{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:33:48Z","timestamp":1793579628952,"version":"4.5.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100010875","name":"Amgen Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010875","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s00198-021-06080-5","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:07:50Z","timestamp":1628640470000},"page":"113-122","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Hip fracture predicts subsequent hip fracture: a retrospective observational study to support a call to early hip fracture prevention efforts in post-fracture patients"],"prefix":"10.1007","volume":"33","author":[{"given":"Emil","family":"Schemitsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques P.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Eric","family":"Tarride","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5027-7989","authenticated-orcid":false,"given":"Lubomira","family":"Slatkovska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"issue":"4","key":"6080_CR1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s001980170116","volume":"12","author":"ME Wiktorowicz","year":"2001","unstructured":"Wiktorowicz ME, Goeree R, Papaioannou A, Adachi JD, Papadimitropoulos E (2001) Economic implications of hip fracture: health service use, institutional care and cost in Canada. Osteoporos Int 12(4):271\u2013278","journal-title":"Osteoporos Int"},{"key":"6080_CR2","unstructured":"Canadian Chronic Disease Surveillance System (CCDSS) (2016) https:\/\/health-infobase.canada.ca\/ccdss\/data-tool\/Age?G=00&V=9&M=4 Accessed 19 Aug 2020."},{"issue":"1","key":"6080_CR3","doi-asserted-by":"publisher","first-page":"E55","DOI":"10.9778\/cmajo.20180126","volume":"7","author":"P Cram","year":"2019","unstructured":"Cram P, Lix LM, Bohm E, Yan L, Roos L, Matelski J et al (2019) Hip fracture care in Manitoba, Canada and New York State, United States: an analysis of administrative data. CMAJ Open 7(1):E55\u2013E62","journal-title":"CMAJ Open"},{"key":"6080_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-021-05877-8","author":"J Tarride","year":"2021","unstructured":"Tarride J, Adachi JD, Brown JP, Schemitsch E, Slatkovska L, Burke N (2021) Incremental costs of fragility fractures: a population-based matched-cohort study from Ontario, Canada. Osteoporos Int. https:\/\/doi.org\/10.1007\/s00198-021-05877-8","journal-title":"Osteoporos Int"},{"issue":"9","key":"6080_CR5","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1007\/s00198-011-1815-7","volume":"23","author":"S Morin","year":"2012","unstructured":"Morin S, Lix LM, Azimaee M, Metge C, Majumdar SR, Leslie WD (2012) Institutionalization following incident non-traumatic fractures in community-dwelling men and women. Osteoporos Int 23(9):2381\u20132386","journal-title":"Osteoporos Int"},{"issue":"8","key":"6080_CR6","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1001\/jamainternmed.2014.2362","volume":"174","author":"MD Neuman","year":"2014","unstructured":"Neuman MD, Silber JH, Magaziner JS, Passarella MA, Mehta S, Werner RM (2014) Survival and functional outcomes after hip fracture among nursing home residents. JAMA Intern Med 174(8):1273\u20131280","journal-title":"JAMA Intern Med"},{"issue":"13","key":"6080_CR7","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1161\/01.CIR.0000142671.06167.91","volume":"110","author":"P Kaul","year":"2004","unstructured":"Kaul P, Armstrong PW, Chang WC, Naylor CD, Granger CB, Lee KL et al (2004) Long-term mortality of patients with acute myocardial infarction in the United States and Canada: comparison of patients enrolled in Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO)-I. Circulation 110(13):1754\u20131760","journal-title":"Circulation"},{"issue":"9","key":"6080_CR8","doi-asserted-by":"publisher","first-page":"e317","DOI":"10.1097\/BOT.0000000000001895","volume":"34","author":"SR Konda","year":"2020","unstructured":"Konda SR, Ranson RA, Solasz SJ, Dedhia N, Lott A, Bird ML et al (2020) Modification of a validated risk stratification tool to characterize geriatric hip fracture outcomes and optimize care in a post-COVID-19 world. J Orthop Trauma 34(9):e317\u2013e324","journal-title":"J Orthop Trauma"},{"issue":"8","key":"6080_CR9","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1097\/BOT.0000000000001849","volume":"34","author":"DG LeBrun","year":"2020","unstructured":"LeBrun DG, Konnaris MA, Ghahramani GC, Premkumar A, DeFrancesco CJ, Gruskay JA et al (2020) Hip fracture outcomes during the COVID-19 pandemic: early results from New York. J Orthop Trauma 34(8):403\u2013410","journal-title":"J Orthop Trauma"},{"issue":"9","key":"6080_CR10","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1302\/0301-620X.102B9.BJJ-2020-1127.R1","volume":"102-B","author":"B Kayani","year":"2020","unstructured":"Kayani B, Onochie E, Patil V, Begum F, Cuthbert R, Ferguson D et al (2020) The effects of COVID-19 on perioperative morbidity and mortality in patients with hip fractures. Bone Jt J 102-B(9):1136\u20131145","journal-title":"Bone Jt J"},{"issue":"13","key":"6080_CR11","doi-asserted-by":"publisher","first-page":"e69","DOI":"10.2106\/JBJS.20.00686","volume":"102","author":"JM Mu\u00f1oz Vives","year":"2020","unstructured":"Mu\u00f1oz Vives JM, Jornet-Gibert M, C\u00e1mara-Cabrera J, Esteban PL, Brunet L, Delgado-Flores L et al (2020) Mortality rates of patients with proximal femoral fracture in a worldwide pandemic: preliminary results of the Spanish HIP-COVID observational study. J Bone Jt Surg Am 102(13):e69","journal-title":"J Bone Jt Surg Am"},{"key":"6080_CR12","unstructured":"Osteoporosis Canada. Fast facts. https:\/\/osteoporosis.ca\/about-the-disease\/fast-facts. Accessed 19 Nov 2020"},{"key":"6080_CR13","unstructured":"International Osteoporosis Foundation. Capture of the fracture: identifying patients. https:\/\/www.capturethefracture.org\/identifying-patients. Accessed 19 Nov\u00a02020"},{"key":"6080_CR14","unstructured":"Centre for Metabolic Bone Diseases, University of Sheffield, UK. Fracture Risk Assessment Tool (FRAX). https:\/\/www.sheffield.ac.uk\/FRAX\/tool.aspx?country=19. Accessed 19 Nov 2020"},{"issue":"1","key":"6080_CR15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00198-018-4732-1","volume":"30","author":"A Balasubramanian","year":"2019","unstructured":"Balasubramanian A, Zhang J, Chen L, Wenkert D, Daigle SG, Grauer A et al (2019) Risk of subsequent fracture after prior fracture among older women. Osteoporos Int 30(1):79\u201392","journal-title":"Osteoporos Int"},{"issue":"11","key":"6080_CR16","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1002\/jbmr.3526","volume":"33","author":"C Beaudoin","year":"2018","unstructured":"Beaudoin C, Jean S, Moore L, Gamache P, Bessette L, Ste-Marie LG (2018) Number, location, and time since prior fracture as predictors of future fracture in the elderly from the general population. J Bone Miner Res 33(11):1956\u20131966","journal-title":"J Bone Miner Res"},{"issue":"5","key":"6080_CR17","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1210\/jc.2019-00221","volume":"104","author":"R Eastell","year":"2019","unstructured":"Eastell R, Rosen CJ, Black DM, Cheung AM, Murad MH, Shoback D (2019) Pharmacological management of osteoporosis in postmenopausal women: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 104(5):1595\u20131622","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"6080_CR18","doi-asserted-by":"publisher","first-page":"564","DOI":"10.4158\/GL-2020-0524","volume":"26","author":"PM Camacho","year":"2020","unstructured":"Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A et al (2020) American Association of Clinical Endocrinologists\/American College of Endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis: 2020 update. Endocr Pract 26(5):564\u2013570","journal-title":"Endocr Pract"},{"issue":"1","key":"6080_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00198-019-05176-3","volume":"31","author":"JA Kanis","year":"2020","unstructured":"Kanis JA, Harvey NC, McCloskey E, Bruy\u00e8re O, Veronese N, Lorentzon M et al (2020) Algorithm for the management of patients at low, high and very high risk of osteoporotic fractures. Osteoporos Int 31(1):1\u201312","journal-title":"Osteoporos Int"},{"issue":"3","key":"6080_CR20","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1210\/clinem\/dgaa048","volume":"105","author":"D Shoback","year":"2020","unstructured":"Shoback D, Rosen CJ, Black DM, Cheung AM, Murad MH, Eastell R (2020) Pharmacological management of osteoporosis in postmenopausal women: an Endocrine Society guideline update. J Clin Endocrinol Metab 105(3):587","journal-title":"J Clin Endocrinol Metab"},{"key":"6080_CR21","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1471-2474-5-11","volume":"5","author":"A Papaioannou","year":"2004","unstructured":"Papaioannou A, Giangregorio L, Kvern B, Boulos P, Ioannidis G, Adachi JD (2004) The osteoporosis care gap in Canada. BMC Musculoskelet Disord 5:11","journal-title":"BMC Musculoskelet Disord"},{"issue":"1","key":"6080_CR22","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00198-007-0426-9","volume":"19","author":"L Bessette","year":"2008","unstructured":"Bessette L, Ste-Marie LG, Jean S, Davison KS, Beaulieu M, Baranci M et al (2008) The care gap in diagnosis and treatment of women with a fragility fracture. Osteoporos Int 19(1):79\u201386","journal-title":"Osteoporos Int"},{"issue":"4","key":"6080_CR23","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s00198-007-0483-0","volume":"19","author":"A Papaioannou","year":"2008","unstructured":"Papaioannou A, Kennedy CC, Ioannidis G, Gao Y, Sawka AM, Goltzman D et al (2008) The osteoporosis care gap in men with fragility fractures: the Canadian Multicentre Osteoporosis Study. Osteoporos Int 19(4):581\u2013587","journal-title":"Osteoporos Int"},{"key":"6080_CR24","unstructured":"Ontario Osteoporosis Strategy (2017) Provincial performance data for osteoporosis management. https:\/\/www.osteostrategy.on.ca\/wp-content\/uploads\/Final-OP-Provincial-Performance-Status-Report-Apr-2017-1.pdf. Accessed 19 Nov 2020."},{"issue":"17\u201318","key":"6080_CR25","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1503\/cmaj.160522","volume":"188","author":"KJ Sheehan","year":"2016","unstructured":"Sheehan KJ, Sobolev B, Guy P, Kuramoto L, Morin SN, Sutherland JM et al (2016) In-hospital mortality after hip fracture by treatment setting. CMAJ 188(17\u201318):1219\u20131225","journal-title":"CMAJ"},{"issue":"27","key":"6080_CR26","doi-asserted-by":"publisher","first-page":"E905","DOI":"10.1503\/cmaj.160576","volume":"189","author":"DI McIsaac","year":"2017","unstructured":"McIsaac DI, Abdulla K, Yang H, Sundaresan S, Doering P, Vaswani SG et al (2017) Association of delay of urgent or emergency surgery with mortality and use of health care resources: a propensity score-matched observational cohort study. CMAJ 189(27):E905\u2013E912","journal-title":"CMAJ"},{"issue":"23","key":"6080_CR27","doi-asserted-by":"publisher","first-page":"E702","DOI":"10.1503\/cmaj.170830","volume":"190","author":"D Pincus","year":"2018","unstructured":"Pincus D, Wasserstein D, Ravi B, Byrne JP, Huang A, Paterson JM et al (2018) Reporting and evaluating wait times for urgent hip fracture surgery in Ontario, Canada. CMAJ 190(23):E702\u2013E709","journal-title":"CMAJ"},{"issue":"31","key":"6080_CR28","doi-asserted-by":"publisher","first-page":"E923","DOI":"10.1503\/cmaj.171512","volume":"190","author":"B Sobolev","year":"2018","unstructured":"Sobolev B, Guy P, Sheehan KJ, Kuramoto L, Sutherland JM, Levy AR et al (2018) Mortality effects of timing alternatives for hip fracture surgery. CMAJ 190(31):E923\u2013E932","journal-title":"CMAJ"},{"issue":"47","key":"6080_CR29","doi-asserted-by":"publisher","first-page":"E1376","DOI":"10.1503\/cmaj.180551","volume":"190","author":"JA Watt","year":"2018","unstructured":"Watt JA, Gomes T, Bronskill SE, Huang A, Austin PC, Ho JM et al (2018) Comparative risk of harm associated with trazodone or atypical antipsychotic use in older adults with dementia: a retrospective cohort study. CMAJ 190(47):E1376\u2013E1383","journal-title":"CMAJ"},{"issue":"6","key":"6080_CR30","doi-asserted-by":"publisher","first-page":"E151","DOI":"10.1503\/cmaj.180564","volume":"191","author":"N Cho","year":"2019","unstructured":"Cho N, Boland L, McIsaac DI (2019) The association of female sex with application of evidence-based practice recommendations for perioperative care in hip fracture surgery. CMAJ 191(6):E151\u2013E158","journal-title":"CMAJ"},{"key":"6080_CR31","unstructured":"ICES. ICES 2020 data. https:\/\/www.ices.on.ca\/Data-and-Privacy\/ICES-data. Accessed\u00a020 July 2017"},{"issue":"2","key":"6080_CR32","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s00198-012-2034-6","volume":"24","author":"M Nikitovic","year":"2013","unstructured":"Nikitovic M, Wodchis WP, Krahn MD, Cadarette SM (2013) Direct health-care costs attributed to hip fractures among seniors: a matched cohort study. Osteoporos Int 24(2):659\u2013669","journal-title":"Osteoporos Int"},{"key":"6080_CR33","unstructured":"Wodchis WP, Bushmeneva K, Nikitovic M, McKillop I (2013) Guidelines on person-level costing using administrative databases in Ontario. Working Paper Series, vol 1. Health System Performance Research Network, Ontario"},{"issue":"10","key":"6080_CR34","doi-asserted-by":"publisher","first-page":"e1001885","DOI":"10.1371\/journal.pmed.1001885","volume":"12","author":"EI Benchimol","year":"2015","unstructured":"Benchimol EI, Smeeth L, Guttmann A, Harron K, Moher D, Petersen I et al (2015) The REporting of studies conducted using observational routinely-collected health data (RECORD) statement. PLoS Med 12(10):e1001885","journal-title":"PLoS Med"},{"issue":"1","key":"6080_CR35","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/s12891-021-04051-9","volume":"22","author":"JD Adachi","year":"2021","unstructured":"Adachi JD, Brown JP, Schemitsch E, Tarride JE, Brown V, Bell AD et al (2021) Fragility fracture identifies patients at imminent risk for subsequent fracture: real-world retrospective database study in Ontario, Canada. BMC Musculoskelet Disord 22(1):224","journal-title":"BMC Musculoskelet Disord"},{"key":"6080_CR36","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.bone.2015.02.003","volume":"75","author":"B Sobolev","year":"2015","unstructured":"Sobolev B, Sheehan KJ, Kuramoto L, Guy P (2015) Risk of second hip fracture persists for years after initial trauma. Bone 75:72\u201376","journal-title":"Bone"},{"issue":"1","key":"6080_CR37","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1136\/ard.2008.092775","volume":"68","author":"TA van Geel","year":"2009","unstructured":"van Geel TA, van Helden S, Geusens PP, Winkens B, Dinant GJ (2009) Clinical subsequent fractures cluster in time after first fractures. Ann Rheum Dis 68(1):99\u2013102","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"6080_CR38","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s11657-019-0598-x","volume":"14","author":"JD Adachi","year":"2019","unstructured":"Adachi JD, Berger C, Barron R, Weycker D, Anastassiades TP, Davison KS et al (2019) Predictors of imminent non-vertebral fracture in elderly women with osteoporosis, low bone mass, or a history of fracture, based on data from the population-based Canadian Multicentre Osteoporosis Study (CaMos). Arch Osteoporos 14(1):53","journal-title":"Arch Osteoporos"},{"issue":"1","key":"6080_CR39","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/s11657-020-00784-7","volume":"15","author":"AA Yusuf","year":"2020","unstructured":"Yusuf AA, Hu Y, Chandler D, Crittenden DB, Barron RL (2020) Predictors of imminent risk of fracture in Medicare-enrolled men and women. Arch Osteoporos 15(1):120","journal-title":"Arch Osteoporos"},{"issue":"3","key":"6080_CR40","doi-asserted-by":"publisher","first-page":"e91","DOI":"10.37765\/ajmc.2020.42641","volume":"26","author":"RL Sheer","year":"2020","unstructured":"Sheer RL, Barron RL, Sudharshan L, Pasquale MK (2020) Validated prediction of imminent risk of fracture for older adults. Am J Manage Care 26(3):e91\u2013e97","journal-title":"Am J Manage Care"},{"issue":"9","key":"6080_CR41","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1002\/jbmr.3118","volume":"32","author":"T Tran","year":"2017","unstructured":"Tran T, Bliuc D, van Geel T, Adachi JD, Berger C, van den Bergh J et al (2017) Population-wide impact of non-hip non-vertebral fractures on mortality. J Bone Miner Res 32(9):1802\u20131810","journal-title":"J Bone Miner Res"},{"issue":"7","key":"6080_CR42","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1007\/s00198-015-3104-3","volume":"26","author":"B Sobolev","year":"2015","unstructured":"Sobolev B, Sheehan KJ, Kuramoto L, Guy P (2015) Excess mortality associated with second hip fracture. Osteoporos Int 26(7):1903\u20131910","journal-title":"Osteoporos Int"},{"issue":"10","key":"6080_CR43","doi-asserted-by":"publisher","first-page":"3023","DOI":"10.1007\/s00198-016-3631-6","volume":"27","author":"RB Hopkins","year":"2016","unstructured":"Hopkins RB, Burke N, Von Keyserlingk C, Leslie WD, Morin SN, Adachi JD et al (2016) The current economic burden of illness of osteoporosis in Canada. Osteoporos Int 27(10):3023\u20133032","journal-title":"Osteoporos Int"},{"issue":"11","key":"6080_CR44","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.1007\/s00198-012-1931-z","volume":"23","author":"JE Tarride","year":"2012","unstructured":"Tarride JE, Hopkins RB, Leslie WD, Morin S, Adachi JD, Papaioannou A et al (2012) The burden of illness of osteoporosis in Canada. Osteoporos Int 23(11):2591\u20132600","journal-title":"Osteoporos Int"},{"key":"6080_CR45","unstructured":"Public Health Agency of Canada (2020) Osteoporosis and related fractures in Canada: report from the Canadian Chronic Disease Surveillance System, 2020. https:\/\/www.canada.ca\/en\/public-health\/services\/publications\/diseases-conditions\/osteoporosis-related-fractures-2020.html. Accessed 15 Jan 2021"},{"issue":"6","key":"6080_CR46","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s00198-020-05325-z","volume":"31","author":"SR Cummings","year":"2020","unstructured":"Cummings SR, Eastell R (2020) Stop (mis)classifying fractures as high- or low-trauma or as fragility fractures. Osteoporos Int 31(6):1023\u20131024","journal-title":"Osteoporos Int"},{"issue":"6","key":"6080_CR47","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1007\/s00198-019-05274-2","volume":"31","author":"WD Leslie","year":"2020","unstructured":"Leslie WD, Schousboe JT, Morin SN, Martineau P, Lix LM, Johansson H et al (2020) Fracture risk following high-trauma versus low-trauma fracture: a registry-based cohort study. Osteoporos Int 31(6):1059\u20131067","journal-title":"Osteoporos Int"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-021-06080-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00198-021-06080-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-021-06080-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T09:13:43Z","timestamp":1642065223000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00198-021-06080-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,11]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["6080"],"URL":"https:\/\/doi.org\/10.1007\/s00198-021-06080-5","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,11]]},"assertion":[{"value":"21 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"ES has received consulting fees from Acumed LLC, Amgen, Implants for Trauma Surgery, Pentopharm, Sanofi-Aventis, Smith & Nephew, Stryker, Swemac; received grant\/research support from Amgen, Biocomposites, Smith & Nephew. JDA has received consulting fees from Amgen; received grant\/research support from AbbVie, Amgen, Celgene, Eli Lilly, Pfizer, Radius. JPB has received consulting fees and honoraria from Amgen and Servier; received research funding from Mereo BioPharma, Radius Health, Servier; served on speakers\u2019 bureau for Amgen. JET has received consulting fees from Amgen, Analytica Laser International, AstraZeneca, Bayer, Edwards Lifesciences, Eli Lilly, The European Commission Initiative on Breast Cancer, Evidera, Flatiron, GSK, Merck, Novartis, PCDI Canada, Pfizer, Roche; received grant\/research support from Amgen, Assurex\/Myriad, AstraZeneca, CSL Behring, Edwards Lifesciences, Novo Nordisk, Sage; served on speakers\u2019 bureau for Allergan. TO, NB and LS are employees and own stock in Amgen.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the Advarra Institutional Review Board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Formal consent is not required for this type of study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}