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CMS, PJB, JAC, NEL, TSRS, DCB, MEW, WMK have nothing to disclose. KLS has received grant funding from Merck. SR has received consulting fees from Jazz Pharma, Respircardia and Eisa Inc and grant support from Jazz Pharma (unrelated to this paper). KPW reports research support from the NIH, Office of Naval Research, Pac-12; Financial relationships: consulting fees Circadian Therapeutics, LTD., Circadian Biotherapies, Philips Respironics. Board of Directors: Sleep Research Society. ESO has received research support from or consulting for Amgen, Mereo and Bayer.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The Institutional Review Board at each clinical site approved the study, and all participants provided written consent. The current analysis used de-identified serum and data and was deemed non-human subject research by the Colorado Multiple Institution Review Board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The SAS Code used to generate these results are not publicly available but are available from the corresponding author on reasonable request.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}