promoter polymorphisms of the genes encoding tumor necrosis factor-\u03b1 and interleukin-1\u03b2 are associated with different subtypes of psoriasis characterized by early and late disease onset. J Invest Dermatol 118:155\u2013163","journal-title":"J Invest Dermatol"},{"key":"4491_CR20","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/1099-1557(200009\/10)9:5<359::AID-PDS507>3.0.CO;2-E","volume":"9","author":"T Staa Van","year":"2000","unstructured":"Van Staa T, Abenhaim L, Cooper C, Zhang B, Leufkens H (2000) The use of a large pharmacoepidemiological database to study exposure to oral corticosteroids and risk of fractures: validation of study population and results. Pharmacoepidemiol Drug Saf 9:359\u2013366","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"4491_CR21","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/jbmr.556","volume":"27","author":"LM Giangregorio","year":"2012","unstructured":"Giangregorio LM, Leslie WD, Lix LM, Johansson H, Oden A, McCloskey E, Kanis JA (2012) FRAX underestimates fracture risk in patients with diabetes. J Bone Miner Res 27:301\u2013308","journal-title":"J Bone Miner Res"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-018-4491-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-018-4491-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-018-4491-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T20:27:25Z","timestamp":1553372845000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-018-4491-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,24]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["4491"],"URL":"https:\/\/doi.org\/10.1007\/s00198-018-4491-z","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,24]]},"assertion":[{"value":"19 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This study was approved by the Independent Scientific Advisory Committee of the CPRD (protocol 15_165RA) on 18th May 2016, before data analysis was conducted. Ethical approval is not needed for database studies and ISAC provide the necessary regulatory approvals. Each practice in CPRD has consented to be included; patients within each consented practice are automatically included.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent"}}]}}