{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:12:40Z","timestamp":1788952360472,"version":"build-2803163510"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Radius Pharma"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s00198-018-4502-0","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T05:42:09Z","timestamp":1528782129000},"page":"1747-1757","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":173,"title":["Characteristics of recurrent fractures"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-4326","authenticated-orcid":false,"given":"J. A.","family":"Kanis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Od\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. C.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Gudnason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. M.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sigurdsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Siggeirsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A.","family":"Fitzpatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Borgstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. V.","family":"McCloskey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"key":"4502_CR1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00198-003-1514-0","volume":"15","author":"O Johnell","year":"2004","unstructured":"Johnell O, Kanis JA, Oden A et al (2004) Fracture risk following an osteoporotic fracture. Osteoporos Int 15:175\u2013179","journal-title":"Osteoporos Int"},{"key":"4502_CR2","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s00198-014-2875-2","volume":"26","author":"L Hansen","year":"2015","unstructured":"Hansen L, Petersen KD, Eriksen SA, Langdahl BL, Eiken PA, Brixen K, Abrahamsen B, Jensen JEB, Harsl\u00f8f T, Vestergaard P (2015) Subsequent fracture rates in a nationwide population-based cohort study with a 10-year perspective. Osteoporos Int 26:513\u2013519","journal-title":"Osteoporos Int"},{"key":"4502_CR3","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.bone.2004.03.024","volume":"35","author":"JA Kanis","year":"2004","unstructured":"Kanis JA, Johnell O, De Laet C et al (2004) A meta-analysis of previous fracture and subsequent fracture risk. Bone 35:375\u2013382","journal-title":"Bone"},{"key":"4502_CR4","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1359\/jbmr.040917","volume":"19","author":"P Haentjens","year":"2004","unstructured":"Haentjens P, Johnell O, Kanis JA, Bouillon R, Cooper C, Lamraski G, Vanderschueren D, Kaufman JM, Boonen S, Network on Male Osteoporosis in Europe (NEMO) (2004) Gender-related differences in short and long-term absolute risk of hip fracture after Colles\u2019 or spine fracture: Colles\u2019 fracture as an early and sensitive marker of skeletal fragility in men. J Bone Miner Res 19:1933\u20131944","journal-title":"J Bone Miner Res"},{"key":"4502_CR5","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1359\/jbmr.2000.15.4.721","volume":"15","author":"CM Klotzbuecher","year":"2000","unstructured":"Klotzbuecher CM, Ross PD, Landsman PB, Abbott TA 3rd, Berger M (2000) Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res 15:721\u2013739","journal-title":"J Bone Miner Res"},{"key":"4502_CR6","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s001980170131","volume":"12","author":"O Johnell","year":"2001","unstructured":"Johnell O, Oden A, Caulin F, Kanis JA (2001) Acute and long-term increase in fracture risk after hospitalization for vertebral fracture. Osteoporos Int 12:207\u2013214","journal-title":"Osteoporos Int"},{"key":"4502_CR7","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1002\/jbmr.35","volume":"25","author":"LM Giangregorio","year":"2010","unstructured":"Giangregorio LM, Leslie WD (2010) Manitoba bone density program. Time since prior fracture is a risk modifier for 10-year osteoporotic fractures. J Bone Miner Res 25:1400\u20131405","journal-title":"J Bone Miner Res"},{"key":"4502_CR8","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1007\/s002239900446","volume":"62","author":"KE Dretakis","year":"1998","unstructured":"Dretakis KE, Dretakis EK, Papakitsou EF, Psarakis S, Steriopoulos K (1998) Possible predisposing factors for the second hip fracture. Calcif Tissue Int 62:366\u2013369","journal-title":"Calcif Tissue Int"},{"key":"4502_CR9","doi-asserted-by":"crossref","unstructured":"Nymark T, Lauritsen JM, Ovesen O, R\u00f6ck ND, Jeune B (2006) Short time-frame from first to second hip fracture in the Funen County Hip Fracture Study. Osteoporos Int 2006;17(9):1353\u20131357","DOI":"10.1007\/s00198-006-0125-y"},{"key":"4502_CR10","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1001\/jama.285.3.320","volume":"285","author":"R Lindsay","year":"2001","unstructured":"Lindsay R, Silverman SL, Cooper C, Hanley DA, Barton I, Broy SB, Licata A, Benhamou L, Geusens P, Flowers K, Stracke H, Seeman E (2001) Risk of new vertebral fracture in the year following a fracture. JAMA 285:320\u2013323","journal-title":"JAMA"},{"key":"4502_CR11","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1359\/jbmr.090207","volume":"24","author":"J Ryg","year":"2009","unstructured":"Ryg J, Rejnmark L, Overgaard S, Brixen K, Vestergaard P (2009) Hip fracture patients at risk of second hip fracture: a nationwide population-based cohort study of 169,145 cases during 1977-2001. J Bone Miner Res 24:1299\u20131307","journal-title":"J Bone Miner Res"},{"key":"4502_CR12","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1136\/ard.2008.092775","volume":"68","author":"TACM Geel van","year":"2016","unstructured":"van Geel TACM, van Helden S, Geusens PP, Winkens B, Dinant G-J (2016) Clinical subsequent fractures cluster in time after first fractures. Ann Rheum Dis 68:99\u2013102","journal-title":"Ann Rheum Dis"},{"key":"4502_CR13","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s00198-016-3868-0","volume":"28","author":"H Johansson","year":"2017","unstructured":"Johansson H, Siggeirsd\u00f3ttir K, Harvey NC, Od\u00e9n A, Gudnason V, McCloskey E, Sigurdsson G, Kanis JA (2017) Imminent risk of fracture after fracture. Osteoporos Int 28:775\u2013780","journal-title":"Osteoporos Int"},{"key":"4502_CR14","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s10654-007-9163-9","volume":"22","author":"K Siggeirsdottir","year":"2007","unstructured":"Siggeirsdottir K, Aspelund T, Sigurdsson G, Mogensen B, Chang M, Jonsdottir B, Eiriksdottir G, Launer LJ, Harris TB, Jonsson BY, Gudnason V (2007) Inaccuracy in self-report of fractures may underestimate association with health outcomes when compared with medical record based fracture registry. Eur J Epidemiol 22:631\u2013639","journal-title":"Eur J Epidemiol"},{"key":"4502_CR15","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s001980170112","volume":"12","author":"JA Kanis","year":"2001","unstructured":"Kanis JA, Oden A, Johnell O, Jonsson B, de Laet C, Dawson A (2001) The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporos Int 12:417\u2013427","journal-title":"Osteoporos Int"},{"key":"4502_CR16","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1016\/j.jse.2011.06.010","volume":"20","author":"P Olerud","year":"2011","unstructured":"Olerud P, Tidermark J, Ponzer S, Ahrengart L, Bergstrom G (2011) Responsiveness of the EQ-5D in patients with proximal humeral fractures. J Shoulder Elb Surg 20:1200\u20131206","journal-title":"J Shoulder Elb Surg"},{"key":"4502_CR17","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s11136-006-9004-4","volume":"16","author":"J Tidermark","year":"2007","unstructured":"Tidermark J, Bergstrom G (2007) Responsiveness of the EuroQol (EQ-5D) and the Nottingham HealthProfile (NHP) in elderly patients with femoral neck fractures. Qual Life Res 16:321\u2013330","journal-title":"Qual Life Res"},{"key":"4502_CR18","unstructured":"Oppe M, Devlin NJ, Szende A (2007) EQ-5D value sets: inventory, comparative review and user guide: Springer"},{"key":"4502_CR19","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s00198-005-0015-8","volume":"17","author":"F Borgstrom","year":"2006","unstructured":"Borgstrom F, Zethraeus N, Johnell O et al (2006) Costs and quality of life associated with osteoporosis-related fractures in Sweden. Osteoporos Int 17:637\u2013650","journal-title":"Osteoporos Int"},{"key":"4502_CR20","doi-asserted-by":"crossref","unstructured":"Svedbom A, Borgst\u00f6m B, Hernlund E et al (2017) Quality of life after hip, vertebral, and distal forearm fragility fractures measured using the EQ-5D-3L, EQ-VAS, and time trade-off: results from the ICUROS. Quality of life research. Osteoporos Int 29: 557\u2013566","DOI":"10.1007\/s00198-017-4317-4"},{"key":"4502_CR21","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1097\/00005650-199711000-00002","volume":"35","author":"P Dolan","year":"1997","unstructured":"Dolan P (1997) Modeling valuations for EuroQol health states. Med Care 35:1095\u20131108","journal-title":"Med Care"},{"key":"4502_CR22","unstructured":"Breslow NE, Day NE (1987) Statistical methods in cancer research. IARC scientific publications no 32 volume II:p 131-135"},{"key":"4502_CR23","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s001980050105","volume":"8","author":"A Oden","year":"1998","unstructured":"Oden A, Dawson A, Dere W, Johnell O, Jonsson B, Kanis JA (1998) Lifetime risk of hip fracture is underestimated. Osteoporos Int 8:599\u2013603","journal-title":"Osteoporos Int"},{"key":"4502_CR24","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1007\/s00198-015-3192-0","volume":"26","author":"MK Javaid","year":"2015","unstructured":"Javaid MK, Kyer C, Mitchell PJ et al (2015) Effective secondary fracture prevention: implementation of a global benchmarking of clinical quality using the IOF capture the fracture\u00ae best practice framework tool. Osteoporos Int 26:2573\u20132578","journal-title":"Osteoporos Int"},{"key":"4502_CR25","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00198-012-2074-y","volume":"24","author":"JA Kanis","year":"2013","unstructured":"Kanis JA, McCloskey EV, Johansson H et al (2013) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 24:23\u201357","journal-title":"Osteoporos Int"},{"key":"4502_CR26","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1056\/NEJMoa074941","volume":"357","author":"KW Lyles","year":"2007","unstructured":"Lyles KW, Col\u00f3n-Emeric CS, Magaziner JS, Adachi JD, Pieper CF, Mautalen C, Hyldstrup L, Recknor C, Nordsletten L, Moore KA, Lavecchia C, Zhang J, Mesenbrink P, Hodgson PK, Abrams K, Orloff JJ, Horowitz Z, Eriksen EF, Boonen S, HORIZON Recurrent Fracture Trial (2007) Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med 357:1799\u20131809","journal-title":"N Engl J Med"},{"key":"4502_CR27","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1001\/jama.291.16.1999","volume":"291","author":"HA Bischoff Ferrari","year":"2004","unstructured":"Bischoff Ferrari HA, Dawson Hughes B, Willett WC et al (2004) Effect of vitamin D on falls: a meta-analysis. JAMA 291:1999\u20132006","journal-title":"JAMA"},{"key":"4502_CR28","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/1471-2474-8-55","volume":"8","author":"S Helden van","year":"2007","unstructured":"van Helden S, Wyers CE, Dagnelie PC et al (2007) Risk of falling in patients with a recent fracture. BMC Musculoskelet Disord 8:55","journal-title":"BMC Musculoskelet Disord"},{"key":"4502_CR29","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-016-0280-5","volume":"11","author":"M Bonafede","year":"2016","unstructured":"Bonafede M, Shi N, Barron R, Li X, Crittenden DB, Chandler D (2016) Predicting imminent risk for fracture in patients aged 50 or older with osteoporosis using US claims data. Arch Osteoporos 11:26. \n                    https:\/\/doi.org\/10.1007\/s11657-016-0280-5","journal-title":"Arch Osteoporos"},{"key":"4502_CR30","unstructured":"Bjornsson G, Bjornsson OJ, Davidsson D et al (1982) Report abc XXIV. Health survey in the Reykjavik area\u2014women. Stages I-III, 1968\u20131969, 1971\u20131972 and 1976\u20131978. Participants, invitation, response etc. The Icelandic Heart Association, Reykjav\u00edk"},{"key":"4502_CR31","unstructured":"Bjornsson OJ, Davidsson D., Olafsson H et al. (1979) Report XVIII. Health survey in the Reykjavik area\u2014men. Stages I\u2013III, 1967\u20131968, 1970\u20131971 and 1974\u20131975. Participants, invitation, response etc. The Icelandic Heart Association, Reykjav\u00edk"},{"key":"4502_CR32","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1007\/s00198-012-1964-3","volume":"23","author":"JA Kanis","year":"2012","unstructured":"Kanis JA, Od\u00e9n A, McCloskey EV, Johansson H, Wahl D, Cyrus Cooper C on behalf of the IOF Working Group on Epidemiology and Quality of Life (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int 23:2239\u20132256","journal-title":"Osteoporos Int"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-018-4502-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-018-4502-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-018-4502-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T19:14:50Z","timestamp":1560280490000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-018-4502-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,12]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["4502"],"URL":"https:\/\/doi.org\/10.1007\/s00198-018-4502-0","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,12]]},"assertion":[{"value":"15 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the National Bioethics Committee and the Data Protection Authority in Iceland. All participants gave informed written consent.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Radius Health, Inc., was the sponsor for this study and provided financial support for its completion. LF is an employee of Radius Health. None of the other authors declare competing interests with regard to this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}