{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:09:15Z","timestamp":1792782555630,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2025ZNSFSC1775"],"award-info":[{"award-number":["2025ZNSFSC1775"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Staring Foundation for Advanced Talents, Sichuan University","award":["YJ202455"],"award-info":[{"award-number":["YJ202455"]}],"id":[{"id":"https:\/\/ror.org\/011ashp19","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Science Fund for Creative Research Groups of Science and Technology Bureau of Sichuan Province","award":["2024NSFTD0030"],"award-info":[{"award-number":["2024NSFTD0030"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s00198-026-07934-6","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T07:44:12Z","timestamp":1774251852000},"page":"1633-1643","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of healthy sleep pattern with the risk of falls and fractures among individuals with cardiovascular disease: a UK Biobank study"],"prefix":"10.1007","volume":"37","author":[{"given":"Yan","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuze","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoma","family":"Diji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9803-0532","authenticated-orcid":false,"given":"Mengyu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"7934_CR1","doi-asserted-by":"publisher","unstructured":"GBD 2019 Ageing Collaborators (2022) Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study. BMJ 376:e068208. https:\/\/doi.org\/10.1136\/bmj-2021-068208","DOI":"10.1136\/bmj-2021-068208"},{"issue":"1","key":"7934_CR2","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/s12877-019-1329-2","volume":"19","author":"NG Choi","year":"2019","unstructured":"Choi NG, Choi BY, DiNitto DM, Marti CN, Kunik ME (2019) Fall-related emergency department visits and hospitalizations among community-dwelling older adults: examination of health problems and injury characteristics. BMC Geriatr 19(1):303. https:\/\/doi.org\/10.1186\/s12877-019-1329-2","journal-title":"BMC Geriatr"},{"issue":"8","key":"7934_CR3","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1007\/s00198-023-06907-3","volume":"49","author":"N Veronese","year":"2018","unstructured":"Veronese N, Maggi S (2018) Epidemiology and social costs of hip fracture. Injury 49(8):1458\u20131460. https:\/\/doi.org\/10.1007\/s00198-023-06907-3","journal-title":"Injury"},{"issue":"1","key":"7934_CR4","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/s2666-7568(21)00172-0","volume":"35","author":"JN Feng","year":"2024","unstructured":"Feng JN, Zhang CG, Li BH, Zhan SY, Wang SF, Song CL (2024) Global burden of hip fracture: The Global Burden of Disease Study. Osteoporos Int 35(1):41\u201352. https:\/\/doi.org\/10.1016\/s2666-7568(21)00172-0","journal-title":"Osteoporos Int"},{"key":"7934_CR5","doi-asserted-by":"publisher","unstructured":"GBD 2019 Fracture Collaborators (2021) Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019. Lancet Healthy Longev 2(9):e580-e592. https:\/\/doi.org\/10.1016\/j.injury.2018.04.015","DOI":"10.1016\/j.injury.2018.04.015"},{"issue":"1","key":"7934_CR6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00198-019-05190-5","volume":"31","author":"NA Goto","year":"2020","unstructured":"Goto NA, Weststrate ACG, Oosterlaan FM et al (2020) The association between chronic kidney disease, falls, and fractures: a systematic review and meta-analysis. Osteoporos Int 31(1):13\u201329. https:\/\/doi.org\/10.1007\/s00198-019-05190-5","journal-title":"Osteoporos Int"},{"key":"7934_CR7","doi-asserted-by":"publisher","unstructured":"Bourke R, Doody P, P\u00e9rez S, Moloney D, Lipsitz LA, Kenny RA (2024) Cardiovascular disorders and falls among older adults: a systematic review and meta-analysis. J Gerontol A Biol Sci Med Sci 79(2). https:\/\/doi.org\/10.1016\/j.tem.2022.11.003","DOI":"10.1016\/j.tem.2022.11.003"},{"issue":"1","key":"7934_CR8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1093\/gerona\/glad221","volume":"34","author":"A Sheu","year":"2023","unstructured":"Sheu A, Greenfield JR, White CP, Center JR (2023) Contributors to impaired bone health in type 2 diabetes. Trends Endocrinol Metab 34(1):34\u201348. https:\/\/doi.org\/10.1093\/gerona\/glad221","journal-title":"Trends Endocrinol Metab"},{"issue":"10","key":"7934_CR9","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1007\/s00198-018-4611-9","volume":"29","author":"JI Barzilay","year":"2018","unstructured":"Barzilay JI, Buzkova P, Cauley JA, Robbins JA, Fink HA, Mukamal KJ (2018) The associations of subclinical atherosclerotic cardiovascular disease with hip fracture risk and bone mineral density in elderly adults. Osteoporos Int 29(10):2219\u20132230. https:\/\/doi.org\/10.1007\/s00198-018-4611-9","journal-title":"Osteoporos Int"},{"issue":"3","key":"7934_CR10","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1093\/ageing\/afu009","volume":"34","author":"JA Cauley","year":"2019","unstructured":"Cauley JA, Hovey KM, Stone KL et al (2019) Characteristics of self-reported sleep and the risk of falls and fractures: The Women\u2019s Health Initiative (WHI). J Bone Miner Res 34(3):464\u2013474. https:\/\/doi.org\/10.1093\/ageing\/afu009","journal-title":"J Bone Miner Res"},{"issue":"5","key":"7934_CR11","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1093\/ageing\/afac205","volume":"43","author":"R Khatib","year":"2014","unstructured":"Khatib R, Yusuf S, Barzilay JI et al (2014) Impact of lifestyle factors on fracture risk in older patients with cardiovascular disease: a prospective cohort study of 26,335 individuals from 40 countries. Age Ageing 43(5):629\u2013635. https:\/\/doi.org\/10.1093\/ageing\/afac205","journal-title":"Age Ageing"},{"key":"7934_CR12","doi-asserted-by":"publisher","unstructured":"Montero-Odasso M, van der Velde N, Martin FC et al (2022) World guidelines for falls prevention and management for older adults: a global initiative. Age Ageing 51(9). https:\/\/doi.org\/10.1002\/jbmr.3619","DOI":"10.1002\/jbmr.3619"},{"issue":"12","key":"7934_CR13","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1038\/s42003-021-02861-0","volume":"14","author":"AK Helbig","year":"2013","unstructured":"Helbig AK, D\u00f6ring A, Heier M et al (2013) Association between sleep disturbances and falls among the elderly: results from the German Cooperative Health Research in the Region of Augsburg-Age study. Sleep Med 14(12):1356\u20131363. https:\/\/doi.org\/10.1038\/s42003-021-02861-0","journal-title":"Sleep Med"},{"issue":"1","key":"7934_CR14","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/j.sleep.2013.09.004","volume":"4","author":"Y Qian","year":"2021","unstructured":"Qian Y, Xia J, Liu KQ et al (2021) Observational and genetic evidence highlight the association of human sleep behaviors with the incidence of fracture. Commun Biol 4(1):1339. https:\/\/doi.org\/10.1016\/j.sleep.2013.09.004","journal-title":"Commun Biol"},{"key":"7934_CR15","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.sleh.2021.11.011","volume":"100","author":"W Zhu","year":"2022","unstructured":"Zhu W, Lin H, Zhang J et al (2022) Real-world association of self-reported sleep duration and quality with falls among older adults: a representative nationwide study of China. Sleep Med 100:212\u2013218. https:\/\/doi.org\/10.1016\/j.sleh.2021.11.011","journal-title":"Sleep Med"},{"issue":"2","key":"7934_CR16","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.sleep.2022.08.019","volume":"8","author":"T Huang","year":"2022","unstructured":"Huang T, Redline S, Gordon CM, Schernhammer E, Curhan GC, Paik JM (2022) Self-reported sleep characteristics and risk for incident vertebral and hip fracture in women. Sleep Health 8(2):234\u2013241. https:\/\/doi.org\/10.1016\/j.sleep.2022.08.019","journal-title":"Sleep Health"},{"issue":"1","key":"7934_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-74581-4","volume":"14","author":"C Zhu","year":"2024","unstructured":"Zhu C, Sun J, Huang Y, Lian Z (2024) Sleep and risk of hip fracture and falls among middle-aged and older Chinese. Sci Rep 14(1):23273. https:\/\/doi.org\/10.1038\/s41598-024-74581-4","journal-title":"Sci Rep"},{"key":"7934_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1234102","volume":"14","author":"T Zhou","year":"2023","unstructured":"Zhou T, Dai X, Yuan Y et al (2023) Adherence to a healthy sleep pattern is associated with lower risks of incident falls and fractures during aging. Front Immunol 14:1234102. https:\/\/doi.org\/10.3389\/fimmu.2023.1234102","journal-title":"Front Immunol"},{"issue":"3","key":"7934_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779","volume":"12","author":"C Sudlow","year":"2015","unstructured":"Sudlow C, Gallacher J, Allen N et al (2015) UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med 12(3):e1001779. https:\/\/doi.org\/10.1371\/journal.pmed.1001779","journal-title":"PLoS Med"},{"issue":"11","key":"7934_CR20","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1093\/eurheartj\/ehz849","volume":"41","author":"M Fan","year":"2020","unstructured":"Fan M, Sun D, Zhou T et al (2020) Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385\u2009292 UK biobank participants. Eur Heart J 41(11):1182\u20131189. https:\/\/doi.org\/10.1093\/eurheartj\/ehz849","journal-title":"Eur Heart J"},{"issue":"2","key":"7934_CR21","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.pcad.2023.02.005","volume":"4","author":"EI Lubetkin","year":"2018","unstructured":"Lubetkin EI, Jia H (2018) Burden of disease due to sleep duration and sleep problems in the elderly. Sleep Health 4(2):182\u2013187. https:\/\/doi.org\/10.1016\/j.pcad.2023.02.005","journal-title":"Sleep Health"},{"key":"7934_CR22","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.sleh.2017.11.007","volume":"77","author":"N Baranwal","year":"2023","unstructured":"Baranwal N, Yu PK, Siegel NS (2023) Sleep physiology, pathophysiology, and sleep hygiene. Prog Cardiovasc Dis 77:59\u201369. https:\/\/doi.org\/10.1016\/j.sleh.2017.11.007","journal-title":"Prog Cardiovasc Dis"},{"issue":"5","key":"7934_CR23","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.1161\/cir.0000000000001078","volume":"146","author":"DM Lloyd-Jones","year":"2022","unstructured":"Lloyd-Jones DM, Allen NB, Anderson CAM et al (2022) Life\u2019s essential 8: updating and enhancing the American Heart Association\u2019s construct of cardiovascular health: a presidential advisory from the American Heart Association. Circulation 146(5):e18\u2013e43. https:\/\/doi.org\/10.1161\/cir.0000000000001078","journal-title":"Circulation"},{"issue":"3","key":"7934_CR24","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jamda.2015.08.022","volume":"17","author":"S Jansen","year":"2016","unstructured":"Jansen S, Bhangu J, de Rooij S, Daams J, Kenny RA, van der Velde N (2016) The association of cardiovascular disorders and falls: a systematic review. J Am Med Dir Assoc 17(3):193\u2013199. https:\/\/doi.org\/10.1016\/j.jamda.2015.08.022","journal-title":"J Am Med Dir Assoc"},{"key":"7934_CR25","doi-asserted-by":"publisher","unstructured":"Baldanzi G, Hammar U, Fall T et al (2022) Evening chronotype is associated with elevated biomarkers of cardiometabolic risk in the EpiHealth cohort: a cross-sectional study. Sleep 45(2). https:\/\/doi.org\/10.1161\/jaha.117.005947","DOI":"10.1161\/jaha.117.005947"},{"key":"7934_CR26","doi-asserted-by":"publisher","unstructured":"Yin J, Jin X, Shan Z et al (2017) Relationship of sleep duration with all-cause mortality and cardiovascular events: a systematic review and dose-response meta-analysis of prospective cohort studies. J Am Heart Assoc 6(9). https:\/\/doi.org\/10.1093\/sleep\/zsab226","DOI":"10.1093\/sleep\/zsab226"},{"issue":"3","key":"7934_CR27","doi-asserted-by":"publisher","first-page":"e214","DOI":"10.1016\/S2666-7568(23)00263-5","volume":"5","author":"P Hanlon","year":"2024","unstructured":"Hanlon P, Wightman H, Politis M et al (2024) The relationship between frailty and social vulnerability: a systematic review. Lancet Healthy Longev 5(3):e214\u2013e226. https:\/\/doi.org\/10.1016\/S2666-7568(23)00263-5","journal-title":"Lancet Healthy Longev"},{"issue":"4","key":"7934_CR28","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/nrendo.2016.153","volume":"13","author":"N Napoli","year":"2017","unstructured":"Napoli N, Chandran M, Pierroz DD et al (2017) Mechanisms of diabetes mellitus-induced bone fragility. Nat Rev Endocrinol 13(4):208\u2013219. https:\/\/doi.org\/10.1038\/nrendo.2016.153","journal-title":"Nat Rev Endocrinol"},{"key":"7934_CR29","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/jbm4.10762","volume":"15","author":"AC Hayley","year":"2015","unstructured":"Hayley AC, Williams LJ, Kennedy GA et al (2015) Excessive daytime sleepiness and falls among older men and women: cross-sectional examination of a population-based sample. BMC Geriatr 15:74. https:\/\/doi.org\/10.1002\/jbm4.10762","journal-title":"BMC Geriatr"},{"key":"7934_CR30","doi-asserted-by":"publisher","unstructured":"Chen TY, Lee S, Buxton OM (2017) A greater extent of insomnia symptoms and physician-recommended sleep medication use predict fall risk in community-dwelling older adults. Sleep 40(11). https:\/\/doi.org\/10.1093\/sleep\/zsx142","DOI":"10.1093\/sleep\/zsx142"},{"issue":"8","key":"7934_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-015-0068-2","volume":"7","author":"JA Cauley","year":"2023","unstructured":"Cauley JA, Kravitz HM, Ruppert K et al (2023) Self-reported sleep disturbances over the menopausal transition and fracture risk: the study of women\u2019s health across the nation. JBMR Plus 7(8):e10762. https:\/\/doi.org\/10.1186\/s12877-015-0068-2","journal-title":"JBMR Plus"},{"issue":"1","key":"7934_CR32","doi-asserted-by":"publisher","first-page":"8005","DOI":"10.1016\/j.chest.2017.01.026","volume":"14","author":"XP Du","year":"2024","unstructured":"Du XP, Zheng ML, Yang XC, Zheng ML (2024) High blood pressure is associated with increased risk of future fracture, but not vice versa. Sci Rep 14(1):8005. https:\/\/doi.org\/10.1016\/j.chest.2017.01.026","journal-title":"Sci Rep"},{"issue":"2","key":"7934_CR33","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/s41598-024-58691-7","volume":"152","author":"S Javaheri","year":"2017","unstructured":"Javaheri S, Redline S (2017) Insomnia and risk of cardiovascular disease. Chest 152(2):435\u2013444. https:\/\/doi.org\/10.1038\/s41598-024-58691-7","journal-title":"Chest"},{"issue":"7","key":"7934_CR34","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/10.1007\/s11883-024-01207-5","volume":"26","author":"VN Jaspan","year":"2024","unstructured":"Jaspan VN, Greenberg GS, Parihar S et al (2024) The role of sleep in cardiovascular disease. Curr Atheroscler Rep 26(7):249\u2013262. https:\/\/doi.org\/10.1038\/10.1007\/s11883-024-01207-5","journal-title":"Curr Atheroscler Rep"},{"issue":"11","key":"7934_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-07166-8","volume":"15","author":"A Ajoolabady","year":"2024","unstructured":"Ajoolabady A, Pratico D, Lin L et al (2024) Inflammation in atherosclerosis: pathophysiology and mechanisms. Cell Death Dis 15(11):817. https:\/\/doi.org\/10.1038\/s41419-024-07166-8","journal-title":"Cell Death Dis"},{"key":"7934_CR36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241814145","author":"B Csoma","year":"2023","unstructured":"Csoma B, Bikov A (2023) The role of the circadian rhythm in dyslipidaemia and vascular inflammation leading to atherosclerosis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms241814145","journal-title":"Int J Mol Sci"},{"issue":"2","key":"7934_CR37","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.smrv.2011.04.003","volume":"16","author":"F Portaluppi","year":"2012","unstructured":"Portaluppi F, Tiseo R, Smolensky MH, Hermida RC, Ayala DE, Fabbian F (2012) Circadian rhythms and cardiovascular health. Sleep Med Rev 16(2):151\u2013166. https:\/\/doi.org\/10.1016\/j.smrv.2011.04.003","journal-title":"Sleep Med Rev"},{"issue":"2","key":"7934_CR38","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1159\/000431091","volume":"62","author":"P Pietschmann","year":"2016","unstructured":"Pietschmann P, Mechtcheriakova D, Meshcheryakova A, F\u00f6ger-Samwald U, Ellinger I (2016) Immunology of osteoporosis: a mini-review. Gerontology 62(2):128\u2013137. https:\/\/doi.org\/10.1159\/000431091","journal-title":"Gerontology"},{"key":"7934_CR39","volume-title":"Modern epidemiology","author":"KJ Rothman","year":"2008","unstructured":"Rothman KJ, Greenland S, Lash TL (2008) Modern epidemiology, 3rd ed. Wolters Kluwer Health\/Lippincott Williams & Wilkins, Philadelphia","edition":"3rd ed"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-026-07934-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00198-026-07934-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-026-07934-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:07:09Z","timestamp":1791950829000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00198-026-07934-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["7934"],"URL":"https:\/\/doi.org\/10.1007\/s00198-026-07934-6","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"24 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All participants provided written informed consent. Ethical approval for this study was obtained by UKB from the National Health Service National Research Ethics Service.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}