{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:54:15Z","timestamp":1780566855541,"version":"3.54.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T00:00:00Z","timestamp":1572220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T00:00:00Z","timestamp":1572220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R24 DK084970"],"award-info":[{"award-number":["R24 DK084970"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 1TR002541"],"award-info":[{"award-number":["UL1 1TR002541"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s00198-019-05193-2","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T02:06:40Z","timestamp":1572228400000},"page":"259-265","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["IGF-1 is associated with estimated bone strength in anorexia nervosa"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1731-2927","authenticated-orcid":false,"given":"P. K.","family":"Fazeli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. T.","family":"Faje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Meenaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. T.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Resulaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Bouxsein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Klibanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,28]]},"reference":[{"key":"5193_CR1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders (DSM-5), 5th edn. Washington, DC","DOI":"10.1176\/appi.books.9780890425596"},{"key":"5193_CR2","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1001\/archinte.165.5.561","volume":"165","author":"KK Miller","year":"2005","unstructured":"Miller KK, Grinspoon SK, Ciampa J, Hier J, Herzog D, Klibanski A (2005) Medical findings in outpatients with anorexia nervosa. Arch Intern Med 165:561\u2013566","journal-title":"Arch Intern Med"},{"key":"5193_CR3","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1001\/jama.1991.03460090081037","volume":"265","author":"NA Rigotti","year":"1991","unstructured":"Rigotti NA, Neer RM, Skates SJ, Herzog DB, Nussbaum SR (1991) The clinical course of osteoporosis in anorexia nervosa. A longitudinal study of cortical bone mass. JAMA 265:1133\u20131138","journal-title":"JAMA"},{"key":"5193_CR4","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1002\/jbmr.3068","volume":"32","author":"JM Nagata","year":"2017","unstructured":"Nagata JM, Golden NH, Leonard MB, Copelovitch L, Denburg MR (2017) Assessment of sex differences in fracture risk among patients with anorexia nervosa: a population-based cohort study using the health improvement network. J Bone Miner Res 32:1082\u20131089","journal-title":"J Bone Miner Res"},{"key":"5193_CR5","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/eat.22248","volume":"47","author":"AT Faje","year":"2014","unstructured":"Faje AT, Fazeli PK, Miller KK, Katzman DK, Ebrahimi S, Lee H, Mendes N, Snelgrove D, Meenaghan E, Misra M, Klibanski A (2014) Fracture risk and areal bone mineral density in adolescent females with anorexia nervosa. Int J Eat Disord 47:458\u2013466","journal-title":"Int J Eat Disord"},{"key":"5193_CR6","doi-asserted-by":"publisher","first-page":"6508","DOI":"10.1210\/jc.2005-1258","volume":"90","author":"S Boutroy","year":"2005","unstructured":"Boutroy S, Bouxsein ML, Munoz F, Delmas PD (2005) In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab 90:6508\u20136515","journal-title":"J Clin Endocrinol Metab"},{"key":"5193_CR7","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1359\/jbmr.071108","volume":"23","author":"S Boutroy","year":"2008","unstructured":"Boutroy S, Van Rietbergen B, Sornay-Rendu E, Munoz F, Bouxsein ML, Delmas PD (2008) Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women. J Bone Miner Res 23:392\u2013399","journal-title":"J Bone Miner Res"},{"key":"5193_CR8","doi-asserted-by":"publisher","first-page":"4434","DOI":"10.1210\/jc.2004-0720","volume":"89","author":"KK Miller","year":"2004","unstructured":"Miller KK, Grinspoon S, Gleysteen S, Grieco KA, Ciampa J, Breu J, Herzog DB, Klibanski A (2004) Preservation of neuroendocrine control of reproductive function despite severe undernutrition. J Clin Endocrinol Metab 89:4434\u20134438","journal-title":"J Clin Endocrinol Metab"},{"key":"5193_CR9","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJMoa040388","volume":"351","author":"CK Welt","year":"2004","unstructured":"Welt CK, Chan JL, Bullen J, Murphy R, Smith P, DePaoli AM, Karalis A, Mantzoros CS (2004) Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med 351:987\u2013997","journal-title":"N Engl J Med"},{"key":"5193_CR10","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1001\/archpsyc.1975.01760240067005","volume":"32","author":"PE Garfinkel","year":"1975","unstructured":"Garfinkel PE, Brown GM, Stancer HC, Moldofsky H (1975) Hypothalamic-pituitary function in anorexia nervosa. Arch Gen Psychiatry 32:739\u2013744","journal-title":"Arch Gen Psychiatry"},{"key":"5193_CR11","first-page":"762","volume":"75","author":"DR Counts","year":"1992","unstructured":"Counts DR, Gwirtsman H, Carlsson LM, Lesem M, Cutler GB Jr (1992) The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins. J Clin Endocrinol Metab 75:762\u2013767","journal-title":"J Clin Endocrinol Metab"},{"key":"5193_CR12","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1172\/JCI0215463","volume":"110","author":"S Yakar","year":"2002","unstructured":"Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, Ooi GT, Setser J, Frystyk J, Boisclair YR, LeRoith D (2002) Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest 110:771\u2013781","journal-title":"J Clin Invest"},{"key":"5193_CR13","first-page":"4257","volume":"83","author":"JA Langlois","year":"1998","unstructured":"Langlois JA, Rosen CJ, Visser M, Hannan MT, Harris T, Wilson PW, Kiel DP (1998) Association between insulin-like growth factor I and bone mineral density in older women and men: the Framingham Heart Study. J Clin Endocrinol Metab 83:4257\u20134262","journal-title":"J Clin Endocrinol Metab"},{"key":"5193_CR14","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/S0140-6736(99)05463-X","volume":"355","author":"P Garnero","year":"2000","unstructured":"Garnero P, Sornay-Rendu E, Delmas PD (2000) Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women. Lancet 355:898\u2013899","journal-title":"Lancet"},{"key":"5193_CR15","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1210\/jc.2009-1152","volume":"95","author":"PK Fazeli","year":"2010","unstructured":"Fazeli PK, Bredella MA, Misra M, Meenaghan E, Rosen CJ, Clemmons DR, Breggia A, Miller KK, Klibanski A (2010) Preadipocyte factor-1 is associated with marrow adiposity and bone mineral density in women with anorexia nervosa. J Clin Endocrinol Metab 95:407\u2013413","journal-title":"J Clin Endocrinol Metab"},{"key":"5193_CR16","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1007\/s00198-009-1120-x","volume":"21","author":"I Legroux-Gerot","year":"2010","unstructured":"Legroux-Gerot I, Vignau J, Biver E, Pigny P, Collier F, Marchandise X, Duquesnoy B, Cortet B (2010) Anorexia nervosa, osteoporosis and circulating leptin: the missing link. Osteoporos Int 21:1715\u20131722","journal-title":"Osteoporos Int"},{"key":"5193_CR17","first-page":"2049","volume":"84","author":"S Grinspoon","year":"1999","unstructured":"Grinspoon S, Miller K, Coyle C, Krempin J, Armstrong C, Pitts S, Herzog D, Klibanski A (1999) Severity of osteopenia in estrogen-deficient women with anorexia nervosa and hypothalamic amenorrhea. J Clin Endocrinol Metab 84:2049\u20132055","journal-title":"J Clin Endocrinol Metab"},{"key":"5193_CR18","first-page":"3864","volume":"81","author":"S Grinspoon","year":"1996","unstructured":"Grinspoon S, Baum H, Lee K, Anderson E, Herzog D, Klibanski A (1996) Effects of short-term recombinant human insulin-like growth factor I administration on bone turnover in osteopenic women with anorexia nervosa. J Clin Endocrinol Metab 81:3864\u20133870","journal-title":"J Clin Endocrinol Metab"},{"key":"5193_CR19","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.bone.2009.06.002","volume":"45","author":"M Misra","year":"2009","unstructured":"Misra M, McGrane J, Miller KK, Goldstein MA, Ebrahimi S, Weigel T, Klibanski A (2009) Effects of rhIGF-1 administration on surrogate markers of bone turnover in adolescents with anorexia nervosa. Bone 45:493\u2013498","journal-title":"Bone"},{"key":"5193_CR20","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1002\/jbmr.1640","volume":"27","author":"PK Fazeli","year":"2012","unstructured":"Fazeli PK, Bredella MA, Freedman L, Thomas BJ, Breggia A, Meenaghan E, Rosen CJ, Klibanski A (2012) Marrow fat and preadipocyte factor-1 levels decrease with recovery in women with anorexia nervosa. J Bone Miner Res 27:1864\u20131871","journal-title":"J Bone Miner Res"},{"key":"5193_CR21","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.bone.2015.04.001","volume":"77","author":"PK Fazeli","year":"2015","unstructured":"Fazeli PK, Faje AT, Cross EJ, Lee H, Rosen CJ, Bouxsein ML, Klibanski A (2015) Serum FGF-21 levels are associated with worsened radial trabecular bone microarchitecture and decreased radial bone strength in women with anorexia nervosa. Bone 77:6\u201311","journal-title":"Bone"},{"key":"5193_CR22","doi-asserted-by":"publisher","unstructured":"Fazeli PK, Faje A, Bredella MA, Polineni S, Russell S, Resulaj M, Rosen CJ, Klibanski A (2018) Changes in marrow adipose tissue with short-term changes in weight in premenopausal women with anorexia nervosa. Eur J Endocrinol. \nhttps:\/\/doi.org\/10.1530\/EJE-18-0824","DOI":"10.1530\/EJE-18-0824"},{"key":"5193_CR23","doi-asserted-by":"publisher","first-page":"4501","DOI":"10.1210\/jc.2019-00843","volume":"104","author":"M Schorr","year":"2019","unstructured":"Schorr M, Fazeli PK, Bachmann KN, Faje AT, Meenaghan E, Kimball A, Singhal V, Ebrahimi S, Gleysteen S, Mickley D, Eddy KT, Misra M, Klibanski A, Miller KK (2019) Differences in trabecular plate and rod structure in premenopausal women across the weight spectrum. J Clin Endocrinol Metab 104:4501\u20134510","journal-title":"J Clin Endocrinol Metab"},{"key":"5193_CR24","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1093\/ajcn\/37.2.311","volume":"37","author":"AR Frisancho","year":"1983","unstructured":"Frisancho AR, Flegel PN (1983) Elbow breadth as a measure of frame size for US males and females. Am J Clin Nutr 37:311\u2013314","journal-title":"Am J Clin Nutr"},{"key":"5193_CR25","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1007\/BF02556113","volume":"49","author":"J Johnson","year":"1991","unstructured":"Johnson J, Dawson-Hughes B (1991) Precision and stability of dual-energy X-ray absorptiometry measurements. Calcif Tissue Int 49:174\u2013178","journal-title":"Calcif Tissue Int"},{"key":"5193_CR26","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/S8756-3282(02)00736-6","volume":"30","author":"W Pistoia","year":"2002","unstructured":"Pistoia W, van Rietbergen B, Lochmuller EM, Lill CA, Eckstein F, Ruegsegger P (2002) Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images. Bone 30:842\u2013848","journal-title":"Bone"},{"key":"5193_CR27","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/j.bone.2008.01.017","volume":"42","author":"JA Macneil","year":"2008","unstructured":"Macneil JA, Boyd SK (2008) Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method. Bone 42:1203\u20131213","journal-title":"Bone"},{"key":"5193_CR28","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1016\/j.bone.2011.02.022","volume":"48","author":"TL Mueller","year":"2011","unstructured":"Mueller TL, Christen D, Sandercott S, Boyd SK, van Rietbergen B, Eckstein F, Lochmuller EM, Muller R, van Lenthe GH (2011) Computational finite element bone mechanics accurately predicts mechanical competence in the human radius of an elderly population. Bone 48:1232\u20131238","journal-title":"Bone"},{"key":"5193_CR29","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s00198-004-1759-2","volume":"16","author":"G Milos","year":"2005","unstructured":"Milos G, Spindler A, Ruegsegger P, Seifert B, Muhlebach S, Uebelhart D, Hauselmann HJ (2005) Cortical and trabecular bone density and structure in anorexia nervosa. Osteoporos Int 16:783\u2013790","journal-title":"Osteoporos Int"},{"key":"5193_CR30","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1148\/radiol.10100222","volume":"257","author":"CJ Walsh","year":"2010","unstructured":"Walsh CJ, Phan CM, Misra M, Bredella MA, Miller KK, Fazeli PK, Bayraktar HH, Klibanski A, Gupta R (2010) Women with anorexia nervosa: finite element and trabecular structure analysis by using flat-panel volume CT. Radiology 257:167\u2013174","journal-title":"Radiology"},{"key":"5193_CR31","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.bone.2009.09.005","volume":"46","author":"EA Lawson","year":"2010","unstructured":"Lawson EA, Miller KK, Bredella MA, Phan C, Misra M, Meenaghan E, Rosenblum L, Donoho D, Gupta R, Klibanski A (2010) Hormone predictors of abnormal bone microarchitecture in women with anorexia nervosa. Bone 46:458\u2013463","journal-title":"Bone"},{"key":"5193_CR32","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s00223-017-0254-7","volume":"101","author":"J Frolich","year":"2017","unstructured":"Frolich J, Hansen S, Winkler LA, Andresen AK, Hermann AP, Stoving RK (2017) The role of body weight on bone in anorexia nervosa: a HR-pQCT Study. Calcif Tissue Int 101:24\u201333","journal-title":"Calcif Tissue Int"},{"key":"5193_CR33","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1007\/s00198-007-0430-0","volume":"18","author":"I Kanazawa","year":"2007","unstructured":"Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T (2007) Serum insulin-like growth factor-I level is associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes mellitus. Osteoporos Int 18:1675\u20131681","journal-title":"Osteoporos Int"},{"key":"5193_CR34","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/jbmr.1734","volume":"28","author":"RT Turner","year":"2013","unstructured":"Turner RT, Kalra SP, Wong CP, Philbrick KA, Lindenmaier LB, Boghossian S, Iwaniec UT (2013) Peripheral leptin regulates bone formation. J Bone Miner Res 28:22\u201334","journal-title":"J Bone Miner Res"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-019-05193-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00198-019-05193-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-019-05193-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:51:11Z","timestamp":1603759871000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00198-019-05193-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,28]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["5193"],"URL":"https:\/\/doi.org\/10.1007\/s00198-019-05193-2","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,28]]},"assertion":[{"value":"1 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the Partners Institutional Review Board and complied with the Health Insurance Portability and Accountability Act guidelines. Written informed consent was obtained from all subjects.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}