{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:08:23Z","timestamp":1790874503536,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1007\/s00198-022-06629-y","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T07:08:57Z","timestamp":1671174537000},"page":"489-499","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Primary hyperparathyroidism and fracture probability"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-4326","authenticated-orcid":false,"given":"John A.","family":"Kanis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas C.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enwu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"Vandenput","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Lorentzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene V.","family":"McCloskey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Bouillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Abrahamsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Rejnmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Danish Primary Hyperparathyroidism Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Sikj\u00e6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Rolighed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette Friberg","family":"Hitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Eiken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Pernille","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens-Erik Beck","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise Sofie","family":"Bislev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"6629_CR1","doi-asserted-by":"publisher","first-page":"3993","DOI":"10.1210\/jc.2018-01225","volume":"103","author":"JP Bilezikian","year":"2018","unstructured":"Bilezikian JP (2018) Primary hyperparathyroidism. J Clin Endocrinol Metab 103:3993\u20134004","journal-title":"J Clin Endocrinol Metab"},{"key":"6629_CR2","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1210\/jc.2014-1413","volume":"99","author":"JP Bilezikian","year":"2014","unstructured":"Bilezikian JP, Brandi ML, Eastell R, Silverberg SJ, Udelsman R, Marcocci C, Potts JT Jr (2014) Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the fourth international workshop. J Clin Endocrinol Metab 99:3561\u20133569","journal-title":"J Clin Endocrinol Metab"},{"key":"6629_CR3","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1001\/jamasurg.2016.2310","volume":"151","author":"SM Wilhelm","year":"2016","unstructured":"Wilhelm SM, Wang TS, Ruan DT, Lee JA, Asa SL, Duh QY, Doherty GM, Herrera MF, Pasieka JL, Perrier ND, Silverberg SJ, Sol\u00f3rzano CC, Sturgeon C, Tublin ME, Udelsman R, Carty SE (2016) The American Association of Endocrine Surgeons guidelines for definitive management of primary hyperparathyroidism. JAMA Surg 151:959\u2013968","journal-title":"JAMA Surg"},{"key":"6629_CR4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1001\/jamainternmed.2021.6437","volume":"182","author":"CD Seib","year":"2022","unstructured":"Seib CD, Meng T, Suh I, Harris AHS, Covinsky KE, Shoback DM, Trickey AW, Kebebew E, Tamura MK (2022) Risk of fracture among older adults with primary hyperparathyroidism receiving parathyroidectomy vs nonoperative management. JAMA Intern Med 182:10\u201318. https:\/\/doi.org\/10.1001\/jamainternmed.2021.6437","journal-title":"JAMA Intern Med"},{"key":"6629_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00198-016-3716-2","volume":"28","author":"AA Khan","year":"2017","unstructured":"Khan AA, Hanley DA, Rizzoli R, Bollerslev J, Young JE, Rejnmark L, Thakker R, D\u2019Amour P, Paul T, Van Uum S, Shrayyef MZ, Goltzman D, Kaiser S, Cusano NE, Bouillon R, Mosekilde L, Kung AW, Rao SD, Bhadada SK, Clarke BL, Liu J, Duh Q, Lewiecki EM, Bandeira F, Eastell R, Marcocci C, Silverberg SJ, Udelsman R, Davison KS, Potts JT Jr, Brandi ML, Bilezikian JP (2017) Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus. Osteoporos Int 28:1\u201319","journal-title":"Osteoporos Int"},{"key":"6629_CR6","doi-asserted-by":"publisher","unstructured":"Bilezikian JP, Silverberg SJ, Bandeira F, Cetani F, Chandran M, Cusano NE, Ebeling PR, Formenti AM, Frost M, Gosnell J, Lewiecki EM, Singer FR, Gittoes N, Khan AA, Marcocci C, Rejnmark L, Ye Z, Guyatt G, Potts JT (2022) Task Force #8: Management of primary hyperparathyroidism. J Bone Miner Res https:\/\/doi.org\/10.1002\/jbmr.4682","DOI":"10.1002\/jbmr.4682"},{"key":"6629_CR7","unstructured":"Kanis JA on behalf of the World Health Organization Scientific Group (2007) Assessment of osteoporosis at the primary health-care level. Technical Report. WHO Collaborating Centre, University of Sheffield, UK. Available at https:\/\/www.sheffield.ac.uk\/FRAX\/pdfs\/WHO_Technical_Report.pdf, accessed 4 April 2022"},{"key":"6629_CR8","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1007\/s11657-018-0510-0","volume":"13","author":"JA Kanis","year":"2018","unstructured":"Kanis JA, Johansson H, Harvey NC, McCloskey EV (2018) A brief history of FRAX. Arch Osteoporos 13:118. https:\/\/doi.org\/10.1007\/s11657-018-0510-0","journal-title":"Arch Osteoporos"},{"key":"6629_CR9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11657-016-0278-z","volume":"11","author":"Kanis JA, Harvey NC, Cooper C, Johansson H, Od\u00e9n A, McCloskey EV; Advisory Board of the National Osteoporosis Guideline Group","year":"2016","unstructured":"Kanis JA, Harvey NC, Cooper C, Johansson H, Od\u00e9n A, McCloskey EV; Advisory Board of the National Osteoporosis Guideline Group (2016) A systematic review of intervention thresholds based on FRAX: a report prepared for the National Osteoporosis Guideline Group and the International Osteoporosis Foundation. Arch Osteoporos 11:25. https:\/\/doi.org\/10.1007\/s11657-016-0278-z","journal-title":"Arch Osteoporos"},{"key":"6629_CR10","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1007\/s00198-021-05822-9","volume":"32","author":"H Ejlsmark-Svensson","year":"2021","unstructured":"Ejlsmark-Svensson H, Rolighed L, Harsl\u00f8f T, Rejnmark L (2021) Risk of fractures in primary hyperparathyroidism: a systematic review and meta-analysis. Osteoporos Int 32:1053\u20131060","journal-title":"Osteoporos Int"},{"issue":"6","key":"6629_CR11","doi-asserted-by":"publisher","first-page":"e2215396","DOI":"10.1001\/jamanetworkopen.2022.15396","volume":"5","author":"KF Axelsson","year":"2022","unstructured":"Axelsson KF, Wallander M, Johansson H, Harvey N, Vandenput L, McCloskey E, Liu E, Kanis JA, Litsne H, Lorentzon M (2022) Analysis of comorbidities, clinical outcomes, and parathyroidectomy in adults with primary hyperparathyroidism. J Am Med Assoc Network Open 5(6):e2215396. https:\/\/doi.org\/10.1001\/jamanetworkopen.2022.15396. (Jun 1)","journal-title":"J Am Med Assoc Network Open"},{"key":"6629_CR12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1365-2265.2009.03766.x","volume":"73","author":"N Yu","year":"2010","unstructured":"Yu N, Donnan PT, Flynn RW, Murphy MJ, Smith D, Rudman A, Leese GP (2010) Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS). Clin Endocrinol (Oxf) 73:30\u201334","journal-title":"Clin Endocrinol (Oxf)"},{"key":"6629_CR13","doi-asserted-by":"publisher","first-page":"116099","DOI":"10.1016\/j.bone.2021.116099","volume":"152","author":"RA Wermers","year":"2021","unstructured":"Wermers RA, Griebeler ML, Thapa P, Hathcock MA, Kearns AE (2021) Survival in primary hyperparathyroidism over five decades (1965\u20132010) a population-based retrospective study. Bone 152:116099. https:\/\/doi.org\/10.1016\/j.bone.2021.116099","journal-title":"Bone"},{"key":"6629_CR14","doi-asserted-by":"publisher","first-page":"449","DOI":"10.2147\/CLEP.S91125","volume":"7","author":"M Schmidt","year":"2015","unstructured":"Schmidt M, Schmidt SA, Sandegaard JL, Ehrenstein V, Pedersen L, Sorensen HT (2015) The Danish National Patient Registry: a review of content, data quality, and research potential. Clin Epidemiol 7:449\u201390","journal-title":"Clin Epidemiol"},{"issue":"1","key":"6629_CR15","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12902-021-00918-z","volume":"22","author":"J Matzen","year":"2022","unstructured":"Matzen J, Bislev LS, Sikj\u00e6r T, Rolighed L, Hitz MF, Eiken P, Hermann AP, Jensen JB, Abrahamsen B, Rejnmark L (2022) The effect of parathyroidectomy compared to non-surgical surveillance on kidney function in primary hyperparathyroidism: a nationwide historic cohort study. BMC Endocr Disord 22(1):14. https:\/\/doi.org\/10.1186\/s12902-021-00918-z. (Jan 6)","journal-title":"BMC Endocr Disord"},{"key":"6629_CR16","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1359\/jbmr.2002.17.7.1237","volume":"17","author":"JA Kanis","year":"2002","unstructured":"Kanis JA, Johnell O, De Laet C, Jonsson B, Oden A, Oglesby A (2002) International variations in hip fracture probabilities: implications for risk assessment. J Bone Miner Res 17:1237\u20131244","journal-title":"J Bone Miner Res"},{"key":"6629_CR17","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1210\/jc.2015-3951","volume":"101","author":"K Albertsson-Wikland","year":"2016","unstructured":"Albertsson-Wikland K, M\u00e5rtensson A, S\u00e4vendahl L, Niklasson A, Bang P, Dahlgren J, Gustafsson J, Kristr\u00f6m B, Norgren S, Pehrsson NG, Od\u00e9n A (2016) Mortality Is not Increased in recombinant human growth hormone-treated patients when adjusting for birth characteristics. J Clin Endocrinol Metab 101:2149\u20132159","journal-title":"J Clin Endocrinol Metab"},{"key":"6629_CR18","unstructured":"Breslow NE, Day NE (1987) Statistical methods in cancer research. Volume II--The design and analysis of cohort studies. IARC Sci Publ: 1\u2013406"},{"key":"6629_CR19","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s00198-007-0543-5","volume":"19","author":"JA Kanis","year":"2008","unstructured":"Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E (2008) FRAX\u2122 and the assessment of fracture probability in men and women from the UK. Osteoporos Int 19:385\u2013397","journal-title":"Osteoporos Int"},{"key":"6629_CR20","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1359\/jbmr.1999.14.10.1700","volume":"14","author":"S Khosla","year":"1999","unstructured":"Khosla S, Melton LJ 3rd, Wermers RA, Crowson CS, Wm O, Bl R (1999) Primary hyperparathyroidism and the risk of fracture: a population-based study. J Bone Miner Res 14:1700\u20131707","journal-title":"J Bone Miner Res"},{"key":"6629_CR21","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1210\/jc.2008-2006","volume":"94","author":"E Vignali","year":"2009","unstructured":"Vignali E, Viccica G, Diacinti D, Cetani F, Cianferotti L, Ambrogini E, Banti C, Del Fiacco R, Bilezikian JP, Pinchera A, Marcocci C (2009) Morphometric vertebral fractures in postmenopausal women with primary hyperparathyroidism. J Clin Endocrinol Metab 94:2306\u20132312","journal-title":"J Clin Endocrinol Metab"},{"key":"6629_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2265.2007.03162.x","volume":"69","author":"L Mosekilde","year":"2008","unstructured":"Mosekilde L (2008) Primary hyperparathyroidism and the skeleton. Clin Endocrinol (Oxf) 69:1\u201319","journal-title":"Clin Endocrinol (Oxf)"},{"key":"6629_CR23","first-page":"415","volume":"155","author":"S De Geronimo","year":"2006","unstructured":"De Geronimo S, Romagnoli E, Diacinti D, D\u2019Erasmo E, Minisola S (2006) The risk of fractures in postmenopausal women with primary hyperparathyroidism Eur. J Endocrinol 155:415\u2013420","journal-title":"J Endocrinol"},{"key":"6629_CR24","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1007\/s00198-020-05803-4","volume":"32","author":"JA Kanis","year":"2021","unstructured":"Kanis JA, Johansson H, Harvey NC, Gudnason V, Sigurdsson G, Siggeirsdottir K, Lorentzon M, Liu M, Vandenput L, McCloskey E (2021) The effect on subsequent fracture risk of age, sex and prior fracture site by recency of prior fracture. Osteoporos Int 32:1547\u20131555","journal-title":"Osteoporos Int"},{"key":"6629_CR25","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1002\/jbmr.1841","volume":"28","author":"EM Stein","year":"2013","unstructured":"Stein EM, Silva BC, Boutroy S, Zhou B, Wang J, Udesky J, Zhang C, McMahon DJ, Romano M, Dworakowski E, Costa AG, Cusano N, Irani D, Cremers S, Shane E, Guo XE, Bilezikian JP (2013) Primary hyperparathyroidism is associated with abnormal cortical and trabecular microstructure and reduced bone stiffness in postmenopausal women. J Bone Miner Res 28:1029\u20131040","journal-title":"J Bone Miner Res"},{"key":"6629_CR26","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1002\/jbmr.2176","volume":"29","author":"BC Silva","year":"2014","unstructured":"Silva BC, Leslie WD, Resch H, Lamy O, Lesnyak O, Binkley N, McCloskey EV, Kanis JA, Bilezikian JP (2014) Trabecular bone score: a non-invasive analytical method based upon the DXA image. J Bone Miner Res 29:518\u2013530","journal-title":"J Bone Miner Res"},{"key":"6629_CR27","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.bone.2012.11.041","volume":"53","author":"E Romagnoli","year":"2013","unstructured":"Romagnoli E, Cipriani C, Nofroni I, Castro C, Angelozzi M, Scarpiello A, Pepe J, Diacinti D, Piemonte S, Carnevale V, Minisola S (2013) \u201cTrabecular Bone Score\u201d (TBS): an indirect measure of bone micro-architecture in postmenopausal patients with primary hyperparathyroidism. Bone 53:154\u2013159","journal-title":"Bone"},{"issue":"6","key":"6629_CR28","doi-asserted-by":"publisher","first-page":"812","DOI":"10.7326\/M21-4416","volume":"175","author":"M Pretorius","year":"2020","unstructured":"Pretorius M, Lundstam K, Heck A, Fagerland MW, Godang K, Mollerup C, Fougner SL, Pernow Y, Aas T, Hessman O, Ros\u00e9n T, Nordenstr\u00f6m J, Jansson S, Hellstr\u00f6m M, Bollerslev J (2020) Mortality and morbidity in mild primary hyperparathyroidism: results from a 10-year prospective randomized controlled trial of parathyroidectomy versus observation. Ann Intern Med 175(6):812\u2013819","journal-title":"Ann Intern Med"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-022-06629-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00198-022-06629-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-022-06629-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T23:25:08Z","timestamp":1701559508000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00198-022-06629-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,16]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["6629"],"URL":"https:\/\/doi.org\/10.1007\/s00198-022-06629-y","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742455351.793597539","asserted-by":"object"}]},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,16]]},"assertion":[{"value":"8 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"JA Kanis led the team that developed FRAX as director of the WHO Collaborating Centre for Metabolic Bone Diseases. EV McCloskey, WD Leslie, M Lorentzon, NC Harvey, E Liu, L Vandenput, and H Johansson are members of the FRAX team. JA Kanis reports no additional competing interests. NC Harvey has received consultancy\/lecture fees\/honoraria\/grant funding from Alliance for Better Bone Health, Amgen, MSD, Eli Lilly, Radius Health, Servier, Shire, UCB, Consilient Healthcare, and Internis Pharma. M Lorentzon has received lecture fees from Amgen, Lilly, Meda, Renapharma, and UCB Pharma and consulting fees from Amgen, Radius Health, UCB Pharma, Renapharma, and Consilient Health, all outside the presented work. EV McCloskey has received consultancy\/lecture fees\/grant funding\/honoraria from AgNovos, Amgen, AstraZeneca, Consilient Healthcare, Fresenius Kabi, Gilead, GSK, Hologic, Internis, Lilly, Merck, Novartis, Pfizer, Radius Health, Redx Oncology, Roche, Sanofi Aventis, UCB, ViiV, Warner Chilcott, and I3 Innovus. E Liu, L Vandenput and H Johansson declare no competing interests in relation to this work. R Bouillon has received lecture fees from FAES Farma (Spain) and Abiogen (Italy). B Abrahamsen has received consultancy\/lecture fees\/grant funding\/honoraria from Amgen, Gedeon Richter, Kyowa-Kirin, Novartis, Pharmacosmos, and UCB. L Rejnmark has received consultancy\/lecture fees\/grant funding\/honoraria from Takeda Pharma, Ascendis Pharma, and Kyowa-Kirin International.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}