{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T04:16:56Z","timestamp":1778991416201,"version":"3.51.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100013703","name":"Royal Osteoporosis Society","doi-asserted-by":"crossref","award":["75\/190"],"award-info":[{"award-number":["75\/190"]}],"id":[{"id":"10.13039\/501100013703","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s00198-021-06001-6","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T23:04:11Z","timestamp":1621033451000},"page":"2267-2277","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bone turnover markers as determinants of bone density and fracture in men with distal forearm fractures: the pathogenesis examined in the Mr F study"],"prefix":"10.1007","volume":"32","author":[{"given":"B.","family":"Hanusch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Prediger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5060-4214","authenticated-orcid":false,"given":"S.P.","family":"Tuck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"McNally","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.K.","family":"Datta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,15]]},"reference":[{"key":"6001_CR1","unstructured":"Tuck SP, Francis RM, Hanusch B (2012) Osteoporosis in men. Oxford Rheumatology Library: Osteoporosis- edited by Gavin Clunie and Richard Keen. Oxford University Press"},{"issue":"8","key":"6001_CR2","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1007\/s001980200085","volume":"13","author":"SP Tuck","year":"2002","unstructured":"Tuck SP, Raj N, Summers GD (2002) Is distal forearm fracture in men due to osteoporosis? Osteoporos Int 13(8):630\u2013636","journal-title":"Osteoporos Int"},{"issue":"10","key":"6001_CR3","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1007\/s00198-017-4122-0","volume":"28","author":"BC Hanusch","year":"2017","unstructured":"Hanusch BC, Tuck SP, McNally RJQ et al (2017) Does regional loss of bone mineral density explain low trauma distal forearm fractures in men (the MrF study)? Osteoporos Int 28(10):2877\u20132886","journal-title":"Osteoporos Int"},{"issue":"2","key":"6001_CR4","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s00198-010-1501-1","volume":"22","author":"S Vasikaran","year":"2011","unstructured":"Vasikaran S, Eastell R, Bruyere O et al (2011) Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international standards. Osteoporos Int 22(2):391\u2013420","journal-title":"Osteoporos Int"},{"issue":"8","key":"6001_CR5","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1007\/s00198-012-1915-z","volume":"23","author":"GJ Atkins","year":"2012","unstructured":"Atkins GJ, Findlay DM (2012) Osteocyte regulation of bone mineral: a little give and take. Osteoporos Int 23(8):2067\u20132079","journal-title":"Osteoporos Int"},{"issue":"5","key":"6001_CR6","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1136\/jcp.2007.048868","volume":"61","author":"HK Datta","year":"2008","unstructured":"Datta HK, Ng WF, Walker JA, Tuck SP, Varanassi SS (2008) Cell biology of bone. J Clin Pathol 61(5):577\u2013587","journal-title":"J Clin Pathol"},{"key":"6001_CR7","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1159\/000446278","volume":"62","author":"E Hay","year":"2016","unstructured":"Hay E, Bouaziz W, Funck-Brentano T, Cohen-Solal M (2016) Sclerostin and bone aging: a mini review. Gerentology 62:618\u2013623","journal-title":"Gerentology"},{"issue":"1","key":"6001_CR8","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.krcp.2015.12.006","volume":"35","author":"E Abdallah","year":"2016","unstructured":"Abdallah E, Mosbath O, Khalifa G, Metwaly A, El-Bendary O (2016) Assessment of the relationship between serum soluble Klotho and carotid intima-media thickness and left ventricular dysfunction in hemodialysis patients. Kidney Res Clin Pract 35(1):42\u201349","journal-title":"Kidney Res Clin Pract"},{"issue":"4","key":"6001_CR9","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1136\/annrheumdis-2011-200216","volume":"71","author":"GR Heiland","year":"2012","unstructured":"Heiland GR, Appel H, Poddabnyy D et al (2012) High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis. Ann Rheum Dis 71(4):572\u2013574","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"6001_CR10","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1111\/j.1365-2125.2012.04471.x","volume":"75","author":"SA Stoch","year":"2013","unstructured":"Stoch SA, Zajic S, Stone JA, Miller DL, van Bortel L, Lasseter KC, Pramanik B, Cilissen C, Liu Q, Liu L, Scott BB, Panebianco D, Ding Y, Gottesdiener K, Wagner JA (2013) Odanacatib, a selective cathepsin K inhibitor to treat osteoporosis: safety, tolerability, pharmacokinetics and pharmacodynamics--results from single oral dose studies in healthy volunteers. Br J Clin Pharmacol 75(5):1240\u20131254","journal-title":"Br J Clin Pharmacol"},{"key":"6001_CR11","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1530\/EJE-12-1074","volume":"168","author":"B Lapauw","year":"2013","unstructured":"Lapauw B, Vandewalle S, Taes Y eta l. (2013) Serum sclerostin levels in men with idiopathic osteoporosis. Eur J Endocrinol 168:615\u2013620","journal-title":"Eur J Endocrinol"},{"key":"6001_CR12","doi-asserted-by":"publisher","first-page":"A639","DOI":"10.1186\/2197-425X-3-S1-A639","volume":"3","author":"P Pernu","year":"2015","unstructured":"Pernu P, Gaddnas F, Risteli J et al (2015) Type 1 and 3 collagen production by bone marrow mesenchymal stromal cells is suppressed in vitro after exposure to sepsis patient serum. Intens Care Med Exp 3:A639","journal-title":"Intens Care Med Exp"},{"issue":"1","key":"6001_CR13","first-page":"192","volume":"86","author":"P Szulc","year":"2001","unstructured":"Szulc P, Munoz F, Claustrat B, Gannero P, Marcland F, Duboeaf F, Delmas PD (2001) Bioavailable estradiol may be an important determinant of osteoporosis in men: the MINOS study. J Clin Endocrinol Metab 86(1):192\u2013199","journal-title":"J Clin Endocrinol Metab"},{"key":"6001_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s00223-001-2018-6","volume":"70","author":"SF Evans","year":"2002","unstructured":"Evans SF, Davie MW (2002) Low body size and elevated SHBG distinguish men with idiopathic vertebral fracture. Calcif Tissue Int 70:9\u201315","journal-title":"Calcif Tissue Int"},{"issue":"5","key":"6001_CR15","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1046\/j.1365-2362.2001.00836.x","volume":"31","author":"P Pietschmann","year":"2001","unstructured":"Pietschmann P, Kudlacek S, Grisar J, Spitzauer S, Woloszczuk W, Willvonseder R, Peterlik M (2001) Bone turnover markers and sex hormones in men with idiopathic osteoporosis. Euro J Clin Inv 31(5):444\u2013451","journal-title":"Euro J Clin Inv"},{"issue":"6","key":"6001_CR16","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.bone.2008.08.123","volume":"43","author":"SP Tuck","year":"2008","unstructured":"Tuck SP, Scane AC, Francis RM et al (2008) A case control study of sex steroids and bone turnover in men with symptomatic vertebral fractures. Bone 43(6):999\u20131005","journal-title":"Bone"},{"issue":"3","key":"6001_CR17","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.maturitas.2014.07.006","volume":"79","author":"MJ Montoya","year":"2014","unstructured":"Montoya MJ, Giner M, Miranda C, V\u00e1zquez MA, Caeiro JR, Guede D, P\u00e9rez-Cano R (2014) Microstructural trabecular bone from patients with osteoporotic hip fracture or osteoarthritis: its relationship with bone mineral density and bone remodelling markers. Maturitas 79(3):299\u2013305","journal-title":"Maturitas"},{"issue":"1","key":"6001_CR18","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1210\/jc.2014-2646","volume":"100","author":"SA Chubb","year":"2015","unstructured":"Chubb SA, Byrnes E, Manning C et al (2015) Reference intervals for bone turnover markers and their association with incident hip fractures in older men: the health in men study. J Clin Endocrinol Metab 100(1):90\u201399","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"6001_CR19","doi-asserted-by":"publisher","first-page":"608","DOI":"10.3109\/s10165-011-0455-2","volume":"21","author":"N Yoshimura","year":"2011","unstructured":"Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T (2011) Biochemical markers of bone turnover as predictors of osteoporosis and osteoporotic fractures in men and women: a 10 years follow up of the Taiji cohort. Mod Rheumatol 21(6):608\u2013620","journal-title":"Mod Rheumatol"},{"issue":"12","key":"6001_CR20","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1002\/jbmr.1718","volume":"27","author":"MS Ardawi","year":"2012","unstructured":"Ardawi MS, Rouzi AA, Al-Sibiani SA et al (2012) High serum sclerostin predicts the occurrence of osteoporotic fractures in postmenopausal women: the Center of Excellence for Osteoporosis Research Study. J Bone Miner Res 27(12):2592\u20132602","journal-title":"J Bone Miner Res"},{"issue":"3","key":"6001_CR21","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1007\/s00198-010-1525-6","volume":"23","author":"SA Polyzos","year":"2012","unstructured":"Polyzos SA, Anatasilakis AD, Bratengeier C et al (2012) Serum sclerostin levels positively correlate with lumbar spinal bone mineral density in postmenopausal women--the six-month effect of risedronate and teriparatide. Osteoporos Int 23(3):1171\u20131176","journal-title":"Osteoporos Int"},{"issue":"2","key":"6001_CR22","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00198-012-1978-x","volume":"24","author":"P Garnero","year":"2013","unstructured":"Garnero P, Sornay-Rendu E, Munoz F, Borel O, Chapurlat RD (2013) Association of serum sclerostin with bone mineral density, bone turnover, steroid and parathyroid hormones, and fracture risk in postmenopausal women: the OFELY study. Osteoporos Int 24(2):489\u2013494","journal-title":"Osteoporos Int"},{"issue":"2","key":"6001_CR23","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1002\/jbmr.2342","volume":"30","author":"S Reppe","year":"2015","unstructured":"Reppe S, Noer A, Grimholt RM, Halld\u00f3rsson BV, Medina-Gomez C, Gautvik VT, Olstad OK, Berg JP, Datta H, Estrada K, Hofman A, Uitterlinden AG, Rivadeneira F, Lyle R, Collas P, Gautvik KM (2015) Methylation of bone sclerostin, its mRNA, and serum sclerostin levels correlate strongly with fracture risk in postmenopausal women. J Bone Miner Res 30(2):249\u2013256","journal-title":"J Bone Miner Res"},{"issue":"5","key":"6001_CR24","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1210\/jc.2010-0067","volume":"95","author":"A Gaudio","year":"2010","unstructured":"Gaudio A, Pennizi P, Bratengeier C et al (2010) Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss. J Clin Endocrinol Metab 95(5):2248\u20132253","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"6001_CR25","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1096\/fj.09-148908","volume":"24","author":"M Kalogeroulos","year":"2010","unstructured":"Kalogeroulos M, Varanasi SS, Olstad OK et al (2010) Zic1 transcription factor in bone: neural developmental protein regulates mechanotransduction in osteocytes. FASEB J 24(8):2893\u20132903","journal-title":"FASEB J"},{"key":"6001_CR26","doi-asserted-by":"publisher","first-page":"4857","DOI":"10.1002\/jbmr.263","volume":"26","author":"MA Mirza","year":"2011","unstructured":"Mirza MA, Karlsson MK, Mellstrom D et al (2011) Serum fibroblast growth factor-23 (FGF-23) and fracture risk in elderly men. J Bone Miner Res 26:4857\u20134864","journal-title":"J Bone Miner Res"},{"issue":"11","key":"6001_CR27","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1002\/jbmr.1985","volume":"28","author":"NE Lane","year":"2013","unstructured":"Lane NE, Parini N, Corr M et al (2013) Association of serum fibroblast growth factor 23 (FGF23) and incident fractures in older men: the Osteoporotic fractures in men (Mr Os) study. J Bone Miner Res 28(11):2325\u20132332","journal-title":"J Bone Miner Res"},{"issue":"6","key":"6001_CR28","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.bone.2004.01.024","volume":"34","author":"C Lourneau","year":"2004","unstructured":"Lourneau C, Soudan B, d\u2019Herbomez M eta l. (2004) Sex hormone binding globulin, estradiol and bone turnover markers in male osteoporosis. Bone 34(6):933\u2013939","journal-title":"Bone"},{"issue":"1","key":"6001_CR29","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/S8756-3282(01)00478-1","volume":"29","author":"E Legrand","year":"2001","unstructured":"Legrand E, Hedde C, Gallois Y et al (2001) Osteoporosis in men: a potential role for the sex hormone binding globulin. Bone 29(1):90\u201395","journal-title":"Bone"},{"key":"6001_CR30","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3109\/13685538.2011.593659","volume":"1591","author":"O Risto","year":"2012","unstructured":"Risto O, Hammer E, Hammer K et al (2012) Elderly men with a history of distal radius fracture have significantly lower calcaneal bone density and free androgen index than age-matched controls. Aging Male 1591:59\u201362","journal-title":"Aging Male"},{"issue":"45","key":"6001_CR31","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1111\/j.1365-2265.2004.02006.x","volume":"60","author":"D Rucker","year":"2004","unstructured":"Rucker D, Ezzat S, Diamandi A, Khosravi J, Hanley DA (2004) IGF-1 and testosterone levels are predictors of bone mineral density in healthy community dwelling men. Clin Endocrinol 60(45):491\u2013499","journal-title":"Clin Endocrinol"},{"issue":"7","key":"6001_CR32","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1172\/JCI119701","volume":"100","author":"CW Slemenda","year":"1997","unstructured":"Slemenda CW, Longcope C, Zhou L, Hui SL, Peacock M, Johnston CC (1997) Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens. J Clin Invest 100(7):1755\u20131759","journal-title":"J Clin Invest"},{"issue":"3","key":"6001_CR33","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/s001980170127","volume":"12","author":"G Martinez Diaz-Guerra","year":"2001","unstructured":"Martinez Diaz-Guerra G, Hawkins F, Rapado A et al (2001) Hormonal and anthropometric predictors of bone mass in healthy elderly men: major effect of sex hormone binding globulin, parathyroid hormone and body weight. Osteoporos Int 12(3):178\u2013184","journal-title":"Osteoporos Int"},{"issue":"7","key":"6001_CR34","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1359\/jbmr.2000.15.7.1405","volume":"15","author":"JR Center","year":"2000","unstructured":"Center JR, Nguyen TV, Sambrood PN, Eisman JA (2000) Hormonal and biochemical parameters and osteoporotic fractures in elderly men. J Bone Miner Res 15(7):1405\u20131411","journal-title":"J Bone Miner Res"},{"issue":"2","key":"6001_CR35","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s00223-007-9035-z","volume":"81","author":"A Bjornerem","year":"2007","unstructured":"Bjornerem A, Emaus N, Berntsen GK et al (2007) circulating sex steroids, sex hormone binding globulin and longitudinal changes in forearm bone density in postmenopausal women and men: the Tromso study. Calcif Tissue Int 81(2):65\u201372","journal-title":"Calcif Tissue Int"},{"key":"6001_CR36","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.bone.2016.01.009","volume":"84","author":"PM Cawthorn","year":"2016","unstructured":"Cawthorn PM, Schousboe JT, Harrison SL et al (2016) Sex hormones, sex hormone binding globulin and vertebral fractures in older men. Bone 84:271\u2013278","journal-title":"Bone"},{"issue":"3","key":"6001_CR37","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1002\/jbmr.2718","volume":"31","author":"L Vandenput","year":"2016","unstructured":"Vandenput L, Mellstrom D, Kindmark A et al (2016) High serum SHBG predicts incident vertebral fractures in elderly men. J Bone Miner Res 31(3):683\u2013689","journal-title":"J Bone Miner Res"},{"issue":"4","key":"6001_CR38","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.bone.2011.06.022","volume":"49","author":"A El Maghraoui","year":"2011","unstructured":"El Maghraoui A, Ouzzif Z, Mounach A et al (2011) The relationship between sex steroids, bone turnover and vertebral fracture prevalence in asymptomatic men. Bone 49(4):853\u2013857","journal-title":"Bone"},{"issue":"10","key":"6001_CR39","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1359\/jbmr.080518","volume":"23","author":"D Mellstrom","year":"2008","unstructured":"Mellstrom D, Vandenput L, Mallmin H et al (2008) Older men with low serum estradiol and high SHBG have an increased risk of fractures. J Bone Miner Res 23(10):1552\u20131560","journal-title":"J Bone Miner Res"},{"key":"6001_CR40","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1471-2474-14.6","volume":"14","author":"C Wolfl","year":"2013","unstructured":"Wolfl C, Englert S, Moghaddam AA et al (2013) Time course of 25(OH) D3 vitamin D3 as well as PTH (parathyroid hormone) during fracture healing of patients with normal and low bone mineral density (BMD). BMC Musculoskelatal Diod 14:6. https:\/\/doi.org\/10.1186\/1471-2474-14.6","journal-title":"BMC Musculoskelatal Diod"},{"key":"6001_CR41","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s001980050246","volume":"10","author":"BM Ingle","year":"1999","unstructured":"Ingle BM, Hay SM, Bottjer HM, Eastell R (1999) Changes in bone mass and bone turnover following distal forearm fracture. Osteoporos Int 10:399\u2013407","journal-title":"Osteoporos Int"},{"key":"6001_CR42","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1007\/s00198-019-05132-1","volume":"30","author":"FD Hojsager","year":"2019","unstructured":"Hojsager FD, Rand MS, Pederson SB, Nissen N, Jorgensen NR (2019) Fracture-induced changes in biomarkers CTX, PINP, OC and BAP- a systematic review. Osteoporos Int 30:2381\u20132389","journal-title":"Osteoporos Int"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-021-06001-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00198-021-06001-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-021-06001-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T10:05:28Z","timestamp":1635847528000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00198-021-06001-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,15]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["6001"],"URL":"https:\/\/doi.org\/10.1007\/s00198-021-06001-6","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,15]]},"assertion":[{"value":"8 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study has been approved by the National Research Ethics Committee North East, UK (REC reference \/H0908\/15) and has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of Human Rights"}},{"value":"Birgit Hanusch, Stephen Tuck and Harish Datta have received grants from the National Osteoporosis Society. Birgit Hanusch, Stephen Tuck, Harish Datta, and Julie Walker are also supported by an innovative award from the National Osteoporosis Society (Grant number CS\/250). Stephen Tuck has received speaker fees from Ely Lilly, Servier, Internist, and Amgen. Richard McNally and Michael Prediger declare that they have no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}