{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:14:19Z","timestamp":1791429259252,"version":"4.3.3"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:00:00Z","timestamp":1526515200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s00198-018-4552-3","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T06:21:12Z","timestamp":1526538072000},"page":"1815-1825","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Subtrochanteric and diaphyseal femoral fractures in hypophosphatasia\u2014not atypical at all"],"prefix":"10.1007","volume":"29","author":[{"given":"F.","family":"Genest","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1154-3388","authenticated-orcid":false,"given":"L.","family":"Seefried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,17]]},"reference":[{"issue":"1","key":"4552_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jbmr.1998","volume":"29","author":"E Shane","year":"2014","unstructured":"Shane E, Burr D, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster DW, Ebeling PR, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O'Keefe R, Papapoulos S, Howe TS, van der Meulen MCH, Weinstein RS, Whyte MP (2014) Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 29(1):1\u201323","journal-title":"J Bone Miner Res"},{"issue":"18","key":"4552_CR2","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1056\/NEJMoa1010650","volume":"364","author":"J Schilcher","year":"2011","unstructured":"Schilcher J, Michaelsson K, Aspenberg P (2011) Bisphosphonate use and atypical fractures of the femoral shaft. N Engl J Med 364(18):1728\u20131737","journal-title":"N Engl J Med"},{"issue":"8","key":"4552_CR3","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1002\/jbmr.1893","volume":"28","author":"L Gedmintas","year":"2013","unstructured":"Gedmintas L, Solomon DH, Kim SC (2013) Bisphosphonates and risk of subtrochanteric, femoral shaft, and atypical femur fracture: a systematic review and meta-analysis. J Bone Miner Res 28(8):1729\u20131737","journal-title":"J Bone Miner Res"},{"issue":"10","key":"4552_CR4","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1056\/NEJMc1403799","volume":"371","author":"J Schilcher","year":"2014","unstructured":"Schilcher J, Koeppen V, Aspenberg P, Micha\u00eblsson K (2014) Risk of atypical femoral fracture during and after bisphosphonate use. N Engl J Med 371(10):974\u2013976","journal-title":"N Engl J Med"},{"issue":"1","key":"4552_CR5","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1002\/jbmr.517","volume":"27","author":"M Maravic","year":"2012","unstructured":"Maravic M, Ostertag A, Cohen-Solal M (2012) Subtrochanteric\/femoral shaft versus hip fractures: incidences and identification of risk factors. J Bone Miner Res 27(1):130\u2013137","journal-title":"J Bone Miner Res"},{"issue":"2","key":"4552_CR6","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1210\/jc.2012-1896","volume":"98","author":"N Napoli","year":"2013","unstructured":"Napoli N, Schwartz AV, Palermo L, Jin JJ, Wustrack R, Cauley JA, Ensrud KE, Kelly M, Black DM (2013) Risk factors for subtrochanteric and diaphyseal fractures: the study of osteoporotic fractures. J Clin Endocrinol Metab 98(2):659\u2013667","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"4552_CR7","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.bone.2013.07.010","volume":"56","author":"P Franceschetti","year":"2013","unstructured":"Franceschetti P, Bondanelli M, Caruso G, Ambrosio MR, Lorusso V, Zatelli MC, Massari L, degli Uberti EC (2013) Risk factors for development of atypical femoral fractures in patients on long-term oral bisphosphonate therapy. Bone 56(2):426\u2013431","journal-title":"Bone"},{"issue":"5","key":"4552_CR8","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1007\/s00198-012-2219-z","volume":"24","author":"AC Ng","year":"2013","unstructured":"Ng AC, Koh JS, Howe TS (2013) Vitamin D and atypical femoral fractures. Osteoporos Int 24(5):1767","journal-title":"Osteoporos Int"},{"issue":"19","key":"4552_CR9","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1056\/NEJMc0910389","volume":"362","author":"CM Girgis","year":"2010","unstructured":"Girgis CM, Sher D, Seibel MJ (2010) Atypical femoral fractures and bisphosphonate use. N Engl J Med 362(19):1848\u20131849","journal-title":"N Engl J Med"},{"key":"4552_CR10","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1016\/j.injury.2017.05.033","volume":"48","author":"JW Kim","year":"2017","unstructured":"Kim JW, Kim JJ, Byun YS, Shon OJ, Oh HK, Park KC, Kim JW, Oh CW (2017) Factors affecting fracture location in atypical femoral fractures: a cross-sectional study with 147 patients. Injury 48:1570\u20131574","journal-title":"Injury"},{"issue":"11","key":"4552_CR11","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1002\/jbmr.2547","volume":"30","author":"J Schilcher","year":"2015","unstructured":"Schilcher J, Howe TS, Png MA, Aspenberg P, Koh JSB (2015) Atypical fractures are mainly subtrochanteric in Singapore and diaphyseal in Sweden: a cross-sectional study. J Bone Miner Res 30(11):2127\u20132132","journal-title":"J Bone Miner Res"},{"issue":"5","key":"4552_CR12","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1002\/jbmr.1550","volume":"27","author":"AC Feldstein","year":"2012","unstructured":"Feldstein AC, Black D, Perrin N, Rosales AG, Friess D, Boardman D, Dell R, Santora A, Chandler JM, Rix MM, Orwoll E (2012) Incidence and demography of femur fractures with and without atypical features. J Bone Miner Res 27(5):977\u2013986","journal-title":"J Bone Miner Res"},{"issue":"3","key":"4552_CR13","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1302\/0301-620X.99B3.BJJ-2016-0276.R2","volume":"99-B","author":"A Koh","year":"2017","unstructured":"Koh A, Guerado E, Giannoudis PV (2017) Atypical femoral fractures related to bisphosphonate treatment: issues and controversies related to their surgical management. Bone Joint J 99-B(3):295\u2013302","journal-title":"Bone Joint J"},{"issue":"12","key":"4552_CR14","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1016\/j.injury.2015.09.031","volume":"46","author":"J Schilcher","year":"2015","unstructured":"Schilcher J (2015) High revision rate but good healing capacity of atypical femoral fractures. A comparison with common shaft fractures. Injury 46(12):2468\u20132473","journal-title":"Injury"},{"issue":"5","key":"4552_CR15","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s00774-014-0617-3","volume":"33","author":"N Miyakoshi","year":"2015","unstructured":"Miyakoshi N, Aizawa T, Sasaki S, Ando S, Maekawa S, Aonuma H, Tsuchie H, Sasaki H, Kasukawa Y, Shimada Y (2015) Healing of bisphosphonate-associated atypical femoral fractures in patients with osteoporosis: a comparison between treatment with and without teriparatide. J Bone Miner Metab 33(5):553\u2013559","journal-title":"J Bone Miner Metab"},{"issue":"6","key":"4552_CR16","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1210\/jc.2010-2520","volume":"96","author":"SJ Gomberg","year":"2011","unstructured":"Gomberg SJ, Wustrack RL, Napoli N, Arnaud CD, Black DM (2011) Teriparatide, vitamin D, and calcium healed bilateral subtrochanteric stress fractures in a postmenopausal woman with a 13-year history of continuous alendronate therapy. J Clin Endocrinol Metab 96(6):1627\u20131632","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"4552_CR17","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1097\/gme.0b013e318260143d","volume":"19","author":"HT Huang","year":"2012","unstructured":"Huang HT, Kang L, Huang PJ, Fu YC, Lin SY, Hsieh CH, Chen JC, Cheng YM, Chen CH (2012) Successful teriparatide treatment of atypical fracture after long-term use of alendronate without surgical procedure in a postmenopausal woman: a case report. Menopause 19(12):1360\u20131363","journal-title":"Menopause"},{"issue":"6","key":"4552_CR18","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1002\/jbmr.308","volume":"26","author":"CJ Yates","year":"2011","unstructured":"Yates CJ, Bartlett MJ, Ebeling PR (2011) An atypical subtrochanteric femoral fracture from pycnodysostosis: a lesson from nature. J Bone Miner Res 26(6):1377\u20131379","journal-title":"J Bone Miner Res"},{"key":"4552_CR19","doi-asserted-by":"crossref","unstructured":"Sonohata M, Mawatari M, Hotokebuchi T, Okubo T, Ono H (2011) Bipolar hip arthroplasty for subtrochanteric femoral nonunion in an adult with autosomal dominant osteopetrosis type II. J Orthop Sci 16(5):652\u2013655","DOI":"10.1007\/s00776-011-0069-8"},{"key":"4552_CR20","doi-asserted-by":"crossref","unstructured":"Birmingham P, McHale KA (2008) Case reports: treatment of subtrochanteric and ipsilateral femoral neck fractures in an adult with osteopetrosis. Clin Orthop Relat Res 466(8):2002\u20132008","DOI":"10.1007\/s11999-008-0256-x"},{"issue":"5","key":"4552_CR21","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1002\/jbmr.3071","volume":"32","author":"P Trejo","year":"2017","unstructured":"Trejo P, Fassier F, Glorieux FH, Rauch F (2017) Diaphyseal femur fractures in osteogenesis imperfecta: characteristics and relationship with bisphosphonate treatment. J Bone Miner Res 32(5):1034\u20131039","journal-title":"J Bone Miner Res"},{"issue":"5","key":"4552_CR22","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1002\/jbmr.1565","volume":"27","author":"RA Sutton","year":"2012","unstructured":"Sutton RA, Mumm S, Coburn SP, Ericson KL, Whyte MP (2012) \u201cAtypical femoral fractures\u201d during bisphosphonate exposure in adult hypophosphatasia. J Bone Miner Res 27(5):987\u2013994","journal-title":"J Bone Miner Res"},{"issue":"6","key":"4552_CR23","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1359\/jbmr.081253","volume":"24","author":"MP Whyte","year":"2009","unstructured":"Whyte MP (2009) Atypical femoral fractures, bisphosphonates, and adult hypophosphatasia. J Bone Miner Res 24(6):1132\u20131134","journal-title":"J Bone Miner Res"},{"issue":"3","key":"4552_CR24","first-page":"66","volume":"5","author":"N Sharma","year":"2015","unstructured":"Sharma N, Bache E, Clare T (2015) Bilateral femoral neck fractures in a young patient suffering from hypophosphatasia, due to a first time epileptic seizure. J Orthop Case Rep 5(3):66\u201368","journal-title":"J Orthop Case Rep"},{"issue":"12","key":"4552_CR25","doi-asserted-by":"publisher","first-page":"5174","DOI":"10.1210\/jc.2010-1168","volume":"95","author":"C Schalin-Jantti","year":"2010","unstructured":"Schalin-Jantti C et al (2010) Parathyroid hormone treatment improves pain and fracture healing in adult hypophosphatasia. J Clin Endocrinol Metab 95(12):5174\u20135179","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"4552_CR26","first-page":"555","volume":"122","author":"JW Fielding","year":"1966","unstructured":"Fielding JW, Magliato HJ (1966) Subtrochanteric fractures. Surg Gynecol Obstet 122(3):555\u2013560","journal-title":"Surg Gynecol Obstet"},{"issue":"3","key":"4552_CR27","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1007\/s00223-014-9887-y","volume":"95","author":"LP Chen","year":"2014","unstructured":"Chen LP, Chang TK, Huang TY, Kwok TG, Lu YC (2014) The correlation between lateral bowing angle of the femur and the location of atypical femur fractures. Calcif Tissue Int 95(3):240\u2013247","journal-title":"Calcif Tissue Int"},{"issue":"7","key":"4552_CR28","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1007\/s00167-014-3006-5","volume":"23","author":"JM Kim","year":"2015","unstructured":"Kim JM, Hong SH, Kim JM, Lee BS, Kim DE, Kim KA, Bin SI (2015) Femoral shaft bowing in the coronal plane has more significant effect on the coronal alignment of TKA than proximal or distal variations of femoral shape. Knee Surg Sports Traumatol Arthrosc 23(7):1936\u20131942","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"1","key":"4552_CR29","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s00296-015-3323-0","volume":"36","author":"D Kim","year":"2016","unstructured":"Kim D, Sung YK, Cho SK, Han M, Kim YS (2016) Factors associated with atypical femoral fracture. Rheumatol Int 36(1):65\u201371","journal-title":"Rheumatol Int"},{"key":"4552_CR30","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.bone.2014.06.008","volume":"66","author":"Y Saita","year":"2014","unstructured":"Saita Y, Ishijima M, Mogami A, Kubota M, Baba T, Kaketa T, Nagao M, Sakamoto Y, Sakai K, Kato R, Nagura N, Miyagawa K, Wada T, Liu L, Obayashi O, Shitoto K, Nozawa M, Kajihara H, Gen H, Kaneko K (2014) The fracture sites of atypical femoral fractures are associated with the weight-bearing lower limb alignment. Bone 66:105\u2013110","journal-title":"Bone"},{"issue":"6","key":"4552_CR31","doi-asserted-by":"publisher","first-page":"676","DOI":"10.4158\/EP.12.6.676","volume":"12","author":"HM Khandwala","year":"2006","unstructured":"Khandwala HM, Mumm S, Whyte MP (2006) Low serum alkaline phosphatase activity and pathologic fracture: case report and brief review of hypophosphatasia diagnosed in adulthood. Endocr Pract 12(6):676\u2013681","journal-title":"Endocr Pract"},{"issue":"6","key":"4552_CR32","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1136\/bjsm.2005.023655","volume":"40","author":"A Ivkovic","year":"2006","unstructured":"Ivkovic A, Bojanic I, Pecina M (2006) Stress fractures of the femoral shaft in athletes: a new treatment algorithm. Br J Sports Med 40(6):518\u2013520 discussion 520","journal-title":"Br J Sports Med"},{"issue":"3","key":"4552_CR33","doi-asserted-by":"publisher","first-page":"324","DOI":"10.11138\/ccmbm\/2017.14.3.324","volume":"14","author":"F Marini","year":"2017","unstructured":"Marini F, Brandi ML (2017) Atypical femur fractures: a distinctive tract of adult hypophosphatasia. Clin Cases Miner Bone Metab 14(3):324\u2013328","journal-title":"Clin Cases Miner Bone Metab"},{"issue":"9","key":"4552_CR34","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1002\/jbmr.2495","volume":"30","author":"T Cundy","year":"2015","unstructured":"Cundy T, Michigami T, Tachikawa K, Dray M, Collins JF, Paschalis EP, Gamsjaeger S, Roschger A, Fratzl-Zelman N, Roschger P, Klaushofer K (2015) Reversible deterioration in Hypophosphatasia caused by renal failure with bisphosphonate treatment. J Bone Miner Res 30(9):1726\u20131737","journal-title":"J Bone Miner Res"},{"issue":"2","key":"4552_CR35","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1172\/JCI112031","volume":"76","author":"MP Whyte","year":"1985","unstructured":"Whyte MP, Mahuren JD, Vrabel LA, Coburn SP (1985) Markedly increased circulating pyridoxal-5\u2032-phosphate levels in hypophosphatasia. Alkaline phosphatase acts in vitamin B6 metabolism. J Clin Invest 76(2):752\u2013756","journal-title":"J Clin Invest"},{"issue":"4","key":"4552_CR36","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1002\/jbmr.2748","volume":"31","author":"Z Mahjoub","year":"2016","unstructured":"Mahjoub Z, Jean S, Leclerc JT, Brown JP, Boulet D, Pelet S, Grondin C, Dumont J, Belzile \u00c9L, Michou L (2016) Incidence and characteristics of atypical femoral fractures: clinical and geometrical data. J Bone Miner Res 31(4):767\u2013776","journal-title":"J Bone Miner Res"},{"key":"4552_CR37","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.bone.2015.02.022","volume":"75","author":"MP Whyte","year":"2015","unstructured":"Whyte MP, Zhang F, Wenkert D, McAlister WH, Mack KE, Benigno MC, Coburn SP, Wagy S, Griffin DM, Ericson KL, Mumm S (2015) Hypophosphatasia: validation and expansion of the clinical nosology for children from 25 years experience with 173 pediatric patients. Bone 75:229\u2013239","journal-title":"Bone"},{"issue":"4","key":"4552_CR38","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nrendo.2016.14","volume":"12","author":"MP Whyte","year":"2016","unstructured":"Whyte MP (2016) Hypophosphatasia\u2014aetiology, nosology, pathogenesis, diagnosis and treatment. Nat Rev Endocrinol 12(4):233\u2013246","journal-title":"Nat Rev Endocrinol"},{"issue":"7","key":"4552_CR39","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1002\/jbmr.2178","volume":"29","author":"FE McKiernan","year":"2014","unstructured":"McKiernan FE, Berg RL, Fuehrer J (2014) Clinical and radiographic findings in adults with persistent hypophosphatasemia. J Bone Miner Res 29(7):1651\u20131660","journal-title":"J Bone Miner Res"},{"issue":"10","key":"4552_CR40","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1007\/s00198-011-1528-y","volume":"22","author":"F Barvencik","year":"2011","unstructured":"Barvencik F, Beil FT, Gebauer M, Busse B, Koehne T, Seitz S, Zustin J, Pogoda P, Schinke T, Amling M (2011) Skeletal mineralization defects in adult hypophosphatasia--a clinical and histological analysis. Osteoporos Int 22(10):2667\u20132675","journal-title":"Osteoporos Int"},{"key":"4552_CR41","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1186\/s12891-016-1191-8","volume":"17","author":"T Bhattacharyya","year":"2016","unstructured":"Bhattacharyya T, Jha S, Wang H, Kastner DL, Remmers EF (2016) Hypophosphatasia and the risk of atypical femur fractures: a case-control study. BMC Musculoskelet Disord 17:332","journal-title":"BMC Musculoskelet Disord"},{"issue":"3","key":"4552_CR42","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.jbspin.2015.10.009","volume":"83","author":"E Maman","year":"2016","unstructured":"Maman E, Briot K, Roux C (2016) Atypical femoral fracture in a 51-year-old woman: revealing a hypophosphatasia. Joint Bone Spine 83(3):346\u2013348","journal-title":"Joint Bone Spine"},{"issue":"7","key":"4552_CR43","doi-asserted-by":"publisher","first-page":"981","DOI":"10.2106\/00004623-198668070-00004","volume":"68","author":"JD Coe","year":"1986","unstructured":"Coe JD, Murphy WA, Whyte MP (1986) Management of femoral fractures and pseudofractures in adult hypophosphatasia. J Bone Joint Surg Am 68(7):981\u2013990","journal-title":"J Bone Joint Surg Am"},{"issue":"5","key":"4552_CR44","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1002\/jbmr.3081","volume":"32","author":"NB Watts","year":"2017","unstructured":"Watts NB, Aggers D, McCarthy EF, Savage T, Martinez S, Patterson R, Carrithers E, Miller PD (2017) Responses to treatment with teriparatide in patients with atypical femur fractures previously treated with bisphosphonates. J Bone Miner Res 32(5):1027\u20131033","journal-title":"J Bone Miner Res"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-018-4552-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-018-4552-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-018-4552-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T19:37:57Z","timestamp":1558035477000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-018-4552-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,17]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["4552"],"URL":"https:\/\/doi.org\/10.1007\/s00198-018-4552-3","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,17]]},"assertion":[{"value":"23 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"FG reports personal fees from Lilly during the course of the study.LS reports grants and personal fees from Novartis and Alexion and personal fees from Lilly and Amgen during the course of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This study is a retrospective evaluation of clinical routine data. For this type of study, formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement"}}]}}