{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:36:19Z","timestamp":1782124579886,"version":"3.54.5"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2018,7,7]],"date-time":"2018-07-07T00:00:00Z","timestamp":1530921600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31401079"],"award-info":[{"award-number":["31401079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s00198-018-4573-y","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T18:05:39Z","timestamp":1530900339000},"page":"2029-2039","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Genome-wide identification of m6A-associated SNPs as potential functional variants for bone mineral density"],"prefix":"10.1007","volume":"29","author":[{"given":"X. B.","family":"Mo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. H.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. F.","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,7]]},"reference":[{"issue":"6","key":"4573_CR1","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s00198-004-1780-5","volume":"16","author":"JA Kanis","year":"2005","unstructured":"Kanis JA, Borgstrom F, De Laet C, Johansson H, Johnell O, Jonsson B, Oden A, Zethraeus N, Pfleger B, Khaltaev N (2005) Assessment of fracture risk. Osteoporos Int 16(6):581\u2013589. \n                    https:\/\/doi.org\/10.1007\/s00198-004-1780-5","journal-title":"Osteoporos Int"},{"issue":"4","key":"4573_CR2","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/jbmr.5650110414","volume":"11","author":"NK Arden","year":"1996","unstructured":"Arden NK, Baker J, Hogg C, Baan K, Spector TD (1996) The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J Bone Miner Res 11(4):530\u2013534. \n                    https:\/\/doi.org\/10.1002\/jbmr.5650110414","journal-title":"J Bone Miner Res"},{"issue":"8","key":"4573_CR3","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1359\/jbmr.1998.13.8.1318","volume":"13","author":"GM Howard","year":"1998","unstructured":"Howard GM, Nguyen TV, Harris M, Kelly PJ, Eisman JA (1998) Genetic and environmental contributions to the association between quantitative ultrasound and bone mineral density measurements: a twin study. J Bone Miner Res 13(8):1318\u20131327. \n                    https:\/\/doi.org\/10.1359\/jbmr.1998.13.8.1318","journal-title":"J Bone Miner Res"},{"issue":"5","key":"4573_CR4","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/ng.2249","volume":"44","author":"K Estrada","year":"2012","unstructured":"Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OM, Amin N, Kemp JP, Koller DL, Li G, Liu CT, Minster RL, Moayyeri A, Vandenput L, Willner D, Xiao SM, Yerges-Armstrong LM, Zheng HF, Alonso N, Eriksson J, Kammerer CM, Kaptoge SK, Leo PJ, Thorleifsson G, Wilson SG, Wilson JF, Aalto V, Alen M, Aragaki AK, Aspelund T, Center JR, Dailiana Z, Duggan DJ, Garcia M, Garcia-Giralt N, Giroux S, Hallmans G, Hocking LJ, Husted LB, Jameson KA, Khusainova R, Kim GS, Kooperberg C, Koromila T, Kruk M, Laaksonen M, Lacroix AZ, Lee SH, Leung PC, Lewis JR, Masi L, Mencej-Bedrac S, Nguyen TV, Nogues X, Patel MS, Prezelj J, Rose LM, Scollen S, Siggeirsdottir K, Smith AV, Svensson O, Trompet S, Trummer O, van Schoor NM, Woo J, Zhu K, Balcells S, Brandi ML, Buckley BM, Cheng S, Christiansen C, Cooper C, Dedoussis G, Ford I, Frost M, Goltzman D, Gonzalez-Macias J, Kahonen M, Karlsson M, Khusnutdinova E, Koh JM, Kollia P, Langdahl BL, Leslie WD, Lips P, Ljunggren O, Lorenc RS, Marc J, Mellstrom D, Obermayer-Pietsch B, Olmos JM, Pettersson-Kymmer U, Reid DM, Riancho JA, Ridker PM, Rousseau F, Slagboom PE, Tang NL, Urreizti R, Van Hul W, Viikari J, Zarrabeitia MT, Aulchenko YS, Castano-Betancourt M, Grundberg E, Herrera L, Ingvarsson T, Johannsdottir H, Kwan T, Li R, Luben R, Medina-Gomez C, Palsson ST, Reppe S, Rotter JI, Sigurdsson G, van Meurs JB, Verlaan D, Williams FM, Wood AR, Zhou Y, Gautvik KM, Pastinen T, Raychaudhuri S, Cauley JA, Chasman DI, Clark GR, Cummings SR, Danoy P, Dennison EM, Eastell R, Eisman JA, Gudnason V, Hofman A, Jackson RD, Jones G, Jukema JW, Khaw KT, Lehtimaki T, Liu Y, Lorentzon M, McCloskey E, Mitchell BD, Nandakumar K, Nicholson GC, Oostra BA, Peacock M, Pols HA, Prince RL, Raitakari O, Reid IR, Robbins J, Sambrook PN, Sham PC, Shuldiner AR, Tylavsky FA, van Duijn CM, Wareham NJ, Cupples LA, Econs MJ, Evans DM, Harris TB, Kung AW, Psaty BM, Reeve J, Spector TD, Streeten EA, Zillikens MC, Thorsteinsdottir U, Ohlsson C, Karasik D, Richards JB, Brown MA, Stefansson K, Uitterlinden AG, Ralston SH, Ioannidis JP, Kiel DP, Rivadeneira F (2012) Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet 44(5):491\u2013501. \n                    https:\/\/doi.org\/10.1038\/ng.2249","journal-title":"Nat Genet"},{"issue":"10","key":"4573_CR5","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1038\/ng.3949","volume":"49","author":"JP Kemp","year":"2017","unstructured":"Kemp JP, Morris JA, Medina-Gomez C, Forgetta V, Warrington NM, Youlten SE, Zheng J, Gregson CL, Grundberg E, Trajanoska K, Logan JG, Pollard AS, Sparkes PC, Ghirardello EJ, Allen R, Leitch VD, Butterfield NC, Komla-Ebri D, Adoum AT, Curry KF, White JK, Kussy F, Greenlaw KM, Xu C, Harvey NC, Cooper C, Adams DJ, Greenwood CMT, Maurano MT, Kaptoge S, Rivadeneira F, Tobias JH, Croucher PI, Ackert-Bicknell CL, Bassett JHD, Williams GR, Richards JB, Evans DM (2017) Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. Nat Genet 49(10):1468\u20131475. \n                    https:\/\/doi.org\/10.1038\/ng.3949","journal-title":"Nat Genet"},{"issue":"7571","key":"4573_CR6","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nature14878","volume":"526","author":"HF Zheng","year":"2015","unstructured":"Zheng HF, Forgetta V, Hsu YH, Estrada K, Rosello-Diez A, Leo PJ, Dahia CL, Park-Min KH, Tobias JH, Kooperberg C, Kleinman A, Styrkarsdottir U, Liu CT, Uggla C, Evans DS, Nielson CM, Walter K, Pettersson-Kymmer U, McCarthy S, Eriksson J, Kwan T, Jhamai M, Trajanoska K, Memari Y, Min J, Huang J, Danecek P, Wilmot B, Li R, Chou WC, Mokry LE, Moayyeri A, Claussnitzer M, Cheng CH, Cheung W, Medina-Gomez C, Ge B, Chen SH, Choi K, Oei L, Fraser J, Kraaij R, Hibbs MA, Gregson CL, Paquette D, Hofman A, Wibom C, Tranah GJ, Marshall M, Gardiner BB, Cremin K, Auer P, Hsu L, Ring S, Tung JY, Thorleifsson G, Enneman AW, van Schoor NM, de Groot LC, van der Velde N, Melin B, Kemp JP, Christiansen C, Sayers A, Zhou Y, Calderari S, van Rooij J, Carlson C, Peters U, Berlivet S, Dostie J, Uitterlinden AG, Williams SR, Farber C, Grinberg D, LaCroix AZ, Haessler J, Chasman DI, Giulianini F, Rose LM, Ridker PM, Eisman JA, Nguyen TV, Center JR, Nogues X, Garcia-Giralt N, Launer LL, Gudnason V, Mellstrom D, Vandenput L, Amin N, van Duijn CM, Karlsson MK, Ljunggren O, Svensson O, Hallmans G, Rousseau F, Giroux S, Bussiere J, Arp PP, Koromani F, Prince RL, Lewis JR, Langdahl BL, Hermann AP, Jensen JE, Kaptoge S, Khaw KT, Reeve J, Formosa MM, Xuereb-Anastasi A, Akesson K, McGuigan FE, Garg G, Olmos JM, Zarrabeitia MT, Riancho JA, Ralston SH, Alonso N, Jiang X, Goltzman D, Pastinen T, Grundberg E, Gauguier D, Orwoll ES, Karasik D, Davey-Smith G, Smith AV, Siggeirsdottir K, Harris TB, Zillikens MC, van Meurs JB, Thorsteinsdottir U, Maurano MT, Timpson NJ, Soranzo N, Durbin R, Wilson SG, Ntzani EE, Brown MA, Stefansson K, Hinds DA, Spector T, Cupples LA, Ohlsson C, Greenwood CM, Jackson RD, Rowe DW, Loomis CA, Evans DM, Ackert-Bicknell CL, Joyner AL, Duncan EL, Kiel DP, Rivadeneira F, Richards JB (2015) Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature 526(7571):112\u2013117. \n                    https:\/\/doi.org\/10.1038\/nature14878","journal-title":"Nature"},{"issue":"D1","key":"4573_CR7","doi-asserted-by":"publisher","first-page":"D154","DOI":"10.1093\/nar\/gkv1308","volume":"44","author":"F Mao","year":"2016","unstructured":"Mao F, Xiao L, Li X, Liang J, Teng H, Cai W, Sun ZS (2016) RBP-Var: a database of functional variants involved in regulation mediated by RNA-binding proteins. Nucleic Acids Res 44(D1):D154\u2013D163. \n                    https:\/\/doi.org\/10.1093\/nar\/gkv1308","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"4573_CR8","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1093\/molbev\/msv251","volume":"33","author":"X Wu","year":"2016","unstructured":"Wu X, Hurst LD (2016) Determinants of the usage of splice-associated cis-motifs predict the distribution of human pathogenic SNPs. Mol Biol Evol 33(2):518\u2013529. \n                    https:\/\/doi.org\/10.1093\/molbev\/msv251","journal-title":"Mol Biol Evol"},{"issue":"8194","key":"4573_CR9","doi-asserted-by":"publisher","first-page":"8194","DOI":"10.1038\/ncomms9194","volume":"6","author":"G Ramaswami","year":"2015","unstructured":"Ramaswami G, Deng P, Zhang R, Anna Carbone M, Mackay TF, Li JB (2015) Genetic mapping uncovers cis-regulatory landscape of RNA editing. Nat Commun 6(8194):8194. \n                    https:\/\/doi.org\/10.1038\/ncomms9194","journal-title":"Nat Commun"},{"issue":"5","key":"4573_CR10","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nrm3785","volume":"15","author":"KD Meyer","year":"2014","unstructured":"Meyer KD, Jaffrey SR (2014) The dynamic epitranscriptome: N6-methyladenosine and gene expression control. Nat Rev Mol Cell Biol 15(5):313\u2013326. \n                    https:\/\/doi.org\/10.1038\/nrm3785","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7481","key":"4573_CR11","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature12730","volume":"505","author":"X Wang","year":"2014","unstructured":"Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G, Ren B, Pan T, He C (2014) N6-methyladenosine-dependent regulation of messenger RNA stability. Nature 505(7481):117\u2013120. \n                    https:\/\/doi.org\/10.1038\/nature12730","journal-title":"Nature"},{"issue":"10","key":"4573_CR12","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1038\/nsmb.3462","volume":"24","author":"RR Edupuganti","year":"2017","unstructured":"Edupuganti RR, Geiger S, RGH L, Shi H, Hsu PJ, Lu Z, Wang SY, MPA B, Jansen P, Rossa M, Muller M, Stunnenberg HG, He C, Carell T, Vermeulen M (2017) N(6)-methyladenosine (m(6)A) recruits and repels proteins to regulate mRNA homeostasis. Nat Struct Mol Biol 24(10):870\u2013878. \n                    https:\/\/doi.org\/10.1038\/nsmb.3462","journal-title":"Nat Struct Mol Biol"},{"key":"4573_CR13","doi-asserted-by":"publisher","unstructured":"Visvanathan A, Somasundaram K (2017) mRNA traffic control reviewed: N6-methyladenosine (m(6) A) takes the driver\u2019s seat. BioEssays \n                    https:\/\/doi.org\/10.1002\/bies.201700093\n                    \n                  , 40","DOI":"10.1002\/bies.201700093"},{"issue":"D1","key":"4573_CR14","doi-asserted-by":"publisher","first-page":"D139","DOI":"10.1093\/nar\/gkx895","volume":"46","author":"Y Zheng","year":"2018","unstructured":"Zheng Y, Nie P, Peng D, He Z, Liu M, Xie Y, Miao Y, Zuo Z, Ren J (2018) m6AVar: a database of functional variants involved in m6A modification. Nucleic Acids Res 46(D1):D139\u2013D145. \n                    https:\/\/doi.org\/10.1093\/nar\/gkx895","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"4573_CR15","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.ajhg.2014.03.004","volume":"94","author":"JK Pickrell","year":"2014","unstructured":"Pickrell JK (2014) Joint analysis of functional genomic data and genome-wide association studies of 18 human traits. Am J Hum Genet 94(4):559\u2013573. \n                    https:\/\/doi.org\/10.1016\/j.ajhg.2014.03.004","journal-title":"Am J Hum Genet"},{"key":"4573_CR16","doi-asserted-by":"publisher","unstructured":"Zheng Y, Nie P, Peng D, He Z, Liu M, Xie Y, Miao Y, Zuo Z, Ren J (2017) m6AVar: a database of functional variants involved in m6A modification. Nucleic Acids Res. doi: \n                    https:\/\/doi.org\/10.1093\/nar\/gkx895","DOI":"10.1093\/nar\/gkx895"},{"issue":"7","key":"4573_CR17","doi-asserted-by":"publisher","first-page":"943","DOI":"10.2217\/epi-2016-0178","volume":"9","author":"XB Mo","year":"2017","unstructured":"Mo XB, Wu LF, Zhu XW, Xia W, Wang L, He P, Bing PF, Lu X, Zhang YH, Deng FY, Lei SF (2017) Identification and evaluation of lncRNA and mRNA integrative modules in human peripheral blood mononuclear cells. Epigenomics 9(7):943\u2013954. \n                    https:\/\/doi.org\/10.2217\/epi-2016-0178","journal-title":"Epigenomics"},{"issue":"13","key":"4573_CR18","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1093\/bioinformatics\/btu143","volume":"30","author":"L Zhang","year":"2014","unstructured":"Zhang L, Pei YF, Fu X, Lin Y, Wang YP, Deng HW (2014) FISH: fast and accurate diploid genotype imputation via segmental hidden Markov model. Bioinformatics 30(13):1876\u20131883. \n                    https:\/\/doi.org\/10.1093\/bioinformatics\/btu143","journal-title":"Bioinformatics"},{"issue":"10","key":"4573_CR19","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1093\/bioinformatics\/bts163","volume":"28","author":"AA Shabalin","year":"2012","unstructured":"Shabalin AA (2012) Matrix eQTL: ultra fast eQTL analysis via large matrix operations. Bioinformatics 28(10):1353\u20131358. \n                    https:\/\/doi.org\/10.1093\/bioinformatics\/bts163","journal-title":"Bioinformatics"},{"issue":"Database issue","key":"4573_CR20","doi-asserted-by":"publisher","first-page":"D930","DOI":"10.1093\/nar\/gkr917","volume":"40","author":"LD Ward","year":"2012","unstructured":"Ward LD, Kellis M (2012) HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res 40(Database issue):D930\u2013D934. \n                    https:\/\/doi.org\/10.1093\/nar\/gkr917","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"4573_CR21","doi-asserted-by":"publisher","first-page":"e45142","DOI":"10.1371\/journal.pone.0045142","volume":"7","author":"P Benisch","year":"2012","unstructured":"Benisch P, Schilling T, Klein-Hitpass L, Frey SP, Seefried L, Raaijmakers N, Krug M, Regensburger M, Zeck S, Schinke T, Amling M, Ebert R, Jakob F (2012) The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors. PLoS One 7(9):e45142. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0045142","journal-title":"PLoS One"},{"issue":"5","key":"4573_CR22","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.bone.2008.05.016","volume":"44","author":"SF Lei","year":"2009","unstructured":"Lei SF, Wu S, Li LM, Deng FY, Xiao SM, Jiang C, Chen Y, Jiang H, Yang F, Tan LJ, Sun X, Zhu XZ, Liu MY, Liu YZ, Chen XD, Deng HW (2009) An in vivo genome wide gene expression study of circulating monocytes suggested GBP1, STAT1 and CXCL10 as novel risk genes for the differentiation of peak bone mass. Bone 44(5):1010\u20131014. \n                    https:\/\/doi.org\/10.1016\/j.bone.2008.05.016","journal-title":"Bone"},{"issue":"32","key":"4573_CR23","doi-asserted-by":"publisher","first-page":"29011","DOI":"10.1074\/jbc.M501164200","volume":"280","author":"YZ Liu","year":"2005","unstructured":"Liu YZ, Dvornyk V, Lu Y, Shen H, Lappe JM, Recker RR, Deng HW (2005) A novel pathophysiological mechanism for osteoporosis suggested by an in vivo gene expression study of circulating monocytes. J Biol Chem 280(32):29011\u201329016. \n                    https:\/\/doi.org\/10.1074\/jbc.M501164200","journal-title":"J Biol Chem"},{"issue":"5","key":"4573_CR24","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1359\/jbmr.080105","volume":"23","author":"P Xiao","year":"2008","unstructured":"Xiao P, Chen Y, Jiang H, Liu YZ, Pan F, Yang TL, Tang ZH, Larsen JA, Lappe JM, Recker RR, Deng HW (2008) In vivo genome-wide expression study on human circulating B cells suggests a novel ESR1 and MAPK3 network for postmenopausal osteoporosis. J Bone Miner Res 23(5):644\u2013654. \n                    https:\/\/doi.org\/10.1359\/jbmr.080105","journal-title":"J Bone Miner Res"},{"issue":"5","key":"4573_CR25","doi-asserted-by":"publisher","first-page":"2976","DOI":"10.1093\/nar\/gkt1249","volume":"42","author":"P Kheradpour","year":"2014","unstructured":"Kheradpour P, Kellis M (2014) Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments. Nucleic Acids Res 42(5):2976\u20132987. \n                    https:\/\/doi.org\/10.1093\/nar\/gkt1249","journal-title":"Nucleic Acids Res"},{"key":"4573_CR26","doi-asserted-by":"publisher","unstructured":"Visvanathan A, Somasundaram K (2018) mRNA traffic control reviewed: N6-methyladenosine (m(6) A) takes the driver\u2019s seat. Bioessays 40 (1). \n                    https:\/\/doi.org\/10.1002\/bies.201700093","DOI":"10.1002\/bies.201700093"},{"key":"4573_CR27","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.molimm.2017.11.009","volume":"93","author":"LJ Li","year":"2018","unstructured":"Li LJ, Fan YG, Leng RX, Pan HF, Ye DQ (2018) Potential link between m(6)A modification and systemic lupus erythematosus. Mol Immunol 93:55\u201363. \n                    https:\/\/doi.org\/10.1016\/j.molimm.2017.11.009","journal-title":"Mol Immunol"},{"key":"4573_CR28","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-60327-411-1_1","volume":"578","author":"BS Shastry","year":"2009","unstructured":"Shastry BS (2009) SNPs: impact on gene function and phenotype. Methods Mol Biol 578:3\u201322. \n                    https:\/\/doi.org\/10.1007\/978-1-60327-411-1_1","journal-title":"Methods Mol Biol"},{"issue":"7","key":"4573_CR29","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1172\/JCI34934","volume":"118","author":"Z Hu","year":"2008","unstructured":"Hu Z, Chen J, Tian T, Zhou X, Gu H, Xu L, Zeng Y, Miao R, Jin G, Ma H, Chen Y, Shen H (2008) Genetic variants of miRNA sequences and non-small cell lung cancer survival. J Clin Invest 118(7):2600\u20132608. \n                    https:\/\/doi.org\/10.1172\/JCI34934","journal-title":"J Clin Invest"},{"issue":"8","key":"4573_CR30","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1002\/humu.21044","volume":"30","author":"J Xu","year":"2009","unstructured":"Xu J, Hu Z, Xu Z, Gu H, Yi L, Cao H, Chen J, Tian T, Liang J, Lin Y, Qiu W, Ma H, Shen H, Chen Y (2009) Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population. Hum Mutat 30(8):1231\u20131236. \n                    https:\/\/doi.org\/10.1002\/humu.21044","journal-title":"Hum Mutat"},{"key":"4573_CR31","doi-asserted-by":"publisher","unstructured":"Karabegovic I, Maas S, Medina-Gomez C, Zrimsek M, Reppe S, Gautvik KM, Uitterlinden AG, Rivadeneira F, Ghanbari M (2017) Genetic polymorphism of miR-196a-2 is associated with bone mineral density (BMD). Int J Mol Sci 18(12). \n                    https:\/\/doi.org\/10.3390\/ijms18122529","DOI":"10.3390\/ijms18122529"},{"issue":"1","key":"4573_CR32","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1002\/jor.23640","volume":"36","author":"TK Ahn","year":"2018","unstructured":"Ahn TK, Kim JO, Kumar H, Choi H, Jo MJ, Sohn S, Ropper AE, Kim NK, Han IB (2018) Polymorphisms of miR-146a, miR-149, miR-196a2, and miR-499 are associated with osteoporotic vertebral compression fractures in Korean postmenopausal women. J Orthop Res 36(1):244\u2013253. \n                    https:\/\/doi.org\/10.1002\/jor.23640","journal-title":"J Orthop Res"},{"issue":"10","key":"4573_CR33","doi-asserted-by":"publisher","first-page":"e110072","DOI":"10.1371\/journal.pone.0110072","volume":"9","author":"M Da","year":"2014","unstructured":"Da M, Feng Y, Xu J, Hu Y, Lin Y, Ni B, Qian B, Hu Z, Mo X (2014) Association of aminoacyl-tRNA synthetases gene polymorphisms with the risk of congenital heart disease in the Chinese Han population. PLoS One 9(10):e110072. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0110072","journal-title":"PLoS One"},{"issue":"24","key":"4573_CR34","doi-asserted-by":"publisher","first-page":"6441","DOI":"10.1093\/hmg\/ddu362","volume":"23","author":"JA Bonomo","year":"2014","unstructured":"Bonomo JA, Guan M, Ng MC, Palmer ND, Hicks PJ, Keaton JM, Lea JP, Langefeld CD, Freedman BI, Bowden DW (2014) The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease. Hum Mol Genet 23(24):6441\u20136447. \n                    https:\/\/doi.org\/10.1093\/hmg\/ddu362","journal-title":"Hum Mol Genet"},{"key":"4573_CR35","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12863-016-0367-4","volume":"17","author":"PK Keshari","year":"2016","unstructured":"Keshari PK, Harbo HF, Myhr KM, Aarseth JH, Bos SD, Berge T (2016) Allelic imbalance of multiple sclerosis susceptibility genes IKZF3 and IQGAP1 in human peripheral blood. BMC Genet 17:59. \n                    https:\/\/doi.org\/10.1186\/s12863-016-0367-4","journal-title":"BMC Genet"},{"issue":"5","key":"4573_CR36","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nrg3706","volume":"15","author":"PC Sham","year":"2014","unstructured":"Sham PC, Purcell SM (2014) Statistical power and significance testing in large-scale genetic studies. Nat Rev Genet 15(5):335\u2013346. \n                    https:\/\/doi.org\/10.1038\/nrg3706","journal-title":"Nat Rev Genet"},{"issue":"3","key":"4573_CR37","doi-asserted-by":"publisher","first-page":"e0121811","DOI":"10.1371\/journal.pone.0121811","volume":"10","author":"XB Mo","year":"2015","unstructured":"Mo XB, Lu X, Zhang YH, Zhang ZL, Deng FY, Lei SF (2015) Gene-based association analysis identified novel genes associated with bone mineral density. PLoS One 10(3):e0121811. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0121811","journal-title":"PLoS One"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-018-4573-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-018-4573-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-018-4573-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T06:27:29Z","timestamp":1569392849000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-018-4573-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,7]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["4573"],"URL":"https:\/\/doi.org\/10.1007\/s00198-018-4573-y","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,7]]},"assertion":[{"value":"26 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the ethical committee of Soochow University. The written informed consent was obtained from all of the participants.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}