{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T14:48:40Z","timestamp":1774795720830,"version":"3.50.1"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Microbiol"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s00203-017-1434-6","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T14:49:18Z","timestamp":1506437358000},"page":"19-31","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Evolution of structural fitness and multifunctional aspects of mycobacterial RND family transporters"],"prefix":"10.1007","volume":"200","author":[{"given":"Padmani","family":"Sandhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9564-9790","authenticated-orcid":false,"given":"Yusuf","family":"Akhter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,9,26]]},"reference":[{"key":"1434_CR1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.gene.2007.10.017","volume":"407","author":"Y Akhter","year":"2008","unstructured":"Akhter Y, Yellaboina S, Farhana A, Ranjan A, Ahmed N, Hasnain SE (2008) Genome scale portrait of cAMP-receptor protein (CRP) regulons in mycobacteria points to their role in pathogenesis. Gene 407:148\u2013158","journal-title":"Gene"},{"key":"1434_CR2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1155\/2007\/986794","volume":"18","author":"PE Alexander","year":"2007","unstructured":"Alexander PE, De P (2007) The emergence of extensively drug-resistant tuberculosis (TB): TB\/HIV coinfection, multidrug-resistant TB and the resulting public health threat from extensively drug-resistant TB, globally and in Canada. Can J Infect Dis Med Microbiol 18:289\u2013291","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"1434_CR3","doi-asserted-by":"crossref","first-page":"5870","DOI":"10.3402\/ljm.v6i0.5870","volume":"6","author":"M Askoura","year":"2011","unstructured":"Askoura M, Mottawea W, Abujamel T, Taher I (2011) Efflux pump inhibitors (EPIs) as new antimicrobial agents against Pseudomonas aeruginosa. Libyan J Med 6:5870","journal-title":"Libyan J Med"},{"key":"1434_CR4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bcp.2015.05.001","volume":"96","author":"R Bailo","year":"2015","unstructured":"Bailo R, Bhatt A, A\u00ednsa JA (2015) Lipid transport in Mycobacterium tuberculosis and its implications in virulence and drug development. Biochem Pharmacol 96:159\u2013167","journal-title":"Biochem Pharmacol"},{"key":"1434_CR5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1128\/CMR.00059-12","volume":"26","author":"A Beceiro","year":"2013","unstructured":"Beceiro A, Tom\u00e1s M, Bou G (2013) Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world? Clin Microbiol Rev 26:185\u2013230","journal-title":"Clin Microbiol Rev"},{"key":"1434_CR6","doi-asserted-by":"crossref","first-page":"27952","DOI":"10.1074\/jbc.M114.581199","volume":"289","author":"JM Belardinelli","year":"2014","unstructured":"Belardinelli JM, Larrouy-Maumus G, Jones V, de Carvalho LPS, McNeil MR, Jackson M (2014) Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis. J Biol Chem 289:27952\u201327965","journal-title":"J Biol Chem"},{"issue":"10","key":"1434_CR7","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1021\/acsinfecdis.6b00095","volume":"2","author":"JM Belardinelli","year":"2016","unstructured":"Belardinelli JM et al (2016) Structure-function profile of MmpL3, the essential mycolic acid transporter from Mycobacterium tuberculosis. ACS Infect Dis 2(10):702\u2013713","journal-title":"ACS Infect Dis"},{"key":"1434_CR8","doi-asserted-by":"crossref","first-page":"e29191","DOI":"10.1371\/journal.pone.0029191","volume":"6","author":"F Bernaudat","year":"2011","unstructured":"Bernaudat F et al (2011) Heterologous expression of membrane proteins: choosing the appropriate host. PLoS One 6:e29191","journal-title":"PLoS One"},{"key":"1434_CR9","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1111\/mmi.13283","volume":"99","author":"A Bernut","year":"2016","unstructured":"Bernut A et al (2016) Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members. Mol Microbiol 99:866\u2013883. doi: 10.1111\/mmi.13283","journal-title":"Mol Microbiol"},{"key":"1434_CR10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.bi.64.070195.000333","volume":"64","author":"PJ Brennan","year":"1995","unstructured":"Brennan PJ, Nikaido H (1995) The envelope of mycobacteria. Annu Rev Biochem 64:29\u201363","journal-title":"Annu Rev Biochem"},{"key":"1434_CR11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.tube.2017.08.001","volume":"107","author":"J Briffotaux","year":"2017","unstructured":"Briffotaux J, Huang W, Wang X, Gicquel B (2017) MmpS5\/MmpL5 as an efflux pump in Mycobacterium species. Tuberculosis 107:13\u201319. doi: 10.1016\/j.tube.2017.08.001","journal-title":"Tuberculosis"},{"key":"1434_CR12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.1365-2958.1999.01593.x","volume":"34","author":"LR Camacho","year":"1999","unstructured":"Camacho LR, Ensergueix D, Perez E, Gicquel B, Guilhot C (1999) Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesis. Mol Microbiol 34:257\u2013267","journal-title":"Mol Microbiol"},{"issue":"3","key":"1434_CR13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.diagmicrobio.2013.02.033","volume":"76","author":"MK Calgin","year":"2013","unstructured":"Calgin MK, Sahin F, Turegun B, Gerceker D, Atasever M, Koksal D, Karasartova D, Kiyan M (2013) Expression analysis of efflux pump genes among drug-susceptible and multidrug-resistant Mycobacterium tuberculosis clinical isolates and reference strains. Diagn Microbiol Infect Dis 76(3):291\u2013297","journal-title":"Diagn Microbiol Infect Dis"},{"key":"1434_CR14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tube.2016.06.004","volume":"100","author":"C Chalut","year":"2016","unstructured":"Chalut C (2016) MmpL transporter-mediated export of cell-wall associated lipids and siderophores in mycobacteria. Tuberculosis 100:32\u201345","journal-title":"Tuberculosis"},{"key":"1434_CR15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.gene.2007.02.021","volume":"396","author":"C-C Chen","year":"2007","unstructured":"Chen C-C, Li W-H, Sung H-M (2007) Patterns of internal gene duplication in the course of metazoan evolution. Gene 396:59\u201365","journal-title":"Gene"},{"key":"1434_CR16","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.chembiol.2015.07.013","volume":"22","author":"N Chim","year":"2015","unstructured":"Chim N et al (2015) The structure and interactions of periplasmic domains of crucial MmpL membrane proteins from Mycobacterium tuberculosis. Chem Biol 22:1098\u20131107","journal-title":"Chem Biol"},{"key":"1434_CR17","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/31159","volume":"393","author":"S Cole","year":"1998","unstructured":"Cole S et al (1998) Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393:537\u2013544","journal-title":"Nature"},{"key":"1434_CR18","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/35059006","volume":"409","author":"S Cole","year":"2001","unstructured":"Cole S et al (2001) Massive gene decay in the leprosy bacillus. Nature 409:1007\u20131011","journal-title":"Nature"},{"key":"1434_CR19","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1073\/pnas.1030024100","volume":"100","author":"SE Converse","year":"2003","unstructured":"Converse SE, Mougous JD, Leavell MD, Leary JA, Bertozzi CR, Cox JS (2003) MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence. Proc Natl Acad Sci USA 100:6121\u20136126","journal-title":"Proc Natl Acad Sci USA"},{"key":"1434_CR20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/47042","volume":"402","author":"JS Cox","year":"1999","unstructured":"Cox JS, Chen B, McNeil M, Jacobs WR (1999) Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 402:79\u201383","journal-title":"Nature"},{"key":"1434_CR21","doi-asserted-by":"crossref","first-page":"20752","DOI":"10.1073\/pnas.0908570106","volume":"106","author":"TJ Crisman","year":"2009","unstructured":"Crisman TJ, Qu S, Kanner BI, Forrest LR (2009) Inward-facing conformation of glutamate transporters as revealed by their inverted-topology structural repeats. Proc Natl Acad Sci USA 106:20752\u201320757","journal-title":"Proc Natl Acad Sci USA"},{"key":"1434_CR22","doi-asserted-by":"crossref","first-page":"10731","DOI":"10.1038\/ncomms10731","volume":"7","author":"L Daury","year":"2016","unstructured":"Daury L et al (2016) Tripartite assembly of RND multidrug efflux pumps. Nat Commun 7:10731","journal-title":"Nat Commun"},{"key":"1434_CR23","doi-asserted-by":"crossref","first-page":"43495","DOI":"10.1038\/srep43495","volume":"7","author":"G Degiacomi","year":"2017","unstructured":"Degiacomi G et al (2017) Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression. Sci Rep 7:43495","journal-title":"Sci Rep"},{"key":"1434_CR24","doi-asserted-by":"publisher","first-page":"28559","DOI":"10.1074\/jbc.M115.683797","volume":"290","author":"JA Delmar","year":"2015","unstructured":"Delmar JA et al (2015) Structural basis for the regulation of the MmpL transporters of Mycobacterium tuberculosis. J Biol Chem 290:28559\u201328574. doi: 10.1074\/jbc.M115.683797","journal-title":"J Biol Chem"},{"key":"1434_CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2148-8-78","volume":"8","author":"C Deshayes","year":"2008","unstructured":"Deshayes C et al (2008) Detecting the molecular scars of evolution in the Mycobacterium tuberculosis complex by analyzing interrupted coding sequences. BMC Evol Biol 8:1","journal-title":"BMC Evol Biol"},{"key":"1434_CR26","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/j.1365-2958.2010.07385.x","volume":"78","author":"C Deshayes","year":"2010","unstructured":"Deshayes C et al (2010) MmpS4 promotes glycopeptidolipids biosynthesis and export in Mycobacterium smegmatis. Mol Microbiol 78:989\u20131003","journal-title":"Mol Microbiol"},{"key":"1434_CR27","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1128\/IAI.73.6.3492-3501.2005","volume":"73","author":"P Domenech","year":"2005","unstructured":"Domenech P, Reed MB, Barry CE (2005) Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance. Infect Immun 73:3492\u20133501","journal-title":"Infect Immun"},{"key":"1434_CR28","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/mmi.13406","volume":"101","author":"C Dupont","year":"2016","unstructured":"Dupont C et al (2016) A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus. Mol Microbiol 101:515\u2013529","journal-title":"Mol Microbiol"},{"key":"1434_CR29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4161\/viru.22329","volume":"4","author":"MA Forrellad","year":"2013","unstructured":"Forrellad MA et al (2013) Virulence factors of the Mycobacterium tuberculosis complex. Virulence 4:3\u201366","journal-title":"Virulence"},{"key":"1434_CR30","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1056\/NEJM199302253280801","volume":"328","author":"TR Frieden","year":"1993","unstructured":"Frieden TR, Sterling T, Pablos-Mendez A, Kilburn JO, Cauthen GM, Dooley SW (1993) The emergence of drug-resistant tuberculosis in New York City. N Engl J Med 328:521\u2013526","journal-title":"N Engl J Med"},{"key":"1434_CR31","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1046\/j.1365-2958.1999.01383.x","volume":"32","author":"SV Gordon","year":"1999","unstructured":"Gordon SV, Brosch R, Billault A, Garnier T, Eiglmeier K, Cole ST (1999) Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays. Mol Microbiol 32:643\u2013655","journal-title":"Mol Microbiol"},{"key":"1434_CR32","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1128\/IAI.9.1.150-158.1974","volume":"9","author":"MB Goren","year":"1974","unstructured":"Goren MB, Brokl O, Schaefer WB (1974) Lipids of putative relevance to virulence in Mycobacterium tuberculosis: phthiocerol dimycocerosate and the attenuation indicator lipid. Infect Immun 9:150\u2013158","journal-title":"Infect Immun"},{"key":"1434_CR33","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/nchembio.794","volume":"8","author":"AE Grzegorzewicz","year":"2012","unstructured":"Grzegorzewicz AE et al (2012) Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol 8:334\u2013341","journal-title":"Nat Chem Biol"},{"key":"1434_CR34","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1471-2180-6-66","volume":"6","author":"P Guglierame","year":"2006","unstructured":"Guglierame P et al (2006) Efflux pump genes of the resistance-nodulation-division family in Burkholderia cenocepacia genome. BMC Microbiol 6:66","journal-title":"BMC Microbiol"},{"key":"1434_CR35","doi-asserted-by":"crossref","first-page":"e02509","DOI":"10.1128\/AAC.02509-16","volume":"61","author":"I Halloum","year":"2017","unstructured":"Halloum I et al (2017) Resistance to thiacetazone derivatives active against Mycobacterium abscessus involves mutations in the MmpL5 transcriptional repressor MAB_4384. Antimicrob Agents Chemother 61:e02509\u2013e02516","journal-title":"Antimicrob Agents Chemother"},{"key":"1434_CR36","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1128\/AAC.00037-14","volume":"58","author":"RC Hartkoorn","year":"2014","unstructured":"Hartkoorn RC, Uplekar S, Cole ST (2014) Cross-resistance between clofazimine and bedaquiline through upregulation of MmpL5 in Mycobacterium tuberculosis. Antimicrob Agents Chemother 58:2979\u20132981","journal-title":"Antimicrob Agents Chemother"},{"key":"1434_CR37","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3201\/eid0805.010267","volume":"8","author":"M Helms","year":"2002","unstructured":"Helms M, Vastrup P, Gerner-Smidt P, M\u00f8lbak K (2002) Excess mortality associated with antimicrobial drug-resistant Salmonella typhimurium. Emerg Infect Dis 8:490\u2013495","journal-title":"Emerg Infect Dis"},{"key":"1434_CR38","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1002\/pro.510","volume":"19","author":"A Hennerdal","year":"2010","unstructured":"Hennerdal A, Falk J, Lindahl E, Elofsson A (2010) Internal duplications in \u03b1-helical membrane protein topologies are common but the nonduplicated forms are rare. Protein Sci 19:2305\u20132318","journal-title":"Protein Sci"},{"key":"1434_CR39","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1371\/journal.ppat.0010002","volume":"1","author":"M Jain","year":"2005","unstructured":"Jain M, Cox JS (2005) Interaction between polyketide synthase and transporter suggests coupled synthesis and export of virulence lipid in M. tuberculosis. PLoS Pathog 1:e2","journal-title":"PLoS Pathog"},{"key":"1434_CR40","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1515\/hsz-2014-0224","volume":"395","author":"R Keller","year":"2014","unstructured":"Keller R, Ziegler C, Schneider D (2014) When two turn into one: evolution of membrane transporters from half modules. Biol Chem 395:1379\u20131388","journal-title":"Biol Chem"},{"key":"1434_CR41","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nprot.2015.053","volume":"10","author":"LA Kelley","year":"2015","unstructured":"Kelley LA, Mezulis S, Yates CM, Wass MN, Sternberg MJ (2015) The Phyre2 web portal for protein modeling, prediction and analysis. Nat Protoc 10:845\u2013858","journal-title":"Nat Protoc"},{"key":"1434_CR42","doi-asserted-by":"crossref","first-page":"10702","DOI":"10.1021\/bi101256x","volume":"49","author":"K Khafizov","year":"2010","unstructured":"Khafizov K, Staritzbichler R, Stamm M, Forrest LR (2010) A study of the evolution of inverted-topology repeats from LeuT-fold transporters using AlignMe. Biochemistry 49:10702\u201310713","journal-title":"Biochemistry"},{"key":"1434_CR43","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1128\/AAC.05270-11","volume":"56","author":"V Rosa La","year":"2012","unstructured":"La Rosa V et al (2012) MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrob Agents Chemother 56:324\u2013331","journal-title":"Antimicrob Agents Chemother"},{"key":"1434_CR44","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1128\/IAI.73.4.2533-2540.2005","volume":"73","author":"G Lamichhane","year":"2005","unstructured":"Lamichhane G, Tyagi S, Bishai WR (2005) Designer arrays for defined mutant analysis to detect genes essential for survival of Mycobacterium tuberculosis in mouse lungs. Infect Immun 73:2533\u20132540","journal-title":"Infect Immun"},{"key":"1434_CR45","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0959-440X(98)80119-X","volume":"8","author":"Y Lange","year":"1998","unstructured":"Lange Y, Steck TL (1998) Four cholesterol-sensing proteins. Curr Opin Struct Biol 8:435\u2013439","journal-title":"Curr Opin Struct Biol"},{"key":"1434_CR46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1128\/AAC.45.1.105-116.2001","volume":"45","author":"O Lomovskaya","year":"2001","unstructured":"Lomovskaya O et al (2001) Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother 45:105\u2013116","journal-title":"Antimicrob Agents Chemother"},{"key":"1434_CR47","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1128\/AAC.01577-08","volume":"53","author":"G Louw","year":"2009","unstructured":"Louw G, Warren R, Van Pittius NG, McEvoy C, Van Helden P, Victor T (2009) A balancing act: efflux\/influx in mycobacterial drug resistance. Antimicrob Agents Chemother 53:3181\u20133189","journal-title":"Antimicrob Agents Chemother"},{"key":"1434_CR48","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.biochi.2005.04.012","volume":"87","author":"B Marquez","year":"2005","unstructured":"Marquez B (2005) Bacterial efflux systems and efflux pumps inhibitors. Biochimie 87:1137\u20131147","journal-title":"Biochimie"},{"key":"1434_CR49","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.chembiol.2013.11.011","volume":"21","author":"H Marrakchi","year":"2014","unstructured":"Marrakchi H, Lan\u00e9elle M-A, Daff\u00e9 M (2014) Mycolic acids: structures, biosynthesis, and beyond. Chem Biol 21:67\u201385","journal-title":"Chem Biol"},{"key":"1434_CR50","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tube.2008.08.003","volume":"89","author":"A Milano","year":"2009","unstructured":"Milano A et al (2009) Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5\u2013MmpL5 efflux system. Tuberculosis 89:84\u201390","journal-title":"Tuberculosis"},{"key":"1434_CR51","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1128\/AAC.43.3.465","volume":"43","author":"RA Moore","year":"1999","unstructured":"Moore RA, DeShazer D, Reckseidler S, Weissman A, Woods DE (1999) Efflux-mediated aminoglycoside and macrolide resistance in Burkholderia pseudomallei. Antimicrob Agents Chemother 43:465\u2013470","journal-title":"Antimicrob Agents Chemother"},{"key":"1434_CR52","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S1369-5274(98)80083-0","volume":"1","author":"H Nikaido","year":"1998","unstructured":"Nikaido H (1998) Multiple antibiotic resistance and efflux. Curr Opin Microbiol 1:516\u2013523","journal-title":"Curr Opin Microbiol"},{"key":"1434_CR53","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.biochem.78.082907.145923","volume":"78","author":"H Nikaido","year":"2009","unstructured":"Nikaido H (2009) Multidrug resistance in bacteria. Annu Rev Biochem 78:119","journal-title":"Annu Rev Biochem"},{"key":"1434_CR54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/9780470920541.ch1","volume":"77","author":"H Nikaido","year":"2011","unstructured":"Nikaido H (2011) Structure and mechanism of RND-type multidrug efflux pumps. Adv Enzymol Relat Areas Mol Biol 77:1","journal-title":"Adv Enzymol Relat Areas Mol Biol"},{"key":"1434_CR55","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3389\/fmicb.2015.00421","volume":"6","author":"TJ Opperman","year":"2015","unstructured":"Opperman TJ, Nguyen ST (2015) Recent advances toward a molecular mechanism of efflux pump inhibition. Front Microbiol 6:421","journal-title":"Front Microbiol"},{"key":"1434_CR56","doi-asserted-by":"crossref","first-page":"24213","DOI":"10.1074\/jbc.M113.473371","volume":"288","author":"SA Pacheco","year":"2013","unstructured":"Pacheco SA, Hsu F-F, Powers KM, Purdy GE (2013) MmpL11 protein transports mycolic acid-containing lipids to the mycobacterial cell wall and contributes to biofilm formation in Mycobacterium smegmatis. J Biol Chem 288:24213\u201324222","journal-title":"J Biol Chem"},{"key":"1434_CR57","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/joim.12264","volume":"277","author":"S Parida","year":"2015","unstructured":"Parida S et al (2015) Totally drug-resistant tuberculosis and adjunct therapies. J Intern Med 277:388\u2013405","journal-title":"J Intern Med"},{"key":"1434_CR58","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1128\/AAC.49.11.4775-4777.2005","volume":"49","author":"M Pasca","year":"2005","unstructured":"Pasca M, Guglierame P, Rossi ED, Zara F, Riccardi G (2005) MmpL7 gene of Mycobacterium tuberculosis is responsible for isoniazid efflux in mycobacterium smegmatis. Antimicrob Agents Chemother 49:4775\u20134777","journal-title":"Antimicrob Agents Chemother"},{"key":"1434_CR59","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1128\/MMBR.60.4.575-608.1996","volume":"60","author":"IT Paulsen","year":"1996","unstructured":"Paulsen IT, Brown MH, Skurray RA (1996) Proton-dependent multidrug efflux systems. Microbiol Rev 60:575\u2013608","journal-title":"Microbiol Rev"},{"key":"1434_CR60","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nrc2789-c1","volume":"10","author":"P Perego","year":"2010","unstructured":"Perego P, Gatti L, Beretta GL (2010) The ABC of glycosylation. Nat Rev Cancer 10:523","journal-title":"Nat Rev Cancer"},{"key":"1434_CR61","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.bbrc.2006.06.164","volume":"348","author":"J Perez","year":"2006","unstructured":"Perez J et al (2006) Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD. Biochem Biophys Res Commun 348:6\u201312. doi: 10.1016\/j.bbrc.2006.06.164","journal-title":"Biochem Biophys Res Commun"},{"key":"1434_CR62","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1128\/CMR.19.2.382-402.2006","volume":"19","author":"LJ Piddock","year":"2006","unstructured":"Piddock LJ (2006) Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev 19:382\u2013402","journal-title":"Clin Microbiol Rev"},{"key":"1434_CR63","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.2174\/1389557516666160118105319","volume":"16","author":"G Poce","year":"2016","unstructured":"Poce G, Consalvi S, Biava M (2016) MmpL3 inhibitors: diverse chemical scaffolds inhibit the same target. Mini Rev Med Chem 16:1274\u20131283","journal-title":"Mini Rev Med Chem"},{"key":"1434_CR64","doi-asserted-by":"crossref","first-page":"214ra168","DOI":"10.1126\/scitranslmed.3007355","volume":"5","author":"SP Rao","year":"2013","unstructured":"Rao SP et al (2013) Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis. Sci Transl Med 5:214ra168","journal-title":"Sci Transl Med"},{"key":"1434_CR65","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1517\/14728222.2014.859677","volume":"18","author":"GV Rayasam","year":"2014","unstructured":"Rayasam GV (2014) MmpL3 a potential new target for development of novel anti-tuberculosis drugs. Expert Opin Ther Targets 18:247\u2013256","journal-title":"Expert Opin Ther Targets"},{"key":"1434_CR66","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1128\/JB.182.15.4348-4351.2000","volume":"182","author":"J Recht","year":"2000","unstructured":"Recht J, Mart\u00ednez A, Torello S, Kolter R (2000) Genetic analysis of sliding motility in Mycobacterium smegmatis. J Bacteriol 182:4348\u20134351","journal-title":"J Bacteriol"},{"key":"1434_CR67","doi-asserted-by":"crossref","first-page":"e60933","DOI":"10.1371\/journal.pone.0060933","volume":"8","author":"MJ Remui\u00f1\u00e1n","year":"2013","unstructured":"Remui\u00f1\u00e1n MJ et al (2013) Tetrahydropyrazolo [1,5-a] pyrimidine-3-carboxamide and N-benzyl-6\u2032,7\u2032-dihydrospiro[piperidine-4,4\u2032-thieno [3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3. PLoS One 8:e60933","journal-title":"PLoS One"},{"key":"1434_CR68","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1365-2958.1994.tb00362.x","volume":"11","author":"M Saier","year":"1994","unstructured":"Saier M, Tam R, Reizer A, Reizer J (1994) Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport. Mol Microbiol 11:841\u2013847","journal-title":"Mol Microbiol"},{"key":"1434_CR69","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ijmm.2015.03.005","volume":"305","author":"P Sandhu","year":"2015","unstructured":"Sandhu P, Akhter Y (2015) The internal gene duplication and interrupted coding sequences in the MmpL genes of Mycobacterium tuberculosis: towards understanding the multidrug transport in an evolutionary perspective. Int J Med Microbiol 305:413\u2013423","journal-title":"Int J Med Microbiol"},{"key":"1434_CR70","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.abb.2016.01.007","volume":"592","author":"P Sandhu","year":"2016","unstructured":"Sandhu P, Akhter Y (2016) The drug binding sites and transport mechanism of the RND pumps from Mycobacterium tuberculosis: Insights from molecular dynamics simulations. Arch Biochem Biophys 592:38\u201349","journal-title":"Arch Biochem Biophys"},{"key":"1434_CR71","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jinorgbio.2017.02.013","volume":"170","author":"P Sandhu","year":"2017","unstructured":"Sandhu P, Akhter Y (2017) Siderophore transport by MmpL5\u2013MmpS5 protein complex in Mycobacterium tuberculosis. J Inorg Biochem 170:75\u201384. doi: 10.1016\/j.jinorgbio.2017.02.013","journal-title":"J Inorg Biochem"},{"key":"1434_CR72","first-page":"48","volume":"2","author":"HP Schweizer","year":"2003","unstructured":"Schweizer HP (2003) Efflux as a mechanism of resistance to antimicrobials in Pseudomonas aeruginosa and related bacteria: unanswered question. Genet Mol Res 2:48\u201362","journal-title":"Genet Mol Res"},{"key":"1434_CR73","doi-asserted-by":"publisher","first-page":"26218","DOI":"10.1074\/jbc.M115.687269","volume":"290","author":"A Singhal","year":"2015","unstructured":"Singhal A et al (2015) Systematic analysis of mycobacterial acylation reveals first example of acylation-mediated regulation of enzyme activity of a bacterial phosphatase. J Biol Chem 290:26218\u201326234. doi: 10.1074\/jbc.M115.687269","journal-title":"J Biol Chem"},{"key":"1434_CR74","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1073\/pnas.1602472113","volume":"113","author":"H Sjuts","year":"2016","unstructured":"Sjuts H et al (2016) Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives. Proc Natl Acad Sci USA 113:3509\u20133514","journal-title":"Proc Natl Acad Sci USA"},{"key":"1434_CR75","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1021\/cb300151m","volume":"7","author":"SA Stanley","year":"2012","unstructured":"Stanley SA et al (2012) Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem Biol 7:1377\u20131384","journal-title":"ACS Chem Biol"},{"key":"1434_CR76","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2174\/138920111795164075","volume":"12","author":"EI Stolarczyk","year":"2011","unstructured":"Stolarczyk EI, Reiling CJ, Paumi CM (2011) Regulation of ABC transporter function via phosphorylation by protein kinases. Curr Pharm Biotechnol 12:621\u2013635","journal-title":"Curr Pharm Biotechnol"},{"key":"1434_CR77","doi-asserted-by":"publisher","first-page":"7173","DOI":"10.1073\/pnas.0900693106","volume":"106","author":"MF Symmons","year":"2009","unstructured":"Symmons MF, Bokma E, Koronakis E, Hughes C, Koronakis V (2009) The assembled structure of a complete tripartite bacterial multidrug efflux pump. Proc Natl Acad Sci USA 106:7173\u20137178. doi: 10.1073\/pnas.0900693106","journal-title":"Proc Natl Acad Sci USA"},{"key":"1434_CR78","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/mmi.13306","volume":"99","author":"R Szekely","year":"2016","unstructured":"Szekely R, Cole S (2016) Mechanistic insight into mycobacterial MmpL protein function. Mol Microbiol 99:831\u2013834","journal-title":"Mol Microbiol"},{"key":"1434_CR79","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1128\/AAC.05708-11","volume":"56","author":"K Tahlan","year":"2012","unstructured":"Tahlan K et al (2012) SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis. Antimicrob Agents Chemother 56:1797\u20131809","journal-title":"Antimicrob Agents Chemother"},{"key":"1434_CR80","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1054\/tuld.1999.0220","volume":"79","author":"F Tekaia","year":"1999","unstructured":"Tekaia F, Gordon S, Garnier T, Brosch R, Barrell B, Cole S (1999) Analysis of the proteome of Mycobacterium tuberculosis in silico. Tuber Lung Dis 79:329\u2013342","journal-title":"Tuber Lung Dis"},{"key":"1434_CR81","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1073\/pnas.1009516108","volume":"108","author":"MV Tullius","year":"2011","unstructured":"Tullius MV et al (2011) Discovery and characterization of a unique mycobacterial heme acquisition system. Proc Natl Acad Sci USA 108:5051\u20135056","journal-title":"Proc Natl Acad Sci USA"},{"key":"1434_CR82","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1094\/MPMI-19-0607","volume":"19","author":"AM Valecillos","year":"2006","unstructured":"Valecillos AM, Palenzuela PR, L\u00f3pez-Solanilla E (2006) The role of several multidrug resistance systems in Erwinia chrysanthemi pathogenesis. Mol Plant Microbe Interact 19:607\u2013613","journal-title":"Mol Plant Microbe Interact"},{"issue":"4","key":"1434_CR83","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.chembiol.2012.03.006","volume":"19","author":"C Varela","year":"2012","unstructured":"Varela C, Rittmann D, Singh A, Krumbach K, Bhatt K, Eggeling L, Besra GS, Bhatt A (2012) MmpL genes are associated with mycolic acid metabolism in mycobacteria and corynebacteria. Chem Biol 19(4):498\u2013506","journal-title":"Chem Biol"},{"key":"1434_CR84","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1378\/chest.08-2427","volume":"136","author":"AA Velayati","year":"2009","unstructured":"Velayati AA et al (2009) Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in Iran. Chest J 136:420\u2013425","journal-title":"Chest J"},{"issue":"6","key":"1434_CR85","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/mmi.13675","volume":"104","author":"A Viljoen","year":"2017","unstructured":"Viljoen A, Dubois V, Girard-Misguich F, Blaise M, Herrmann JL, Kremer L (2017) The diverse family of MmpL transporters in mycobacteria: from regulation to antimicrobial developments. Mol Microbiol 104(6):889\u2013904","journal-title":"Mol Microbiol"},{"key":"1434_CR86","doi-asserted-by":"publisher","first-page":"e1003120","DOI":"10.1371\/journal.ppat.1003120","volume":"9","author":"RM Wells","year":"2013","unstructured":"Wells RM et al (2013) Discovery of a siderophore export system essential for virulence of Mycobacterium tuberculosis. PLoS Pathog 9:e1003120. doi: 10.1371\/journal.ppat.1003120","journal-title":"PLoS Pathog"},{"key":"1434_CR87","volume-title":"Drug-resistant TB: surveillance and response: supplement to global tuberculosis report 2014","author":"WHO","year":"2014","unstructured":"WHO (2014) Drug-resistant TB: surveillance and response: supplement to global tuberculosis report 2014. WHO, Geneva"},{"key":"1434_CR88","volume-title":"Global tuberculosis report 2015","author":"WHO","year":"2016","unstructured":"WHO (2016) Global tuberculosis report 2015. World Health Organization, Geneva"},{"key":"1434_CR89","doi-asserted-by":"publisher","first-page":"4234","DOI":"10.1128\/jb.00201-07","volume":"189","author":"EP Williams","year":"2007","unstructured":"Williams EP, Lee JH, Bishai WR, Colantuoni C, Karakousis PC (2007) Mycobacterium tuberculosis SigF regulates genes encoding cell wall-associated proteins and directly regulates the transcriptional regulatory gene phoY1. J Bacteriol 189:4234\u20134242. doi: 10.1128\/jb.00201-07","journal-title":"J Bacteriol"},{"key":"1434_CR90","doi-asserted-by":"publisher","unstructured":"Wright CC, Hsu FF, Arnett E, Dunaj JL, Davidson PM, Pacheco SA, Harriff MJ, Lewinsohn DM, Schlesinger LS, Purdy GE (2017) The Mycobacterium tuberculosis MmpL11 cell wall lipid transporter is important for biofilm formation, intracellular growth, and nonreplicating persistence. Infect Immun 85(8). doi: 10.1128\/IAI.00131-17","DOI":"10.1128\/IAI.00131-17"},{"issue":"30","key":"1434_CR91","doi-asserted-by":"crossref","first-page":"7993","DOI":"10.1073\/pnas.1700062114","volume":"114","author":"Z Xu","year":"2017","unstructured":"Xu Z, Meshcheryakov VA, Poce G, Chng S-S (2017) MmpL3 is the flippase for mycolic acids in mycobacteria. Proc Natl Acad Sci USA 114(30):7993\u20137998","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Archives of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00203-017-1434-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-017-1434-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-017-1434-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T11:12:12Z","timestamp":1693048332000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00203-017-1434-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,26]]},"references-count":91,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["1434"],"URL":"https:\/\/doi.org\/10.1007\/s00203-017-1434-6","relation":{},"ISSN":["0302-8933","1432-072X"],"issn-type":[{"value":"0302-8933","type":"print"},{"value":"1432-072X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,26]]}}}