{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:15:16Z","timestamp":1770293716509,"version":"3.49.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20210432"],"award-info":[{"award-number":["Y20210432"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s00198-022-06404-z","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T15:02:48Z","timestamp":1650639768000},"page":"1715-1724","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Associations between bone mineral density and subclinical peripheral arterial disease in elderly men with type 2 diabetes mellitus"],"prefix":"10.1007","volume":"33","author":[{"given":"X.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0639-180X","authenticated-orcid":false,"given":"M.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,22]]},"reference":[{"key":"6404_CR1","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1016\/S0140-6736(06)68891-0","volume":"367","author":"P Sambrook","year":"2006","unstructured":"Sambrook P, Cooper C (2006) Osteoporosis Lancet 367:2010\u20132018. https:\/\/doi.org\/10.1016\/S0140-6736(06)68891-0","journal-title":"Osteoporosis Lancet"},{"key":"6404_CR2","doi-asserted-by":"publisher","unstructured":"(2022) Clinical guidelines for prevention and treatment of type 2 diabetes mellitus in the elderly in China (2022 edition). Chinese Journal of Internal Medicine 61: 12-50https:\/\/doi.org\/10.3760\/cma.j.cn112138-20211027-00751","DOI":"10.3760\/cma.j.cn112138-20211027-00751"},{"key":"6404_CR3","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","volume":"359","author":"SR Cummings","year":"2002","unstructured":"Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359:1761\u20131767. https:\/\/doi.org\/10.1016\/S0140-6736(02)08657-9","journal-title":"Lancet"},{"key":"6404_CR4","doi-asserted-by":"publisher","first-page":"380","DOI":"10.7326\/0003-4819-152-6-201003160-00008","volume":"152","author":"P Haentjens","year":"2010","unstructured":"Haentjens P, Magaziner J, Colon-Emeric CS, Vanderschueren D, Milisen K, Velkeniers B et al (2010) Meta-analysis: excess mortality after hip fracture among older women and men. Ann Intern Med 152:380\u2013390. https:\/\/doi.org\/10.7326\/0003-4819-152-6-201003160-00008","journal-title":"Ann Intern Med"},{"key":"6404_CR5","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1007\/s00198-005-1950-0","volume":"16","author":"AC Feldstein","year":"2005","unstructured":"Feldstein AC, Nichols G, Orwoll E, Elmer PJ, Smith DH, Herson M et al (2005) The near absence of osteoporosis treatment in older men with fractures. Osteoporos Int 16:953\u2013962. https:\/\/doi.org\/10.1007\/s00198-005-1950-0","journal-title":"Osteoporos Int"},{"key":"6404_CR6","doi-asserted-by":"publisher","unstructured":"Research C S o O a B M (2020) Guideline for diagnosis and treatment of osteoprosis in men. CHIN J OSTEOPOROS BONE MINER RES 13: 381-395.https:\/\/doi.org\/10.3969\/j.issn.1674-2591.2020.05.001","DOI":"10.3969\/j.issn.1674-2591.2020.05.001"},{"key":"6404_CR7","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nrendo.2013.171","volume":"9","author":"JS Walsh","year":"2013","unstructured":"Walsh JS, Eastell R (2013) Osteoporosis in men. Nat Rev Endocrinol 9:637\u2013645. https:\/\/doi.org\/10.1038\/nrendo.2013.171","journal-title":"Nat Rev Endocrinol"},{"key":"6404_CR8","doi-asserted-by":"publisher","unstructured":"Research t C S o O a B M (2019) \u4e2d\u56fd\u9aa8\u8d28\u758f\u677e\u75c7\u6d41\u884c\u75c5\u5b66\u8c03\u67e5\u53ca \u201c\u5065\u5eb7\u9aa8\u9abc\u201d\u4e13\u9879\u884c\u52a8\u7ed3\u679c\u53d1\u5e03. CHIN J OSTEOPOROSIS & BONE MINER RES 12: 317-318https:\/\/doi.org\/10.3969\/j.issn.1674-2591.2019.04.001","DOI":"10.3969\/j.issn.1674-2591.2019.04.001"},{"key":"6404_CR9","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/nrendo.2016.153","volume":"13","author":"N Napoli","year":"2017","unstructured":"Napoli N, Chandran M, Pierroz DD, Abrahamsen B, Schwartz AV, Ferrari SL et al (2017) Mechanisms of diabetes mellitus-induced bone fragility. Nat Rev Endocrinol 13:208\u2013219. https:\/\/doi.org\/10.1038\/nrendo.2016.153","journal-title":"Nat Rev Endocrinol"},{"key":"6404_CR10","doi-asserted-by":"publisher","first-page":"m997","DOI":"10.1136\/bmj.m997","volume":"369","author":"Y Li","year":"2020","unstructured":"Li Y, Teng D, Shi X, Qin G, Qin Y, Quan H et al (2020) Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study. BMJ 369:m997. https:\/\/doi.org\/10.1136\/bmj.m997","journal-title":"BMJ"},{"key":"6404_CR11","first-page":"1203","volume":"48","author":"Y Si","year":"2019","unstructured":"Si Y, Wang C, Guo Y, Xu G, Ma Y (2019) Prevalence of Osteoporosis in Patients with Type 2 Diabetes Mellitus in the Chinese Mainland: A Systematic Review and Meta-Analysis. Iran J Public Health 48:1203\u20131214","journal-title":"Iran J Public Health"},{"key":"6404_CR12","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1210\/jc.2011-3045","volume":"97","author":"NB Watts","year":"2012","unstructured":"Watts NB, Adler RA, Bilezikian JP, Drake MT, Eastell R, Orwoll ES et al (2012) Osteoporosis in men: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 97:1802\u20131822. https:\/\/doi.org\/10.1210\/jc.2011-3045","journal-title":"J Clin Endocrinol Metab"},{"key":"6404_CR13","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1007\/s00198-015-3057-6","volume":"26","author":"A Gaudio","year":"2015","unstructured":"Gaudio A, Muratore F, Fiore V, Rapisarda R, Signorelli SS, Fiore CE (2015) Decreased bone cortical density at the forearm in subjects with subclinical peripheral arterial disease. Osteoporos Int 26:1747\u20131753. https:\/\/doi.org\/10.1007\/s00198-015-3057-6","journal-title":"Osteoporos Int"},{"key":"6404_CR14","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00198-006-0253-4","volume":"18","author":"P Vestergaard","year":"2007","unstructured":"Vestergaard P (2007) Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes\u2013a meta-analysis. Osteoporos Int 18:427\u2013444. https:\/\/doi.org\/10.1007\/s00198-006-0253-4","journal-title":"Osteoporos Int"},{"key":"6404_CR15","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/jbmr.556","volume":"27","author":"LM Giangregorio","year":"2012","unstructured":"Giangregorio LM, Leslie WD, Lix LM, Johansson H, Oden A, McCloskey E et al (2012) FRAX underestimates fracture risk in patients with diabetes. J Bone Miner Res 27:301\u2013308. https:\/\/doi.org\/10.1002\/jbmr.556","journal-title":"J Bone Miner Res"},{"key":"6404_CR16","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1093\/eurheartj\/ehx095","volume":"39","author":"V Aboyans","year":"2018","unstructured":"Aboyans V, Ricco JB, Bartelink MEL, Bjorck M, Brodmann M, Cohnert T et al (2018) 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteriesEndorsed by: the European Stroke Organization (ESO)The Task Force for the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS). Eur Heart J 39:763\u2013816. https:\/\/doi.org\/10.1093\/eurheartj\/ehx095","journal-title":"Eur Heart J"},{"key":"6404_CR17","first-page":"103","volume":"21","author":"M Laroche","year":"2003","unstructured":"Laroche M, Moulinier L, Leger P, Lefebvre D, Mazieres B, Boccalon H (2003) Bone mineral decrease in the leg with unilateral chronic occlusive arterial disease. Clin Exp Rheumatol 21:103\u2013106","journal-title":"Clin Exp Rheumatol"},{"key":"6404_CR18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1177\/1358863X16672740","volume":"22","author":"MJ Baldwin","year":"2017","unstructured":"Baldwin MJ, Policha A, Maldonado T, Hiramoto JS, Honig S, Conte MS et al (2017) Novel association between bone mineral density scores and the prevalence of peripheral artery disease in both sexes. Vasc Med (London, England) 22:13\u201320. https:\/\/doi.org\/10.1177\/1358863X16672740","journal-title":"Vasc Med (London, England)"},{"key":"6404_CR19","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1161\/CIRCULATIONAHA.108.820993","volume":"119","author":"TC Collins","year":"2009","unstructured":"Collins TC, Ewing SK, Diem SJ, Taylor BC, Orwoll ES, Cummings SR et al (2009) Peripheral arterial disease is associated with higher rates of hip bone loss and increased fracture risk in older men. Circulation 119:2305\u20132312. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.108.820993","journal-title":"Circulation"},{"key":"6404_CR20","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1007\/s00198-005-1968-3","volume":"16","author":"SY Wong","year":"2005","unstructured":"Wong SY, Kwok T, Woo J, Lynn H, Griffith JF, Leung J et al (2005) Bone mineral density and the risk of peripheral arterial disease in men and women: results from Mr. and Ms Os. Hong Kong Osteoporos Int 16:1933\u20131938. https:\/\/doi.org\/10.1007\/s00198-005-1968-3","journal-title":"Hong Kong Osteoporos Int"},{"key":"6404_CR21","doi-asserted-by":"publisher","unstructured":"Liu J, Zhao L, Yang X, Liu C, Kong N, Yu Y et al (2022) Bone mineral density, bone metabolism-related factors, and microRNA-218 are correlated with disease activities in Chinese ankylosing spondylitis patients. J Clin Lab Anal 36(2):e24223. https:\/\/doi.org\/10.1002\/jcla.24223","DOI":"10.1002\/jcla.24223"},{"key":"6404_CR22","first-page":"45","volume":"5","author":"CE Fiore","year":"2008","unstructured":"Fiore CE, Pennisi P, Tine M (2008) Therapeutic perspectives. Clin Cases Miner Bone Metab 5:45\u201348","journal-title":"Clin Cases Miner Bone Metab"},{"key":"6404_CR23","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s00774-005-0658-8","volume":"24","author":"RA Mangiafico","year":"2006","unstructured":"Mangiafico RA, Russo E, Riccobene S, Pennisi P, Mangiafico M, D\u2019Amico F et al (2006) Increased prevalence of peripheral arterial disease in osteoporotic postmenopausal women. J Bone Miner Metab 24:125\u2013131. https:\/\/doi.org\/10.1007\/s00774-005-0658-8","journal-title":"J Bone Miner Metab"},{"key":"6404_CR24","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1161\/CIR.0b013e31828b82aa","volume":"127","author":"JL Anderson","year":"2013","unstructured":"Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH et al (2013) Management of patients with peripheral artery disease (compilation of 2005 and 2011 ACCF\/AHA guideline recommendations): a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines. Circulation 127:1425\u20131443. https:\/\/doi.org\/10.1161\/CIR.0b013e31828b82aa","journal-title":"Circulation"},{"key":"6404_CR25","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1359\/jbmr.060903","volume":"21","author":"GN Farhat","year":"2006","unstructured":"Farhat GN, Cauley JA, Matthews KA, Newman AB, Johnston J, Mackey R et al (2006) Volumetric BMD and vascular calcification in middle-aged women: the Study of Women\u2019s Health Across the Nation. J Bone Miner Res 21:1839\u20131846. https:\/\/doi.org\/10.1359\/jbmr.060903","journal-title":"J Bone Miner Res"},{"key":"6404_CR26","unstructured":"Kurabayashi M (2016) [Interaction between bone and artery]. Clin Calcium 26:1119\u20131126 CliCa160811191126"},{"key":"6404_CR27","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.2337\/dc21-S002","volume":"44","author":"A American Diabetes","year":"2021","unstructured":"American Diabetes A (2021) 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2021. Diabetes Care 44:S15\u2013S33. https:\/\/doi.org\/10.2337\/dc21-S002","journal-title":"Diabetes Care"},{"key":"6404_CR28","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.hlc.2017.10.014","volume":"27","author":"SM Conte","year":"2018","unstructured":"Conte SM, Vale PR (2018) Peripheral Arterial Disease. Heart Lung Circ 27:427\u2013432. https:\/\/doi.org\/10.1016\/j.hlc.2017.10.014","journal-title":"Heart Lung Circ"},{"key":"6404_CR29","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.jocd.2019.07.001","volume":"22","author":"CR Shuhart","year":"2019","unstructured":"Shuhart CR, Yeap SS, Anderson PA, Jankowski LG, Lewiecki EM, Morse LR et al (2019) Executive Summary of the 2019 ISCD Position Development Conference on Monitoring Treatment, DXA Cross-calibration and Least Significant Change, Spinal Cord Injury, Peri-prosthetic and Orthopedic Bone Health, Transgender Medicine, and Pediatrics. J Clin Densitom 22:453\u2013471. https:\/\/doi.org\/10.1016\/j.jocd.2019.07.001","journal-title":"J Clin Densitom"},{"key":"6404_CR30","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/1753-0407.12474","volume":"9","author":"SL Yang","year":"2017","unstructured":"Yang SL, Zhu LY, Han R, Sun LL, Li JX, Dou JT (2017) Pathophysiology of peripheral arterial disease in diabetes mellitus. J Diabetes 9:133\u2013140. https:\/\/doi.org\/10.1111\/1753-0407.12474","journal-title":"J Diabetes"},{"key":"6404_CR31","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s12020-014-0292-0","volume":"48","author":"M Yamauchi","year":"2015","unstructured":"Yamauchi M, Yamaguchi T, Nawata K, Tanaka K, Takaoka S, Sugimoto T (2015) Increased low-density lipoprotein cholesterol level is associated with non-vertebral fractures in postmenopausal women. Endocrine 48:279\u2013286. https:\/\/doi.org\/10.1007\/s12020-014-0292-0","journal-title":"Endocrine"},{"key":"6404_CR32","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s00223-006-0052-0","volume":"79","author":"GN Farhat","year":"2006","unstructured":"Farhat GN, Strotmeyer ES, Newman AB, Sutton-Tyrrell K, Bauer DC, Harris T et al (2006) Volumetric and areal bone mineral density measures are associated with cardiovascular disease in older men and women: the health, aging, and body composition study. Calcif Tissue Int 79:102\u2013111","journal-title":"Calcif Tissue Int"},{"key":"6404_CR33","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.atherosclerosis.2009.09.011","volume":"209","author":"JA Hyder","year":"2010","unstructured":"Hyder JA, Allison MA, Barrett-Connor E, Detrano R, Wong ND, Sirlin C et al (2010) Bone mineral density and atherosclerosis: the Multi-Ethnic Study of Atherosclerosis, Abdominal Aortic Calcium Study. Atherosclerosis 209:283\u2013289. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2009.09.011","journal-title":"Atherosclerosis"},{"key":"6404_CR34","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1210\/jc.2013-2572","volume":"99","author":"D-K Liang","year":"2014","unstructured":"Liang D-K, Bai X-J, Wu B, Han L-L, Wang X-N, Yang J et al (2014) Associations between bone mineral density and subclinical atherosclerosis: a cross-sectional study of a Chinese population. J Clin Endocrinol Metab 99:469\u2013477. https:\/\/doi.org\/10.1210\/jc.2013-2572","journal-title":"J Clin Endocrinol Metab"},{"key":"6404_CR35","doi-asserted-by":"publisher","first-page":"790","DOI":"10.3978\/j.issn.2072-1439.2015.04.47","volume":"7","author":"Y-Q Wang","year":"2015","unstructured":"Wang Y-Q, Yang P-T, Yuan H, Cao X, Zhu X-L, Xu G et al (2015) Low bone mineral density is associated with increased arterial stiffness in participants of a health records based study. J Thorac Dis 7:790\u2013798. https:\/\/doi.org\/10.3978\/j.issn.2072-1439.2015.04.47","journal-title":"J Thorac Dis"},{"key":"6404_CR36","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1007\/s00223-007-9079-0","volume":"81","author":"JR Shaffer","year":"2007","unstructured":"Shaffer JR, Kammerer CM, Rainwater DL, O\u2019Leary DH, Bruder JM, Bauer RL et al (2007) Decreased bone mineral density is correlated with increased subclinical atherosclerosis in older, but not younger, Mexican American women and men: the San Antonio Family Osteoporosis Study. Calcif Tissue Int 81:430\u2013441. https:\/\/doi.org\/10.1007\/s00223-007-9079-0","journal-title":"Calcif Tissue Int"},{"key":"6404_CR37","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1007\/s00198-009-0912-3","volume":"20","author":"D von Muhlen","year":"2009","unstructured":"von Muhlen D, Allison M, Jassal SK, Barrett-Connor E (2009) Peripheral arterial disease and osteoporosis in older adults: the Rancho Bernardo Study. Osteoporos Int 20:2071\u20132078. https:\/\/doi.org\/10.1007\/s00198-009-0912-3","journal-title":"Osteoporos Int"},{"key":"6404_CR38","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s00223-001-2076-9","volume":"70","author":"M van der Klift","year":"2002","unstructured":"van der Klift M, Pols HA, Hak AE, Witteman JC, Hofman A, de Laet CE (2002) Bone mineral density and the risk of peripheral arterial disease: the Rotterdam Study. Calcif Tissue Int 70:443\u2013449. https:\/\/doi.org\/10.1007\/s00223-001-2076-9","journal-title":"Calcif Tissue Int"},{"key":"6404_CR39","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1007\/s00198-008-0712-1","volume":"19","author":"JA Kanis","year":"2008","unstructured":"Kanis JA, McCloskey EV, Johansson H, Strom O, Borgstrom F, Oden A et al (2008) Case finding for the management of osteoporosis with FRAX\u2013assessment and intervention thresholds for the UK. Osteoporos Int 19:1395\u20131408. https:\/\/doi.org\/10.1007\/s00198-008-0712-1","journal-title":"Osteoporos Int"},{"key":"6404_CR40","first-page":"1","volume":"6","author":"M de Almeida Pereira Coutinho","year":"2013","unstructured":"de Almeida Pereira Coutinho M, Bandeira E, de Almeida JM, Godoi ET, Vasconcelos G, Bandeira F (2013) Low Bone Mass is Associated with Increased Carotid Intima Media Thickness in Men with Type 2 Diabetes Mellitus. Clin Med Insights Endocrinol Diabetes 6:1\u20136","journal-title":"Clin Med Insights Endocrinol Diabetes"},{"key":"6404_CR41","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/nrrheum.2012.120","volume":"8","author":"CE Lampropoulos","year":"2012","unstructured":"Lampropoulos CE, Papaioannou I, D\u2019Cruz DP (2012) Osteoporosis\u2013a risk factor for cardiovascular disease? Nat Rev Rheumatol 8:587\u2013598. https:\/\/doi.org\/10.1038\/nrrheum.2012.120","journal-title":"Nat Rev Rheumatol"},{"key":"6404_CR42","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.1210\/jc.2008-2498","volume":"94","author":"AV Schwartz","year":"2009","unstructured":"Schwartz AV, Garnero P, Hillier TA, Sellmeyer DE, Strotmeyer ES, Feingold KR et al (2009) Pentosidine and increased fracture risk in older adults with type 2 diabetes. J Clin Endocrinol Metab 94:2380\u20132386. https:\/\/doi.org\/10.1210\/jc.2008-2498","journal-title":"J Clin Endocrinol Metab"},{"key":"6404_CR43","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.lfs.2004.09.010","volume":"76","author":"Q Dan","year":"2004","unstructured":"Dan Q, Wong R, Chung SK, Chung SS, Lam KS (2004) Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion. Life Sci 76:445\u2013459. https:\/\/doi.org\/10.1016\/j.lfs.2004.09.010","journal-title":"Life Sci"},{"key":"6404_CR44","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1002\/jbmr.2083","volume":"29","author":"P Srikanthan","year":"2014","unstructured":"Srikanthan P, Crandall CJ, Miller-Martinez D, Seeman TE, Greendale GA, Binkley N et al (2014) Insulin resistance and bone strength: findings from the study of midlife in the United States. J Bone Miner Res 29:796\u2013803. https:\/\/doi.org\/10.1002\/jbmr.2083","journal-title":"J Bone Miner Res"},{"key":"6404_CR45","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1177\/0022034513485600","volume":"92","author":"SN Pramojanee","year":"2013","unstructured":"Pramojanee SN, Phimphilai M, Kumphune S, Chattipakorn N, Chattipakorn SC (2013) Decreased jaw bone density and osteoblastic insulin signaling in a model of obesity. J Dent Res 92:560\u2013565. https:\/\/doi.org\/10.1177\/0022034513485600","journal-title":"J Dent Res"},{"key":"6404_CR46","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.2337\/db15-1552","volume":"65","author":"T Scherer","year":"2016","unstructured":"Scherer T, Lindtner C, O\u2019Hare J, Hackl M, Zielinski E, Freudenthaler A et al (2016) Insulin Regulates Hepatic Triglyceride Secretion and Lipid Content via Signaling in the Brain. Diabetes 65:1511\u20131520. https:\/\/doi.org\/10.2337\/db15-1552","journal-title":"Diabetes"},{"key":"6404_CR47","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1016\/j.jacc.2005.12.054","volume":"47","author":"DV Anand","year":"2006","unstructured":"Anand DV, Lahiri A, Lim E, Hopkins D, Corder R (2006) The relationship between plasma osteoprotegerin levels and coronary artery calcification in uncomplicated type 2 diabetic subjects. J Am Coll Cardiol 47:1850\u20131857. https:\/\/doi.org\/10.1016\/j.jacc.2005.12.054","journal-title":"J Am Coll Cardiol"},{"key":"6404_CR48","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.acvd.2015.01.015","volume":"108","author":"A Esteghamati","year":"2015","unstructured":"Esteghamati A, Aflatoonian M, Rad MV, Mazaheri T, Mousavizadeh M, Nakhjavani M et al (2015) Association of osteoprotegerin with peripheral artery disease in patients with type 2 diabetes. Arch Cardiovasc Dis 108:412\u2013419. https:\/\/doi.org\/10.1016\/j.acvd.2015.01.015","journal-title":"Arch Cardiovasc Dis"},{"key":"6404_CR49","doi-asserted-by":"publisher","first-page":"3540","DOI":"10.1073\/pnas.96.7.3540","volume":"96","author":"H Hsu","year":"1999","unstructured":"Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E et al (1999) Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci U S A 96:3540\u20133545. https:\/\/doi.org\/10.1073\/pnas.96.7.3540","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6404_CR50","doi-asserted-by":"publisher","first-page":"20659","DOI":"10.1074\/jbc.M010153200","volume":"276","author":"P Collin-Osdoby","year":"2001","unstructured":"Collin-Osdoby P, Rothe L, Anderson F, Nelson M, Maloney W, Osdoby P (2001) Receptor activator of NF-kappa B and osteoprotegerin expression by human microvascular endothelial cells, regulation by inflammatory cytokines, and role in human osteoclastogenesis. J Biol Chem 276:20659\u201320672. https:\/\/doi.org\/10.1074\/jbc.M010153200","journal-title":"J Biol Chem"},{"key":"6404_CR51","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1007\/s00198-009-1035-6","volume":"21","author":"L Jorgensen","year":"2010","unstructured":"Jorgensen L, Vik A, Emaus N, Brox J, Hansen JB, Mathiesen E et al (2010) Bone loss in relation to serum levels of osteoprotegerin and nuclear factor-kappaB ligand: the Tromso Study. Osteoporos Int 21:931\u2013938. https:\/\/doi.org\/10.1007\/s00198-009-1035-6","journal-title":"Osteoporos Int"},{"key":"6404_CR52","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1530\/EJE-06-0753","volume":"156","author":"A Stern","year":"2007","unstructured":"Stern A, Laughlin GA, Bergstrom J, Barrett-Connor E (2007) The sex-specific association of serum osteoprotegerin and receptor activator of nuclear factor kappaB legend with bone mineral density in older adults: the Rancho Bernardo study. Eur J Endocrinol 156:555\u2013562. https:\/\/doi.org\/10.1530\/EJE-06-0753","journal-title":"Eur J Endocrinol"},{"key":"6404_CR53","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1024\/0301-1526\/a000640","volume":"46","author":"A Pleskovic","year":"2017","unstructured":"Pleskovic A, Ramus SM, Praznikar ZJ, Santl Letonja M, Cokan Vujkovac A, Gazdikova K et al (2017) Polymorphism rs2073618 of the osteoprotegerin gene as a potential marker of subclinical carotid atherosclerosis in Caucasians with type 2 diabetes mellitus. Vasa 46:355\u2013362. https:\/\/doi.org\/10.1024\/0301-1526\/a000640","journal-title":"Vasa"},{"key":"6404_CR54","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.maturitas.2010.07.013","volume":"67","author":"P Pennisi","year":"2010","unstructured":"Pennisi P, Russo E, Gaudio A, Veca R, D\u2019Amico F, Mangiafico RA et al (2010) The association between carotid or femoral atherosclerosis and low bone mass in postmenopausal women referred for osteoporosis screening. Does osteoprotegerin play a role? Maturitas 67:358\u2013362. https:\/\/doi.org\/10.1016\/j.maturitas.2010.07.013","journal-title":"Maturitas"},{"key":"6404_CR55","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1161\/01.CIR.0000127957.43874.BB","volume":"109","author":"S Kiechl","year":"2004","unstructured":"Kiechl S, Schett G, Wenning G, Redlich K, Oberhollenzer M, Mayr A et al (2004) Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease. Circulation 109:2175\u20132180. https:\/\/doi.org\/10.1161\/01.CIR.0000127957.43874.BB","journal-title":"Circulation"},{"key":"6404_CR56","doi-asserted-by":"publisher","first-page":"4104","DOI":"10.1210\/jc.2003-031432","volume":"89","author":"M Schoppet","year":"2004","unstructured":"Schoppet M, Al-Fakhri N, Franke FE, Katz N, Barth PJ, Maisch B et al (2004) Localization of osteoprotegerin, tumor necrosis factor-related apoptosis-inducing ligand, and receptor activator of nuclear factor-kappaB ligand in Monckeberg\u2019s sclerosis and atherosclerosis. J Clin Endocrinol Metab 89:4104\u20134112. https:\/\/doi.org\/10.1210\/jc.2003-031432","journal-title":"J Clin Endocrinol Metab"},{"key":"6404_CR57","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.cardiores.2007.07.017","volume":"76","author":"SH Mangan","year":"2007","unstructured":"Mangan SH, Van Campenhout A, Rush C, Golledge J (2007) Osteoprotegerin upregulates endothelial cell adhesion molecule response to tumor necrosis factor-alpha associated with induction of angiopoietin-2. Cardiovasc Res 76:494\u2013505. https:\/\/doi.org\/10.1016\/j.cardiores.2007.07.017","journal-title":"Cardiovasc Res"},{"key":"6404_CR58","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/BF02243003","volume":"13","author":"M Laroche","year":"1994","unstructured":"Laroche M, Pouilles JM, Ribot C, Bendayan P, Bernard J, Boccalon H et al (1994) Comparison of the bone mineral content of the lower limbs in men with ischaemic atherosclerotic disease. Clin Rheumatol 13:611\u2013614. https:\/\/doi.org\/10.1007\/BF02243003","journal-title":"Clin Rheumatol"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-022-06404-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00198-022-06404-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-022-06404-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T17:10:16Z","timestamp":1663866616000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00198-022-06404-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,22]]},"references-count":58,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["6404"],"URL":"https:\/\/doi.org\/10.1007\/s00198-022-06404-z","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,22]]},"assertion":[{"value":"25 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Medical Ethics Review Committees of the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The requirement of informed consent was waived due to the retrospective design of the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Xiumeng Zhang, Yu Xu, Feida Li, and Mochuan Chen declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}