{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:09:59Z","timestamp":1792782599900,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)","id":[{"id":"https:\/\/ror.org\/01zgy1s35","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s00198-026-07935-5","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:02:22Z","timestamp":1775887342000},"page":"1789-1800","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Calcium isotope ratio (\u03b444\/42Ca) reflects kidney function and calcium excretion but not bone mineral density or bone turnover: a cross-sectional study"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-6794","authenticated-orcid":false,"given":"Felix N.","family":"von Brackel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikolaj","family":"Bartosik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Munzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Barvencik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Schinke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Oheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Amling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,11]]},"reference":[{"issue":"1","key":"7935_CR1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00402-023-05070-y","volume":"144","author":"E Boehm","year":"2024","unstructured":"E Boehm E Kraft JT Biebl B Wegener R Stahl I Feist-Pagenstert 2024 Quantitative computed tomography has higher sensitivity detecting critical bone mineral density compared to dual-energy X-ray absorptiometry in postmenopausal women and elderly men with osteoporotic fractures: a real-life study Arch Orthop Trauma Surg 144 1 179 188","journal-title":"Arch Orthop Trauma Surg"},{"issue":"3","key":"7935_CR2","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1002\/jbmr.3901","volume":"35","author":"N Mikolajewicz","year":"2020","unstructured":"Mikolajewicz N, Bishop N, Burghardt AJ, Folkestad L, Hall A, Kozloff KM, Lukey PT, Molloy-Bland M, Morin SN, Offiah AC, Shapiro J, Rietbergen van K B, Wager BM, Willie BM, Komarova SV, Glorieux FH (2020) HR-pQCT measures of bone microarchitecture predict fracture: systematic review and meta-analysis. J Bone Miner Res 35(3):446\u2013459","journal-title":"J Bone Miner Res"},{"issue":"5","key":"7935_CR3","doi-asserted-by":"publisher","DOI":"10.1530\/EC-25-0048","volume":"14","author":"A Frank","year":"2025","unstructured":"A Frank JC Witzel C Heppner A Lamersdorf A Leha H Siggelkow 2025 May 1 German DVO risk score identified more patients requiring treatment compared to FRAX Endocr Connect 14 5 e250048","journal-title":"Endocr Connect"},{"issue":"11","key":"7935_CR4","doi-asserted-by":"publisher","first-page":"3099","DOI":"10.1007\/s00198-017-4160-7","volume":"28","author":"H Johansson","year":"2017","unstructured":"H Johansson F Azizieh N Al Ali T Alessa NC Harvey E McCloskey JA Kanis 2017 FRAX- vs. T-score-based intervention thresholds for osteoporosis Osteoporos Int 28 11 3099 3105","journal-title":"Osteoporos Int"},{"issue":"24","key":"7935_CR5","doi-asserted-by":"publisher","first-page":"13709","DOI":"10.1073\/pnas.96.24.13709","volume":"96","author":"J Skulan","year":"1999","unstructured":"J Skulan DJ DePaolo 1999 Nov 23 Calcium isotope fractionation between soft and mineralized tissues as a monitor of calcium use in vertebrates Proc Natl Acad Sci U S A 96 24 13709 13713","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"7935_CR6","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/jbmr.5650040403","volume":"4","author":"R Eastell","year":"1989","unstructured":"R Eastell NE Vieira AL Yergey BL Riggs 1989 One-day test using stable isotopes to measure true fractional calcium absorption J Bone Miner Res 4 4 463 468","journal-title":"J Bone Miner Res"},{"issue":"6","key":"7935_CR7","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1373\/clinchem.2006.080143","volume":"53","author":"J Skulan","year":"2007","unstructured":"J Skulan T Bullen AD Anbar JE Puzas L Shackelford A LeBlanc SM Smith 2007 Natural calcium isotopic composition of urine as a marker of bone mineral balance Clin Chem 53 6 1155 1158","journal-title":"Clin Chem"},{"issue":"4","key":"7935_CR8","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/j.bone.2009.11.037","volume":"46","author":"A Heuser","year":"2010","unstructured":"A Heuser A Eisenhauer 2010 A pilot study on the use of natural calcium isotope (44Ca\/40Ca) fractionation in urine as a proxy for the human body calcium balance Bone 46 4 889 896","journal-title":"Bone"},{"key":"7935_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2019.100200","volume":"10","author":"A Eisenhauer","year":"2019","unstructured":"A Eisenhauer M M\u00fcller A Heuser A Kolevica C-C Gl\u00fcer M Both C Laue UV Hehn S Kloth R Shroff J Schrezenmeir 2019 Calcium isotope ratios in blood and urine: a new biomarker for the diagnosis of osteoporosis Bone Rep 10 100200","journal-title":"Bone Rep"},{"key":"7935_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00012","author":"A Heuser","year":"2019","unstructured":"Heuser A, Frings-Meuthen P, Rittweger J, Galer SJG (2019) Calcium Isotopes in Human Urine as a Diagnostic Tool for Bone Loss: Additional Evidence for Time Delays in Bone Response to Experimental Bed Rest. Front Physiol. https:\/\/doi.org\/10.3389\/fphys.2019.00012","journal-title":"Front. Physiol."},{"issue":"3","key":"7935_CR11","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.kint.2022.04.024","volume":"102","author":"R Shroff","year":"2022","unstructured":"R Shroff AD Lalayiannis M Fewtrell CP Schmitt A Bayazit V Askiti A Jankauskiene J Bacchetta S Silva N Goodman L McAlister L Biassoni N Crabtree A Rahn D-C Fischer A Heuser A Kolevica A Eisenhauer 2022 Naturally occurring stable calcium isotope ratios are a novel biomarker of bone calcium balance in chronic kidney disease Kidney Int 102 3 613 623","journal-title":"Kidney Int"},{"issue":"1","key":"7935_CR12","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/jbmr.4158","volume":"36","author":"R Shroff","year":"2021","unstructured":"R Shroff M Fewtrell A Heuser A Kolevica A Lalayiannis L McAlister S Silva N Goodman CP Schmitt L Biassoni A Rahn D-C Fischer A Eisenhauer 2021 Naturally occurring stable calcium isotope ratios in body compartments provide a novel biomarker of bone mineral balance in children and young adults J Bone Miner Res 36 1 133 142","journal-title":"J Bone Miner Res"},{"issue":"3","key":"7935_CR13","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/ki.1994.328","volume":"46","author":"M Amling","year":"1994","unstructured":"M Amling HJ Grote M Vogel M Hahn G Delling 1994 Three-dimensional analysis of the spine in autopsy cases with renal osteodystrophy Kidney Int 46 3 733 743","journal-title":"Kidney Int"},{"key":"7935_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2024.117210","volume":"188","author":"A Eisenhauer","year":"2024","unstructured":"A Eisenhauer A Hastuti A Heuser A Kolevica B Brandt R Shroff J Oehme M M\u00fcller 2024 Calcium isotope composition in serum and urine for the assessment of bone mineral balance (BMB) - the Osteolabs post-market follow-up study Bone 188 117210","journal-title":"Bone"},{"key":"7935_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2025.117522","volume":"198","author":"A Eisenhauer","year":"2025","unstructured":"A Eisenhauer S S\u00f6nnichsen A Hastuti R Shroff A Heuser A Kolevica A Lubnow B Brandt M M\u00fcller 2025 Monitoring denosumab therapy using the calcium isotope marker (CIM) technology Bone 198 117522","journal-title":"Bone"},{"key":"7935_CR16","doi-asserted-by":"crossref","unstructured":"Tissot FLH, Cleveland D, Grigoryan R, Kipp MA, Shafiee RT, Miaou E, Chunduri R, Melton H, Tacail T, Razionale D (2024 Nov 7) Magnitude and timescales of Ca isotope variability in human urine: implications for bone mass balance monitoring. Metallomics 16(11):mfae050","DOI":"10.1093\/mtomcs\/mfae050"},{"key":"7935_CR17","doi-asserted-by":"crossref","unstructured":"Morgan JLL, Skulan JL, Gordon GW, Romaniello SJ, Smith SM, Anbar AD (2012 June 19) Rapidly assessing changes in bone mineral balance using natural stable calcium isotopes. Proceedings of the National Academy of Sciences. Proc Natl Acad Sci 109(25):9989\u201394","DOI":"10.1073\/pnas.1119587109"},{"key":"7935_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104817","volume":"97","author":"K David","year":"2023","unstructured":"K David G Devos N Narinx L Antonio W Devlies L Deboel D Schollaert A Eisenhauer E Cavalier D Vanderschueren F Claessens S Joniau B Decallonne 2023 Changes in bone and mineral homeostasis after short-term androgen deprivation therapy with or without androgen receptor signalling inhibitor - substudy of a single-centre, double blind, randomised, placebo-controlled phase 2 trial EBioMedicine 97 104817","journal-title":"EBioMedicine"},{"issue":"3","key":"7935_CR19","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s00198-025-07395-3","volume":"36","author":"CM Naso","year":"2025","unstructured":"Naso CM, Lin S-Y, Song G, Xue H (2025) Time trend analysis of osteoporosis prevalence among adults 50 years of age and older in the USA, 2005-2018. Osteoporos Int 36(3):547\u2013554","journal-title":"Osteoporos Int"},{"issue":"5","key":"7935_CR20","doi-asserted-by":"publisher","DOI":"10.1093\/jbmrpl\/ziaf032","volume":"9","author":"R Munzinger","year":"2025","unstructured":"Munzinger R, Brackel von FN, Bartosik M, Barvencik F, Amling M, Oheim R (2025) Calcium isotope ratio in patients with monogenic bone diseases: a prospective, cross-sectional, single-center pilot study. JBMR Plus 9(5):ziaf032","journal-title":"JBMR Plus"},{"issue":"10","key":"7935_CR21","first-page":"670","volume":"337","author":"B Dawson-Hughes","year":"1997","unstructured":"Dawson-Hughes B, Harris SS, Krall EA, Dallal GE (1997) Sept 4) Effect of Calcium and Vitamin D Supplementation on Bone Density in Men and Women 65 Years of Age or Older. New England J Med Mass Med Soc 337(10):670\u20136","journal-title":"New England J Med Mass Med Soc"},{"issue":"1","key":"7935_CR22","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10246","volume":"4","author":"RL Bailey","year":"2020","unstructured":"RL Bailey P Zou TC Wallace GP McCabe BA Craig S Jun JA Cauley CM Weaver 2020 Calcium supplement use is associated with less bone mineral density loss, but does not lessen the risk of bone fracture across the menopause transition: data from the study of women\u2019s health across the nation JBMR Plus 4 1 e10246","journal-title":"JBMR Plus"},{"issue":"3","key":"7935_CR23","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1210\/endrev\/bnac031","volume":"44","author":"M Schini","year":"2022","unstructured":"M Schini T Vilaca F Gossiel S Salam R Eastell 2022 Dec 13 Bone Turnover Markers: Basic Biology to Clinical Applications Endocr Rev 44 3 417 473","journal-title":"Endocr Rev"},{"issue":"1","key":"7935_CR24","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1359\/jbmr.1997.12.1.59","volume":"12","author":"J Dr. Eastell R, Colwell A, Hampton L","year":"1997","unstructured":"Dr. Eastell R, Colwell A, Hampton L, Reeve J (1997Jan 1) Biochemical Markers of Bone Resorption Compared with Estimates of Bone Resorption from Radiotracer Kinetic Studies in Osteoporosis. J Bone Miner Res 12(1):59\u201365","journal-title":"J Bone Miner Res"},{"issue":"4","key":"7935_CR25","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1210\/jcem-67-4-741","volume":"67","author":"R Eastell","year":"1988","unstructured":"Eastell R, Delmas PD, Hodgson SF, Eriksen EF, Mann KG, Riggs BL (1988Oct 1) Bone Formation Rate in Older Normal Women: Concurrent Assessment with Bone Histomorphometry, Calcium Kinetics, and Biochemical Markers*. J Clin Endocrinol Metab 67(4):741\u20138","journal-title":"J Clin Endocrinol Metab"},{"issue":"5189","key":"7935_CR26","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/222146a0","volume":"222","author":"L Burkinshaw","year":"1969","unstructured":"Burkinshaw L, Marshall DH, Oxby CB, Spiers FW, Nordin BEC, Young MM, Nat Publ Group (1969) Bone Turnover Model based on a Continuously Expanding Exchangeable Calcium Pool. Nature 222(5189):146\u20138","journal-title":"Nature"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-026-07935-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00198-026-07935-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-026-07935-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:01:46Z","timestamp":1792270906000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00198-026-07935-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,11]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["7935"],"URL":"https:\/\/doi.org\/10.1007\/s00198-026-07935-5","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,11]]},"assertion":[{"value":"10 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"RM, MB, and MA have no conflict of interest. FvB has received a speakers\u2019 fee from UCB. FB has received speakers\u2019 fees from Alexion, UCB, and Diasorin, and has received institutional research grants from UCB and Alexion. RO has served as a speaker and advisory board member for Kyowa Kirin, Inozyme, Ipsen, Pharmacosmos, Mereo, and UCB and has received an institutional research grant from Kyowa Kirin and UCB.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}