{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:44:02Z","timestamp":1792273442052,"version":"4.4.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Osteoporos Int"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s00198-026-08028-z","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:05:16Z","timestamp":1777367116000},"page":"1881-1891","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of fracture among patients with rheumatoid arthritis according to serological status: a population-based retrospective cohort study"],"prefix":"10.1007","volume":"37","author":[{"given":"Seonghye","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Do","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhyung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeonjin","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonyoung","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungjin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6240-9026","authenticated-orcid":false,"given":"In Young","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8128-8920","authenticated-orcid":false,"given":"Dong Wook","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"8028_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/s41927-023-00347-6","volume":"7","author":"S Ajeganova","year":"2023","unstructured":"Ajeganova S, Andersson M, Forslind K, Gjertsson I, Nyh\u00e4ll-W\u00e5hlin BM, Svensson B, Hafstr\u00f6m I (2023) Long-term fracture risk in rheumatoid arthritis: impact of early sustained DAS28-remission and restored function, progressive erosive disease, body mass index, autoantibody positivity and glucocorticoids. A cohort study over 10 years. BMC Rheumatol 7:23","journal-title":"BMC Rheumatol"},{"key":"8028_CR2","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41584-024-01120-w","volume":"20","author":"F Buttgereit","year":"2024","unstructured":"Buttgereit F, Palmowski A, Bond M, Adami G, Dejaco C (2024) Osteoporosis and fracture risk are multifactorial in patients with inflammatory rheumatic diseases. Nat Rev Rheumatol 20:417\u2013431","journal-title":"Nat Rev Rheumatol"},{"key":"8028_CR3","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1002\/art.41623","volume":"73","author":"J Amkreutz","year":"2021","unstructured":"Amkreutz J, de Moel EC, Theander L et al (2021) Association between bone mineral density and autoantibodies in patients with rheumatoid arthritis. Arthritis Rheumatol 73:921\u2013930","journal-title":"Arthritis Rheumatol"},{"key":"8028_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.701922","volume":"12","author":"S Bugatti","year":"2021","unstructured":"Bugatti S, Bogliolo L, Manzo A, De Stefano L, Delvino P, Motta F, Montecucco C (2021) Impact of anti-citrullinated protein antibodies on progressive systemic bone mineral density loss in patients with early rheumatoid arthritis after two years of treat-to-target. Front Immunol 12:701922","journal-title":"Front Immunol"},{"key":"8028_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.885801","volume":"9","author":"SF Yu","year":"2022","unstructured":"Yu SF, Chen JF, Chen YC, Wang YW, Hsu CY, Lai HM, He HR, Ko CH, Chiu WC, Cheng TT (2022) The impact of seropositivity on systemic bone loss in rheumatoid arthritis-a 3-year interim analysis of a longitudinal observational cohort study. Front Med (Lausanne) 9:885801","journal-title":"Front Med (Lausanne)"},{"key":"8028_CR6","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jocd.2011.05.012","volume":"14","author":"SB Broy","year":"2011","unstructured":"Broy SB, Tanner SB (2011) Official positions for FRAX\u00ae clinical regarding rheumatoid arthritis from joint official positions development conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX\u00ae. J Clin Densitom 14:184\u2013189","journal-title":"J Clin Densitom"},{"key":"8028_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1136\/ard-2022-223356","volume":"82","author":"JS Smolen","year":"2023","unstructured":"Smolen JS, Landew\u00e9 RBM, Bergstra SA et al (2023) EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update. Ann Rheum Dis 82:3\u201318","journal-title":"Ann Rheum Dis"},{"key":"8028_CR8","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.amjmed.2022.01.017","volume":"135","author":"S Abtahi","year":"2022","unstructured":"Abtahi S, Cordtz R, Dreyer L, Driessen JHM, Boonen A, Burden AM (2022) Biological disease-modifying antirheumatic drugs and osteoporotic fracture risk in patients with rheumatoid arthritis: a Danish cohort study. Am J Med 135:879-888.e873","journal-title":"Am J Med"},{"key":"8028_CR9","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2023-003919","author":"I Tronstad","year":"2024","unstructured":"Tronstad I, Hoff M, Horn J, Vikjord SAA, Videm V, Johansson J, Nilsen TIL, Langhammer A (2024) Rheumatoid arthritis, disease-modifying antirheumatic drugs and risk of major osteoporotic fracture: prospective data from the HUNT Study, Norway. RMD Open. https:\/\/doi.org\/10.1136\/rmdopen-2023-003919","journal-title":"RMD Open"},{"key":"8028_CR10","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1093\/rheumatology\/kez655","volume":"59","author":"JF Chen","year":"2020","unstructured":"Chen JF, Hsu CY, Yu SF, Ko CH, Chiu WC, Lai HM, Chen YC, Su YJ, Cheng TT (2020) The impact of long-term biologics\/target therapy on bone mineral density in rheumatoid arthritis: a propensity score-matched analysis. Rheumatology (Oxford) 59:2471\u20132480","journal-title":"Rheumatology (Oxford)"},{"key":"8028_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23084111","author":"TL Chen","year":"2022","unstructured":"Chen TL, Chang KH, Su KY (2022) Effects of biological\/targeted therapies on bone mineral density in inflammatory arthritis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23084111","journal-title":"Int J Mol Sci"},{"key":"8028_CR12","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1007\/s00198-021-05871-0","volume":"32","author":"A Hamar","year":"2021","unstructured":"Hamar A, Szekanecz Z, Pusztai A et al (2021) Effects of one-year tofacitinib therapy on bone metabolism in rheumatoid arthritis. Osteoporos Int 32:1621\u20131629","journal-title":"Osteoporos Int"},{"key":"8028_CR13","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1002\/acr2.11292","volume":"3","author":"A Pawar","year":"2021","unstructured":"Pawar A, Desai RJ, He M, Bessette L, Kim SC (2021) Comparative risk of nonvertebral fractures among patients with rheumatoid arthritis treated with biologic or targeted synthetic disease-modifying antirheumatic drugs. ACR Open Rheumatol 3:531\u2013539","journal-title":"ACR Open Rheumatol"},{"key":"8028_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.23838\/pfm.2021.00135","volume":"6","author":"DW Shin","year":"2022","unstructured":"Shin DW, Cho J, Park JH, Cho B (2022) National general health screening program in Korea: history, current status, and future direction. Precis Future Med 6:9\u201331","journal-title":"Precis Future Med"},{"key":"8028_CR15","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.jtho.2023.10.006","volume":"19","author":"MH Cho","year":"2024","unstructured":"Cho MH, Cho JH, Eun Y et al (2024) Rheumatoid arthritis and risk of lung cancer: a nationwide cohort study. J Thorac Oncol 19:216\u2013226","journal-title":"J Thorac Oncol"},{"key":"8028_CR16","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.1007\/s00296-013-2833-x","volume":"33","author":"SK Cho","year":"2013","unstructured":"Cho SK, Sung YK, Choi CB, Kwon JM, Lee EK, Bae SC (2013) Development of an algorithm for identifying rheumatoid arthritis in the Korean National Health Insurance claims database. Rheumatol Int 33:2985\u20132992","journal-title":"Rheumatol Int"},{"key":"8028_CR17","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1016\/j.chest.2024.02.014","volume":"165","author":"C Chung","year":"2024","unstructured":"Chung C, Kim H, Han K, Jung J, Eun Y, Lee H, Park J, Shin DW, Lee SW (2024) Does rheumatoid arthritis increase the risk of COPD?: a nationwide retrospective cohort study. Chest 165:1362\u20131371","journal-title":"Chest"},{"key":"8028_CR18","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1001\/jamaneurol.2023.0932","volume":"80","author":"J Kang","year":"2023","unstructured":"Kang J, Eun Y, Jang W, Cho MH, Han K, Jung J, Kim Y, Kim GT, Shin DW, Kim H (2023) Rheumatoid arthritis and risk of Parkinson disease in Korea. JAMA Neurol 80:634\u2013641","journal-title":"JAMA Neurol"},{"key":"8028_CR19","doi-asserted-by":"publisher","first-page":"60","DOI":"10.4078\/jrd.2021.28.2.60","volume":"28","author":"H Kim","year":"2021","unstructured":"Kim H, Sung YK (2021) Epidemiology of rheumatoid arthritis in Korea. J Rheum Dis 28:60\u201367","journal-title":"J Rheum Dis"},{"key":"8028_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare12131362","author":"H Cho","year":"2024","unstructured":"Cho H, Park J, Kim B, Han K, Choi HL, Shin DW (2024) Increased risk of fracture after traumatic amputation: a nationwide retrospective cohort study. Healthcare (Basel). https:\/\/doi.org\/10.3390\/healthcare12131362","journal-title":"Healthcare (Basel)"},{"key":"8028_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2024.117093","volume":"183","author":"S Kim","year":"2024","unstructured":"Kim S, Kim B, Han KD, Park J, Yoo JE, Choi HL, Chang WH, Cho IY, Shin DW (2024) Risk of fracture among patients with spinal cord injury: a nationwide cohort study in South Korea. Bone 183:117093","journal-title":"Bone"},{"key":"8028_CR22","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s00198-022-06562-0","volume":"34","author":"HY Koo","year":"2023","unstructured":"Koo HY, Cho EB, Kong SH, Han K, Lee KN, Yoo JE, Min JH, Chun S, Shin DW (2023) Fracture risk in Parkinson\u2019s disease according to its severity and duration. Osteoporos Int 34:81\u201389","journal-title":"Osteoporos Int"},{"key":"8028_CR23","doi-asserted-by":"publisher","DOI":"10.1177\/2040622320981517","volume":"11","author":"CY Hsu","year":"2020","unstructured":"Hsu CY, Chen JF, Su YJ, Chen YC, Lai HM, Yu SF, He HR, Cheng TT (2020) Time-averaged disease activity of rheumatoid arthritis associated with long-term bone mineral density changes. Ther Adv Chronic Dis 11:2040622320981517","journal-title":"Ther Adv Chronic Dis"},{"key":"8028_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1156996","volume":"14","author":"GE Chung","year":"2023","unstructured":"Chung GE, Cho EJ, Kim MJ et al (2023) Association between the fatty liver index and the risk of fracture among individuals over the age of 50 years: a nationwide population-based study. Front Endocrinol (Lausanne) 14:1156996","journal-title":"Front Endocrinol (Lausanne)"},{"key":"8028_CR25","unstructured":"World Health Organization (2000) International association for the study of obesity, international obesity task force. The Asia-Pacific perspective: Redefining obesity and its treat ment. Health Communications Australia, Sydney. https:\/\/iris.who.int\/bitstream\/handle\/10665\/206936\/0957708211_eng.pdf"},{"key":"8028_CR26","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006983","volume":"96","author":"AL Xue","year":"2017","unstructured":"Xue AL, Wu SY, Jiang L, Feng AM, Guo HF, Zhao P (2017) Bone fracture risk in patients with rheumatoid arthritis: a meta-analysis. Medicine (Baltimore) 96:e6983","journal-title":"Medicine (Baltimore)"},{"key":"8028_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s41927-023-00354-7","volume":"7","author":"L Theander","year":"2023","unstructured":"Theander L, Jacobsson LTH, Turesson C (2023) Osteoporosis-related fractures in men and women with established and early rheumatoid arthritis: predictors and risk compared with the general population. BMC Rheumatol 7:28","journal-title":"BMC Rheumatol"},{"key":"8028_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2024.152497","volume":"68","author":"L Theander","year":"2024","unstructured":"Theander L, Sharma A, Karlsson MK, \u00c5kesson KE, Jacobsson LTH, Turesson C (2024) Risk and predictors of fractures in early rheumatoid arthritis - a long term follow up study of an inception cohort. Semin Arthritis Rheum 68:152497","journal-title":"Semin Arthritis Rheum"},{"key":"8028_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01331-9","volume":"8","author":"Q Ding","year":"2023","unstructured":"Ding Q, Hu W, Wang R, Yang Q, Zhu M, Li M, Cai J, Rose P, Mao J, Zhu YZ (2023) Signaling pathways in rheumatoid arthritis: implications for targeted therapy. Signal Transduct Target Ther 8:68","journal-title":"Signal Transduct Target Ther"},{"key":"8028_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158740","author":"P Pietschmann","year":"2022","unstructured":"Pietschmann P, Butylina M, Kerschan-Schindl K, Sipos W (2022) Mechanisms of systemic osteoporosis in rheumatoid arthritis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23158740","journal-title":"Int J Mol Sci"},{"key":"8028_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01483","volume":"10","author":"U Steffen","year":"2019","unstructured":"Steffen U, Schett G, Bozec A (2019) How autoantibodies regulate osteoclast induced bone loss in rheumatoid arthritis. Front Immunol 10:1483","journal-title":"Front Immunol"},{"key":"8028_CR32","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s00223-022-01001-y","volume":"111","author":"B Hauser","year":"2022","unstructured":"Hauser B, Raterman H, Ralston SH, Lems WF (2022) The effect of anti-rheumatic drugs on the skeleton. Calcif Tissue Int 111:445\u2013456","journal-title":"Calcif Tissue Int"},{"key":"8028_CR33","doi-asserted-by":"publisher","first-page":"3531","DOI":"10.1002\/art.34649","volume":"64","author":"TP LaBranche","year":"2012","unstructured":"LaBranche TP, Jesson MI, Radi ZA et al (2012) JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production. Arthritis Rheum 64:3531\u20133542","journal-title":"Arthritis Rheum"},{"key":"8028_CR34","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s10067-023-06735-0","volume":"43","author":"YW Chen","year":"2024","unstructured":"Chen YW, Chen HH, Huang WN, Chen JP, Chen YH, Chen YM (2024) Potential alleviation of bone mineral density loss with Janus kinase inhibitors in rheumatoid arthritis. Clin Rheumatol 43:117\u2013128","journal-title":"Clin Rheumatol"},{"key":"8028_CR35","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1056\/NEJMc2033206","volume":"384","author":"D Felson","year":"2021","unstructured":"Felson D, Smolen JS (2021) Trial of upadacitinib or abatacept in rheumatoid arthritis. N Engl J Med 384:83","journal-title":"N Engl J Med"},{"key":"8028_CR36","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1007\/s00011-023-01717-z","volume":"72","author":"C Langbour","year":"2023","unstructured":"Langbour C, Rene J, Goupille P, Carvajal Alegria G (2023) Efficacy of Janus kinase inhibitors in rheumatoid arthritis. Inflamm Res 72:1121\u20131132","journal-title":"Inflamm Res"},{"key":"8028_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104354","volume":"147","author":"G Orsolini","year":"2019","unstructured":"Orsolini G, Fassio A, Rossini M, Adami G, Giollo A, Caimmi C, Idolazzi L, Viapiana O, Gatti D (2019) Effects of biological and targeted synthetic DMARDs on bone loss in rheumatoid arthritis. Pharmacol Res 147:104354","journal-title":"Pharmacol Res"},{"key":"8028_CR38","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1016\/S2213-8587(25)00251-7","volume":"13","author":"LC Hofbauer","year":"2025","unstructured":"Hofbauer LC, Compston JE, Saag KG, Rauner M, Tsourdi E (2025) Glucocorticoid-induced osteoporosis: novel concepts and clinical implications. Lancet Diabetes Endocrinol 13:964\u2013979","journal-title":"Lancet Diabetes Endocrinol"}],"container-title":["Osteoporosis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-026-08028-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00198-026-08028-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00198-026-08028-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:01:41Z","timestamp":1792270901000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00198-026-08028-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["8028"],"URL":"https:\/\/doi.org\/10.1007\/s00198-026-08028-z","relation":{},"ISSN":["0937-941X","1433-2965"],"issn-type":[{"value":"0937-941X","type":"print"},{"value":"1433-2965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"22 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol was approved by the Institutional Review Board (IRB) of Samsung Medical Center (IRB file no. SMC 2022\u201306-141). All data were de-identified under confidentiality guidelines, and the requirement for informed consent was waived.","order":1,"name":"Ethics","label":"Institutional review board\u00a0","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}