{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:45:12Z","timestamp":1792691112070,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI22C0049"],"award-info":[{"award-number":["HI22C0049"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s00198-025-07574-2","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T05:22:26Z","timestamp":1751952146000},"page":"1951-1963","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fracture risks in patients aged 50 years and older with panhypopituitarism: a nationwide cohort study"],"prefix":"10.1007","volume":"36","author":[{"given":"Seung Shin","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunmook","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Ho","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jeong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hye","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Wan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Soo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Hwy","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangsoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1932-0234","authenticated-orcid":false,"given":"Jung Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"7574_CR1","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1046\/j.1365-2265.2001.01406.x","volume":"55","author":"M Regal","year":"2001","unstructured":"Regal M, P\u00e1ramo C, Sierra SM, Garcia-Mayor RV (2001) Prevalence and incidence of hypopituitarism in an adult Caucasian population in northwestern Spain. Clin Endocrinol (Oxf) 55:735\u2013740","journal-title":"Clin Endocrinol (Oxf)"},{"key":"7574_CR2","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1210\/er.2009-0033","volume":"31","author":"M Sherlock","year":"2010","unstructured":"Sherlock M, Ayuk J, Tomlinson JW, Toogood AA, Aragon-Alonso A, Sheppard MC, Bates AS, Stewart PM (2010) Mortality in patients with pituitary disease. Endocr Rev 31:301\u2013342","journal-title":"Endocr Rev"},{"key":"7574_CR3","first-page":"1420","volume":"85","author":"B Nilsson","year":"2000","unstructured":"Nilsson B, Gustavasson-Kadaka E, Bengtsson BA, Jonsson B (2000) Pituitary adenomas in Sweden between 1958 and 1991: incidence, survival, and mortality. J Clin Endocrinol Metab 85:1420\u20131425","journal-title":"J Clin Endocrinol Metab"},{"key":"7574_CR4","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1016\/S0140-6736(16)30053-8","volume":"388","author":"CE Higham","year":"2016","unstructured":"Higham CE, Johannsson G, Shalet SM (2016) Hypopituitarism Lancet 388:2403\u20132415","journal-title":"Hypopituitarism Lancet"},{"key":"7574_CR5","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/0140-6736(90)91812-O","volume":"336","author":"T Ros\u00e9n","year":"1990","unstructured":"Ros\u00e9n T, Bengtsson BA (1990) Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 336:285\u2013288","journal-title":"Lancet"},{"key":"7574_CR6","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1046\/j.1365-2265.1997.d01-1749.x","volume":"46","author":"B B\u00fclow","year":"1997","unstructured":"B\u00fclow B, Hagmar L, Mikoczy Z, Nordstr\u00f6m CH, Erfurth EM (1997) Increased cerebrovascular mortality in patients with hypopituitarism. Clin Endocrinol (Oxf) 46:75\u201381","journal-title":"Clin Endocrinol (Oxf)"},{"key":"7574_CR7","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1056\/NEJMcp1513724","volume":"374","author":"DM Black","year":"2016","unstructured":"Black DM, Rosen CJ (2016) Clinical Practice. Postmenopausal Osteoporosis N Engl J Med 374:254\u2013262","journal-title":"Postmenopausal Osteoporosis N Engl J Med"},{"key":"7574_CR8","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1001\/jama.2009.50","volume":"301","author":"D Bliuc","year":"2009","unstructured":"Bliuc D, Nguyen ND, Milch VE, Nguyen TV, Eisman JA, Center JR (2009) Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA 301:513\u2013521","journal-title":"JAMA"},{"key":"7574_CR9","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1002\/jbmr.3118","volume":"32","author":"T Tran","year":"2017","unstructured":"Tran T, Bliuc D, van Geel T et al (2017) Population-Wide Impact of Non-Hip Non-Vertebral Fractures on Mortality. J Bone Miner Res 32:1802\u20131810","journal-title":"J Bone Miner Res"},{"key":"7574_CR10","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1007\/s00198-012-2225-1","volume":"24","author":"LJ Melton 3rd","year":"2013","unstructured":"Melton LJ 3rd, Achenbach SJ, Atkinson EJ, Therneau TM, Amin S (2013) Long-term mortality following fractures at different skeletal sites: a population-based cohort study. Osteoporos Int 24:1689\u20131696","journal-title":"Osteoporos Int"},{"key":"7574_CR11","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1359\/jbmr.2001.16.2.398","volume":"16","author":"C W\u00fcster","year":"2001","unstructured":"W\u00fcster C, Abs R, Bengtsson BA, Bennmarker H, Feldt-Rasmussen U, Hernberg-St\u00e5hl E, Monson JP, Westberg B, Wilton P (2001) The influence of growth hormone deficiency, growth hormone replacement therapy, and other aspects of hypopituitarism on fracture rate and bone mineral density. J Bone Miner Res 16:398\u2013405","journal-title":"J Bone Miner Res"},{"key":"7574_CR12","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1210\/endrev\/bnab028","volume":"43","author":"PR Ebeling","year":"2022","unstructured":"Ebeling PR, Nguyen HH, Aleksova J, Vincent AJ, Wong P, Milat F (2022) Secondary Osteoporosis. Endocr Rev 43:240\u2013313","journal-title":"Endocr Rev"},{"key":"7574_CR13","doi-asserted-by":"crossref","unstructured":"Kuliczkowska-P\u0142aksej J, Zdrojowy-We\u0142na A, Jawiarczyk-Przyby\u0142owska A, Gojny \u0141, Bolanowski M (2024) Diagnosis and therapeutic approach to bone health in patients with hypopituitarism.\u00a0Rev Endocr Metab Disord. https:\/\/doi.org\/10.1007\/s11154-024-09878-w","DOI":"10.1007\/s11154-024-09878-w"},{"key":"7574_CR14","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1359\/jbmr.060110","volume":"21","author":"D Mellstr\u00f6m","year":"2006","unstructured":"Mellstr\u00f6m D, Johnell O, Ljunggren \u00d6, Eriksson AL, Lorentzon M, Mallmin H, Holmberg A, Redlund-Johnell I, Orwoll E, Ohlsson C (2006) Free Testosterone is an Independent Predictor of BMD and Prevalent Fractures in Elderly Men: MrOS Sweden. J Bone Miner Res 21:529\u2013535","journal-title":"J Bone Miner Res"},{"key":"7574_CR15","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1210\/clinem\/dgaa115","volume":"105","author":"BB Yeap","year":"2020","unstructured":"Yeap BB, Alfonso H, Chubb SAP, Center JR, Beilin J, Hankey GJ, Almeida OP, Golledge J, Norman PE, Flicker L (2020) U-Shaped Association of Plasma Testosterone, and no Association of Plasma Estradiol, with Incidence of Fractures in Men. J Clin Endocrinol Metab 105:1489\u20131500","journal-title":"J Clin Endocrinol Metab"},{"key":"7574_CR16","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s12020-021-02723-z","volume":"74","author":"L Li","year":"2021","unstructured":"Li L, Bensing S, Falhammar H (2021) Rate of fracture in patients with glucocorticoid replacement therapy: a systematic review and meta-analysis. Endocrine 74:29\u201337","journal-title":"Endocrine"},{"key":"7574_CR17","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/8756-3282(86)90681-2","volume":"7","author":"EF Eriksen","year":"1986","unstructured":"Eriksen EF, Mosekilde L, Melsen F (1986) Kinetics of trabecular bone resorption and formation in hypothyroidism: evidence for a positive balance per remodeling cycle. Bone 7:101\u2013108","journal-title":"Bone"},{"key":"7574_CR18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d2238","volume":"342","author":"MR Turner","year":"2011","unstructured":"Turner MR, Camacho X, Fischer HD, Austin PC, Anderson GM, Rochon PA, Lipscombe LL (2011) Levothyroxine dose and risk of fractures in older adults: nested case-control study. BMJ 342:d2238","journal-title":"BMJ"},{"key":"7574_CR19","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1530\/EJE-12-1088","volume":"169","author":"NM Appelman-Dijkstra","year":"2013","unstructured":"Appelman-Dijkstra NM, Claessen KM, Roelfsema F, Pereira AM, Biermasz NR (2013) Long-term effects of recombinant human GH replacement in adults with GH deficiency: a systematic review. Eur J Endocrinol 169:R1-14","journal-title":"Eur J Endocrinol"},{"key":"7574_CR20","doi-asserted-by":"publisher","first-page":"4657","DOI":"10.1210\/jcem.86.10.7887","volume":"86","author":"G G\u00f6therstr\u00f6m","year":"2001","unstructured":"G\u00f6therstr\u00f6m G, Svensson J, Koranyi J, Alpsten M, Bosaeus I, Bengtsson B, Johannsson G (2001) A prospective study of 5 years of GH replacement therapy in GH-deficient adults: sustained effects on body composition, bone mass, and metabolic indices. J Clin Endocrinol Metab 86:4657\u20134665","journal-title":"J Clin Endocrinol Metab"},{"key":"7574_CR21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1530\/eje.1.02317","volume":"156","author":"G G\u00f6therstr\u00f6m","year":"2007","unstructured":"G\u00f6therstr\u00f6m G, Bengtsson BA, Bosaeus I, Johannsson G, Svensson J (2007) Ten-year GH replacement increases bone mineral density in hypopituitary patients with adult onset GH deficiency. Eur J Endocrinol 156:55\u201364","journal-title":"Eur J Endocrinol"},{"key":"7574_CR22","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/S2213-8587(15)00098-4","volume":"3","author":"D Mo","year":"2015","unstructured":"Mo D, Fleseriu M, Qi R, Jia N, Child CJ, Bouillon R, Hardin DS (2015) Fracture risk in adult patients treated with growth hormone replacement therapy for growth hormone deficiency: a prospective observational cohort study. Lancet Diabetes Endocrinol 3:331\u2013338","journal-title":"Lancet Diabetes Endocrinol"},{"key":"7574_CR23","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3803\/EnM.2023.102","volume":"38","author":"SW Cho","year":"2023","unstructured":"Cho SW, Kim JH, Choi HS, Ahn HY, Kim MK, Rhee EJ (2023) Big Data Research in the Field of Endocrine Diseases Using the Korean National Health Information Database. Endocrinol Metab (Seoul) 38:10\u201324","journal-title":"Endocrinol Metab (Seoul)"},{"key":"7574_CR24","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1093\/jbmr\/zjad010","volume":"39","author":"C Ye","year":"2024","unstructured":"Ye C, Schousboe JT, Morin SN, Lix LM, McCloskey EV, Johansson H, Harvey NC, Kanis JA, Leslie WD (2024) FRAX predicts cardiovascular risk in women undergoing osteoporosis screening: the Manitoba bone mineral density registry. J Bone Miner Res 39:30\u201338","journal-title":"J Bone Miner Res"},{"key":"7574_CR25","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1007\/s00198-019-05122-3","volume":"30","author":"C Teb\u00e9","year":"2019","unstructured":"Teb\u00e9 C, Mart\u00ednez-Laguna D, Carbonell-Abella C, Reyes C, Moreno V, Diez-Perez A, Collins GS, Prieto-Alhambra D (2019) The association between type 2 diabetes mellitus, hip fracture, and post-hip fracture mortality: a multi-state cohort analysis. Osteoporos Int 30:2407\u20132415","journal-title":"Osteoporos Int"},{"key":"7574_CR26","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/s41416-023-02353-4","volume":"129","author":"IY Gong","year":"2023","unstructured":"Gong IY, Chan KKW, Lipscombe LL, Cheung MC, Mozessohn L (2023) Fracture risk among patients with cancer compared to individuals without cancer: a population-based study. Br J Cancer 129:665\u2013671","journal-title":"Br J Cancer"},{"key":"7574_CR27","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1530\/eje.0.1370240","volume":"137","author":"T Ros\u00e9n","year":"1997","unstructured":"Ros\u00e9n T, Wilhelmsen L, Landin-Wilhelmsen K, Lappas G, Bengtsson BA (1997) Increased fracture frequency in adult patients with hypopituitarism and GH deficiency. Eur J Endocrinol 137:240\u2013245","journal-title":"Eur J Endocrinol"},{"key":"7574_CR28","doi-asserted-by":"publisher","first-page":"S121","DOI":"10.33549\/physiolres.934303","volume":"68","author":"M Ku\u017ema","year":"2019","unstructured":"Ku\u017ema M, Killinger Z, Jackuliak P, Va\u0148uga P, Hans D, Binkley N, Payer J (2019) Pathophysiology of growth hormone secretion disorders and their impact on bone microstructure as measured by trabecular bone score. Physiol Res 68:S121-s129","journal-title":"Physiol Res"},{"key":"7574_CR29","doi-asserted-by":"crossref","unstructured":"Kuliczkowska-P\u0142aksej J, Zdrojowy-We\u0142na A, Jawiarczyk-Przyby\u0142owska A, Gojny \u0141, Bolanowski M (2024) Diagnosis and therapeutic approach to bone health in patients with hypopituitarism. Rev Endocr Metab Disord.\u00a0https:\/\/doi.org\/10.1007\/s11154-024-09878-w","DOI":"10.1007\/s11154-024-09878-w"},{"key":"7574_CR30","doi-asserted-by":"publisher","first-page":"239","DOI":"10.5114\/reum\/170244","volume":"61","author":"A Wydra","year":"2023","unstructured":"Wydra A, Czajka-Oraniec I, Wydra J, Zgliczy\u0144ski W (2023) The influence of growth hormone deficiency on bone health and metabolisms. Reumatologia 61:239\u2013247","journal-title":"Reumatologia"},{"key":"7574_CR31","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1046\/j.0300-0664.2001.01464.x","volume":"56","author":"P Vestergaard","year":"2002","unstructured":"Vestergaard P, J\u00f8rgensen JO, Hagen C et al (2002) Fracture risk is increased in patients with GH deficiency or untreated prolactinomas\u2013a case-control study. Clin Endocrinol (Oxf) 56:159\u2013167","journal-title":"Clin Endocrinol (Oxf)"},{"key":"7574_CR32","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1359\/jbmr.070811","volume":"22","author":"H Holmer","year":"2007","unstructured":"Holmer H, Svensson J, Rylander L et al (2007) Fracture incidence in GH-deficient patients on complete hormone replacement including GH. J Bone Miner Res 22:1842\u20131850","journal-title":"J Bone Miner Res"},{"key":"7574_CR33","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.steroids.2014.12.010","volume":"99","author":"JA Cauley","year":"2015","unstructured":"Cauley JA (2015) Estrogen and bone health in men and women. Steroids 99:11\u201315","journal-title":"Steroids"},{"key":"7574_CR34","first-page":"107","volume":"1","author":"H Zhou","year":"2013","unstructured":"Zhou H, Cooper MS, Seibel MJ (2013) Endogenous Glucocorticoids and Bone Bone Res 1:107\u2013119","journal-title":"Endogenous Glucocorticoids and Bone Bone Res"},{"key":"7574_CR35","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1210\/er.2018-00097","volume":"39","author":"RS Hardy","year":"2018","unstructured":"Hardy RS, Zhou H, Seibel MJ, Cooper MS (2018) Glucocorticoids and Bone: Consequences of Endogenous and Exogenous Excess and Replacement Therapy. Endocr Rev 39:519\u2013548","journal-title":"Endocr Rev"},{"key":"7574_CR36","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/cen.13267","volume":"86","author":"RD Murray","year":"2017","unstructured":"Murray RD, Ekman B, Uddin S, Marelli C, Quinkler M, Zelissen PM (2017) Management of glucocorticoid replacement in adrenal insufficiency shows notable heterogeneity - data from the EU-AIR. Clin Endocrinol (Oxf) 86:340\u2013346","journal-title":"Clin Endocrinol (Oxf)"},{"key":"7574_CR37","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1530\/EJE-14-0097","volume":"170","author":"G Mazziotti","year":"2014","unstructured":"Mazziotti G, Mormando M, Cristiano A, Bianchi A, Porcelli T, Giampietro A, Maffezzoni F, Serra V, De Marinis L, Giustina A (2014) Association between l-thyroxine treatment, GH deficiency, and radiological vertebral fractures in patients with adult-onset hypopituitarism. Eur J Endocrinol 170:893\u2013899","journal-title":"Eur J Endocrinol"},{"key":"7574_CR38","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13044-014-0012-0","volume":"7","author":"D Tuchendler","year":"2014","unstructured":"Tuchendler D, Bolanowski M (2014) The influence of thyroid dysfunction on bone metabolism. Thyroid Res 7:12","journal-title":"Thyroid Res"},{"key":"7574_CR39","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1172\/JCI113523","volume":"81","author":"SL Hui","year":"1988","unstructured":"Hui SL, Slemenda CW, Johnston CC Jr (1988) Age and bone mass as predictors of fracture in a prospective study. J Clin Invest 81:1804\u20131809","journal-title":"J Clin Invest"},{"key":"7574_CR40","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.bone.2004.03.024","volume":"35","author":"JA Kanis","year":"2004","unstructured":"Kanis JA, Johnell O, De Laet C et al (2004) A meta-analysis of previous fracture and subsequent fracture risk. Bone 35:375\u2013382","journal-title":"Bone"},{"key":"7574_CR41","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s11914-008-0010-z","volume":"6","author":"SJ Birge","year":"2008","unstructured":"Birge SJ (2008) Osteoporotic fractures: a brain or bone disease? Curr Osteoporos Rep 6:57\u201361","journal-title":"Curr Osteoporos Rep"},{"key":"7574_CR42","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s12883-014-0175-2","volume":"14","author":"HK Wang","year":"2014","unstructured":"Wang HK, Hung CM, Lin SH et al (2014) Increased risk of hip fractures in patients with dementia: a nationwide population-based study. BMC Neurol 14:175","journal-title":"BMC Neurol"},{"key":"7574_CR43","doi-asserted-by":"crossref","unstructured":"Zabawa L, Choubey AS, Drake B, Mayo J, Mejia A (2023) Dementia and hip fractures: a comprehensive review of management approaches. JBJS Reviews 11. https:\/\/doi.org\/10.2106\/JBJS.RVW.23.00157","DOI":"10.2106\/JBJS.RVW.23.00157"},{"key":"7574_CR44","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1007\/s00198-008-0822-9","volume":"20","author":"SL Brennan","year":"2009","unstructured":"Brennan SL, Pasco JA, Urquhart DM, Oldenburg B, Hanna F, Wluka AE (2009) The association between socioeconomic status and osteoporotic fracture in population-based adults: a systematic review. Osteoporos Int 20:1487\u20131497","journal-title":"Osteoporos Int"},{"key":"7574_CR45","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s001980070060","volume":"11","author":"BY Farahmand","year":"2000","unstructured":"Farahmand BY, Persson PG, Micha\u00eblsson K, Baron JA, Parker MG, Ljunghall S (2000) Socioeconomic status, marital status and hip fracture risk: a population-based case-control study. Osteoporos Int 11:803\u2013808","journal-title":"Osteoporos Int"},{"key":"7574_CR46","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1590\/S0036-36342003000300008","volume":"45","author":"L Hern\u00e1ndez-Ronquillo","year":"2003","unstructured":"Hern\u00e1ndez-Ronquillo L, T\u00e9llez-Zenteno JF, Gardu\u00f1o-Espinosa J, Gonz\u00e1lez-Acevez E (2003) Factors associated with therapy noncompliance in type-2 diabetes patients. Salud Publica Mex 45:191\u2013197","journal-title":"Salud Publica Mex"},{"key":"7574_CR47","doi-asserted-by":"crossref","unstructured":"Shah R, Desai S, Gajjar B, Shah A (2013) Factors responsible for noncompliance to drug therapy in the elderly and the impact of patient education on improving compliance.\u00a0Drugs Ther Perspect\u00a029","DOI":"10.1007\/s40267-013-0075-3"},{"key":"7574_CR48","doi-asserted-by":"publisher","first-page":"281","DOI":"10.11005\/jbm.2020.27.4.281","volume":"27","author":"SH Ahn","year":"2020","unstructured":"Ahn SH, Park SM, Park SY et al (2020) Osteoporosis and Osteoporotic Fracture Fact Sheet in Korea. J Bone Metab 27:281\u2013290","journal-title":"J Bone Metab"},{"key":"7574_CR49","doi-asserted-by":"publisher","first-page":"719","DOI":"10.3803\/EnM.2022.1573","volume":"37","author":"SM Kim","year":"2022","unstructured":"Kim SM, Sultana F, Korkmaz F, Lizneva D, Yuen T, Zaidi M (2022) Independent Skeletal Actions of Pituitary Hormones. Endocrinol Metab (Seoul) 37:719\u2013731","journal-title":"Endocrinol Metab (Seoul)"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-025-07574-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00198-025-07574-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-025-07574-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T07:03:14Z","timestamp":1762930994000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00198-025-07574-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,8]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["7574"],"URL":"https:\/\/doi.org\/10.1007\/s00198-025-07574-2","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,8]]},"assertion":[{"value":"2 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Seung Shin Park, Hyunmook Jeong, Chang Ho Ahn, Min Jeong Park, Sung Hye Kong, Sang Wan Kim, Chan Soo Shin, Yong Hwy Kim, Kwangsoo Kim, and Jung Hee Kim declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}