{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:29:48Z","timestamp":1784071788833,"version":"3.55.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s00198-025-07799-1","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:57:47Z","timestamp":1765357067000},"page":"397-406","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biconcave vertebral fractures as a possible distinctive feature of indolent systemic mastocytosis compared with primary osteoporosis"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0409-4449","authenticated-orcid":false,"given":"Gaetano Paride","family":"Arcidiacono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1426-1452","authenticated-orcid":false,"given":"Marco Onofrio","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Zanchetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5840-7290","authenticated-orcid":false,"given":"Sofia","family":"Testoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3580-4602","authenticated-orcid":false,"given":"Giovanni","family":"Tripepi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberta","family":"Cecchinato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Diogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9413-3710","authenticated-orcid":false,"given":"Mor","family":"Peleg Falb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Guidolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2888-9596","authenticated-orcid":false,"given":"Irene","family":"Bertozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-7317","authenticated-orcid":false,"given":"Marco","family":"Pizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2246-9144","authenticated-orcid":false,"given":"Mauro","family":"Cancian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7987-8235","authenticated-orcid":false,"given":"Riccardo","family":"Senter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Gianesello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3583-0816","authenticated-orcid":false,"given":"Francesca","family":"Caroppo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8177-374X","authenticated-orcid":false,"given":"Ilaria","family":"Tanasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2871-9730","authenticated-orcid":false,"given":"Roberta","family":"Zanotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Belletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-4851","authenticated-orcid":false,"given":"Maria","family":"Fusaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0377-3741","authenticated-orcid":false,"given":"Elena","family":"Campello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8645-4067","authenticated-orcid":false,"given":"Stefania","family":"Sella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6744-383X","authenticated-orcid":false,"given":"Paolo","family":"Simioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0796-9749","authenticated-orcid":false,"given":"Sandro","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"7799_CR1","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1182\/blood-2007-11-078097","volume":"112","author":"DD Metcalfe","year":"2008","unstructured":"Metcalfe DD (2008) Mast cells and mastocytosis. Blood 112:946\u2013956. https:\/\/doi.org\/10.1182\/blood-2007-11-078097","journal-title":"Blood"},{"key":"7799_CR2","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","volume":"36","author":"JD Khoury","year":"2022","unstructured":"Khoury JD, Solary E, Abla O et al (2022) The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic\/dendritic neoplasms. Leukemia 36:1703\u20131719. https:\/\/doi.org\/10.1038\/s41375-022-01613-1","journal-title":"Leukemia"},{"key":"7799_CR3","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1182\/blood.2022015850","volume":"140","author":"DA Arber","year":"2022","unstructured":"Arber DA, Orazi A, Hasserjian RP et al (2022) International consensus classification of myeloid neoplasms and acute leukemias: integrating morphologic, clinical, and genomic data. Blood 140:1200\u20131228. https:\/\/doi.org\/10.1182\/blood.2022015850","journal-title":"Blood"},{"key":"7799_CR4","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.jaci.2009.05.003","volume":"124","author":"L Escribano","year":"2009","unstructured":"Escribano L, Alvarez-Twose I, S\u00e1nchez-Mu\u00f1oz L et al (2009) Prognosis in adult indolent systemic mastocytosis: a long-term study of the Spanish Network on Mastocytosis in a series of 145 patients. J Allergy Clin Immunol 124:514\u2013521. https:\/\/doi.org\/10.1016\/j.jaci.2009.05.003","journal-title":"J Allergy Clin Immunol"},{"key":"7799_CR5","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.iac.2014.01.011","volume":"34","author":"M Rossini","year":"2014","unstructured":"Rossini M, Zanotti R, Viapiana O et al (2014) Bone involvement and osteoporosis in mastocytosis. Immunol Allergy Clin North Am 34:383\u2013396. https:\/\/doi.org\/10.1016\/j.iac.2014.01.011","journal-title":"Immunol Allergy Clin North Am"},{"key":"7799_CR6","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1136\/ard.2009.124511","volume":"69","author":"S Barete","year":"2010","unstructured":"Barete S, Assous N, De Gennes C et al (2010) Systemic mastocytosis and bone involvement in a cohort of 75 patients. Ann Rheum Dis 69:1838\u20131841. https:\/\/doi.org\/10.1136\/ard.2009.124511","journal-title":"Ann Rheum Dis"},{"key":"7799_CR7","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/j.1398-9995.2011.02780.x","volume":"67","author":"E van der Veer","year":"2012","unstructured":"van der Veer E, De Monchy JGR, De Monchy JGR et al (2012) High prevalence of fractures and osteoporosis in patients with indolent systemic mastocytosis. Allergy 67:431\u2013438. https:\/\/doi.org\/10.1111\/j.1398-9995.2011.02780.x","journal-title":"Allergy"},{"key":"7799_CR8","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.bone.2017.09.005","volume":"105","author":"Y Degbo\u00e9","year":"2017","unstructured":"Degbo\u00e9 Y, Eischen M, Nigon D et al (2017) Prevalence and risk factors for fragility fracture in systemic mastocytosis. Bone 105:219\u2013225. https:\/\/doi.org\/10.1016\/j.bone.2017.09.005","journal-title":"Bone"},{"key":"7799_CR9","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.iac.2018.04.013","volume":"38","author":"G Orsolini","year":"2018","unstructured":"Orsolini G, Viapiana O, Rossini M et al (2018) Bone disease in mastocytosis. Immunol Allergy Clin North Am 38:443\u2013454. https:\/\/doi.org\/10.1016\/j.iac.2018.04.013","journal-title":"Immunol Allergy Clin North Am"},{"key":"7799_CR10","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s00223-021-00887-4","volume":"109","author":"M Gehlen","year":"2021","unstructured":"Gehlen M, Schmidt N, Pfeifer M et al (2021) Osteoporosis caused by systemic mastocytosis: prevalence in a cohort of 8392 patients with osteoporosis. Calcif Tissue Int 109:685\u2013695. https:\/\/doi.org\/10.1007\/s00223-021-00887-4","journal-title":"Calcif Tissue Int"},{"key":"7799_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314896","volume":"23","author":"L Cianferotti","year":"2022","unstructured":"Cianferotti L (2022) Osteomalacia is not a single disease. Int J Mol Sci 23:14896. https:\/\/doi.org\/10.3390\/ijms232314896","journal-title":"Int J Mol Sci"},{"key":"7799_CR12","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s00223-017-0286-z","volume":"101","author":"M Garc\u00eda-Carrasco","year":"2017","unstructured":"Garc\u00eda-Carrasco M, Mendoza-Pinto C, Le\u00f3n-V\u00e1zquez MDLL et al (2017) Incidence of vertebral fractures in women with systemic lupus erythematosus after 8 years of follow-up. Calcif Tissue Int 101:291\u2013299. https:\/\/doi.org\/10.1007\/s00223-017-0286-z","journal-title":"Calcif Tissue Int"},{"key":"7799_CR13","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12891-023-06253-9","volume":"24","author":"J Cheng","year":"2023","unstructured":"Cheng J, Ju S, Zhang Z (2023) Osteoporotic vertebral compression fractures caused by Cushing\u2019s syndrome in young women: case report and literature review. BMC Musculoskelet Disord 24:167. https:\/\/doi.org\/10.1186\/s12891-023-06253-9","journal-title":"BMC Musculoskelet Disord"},{"key":"7799_CR14","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1007\/s00198-016-3539-1","volume":"27","author":"M Rossini","year":"2016","unstructured":"Rossini M, Zanotti R, Orsolini G et al (2016) Prevalence, pathogenesis, and treatment options for mastocytosis-related osteoporosis. Osteoporos Int 27:2411\u20132421. https:\/\/doi.org\/10.1007\/s00198-016-3539-1","journal-title":"Osteoporos Int"},{"key":"7799_CR15","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5785378","volume":"2020","author":"G Carosi","year":"2020","unstructured":"Carosi G, Guabello G, Longhi M et al (2020) Hypertryptasemia and mast cell-related disorders in severe osteoporotic patients. Mediators Inflamm 2020:5785378. https:\/\/doi.org\/10.1155\/2020\/5785378","journal-title":"Mediators Inflamm"},{"key":"7799_CR16","doi-asserted-by":"publisher","first-page":"418","DOI":"10.3238\/arztebl.2018.0418","volume":"115","author":"M Gehlen","year":"2018","unstructured":"Gehlen M, Doina Lazarescu A, Hinz C (2018) 12 vertebral-body fractures and simultaneous skin changes. Dtsch Arztebl Int 115:418. https:\/\/doi.org\/10.3238\/arztebl.2018.0418","journal-title":"Dtsch Arztebl Int"},{"key":"7799_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55090528","volume":"55","author":"M Cancian","year":"2019","unstructured":"Cancian M, Cosi E, Pizzi M et al (2019) Systemic mastocytosis and essential thrombocythemia: case report and literature overview. Medicina (Mex) 55:528. https:\/\/doi.org\/10.3390\/medicina55090528","journal-title":"Medicina (Mex)"},{"key":"7799_CR18","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1056\/NEJMoa2102953","volume":"385","author":"LA Inker","year":"2021","unstructured":"Inker LA, Eneanya ND, Coresh J et al (2021) New creatinine- and cystatin C-based equations to estimate GFR without race. N Engl J Med 385:1737\u20131749. https:\/\/doi.org\/10.1056\/NEJMoa2102953","journal-title":"N Engl J Med"},{"key":"7799_CR19","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0145-2126(01)00041-8","volume":"25","author":"WR Sperr","year":"2001","unstructured":"Sperr WR, Escribano L, Jordan J-H et al (2001) Morphologic properties of neoplastic mast cells: delineation of stages of maturation and implication for cytological grading of mastocytosis. Leuk Res 25:529\u2013536. https:\/\/doi.org\/10.1016\/S0145-2126(01)00041-8","journal-title":"Leuk Res"},{"key":"7799_CR20","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.jaci.2008.11.018","volume":"123","author":"P Bonadonna","year":"2009","unstructured":"Bonadonna P, Perbellini O, Passalacqua G et al (2009) Clonal mast cell disorders in patients with systemic reactions to Hymenoptera stings and increased serum tryptase levels. J Allergy Clin Immunol 123:680\u2013686. https:\/\/doi.org\/10.1016\/j.jaci.2008.11.018","journal-title":"J Allergy Clin Immunol"},{"key":"7799_CR21","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1002\/cyto.b.20606","volume":"80B","author":"O Perbellini","year":"2011","unstructured":"Perbellini O, Zam\u00f2 A, Colarossi S et al (2011) Primary role of multiparametric flow cytometry in the diagnostic work-up of indolent clonal mast cell disorders. Cytometry B Clin Cytom 80B:362\u2013368. https:\/\/doi.org\/10.1002\/cyto.b.20606","journal-title":"Cytometry B Clin Cytom"},{"key":"7799_CR22","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1111\/his.12221","volume":"63","author":"JM Morgado","year":"2013","unstructured":"Morgado JM, Perbellini O, Johnson RC et al (2013) CD30 expression by bone marrow mast cells from different diagnostic variants of systemic mastocytosis. Histopathology 63:780\u2013787. https:\/\/doi.org\/10.1111\/his.12221","journal-title":"Histopathology"},{"key":"7799_CR23","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.leukres.2014.11.029","volume":"39","author":"G De Matteis","year":"2015","unstructured":"De Matteis G, Zanotti R, Colarossi S et al (2015) The impact of sensitive KIT D816V detection on recognition of indolent systemic mastocytosis. Leuk Res 39:273\u2013278. https:\/\/doi.org\/10.1016\/j.leukres.2014.11.029","journal-title":"Leuk Res"},{"key":"7799_CR24","unstructured":"NIH Image to ImageJ: 25 years of image analysis | Nature Methods. https:\/\/www.nature.com\/articles\/nmeth.2089. Accessed 13 Jan 2024"},{"key":"7799_CR25","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","volume":"8","author":"HK Genant","year":"1993","unstructured":"Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8:1137\u20131148. https:\/\/doi.org\/10.1002\/jbmr.5650080915","journal-title":"J Bone Miner Res"},{"key":"7799_CR26","doi-asserted-by":"publisher","unstructured":"Youden WJ (1950) Index for rating diagnostic tests. Cancer 3:32\u201335. https:\/\/doi.org\/10.1002\/1097-0142(1950)3:1%3c32::aid-cncr2820030106%3e3.0.co;2-3","DOI":"10.1002\/1097-0142(1950)3:1%3c32::aid-cncr2820030106%3e3.0.co;2-3"},{"key":"7799_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2024.100316","volume":"3","author":"KY Tse","year":"2024","unstructured":"Tse KY, Chen W, Puttock EJ et al (2024) Mastering systemic mastocytosis: lessons learned from a large patient cohort. Journal of Allergy and Clinical Immunology: Global 3:100316. https:\/\/doi.org\/10.1016\/j.jacig.2024.100316","journal-title":"Journal of Allergy and Clinical Immunology: Global"},{"key":"7799_CR28","doi-asserted-by":"publisher","DOI":"10.4084\/MJHID.2021.068","volume":"13","author":"R Zanotti","year":"2021","unstructured":"Zanotti R, Bonifacio M, Tanasi I et al (2021) Systemic mastocytosis: multidisciplinary approach. Mediterr J Hematol Infect Dis 13:e2021068. https:\/\/doi.org\/10.4084\/MJHID.2021.068","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"7799_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2024.117141","volume":"186","author":"I Tanasi","year":"2024","unstructured":"Tanasi I, Crosera L, Taus F et al (2024) Underlying systemic mastocytosis in patients with unexplained osteoporosis: score proposal. Bone 186:117141. https:\/\/doi.org\/10.1016\/j.bone.2024.117141","journal-title":"Bone"},{"key":"7799_CR30","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1359\/JBMR.040215","volume":"19","author":"M Van Der Klift","year":"2004","unstructured":"Van Der Klift M, De Laet CE, McCloskey EV et al (2004) Risk factors for incident vertebral fractures in men and women: the Rotterdam study. J Bone Miner Res 19:1172\u20131180. https:\/\/doi.org\/10.1359\/JBMR.040215","journal-title":"J Bone Miner Res"},{"key":"7799_CR31","doi-asserted-by":"publisher","first-page":"1127.e1","DOI":"10.1016\/j.amjmed.2014.06.015","volume":"127","author":"M Rossini","year":"2014","unstructured":"Rossini M, Zanotti R, Viapiana O et al (2014) Zoledronic acid in osteoporosis secondary to mastocytosis. Am J Med 127:1127.e1-1127.e4. https:\/\/doi.org\/10.1016\/j.amjmed.2014.06.015","journal-title":"Am J Med"},{"key":"7799_CR32","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00198-018-4704-5","volume":"30","author":"JA Kanis","year":"2019","unstructured":"Kanis JA, Cooper C, Rizzoli R et al (2019) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 30:3\u201344. https:\/\/doi.org\/10.1007\/s00198-018-4704-5","journal-title":"Osteoporos Int"},{"key":"7799_CR33","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.3390\/medicina60111752","volume":"60","author":"G Mauro","year":"2024","unstructured":"Mauro G, Accomando J, Tomasello S et al (2024) Osteoporosis in Systemic Mastocytosis: A Scoping Review. Medicina (Mex) 60:1752. https:\/\/doi.org\/10.3390\/medicina60111752","journal-title":"Medicina (Mex)"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-025-07799-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00198-025-07799-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-025-07799-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:05:16Z","timestamp":1772582716000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00198-025-07799-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["7799"],"URL":"https:\/\/doi.org\/10.1007\/s00198-025-07799-1","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,10]]},"assertion":[{"value":"30 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was performed in accordance with the 1964 Helsinki declaration and its later amendments. The study was authorized by the local Ethics Committee (Comitato Etico Territoriale Area Centro-Est Veneto, 6223\/AO\/25). The committee provided ethical approval for the research protocol, ensuring that the study complies with the ethical standards for research involving human participants. Written informed consent was obtained for all study participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Informed Consent"}},{"value":"Gaetano Paride Arcidiacono, Marco Onofrio Torres, Francesca Zanchetta, Sofia Testoni, Giovanni Tripepi, Alberta Cecchinato, Martin Diogo, Mor Peleg Falb, Francesca Guidolin, Irene Bertozzi, Marco Pizzi, Mauro Cancian, Riccardo Senter, Ilaria Gianesello, Francesca Caroppo, Ilaria Tanasi, Roberta Zanotti, Lorenza Belletti, Maria Fusaro, Elena Campello, Stefania Sella, Paolo Simioni, and Sandro Giannini declare that they have no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}]}}