{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T02:36:54Z","timestamp":1777775814627,"version":"3.51.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI22C0049"],"award-info":[{"award-number":["HI22C0049"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00198-026-07849-2","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T07:49:40Z","timestamp":1769586580000},"page":"759-770","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fracture risks in patients with arginine vasopressin deficiency: a nationwide matched cohort study"],"prefix":"10.1007","volume":"37","author":[{"given":"Seung Shin","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunmook","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Ho","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jeong","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Hye","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Wan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Soo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Hwy","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4586-5062","authenticated-orcid":false,"given":"Kwangsoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1932-0234","authenticated-orcid":false,"given":"Jung Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"7849_CR1","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/s11154-023-09862-w","volume":"25","author":"J Refardt","year":"2024","unstructured":"Refardt J, Atila C, Christ-Crain M (2024) New insights on diagnosis and treatment of AVP deficiency. Rev Endocr Metab Disord 25:639\u2013649","journal-title":"Rev Endocr Metab Disord"},{"key":"7849_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-024-00985-x","author":"C Atila","year":"2024","unstructured":"Atila C, Refardt J, Christ-Crain M (2024) Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency. Nat Rev Endocrinol. https:\/\/doi.org\/10.1038\/s41574-024-00985-x","journal-title":"Nat Rev Endocrinol"},{"key":"7849_CR3","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1210\/jc.2013-4411","volume":"99","author":"KV Juul","year":"2014","unstructured":"Juul KV, Schroeder M, Rittig S, N\u00f8rgaard JP (2014) National surveillance of central Diabetes Insipidus (CDI) in Denmark: results from 5 years registration of 9309 prescriptions of desmopressin to 1285 CDI patients. J Clin Endocrinol Metab 99:2181\u20132187","journal-title":"J Clin Endocrinol Metab"},{"key":"7849_CR4","doi-asserted-by":"publisher","first-page":"3958","DOI":"10.1210\/jc.2013-2326","volume":"98","author":"Y Oiso","year":"2013","unstructured":"Oiso Y, Robertson GL, N\u00f8rgaard JP, Juul KV (2013) Clinical review: Treatment of neurohypophyseal diabetes insipidus. J Clin Endocrinol Metab 98:3958\u20133967","journal-title":"J Clin Endocrinol Metab"},{"key":"7849_CR5","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1210\/jc.2014-3525","volume":"100","author":"DS Olsson","year":"2015","unstructured":"Olsson DS, Andersson E, Bryngelsson IL, Nilsson AG, Johannsson G (2015) Excess mortality and morbidity in patients with craniopharyngioma, especially in patients with childhood onset: a population-based study in Sweden. J Clin Endocrinol Metab 100:467\u2013474","journal-title":"J Clin Endocrinol Metab"},{"key":"7849_CR6","doi-asserted-by":"publisher","first-page":"101385","DOI":"10.1016\/j.beem.2020.101385","volume":"34","author":"A Garrahy","year":"2020","unstructured":"Garrahy A, Thompson CJ (2020) Management of central diabetes insipidus. Best Pract Res Clin Endocrinol Metab 34:101385","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"7849_CR7","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1530\/EJE-14-0719","volume":"172","author":"LA Behan","year":"2015","unstructured":"Behan LA, Sherlock M, Moyles P et al (2015) Abnormal plasma sodium concentrations in patients treated with desmopressin for cranial diabetes insipidus: results of a long-term retrospective study. Eur J Endocrinol 172:243\u2013250","journal-title":"Eur J Endocrinol"},{"key":"7849_CR8","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/cen.13790","volume":"89","author":"G Corona","year":"2018","unstructured":"Corona G, Norello D, Parenti G, Sforza A, Maggi M, Peri A (2018) Hyponatremia, falls and bone fractures: a systematic review and meta-analysis. Clin Endocrinol (Oxf) 89:505\u2013513","journal-title":"Clin Endocrinol (Oxf)"},{"key":"7849_CR9","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s11255-009-9585-2","volume":"41","author":"HS Sandhu","year":"2009","unstructured":"Sandhu HS, Gilles E, DeVita MV, Panagopoulos G, Michelis MF (2009) Hyponatremia associated with large-bone fracture in elderly patients. Int Urol Nephrol 41:733\u2013737","journal-title":"Int Urol Nephrol"},{"key":"7849_CR10","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1093\/qjmed\/hcn061","volume":"101","author":"F GankamKengne","year":"2008","unstructured":"GankamKengne F, Andres C, Sattar L, Melot C, Decaux G (2008) Mild hyponatremia and risk of fracture in the ambulatory elderly. QJM 101:583\u2013588","journal-title":"QJM"},{"key":"7849_CR11","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1002\/jbmr.2383","volume":"30","author":"SA Jamal","year":"2015","unstructured":"Jamal SA, Arampatzis S, Harrison SL, Bucur RC, Ensrud K, Orwoll ES, Bauer DC (2015) Hyponatremia and fractures: findings from the MrOS study. J Bone Miner Res 30:970\u2013975","journal-title":"J Bone Miner Res"},{"key":"7849_CR12","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3803\/EnM.2023.102","volume":"38","author":"SW Cho","year":"2023","unstructured":"Cho SW, Kim JH, Choi HS, Ahn HY, Kim MK, Rhee EJ (2023) Big data research in the field of endocrine diseases using the Korean National Health Information Database. Endocrinol Metab (Seoul) 38:10\u201324","journal-title":"Endocrinol Metab (Seoul)"},{"key":"7849_CR13","first-page":"2275","volume":"83","author":"R Pivonello","year":"1998","unstructured":"Pivonello R, Colao A, Di Somma C, Facciolli G, Klain M, Faggiano A, Salvatore M, Lombardi G (1998) Impairment of bone status in patients with central diabetes insipidus. J Clin Endocrinol Metab 83:2275\u20132280","journal-title":"J Clin Endocrinol Metab"},{"key":"7849_CR14","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1359\/jbmr.090827","volume":"25","author":"JG Verbalis","year":"2010","unstructured":"Verbalis JG, Barsony J, Sugimura Y, Tian Y, Adams DJ, Carter EA, Resnick HE (2010) Hyponatremia-induced osteoporosis. J Bone Miner Res 25:554\u2013563","journal-title":"J Bone Miner Res"},{"key":"7849_CR15","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1002\/jbmr.380","volume":"26","author":"EJ Hoorn","year":"2011","unstructured":"Hoorn EJ, Rivadeneira F, van Meurs JB, Ziere G, Stricker BH, Hofman A, Pols HA, Zietse R, Uitterlinden AG, Zillikens MC (2011) Mild hyponatremia as a risk factor for fractures: the Rotterdam study. J Bone Miner Res 26:1822\u20131828","journal-title":"J Bone Miner Res"},{"key":"7849_CR16","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1007\/s11102-024-01391-2","volume":"27","author":"A Akirov","year":"2024","unstructured":"Akirov A, Rudman Y, Fleseriu M (2024) Hypopituitarism and bone disease: pathophysiology, diagnosis and treatment outcomes. Pituitary 27:778\u2013788","journal-title":"Pituitary"},{"key":"7849_CR17","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1210\/en.2014-1812","volume":"156","author":"G Tamma","year":"2015","unstructured":"Tamma G, Goswami N, Reichmuth J, De Santo NG, Valenti G (2015) Aquaporins, vasopressin, and aging: current perspectives. Endocrinology 156:777\u2013788","journal-title":"Endocrinology"},{"key":"7849_CR18","doi-asserted-by":"publisher","first-page":"71.e71","DOI":"10.1016\/j.amjmed.2005.09.026","volume":"119","author":"B Renneboog","year":"2006","unstructured":"Renneboog B, Musch W, Vandemergel X, Manto MU, Decaux G (2006) Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med 119:71.e71-78","journal-title":"Am J Med"},{"key":"7849_CR19","doi-asserted-by":"publisher","first-page":"10864","DOI":"10.1074\/jbc.M110.155002","volume":"286","author":"J Barsony","year":"2011","unstructured":"Barsony J, Sugimura Y, Verbalis JG (2011) Osteoclast response to low extracellular sodium and the mechanism of hyponatremia-induced bone loss. J Biol Chem 286:10864\u201310875","journal-title":"J Biol Chem"},{"key":"7849_CR20","doi-asserted-by":"publisher","first-page":"7149","DOI":"10.1073\/pnas.0901890106","volume":"106","author":"R Tamma","year":"2009","unstructured":"Tamma R, Colaianni G, Zhu LL et al (2009) Oxytocin is an anabolic bone hormone. Proc Natl Acad Sci U S A 106:7149\u20137154","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7849_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168551","author":"V Breuil","year":"2021","unstructured":"Breuil V, Trojani MC, Ez-Zoubir A (2021) Oxytocin and bone: review and perspectives. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms22168551","journal-title":"Int J Mol Sci"},{"key":"7849_CR22","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1634\/stemcells.2008-0127","volume":"26","author":"C Elabd","year":"2008","unstructured":"Elabd C, Basillais A, Beaupied H et al (2008) Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis. Stem Cells 26:2399\u20132407","journal-title":"Stem Cells"},{"key":"7849_CR23","doi-asserted-by":"publisher","first-page":"E634","DOI":"10.1210\/jc.2013-4126","volume":"99","author":"V Breuil","year":"2014","unstructured":"Breuil V, Panaia-Ferrari P, Fontas E et al (2014) Oxytocin, a new determinant of bone mineral density in post-menopausal women: analysis of the OPUS cohort. J Clin Endocrinol Metab 99:E634-641","journal-title":"J Clin Endocrinol Metab"},{"key":"7849_CR24","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s11102-019-00936-0","volume":"22","author":"Y Eisenberg","year":"2019","unstructured":"Eisenberg Y, Murad S, Casagrande A, McArthur M, Dugas LR, Barengolts E, Layden BT (2019) Oxytocin alterations and neurocognitive domains in patients with hypopituitarism. Pituitary 22:105\u2013112","journal-title":"Pituitary"},{"key":"7849_CR25","doi-asserted-by":"publisher","first-page":"F1116","DOI":"10.1152\/ajprenal.00741.2010","volume":"300","author":"KV Juul","year":"2011","unstructured":"Juul KV, Klein BM, Sandstr\u00f6m R, Erichsen L, N\u00f8rgaard JP (2011) Gender difference in antidiuretic response to desmopressin. Am J Physiol Renal Physiol 300:F1116-1122","journal-title":"Am J Physiol Renal Physiol"},{"key":"7849_CR26","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/nau.20168","volume":"25","author":"A Rembratt","year":"2006","unstructured":"Rembratt A, Riis A, Norgaard JP (2006) Desmopressin treatment in nocturia; an analysis of risk factors for hyponatremia. Neurourol Urodyn 25:105\u2013109","journal-title":"Neurourol Urodyn"},{"key":"7849_CR27","doi-asserted-by":"publisher","first-page":"58","DOI":"10.2174\/1745017901915010058","volume":"15","author":"D Marazziti","year":"2019","unstructured":"Marazziti D, Baroni S, Mucci F, Piccinni A, Moroni I, Giannaccini G, Carmassi C, Massimetti E, Dell\u2019Osso L (2019) Sex-related differences in plasma oxytocin levels in humans. Clin Pract Epidemiol Ment Health 15:58\u201363","journal-title":"Clin Pract Epidemiol Ment Health"},{"key":"7849_CR28","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s11914-009-0022-3","volume":"7","author":"JL Kelsey","year":"2009","unstructured":"Kelsey JL, Samelson EJ (2009) Variation in risk factors for fractures at different sites. Curr Osteoporos Rep 7:127\u2013133","journal-title":"Curr Osteoporos Rep"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-026-07849-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00198-026-07849-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-026-07849-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T09:37:43Z","timestamp":1776245863000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00198-026-07849-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["7849"],"URL":"https:\/\/doi.org\/10.1007\/s00198-026-07849-2","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]},"assertion":[{"value":"6 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Seung Shin Park, Hyunmook Jeong, Chang Ho Ahn, Min Jeong Park, Sung Hye Kong, Sang Wan Kim, Chan Soo Shin, Yong Hwy Kim, Kwangsoo Kim, Jung Hee Kim declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}