{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:58:40Z","timestamp":1790891920415,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T00:00:00Z","timestamp":1641686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T00:00:00Z","timestamp":1641686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Microbiol"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s00203-021-02747-z","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T09:02:34Z","timestamp":1641718954000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Antibacterial and antibiofilm activity of Peganum harmala seed extract against multidrug-resistant Pseudomonas aeruginosa pathogenic isolates and molecular mechanism of action"],"prefix":"10.1007","volume":"204","author":[{"given":"Nadine","family":"Khadraoui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rym","family":"Essid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"Jallouli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilel","family":"Damergi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iheb","family":"Ben Takfa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghassen","family":"Abid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Jedidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Bachali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameni","family":"Ayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferid","family":"Limam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4517-8211","authenticated-orcid":false,"given":"Olfa","family":"Tabbene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,9]]},"reference":[{"key":"2747_CR1","doi-asserted-by":"publisher","first-page":"6084","DOI":"10.3390\/molecules26196084","volume":"26","author":"MW Abbas","year":"2021","unstructured":"Abbas MW, Hussain M, Qamar M, Ali S, Shafiq Z, Wilairatana P, Mubarak MS (2021) Antioxidant and anti-inflammatory effects of Peganum harmala extracts: an in vitro and in vivo study. Molecules 26:6084. https:\/\/doi.org\/10.3390\/molecules26196084","journal-title":"Molecules"},{"key":"2747_CR2","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s40995-017-0411-x","volume":"43","author":"LA Abderrahim","year":"2017","unstructured":"Abderrahim LA, Ta\u00efbi K, AitAbderrahim C (2017) Assessment of the antimicrobial and antioxidant activities of Ziziphus lotus and Peganum harmala. Iran J Sci Technol Trans Sci 43:409\u2013414. https:\/\/doi.org\/10.1007\/s40995-017-0411-x","journal-title":"Iran J Sci Technol Trans Sci"},{"issue":"8","key":"2747_CR3","doi-asserted-by":"publisher","first-page":"e00320","DOI":"10.1128\/AAC.00320-18","volume":"62","author":"MN Ahmed","year":"2018","unstructured":"Ahmed MN, Porse A, Sommer MOA, H\u00f8iby N, Ciofu O (2018) Evolution of antibiotic resistance in biofilm and planktonic Pseudomonas aeruginosa populations exposed to sub-inhibitory levels of ciprofloxacin. Antimicrob Agents Chemother 62(8):e00320-e418. https:\/\/doi.org\/10.1128\/AAC.00320-18","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"2747_CR4","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/S2222-1808(16)61139-8","volume":"6","author":"F Bouabedelli","year":"2016","unstructured":"Bouabedelli F, Missoun F, ElA B, Djebli N (2016) Phytochemical and antimicrobial study of the seeds and leaves of Peganum harmala L. against urinary tract infection pathogens. Asian Pac J Trop Dis 6(10):822\u2013826. https:\/\/doi.org\/10.1016\/S2222-1808(16)61139-8","journal-title":"Asian Pac J Trop Dis"},{"key":"2747_CR5","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3389\/fmicb.2019.00913","volume":"10","author":"O Ciofu","year":"2019","unstructured":"Ciofu O, Tolker-Nielsen T (2019) Tolerance and resistance of Pseudomonas aeruginosa biofilms to antimicrobial agents-How P. aeruginosa can escape antibiotics. Front Microbiol 10:913. https:\/\/doi.org\/10.3389\/fmicb.2019.00913","journal-title":"Front Microbiol"},{"issue":"7","key":"2747_CR6","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1016\/j.bpj.2011.02.020","volume":"100","author":"JC Conrad","year":"2011","unstructured":"Conrad JC, Gibiansky ML, Jin F, Gordon VD, Motto DA, Mathewson MA, Stopka WG, Zelasko DC, Shrout JD, Wong GC (2011) Flagella and pili-mediated near-surface single-cell motility mechanisms in P. aeruginosa. Biophys J 100(7):1608\u20131616. https:\/\/doi.org\/10.1016\/j.bpj.2011.02.020","journal-title":"Biophys J"},{"key":"2747_CR7","first-page":"252","volume":"10","author":"E Darabpour","year":"2011","unstructured":"Darabpour E, Poshtkouhian A, Motamedi H, Nejad SMS (2011) Antibacterial activity of different parts of Peganum harmala L. growing in Iran against multi-drug resistant bacteria. EXCLI J 10:252\u2013263","journal-title":"EXCLI J"},{"issue":"4","key":"2747_CR8","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1128\/AEM.67.4.1865-1873.2001","volume":"67","author":"TR De Kievit","year":"2001","unstructured":"De Kievit TR, Gillis R, Marx S, Brown C, Iglewski BH (2001) Quorum-sensing genes in Pseudomonas aeruginosa biofilms: their role and expression patterns. Appl Environ Microbiol 67(4):1865\u20131873. https:\/\/doi.org\/10.1128\/AEM.67.4.1865-1873.2001","journal-title":"Appl Environ Microbiol"},{"issue":"11","key":"2747_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002184","volume":"13","author":"MEA De Kraker","year":"2016","unstructured":"De Kraker MEA, Stewardson AJ, Harbarth S (2016) Will 10 million people die a year due to antimicrobial resistance by 2050? PloS Med 13(11):e1002184. https:\/\/doi.org\/10.1371\/journal.pmed.1002184","journal-title":"PloS Med"},{"issue":"10","key":"2747_CR10","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1021\/jf0115589","volume":"50","author":"V Dewanto","year":"2002","unstructured":"Dewanto V, Wu X, Adom KK, Liu RH (2002) Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant activity. J Agric Food Chem 50(10):3010\u20133014. https:\/\/doi.org\/10.1021\/jf0115589","journal-title":"J Agric Food Chem"},{"issue":"9","key":"2747_CR11","doi-asserted-by":"publisher","first-page":"526","DOI":"10.3390\/antibiotics9090526","volume":"9","author":"NR El-Sayed","year":"2020","unstructured":"El-Sayed NR, Samir R, Jamil M, Abdel-Hafez L, Ramadan MA (2020) Olive leaf extract modulates quorum sensing genes and biofilm formation in multi-drug resistant Pseudomonas aeruginosa. Antibiotics 9(9):526. https:\/\/doi.org\/10.3390\/antibiotics9090526","journal-title":"Antibiotics"},{"issue":"18","key":"2747_CR12","doi-asserted-by":"publisher","first-page":"6993","DOI":"10.1007\/s00253-017-8442-y","volume":"101","author":"R Essid","year":"2017","unstructured":"Essid R, Hammami M, Gharbi D, Karkouch I, Ben Hamouda T, Elkahoui S, Limam F, Tabbene O (2017) Antifungal mechanism of the combination of Cinnamomum verum and Pelargonium graveolens essential oils with fluconazole against pathogenic Candida strains. Appl Microbiol Biotechnol 101(18):6993\u20137006. https:\/\/doi.org\/10.1007\/s00253-017-8442-y","journal-title":"Appl Microbiol Biotechnol"},{"key":"2747_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2019.111720","volume":"140","author":"R Essid","year":"2019","unstructured":"Essid R, Gharbi D, Abid G, Karkouch I, Ben Hamouda T, Fares N, Trabelsi D, Mhadhbi H, Elkahoui S, Limam F, Tabbene O (2019) Combined effect of Thymus capitatus and Cinnamomumverum essential oils with conventional drugs against Candida albicans biofilm formation and elucidation of the molecular mechanism of action. Ind Crops Prod 140:111720. https:\/\/doi.org\/10.1016\/j.indcrop.2019.111720","journal-title":"Ind Crops Prod"},{"issue":"1","key":"2747_CR14","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s12906-019-2547-z","volume":"19","author":"IM Famuyide","year":"2019","unstructured":"Famuyide IM, Aro AO, Fasina FO, Eloff NJ, Mc Gaw LJ (2019) Antibacterial and antibiofilm activity of acetone leaf extracts of nine under-investigated south African eugenia and syzygium (Myrtaceae) species and their selectivity indices. BMC Complement Altern Med 19(1):141. https:\/\/doi.org\/10.1186\/s12906-019-2547-z","journal-title":"BMC Complement Altern Med"},{"issue":"4","key":"2747_CR15","doi-asserted-by":"publisher","first-page":"273","DOI":"10.4161\/viru.23987","volume":"4","author":"SS Grant","year":"2013","unstructured":"Grant SS, Hung DT (2013) Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response. Virulence 4(4):273\u2013283. https:\/\/doi.org\/10.4161\/viru.23987","journal-title":"Virulence"},{"issue":"4","key":"2747_CR16","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.jaim.2017.05.004","volume":"8","author":"PD Gupta","year":"2017","unstructured":"Gupta PD, Birdi TJ (2017) Development of botanicals to combat antibiotic resistance. J Ayurveda Integr Med 8(4):266\u2013275. https:\/\/doi.org\/10.1016\/j.jaim.2017.05.004","journal-title":"J Ayurveda Integr Med"},{"issue":"1","key":"2747_CR17","doi-asserted-by":"publisher","first-page":"10618","DOI":"10.1038\/s41598-017-10997-5","volume":"7","author":"MA Hossain","year":"2017","unstructured":"Hossain MA, Lee SJ, Park NH, Mechesso AF, Birhanu BT, Kang J, Reza MA, Suh JW, Park SC (2017) Impact of phenolic compounds in the acyl homoserine lactone-mediated quorum sensing regulatory pathways. Sci Rep 7(1):10618. https:\/\/doi.org\/10.1038\/s41598-017-10997-5","journal-title":"Sci Rep"},{"issue":"9","key":"2747_CR18","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3390\/antibiotics9090623","volume":"9","author":"RE Impey","year":"2020","unstructured":"Impey RE, Hawkins DA, Sutton JM, da Costa TPS (2020) Overcoming intrinsic and acquired resistance mechanisms associated with the cell wall of Gram-negative bacteria. Antibiotics 9(9):623. https:\/\/doi.org\/10.3390\/antibiotics9090623","journal-title":"Antibiotics"},{"issue":"1","key":"2747_CR19","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jcma.2017.07.012","volume":"81","author":"M Jamal","year":"2018","unstructured":"Jamal M, Ahmad W, Andleeb S, Jalil F, Imran M, Nawaz MA, Hussain T, Ali M, Rafiq M, Kamil MA (2018) Bacterial biofilm and associated infections. J Chin Med Assoc 81(1):7\u201311. https:\/\/doi.org\/10.1016\/j.jcma.2017.07.012","journal-title":"J Chin Med Assoc"},{"issue":"2","key":"2747_CR20","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1021\/jf00062a013","volume":"33","author":"R Julkunen-Titto","year":"1985","unstructured":"Julkunen-Titto R (1985) Phenolics constituents in the leaves of northern willos: methods for the analysis of certain phenolics. J Agric Food Chem 33(2):213\u2013217. https:\/\/doi.org\/10.1021\/jf00062a013","journal-title":"J Agric Food Chem"},{"issue":"8","key":"2747_CR21","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.tim.2020.03.016","volume":"28","author":"L Karygianni","year":"2020","unstructured":"Karygianni L, Ren Z, Koo H, Thurnheer T (2020) Biofilm matrixome: extracellular components in structured microbial communities. Trends Microbiol 28(8):668\u2013681. https:\/\/doi.org\/10.1016\/j.tim.2020.03.016","journal-title":"Trends Microbiol"},{"key":"2747_CR22","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.12688\/f1000research.10506.1","volume":"6","author":"J Klockgether","year":"2017","unstructured":"Klockgether J, T\u00fcmmler B (2017) Recent advances in understanding Pseudomonas aeruginosa as a pathogen. F1000 Res 6:1261. https:\/\/doi.org\/10.12688\/f1000research.10506.1","journal-title":"F1000 Res"},{"issue":"2","key":"2747_CR23","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s12038-019-9868-4","volume":"44","author":"D Lahiri","year":"2019","unstructured":"Lahiri D, Dash S, Dutta R, Nag M (2019) Elucidating the effect of anti-biofilm activity of bioactive compounds extracted from plants. J Biosci 44(2):52. https:\/\/doi.org\/10.1007\/s12038-019-9868-4","journal-title":"J Biosci"},{"issue":"4","key":"2747_CR24","first-page":"699","volume":"26","author":"F Lamchouri","year":"2013","unstructured":"Lamchouri F, Zemzami M, Jossang A, Abdellatif A, Israili ZH, LyoussiB, (2013) Cytotoxicity of alkaloids isolated from Peganum harmala seeds. Pak J Pharm Sci 26(4):699\u2013706 (PMID: 23811445)","journal-title":"Pak J Pharm Sci"},{"key":"2747_CR25","doi-asserted-by":"publisher","first-page":"346","DOI":"10.3389\/fphar.2018.00346","volume":"9","author":"SP Li","year":"2018","unstructured":"Li SP, Wang YW, Qi SL, Zhang YP, Deng G, Ding WZ, Ma C, Lin QY, Guan HD, Liu W, Cheng XM, Wang CH (2018) Analogous \u03b2-Carboline alkaloids Harmaline and Harmine ameliorate scopolamine-induced cognition dysfunction by attenuating acetylcholinesterase activity, oxidative stress, and inflammation in mice. Front Pharmacol 9:346. https:\/\/doi.org\/10.3389\/fphar.2018.00346","journal-title":"Front Pharmacol"},{"issue":"6","key":"2747_CR26","first-page":"53","volume":"3","author":"N Mahdeb","year":"2013","unstructured":"Mahdeb N, Mayouf S, Boukhari F, Souilah S, Bouzidi A (2013) Hemolytic effect of total alkaloids from the seeds of Peganumharmala in vitro on erythrocytes of ruminants: sheep, cattle and goats. Asian J Plant Sci 3(6):53\u201359","journal-title":"Asian J Plant Sci"},{"key":"2747_CR27","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1046\/j.1432-1327.2000.01143.x","volume":"267","author":"ML Mangoni","year":"2000","unstructured":"Mangoni ML, Rinaldi AC, Di Giulio A, Mignogna G, Bozzi A, Barra D, Simmaco M (2000) Structure-function relationships of temporins, small antimicrobial peptides from amphibian skin. Eur J Biochem 267:1447\u20131454. https:\/\/doi.org\/10.1046\/j.1432-1327.2000.01143.x","journal-title":"Eur J Biochem"},{"issue":"38","key":"2747_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcimb.2014.00038","volume":"4","author":"LC Mart\u00ednez","year":"2014","unstructured":"Mart\u00ednez LC, Vadyvaloo V (2014) Mechanisms of post-transcriptional gene regulation in bacterial biofilms. Front Cell Infect Microbiol 4(38):1\u201315. https:\/\/doi.org\/10.3389\/fcimb.2014.00038","journal-title":"Front Cell Infect Microbiol"},{"issue":"5","key":"2747_CR29","first-page":"2341","volume":"32","author":"AzeemM MirzaR","year":"2019","unstructured":"MirzaR AzeemM, QaisarU, (2019) Influence of Peganum harmala peptides on the transcriptional activity of biofilm related genes in sensitive and resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus. Pak J PharmSci 32(5):2341\u20132345 (PMID: 31894064)","journal-title":"Pak J PharmSci"},{"key":"2747_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.566325","volume":"11","author":"R Mishra","year":"2020","unstructured":"Mishra R, Panda AK, De Mandal S, Shakeel M, Bisht SS, Khan J (2020) Natural anti-biofilm agents: strategies to control biofilm-forming pathogens. Front Microbiol 11:566325. https:\/\/doi.org\/10.3389\/fmicb.2020.566325","journal-title":"Front Microbiol"},{"issue":"16","key":"2747_CR31","first-page":"109","volume":"4","author":"Z Mohsenipour","year":"2016","unstructured":"Mohsenipour Z, Hassanshahian M (2016) Antibacterial activity of Espand (Peganum harmala) alcoholic extracts against six pathogenic bacteria in planktonic and biofilm forms. Biol J Microorg 4(16):109\u2013120","journal-title":"Biol J Microorg"},{"key":"2747_CR32","doi-asserted-by":"publisher","first-page":"539","DOI":"10.3389\/fmicb.2019.00539","volume":"10","author":"SM Mulani","year":"2019","unstructured":"Mulani SM, Kamble EE, Kumkar NS, Tawre SM, Pardesi SK (2019) Emerging strategies to combat ESKAPE pathogens in the era of antimicrobial resistance: a Review. Front Microbiol 10:539. https:\/\/doi.org\/10.3389\/fmicb.2019.00539","journal-title":"Front Microbiol"},{"key":"2747_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/8836983","volume":"2020","author":"S Munir","year":"2020","unstructured":"Munir S, Shahid A, Aslam B, Ashfaq UA, Akash MSH, Ali MA, Almatroudi A, AllemailemKS RajokaMSR, Khurshid M (2020) The therapeutic prospects of naturally occurring and synthetic indole alkaloids for depression and anxiety disorders. Evid Based Complement Alternat Med 2020:1\u201311. https:\/\/doi.org\/10.1155\/2020\/8836983","journal-title":"Evid Based Complement Alternat Med"},{"key":"2747_CR34","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.fitote.2010.04.004","volume":"81","author":"G Nenaah","year":"2010","unstructured":"Nenaah G (2010) Antibacterial and antifungal activities of (beta)-carboline alkaloids of Peganumharmala (L) seeds and their combination effects. Fitoterapia 81:779\u2013782. https:\/\/doi.org\/10.1016\/j.fitote.2010.04.004","journal-title":"Fitoterapia"},{"issue":"2","key":"2747_CR35","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1046\/j.1365-2958.1998.01062.x","volume":"30","author":"GA O\u2019Toole","year":"1998","unstructured":"O\u2019Toole GA, Kolter R (1998) Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development. Mol Microbiol 30(2):295\u2013304. https:\/\/doi.org\/10.1046\/j.1365-2958.1998.01062.x","journal-title":"Mol Microbiol"},{"key":"2747_CR36","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.gendis.2019.04.001","volume":"6","author":"P Pachori","year":"2019","unstructured":"Pachori P, Gothalwal R, Gandhi P (2019) Emergence of antibiotic resistance Pseudomonas aeruginosa in intensive care unit; a critical review. Genes Dis 6:109\u2013119","journal-title":"Genes Dis"},{"issue":"1","key":"2747_CR37","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.biotechadv.2018.11.013","volume":"37","author":"Z Pang","year":"2019","unstructured":"Pang Z, Raudonis R, Glick BR, Lin TJ, Cheng Z (2019) Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies. Biotechnol Adv 37(1):177\u2013192. https:\/\/doi.org\/10.1016\/j.biotechadv.2018.11.013","journal-title":"Biotechnol Adv"},{"issue":"4","key":"2747_CR38","doi-asserted-by":"publisher","first-page":"493","DOI":"10.4155\/fmc.15.6","volume":"7","author":"N Rabin","year":"2015","unstructured":"Rabin N, Zheng Y, Opoku-Temeng C, Du Y, Bonsu E, Sintim HO (2015) Biofilm formation mechanisms and targets for developing antibiofilm agents. Future Med Chem 7(4):493\u2013512. https:\/\/doi.org\/10.4155\/fmc.15.6","journal-title":"Future Med Chem"},{"key":"2747_CR39","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3923\/jbs.2010.316.324","volume":"10","author":"W Rached","year":"2010","unstructured":"Rached W, Benamar H, Bennaceur M, Marouf A (2010) Screening of the antioxidant potential of some Algerian indigenous plants. J Biol Sci 10:316\u2013324. https:\/\/doi.org\/10.3923\/jbs.2010.316.324","journal-title":"J Biol Sci"},{"issue":"1","key":"2747_CR40","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1080\/21505594.2017.1313372","volume":"9","author":"R Roy","year":"2018","unstructured":"Roy R, Tiwari M, Donelli G, Tiwari V (2018) Strategies for combating bacterial biofilms: a focus on anti-biofilm agents and their mechanisms of action. Virulence 9(1):522\u2013554. https:\/\/doi.org\/10.1080\/21505594.2017.1313372","journal-title":"Virulence"},{"issue":"3","key":"2747_CR41","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.3390\/molecules18032623","volume":"18","author":"H Shao","year":"2013","unstructured":"Shao H, Huang X, Zhang Y, Zhang C (2013) Main alkaloids of Peganum harmala L. and their different effects on dicot and monocot crops. Molecules 18(3):2623\u20132634. https:\/\/doi.org\/10.3390\/molecules18032623","journal-title":"Molecules"},{"key":"2747_CR42","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.3389\/fmicb.2020.02057","volume":"11","author":"A Soares","year":"2020","unstructured":"Soares A, Alexandre K, Etienne M (2020) Tolerance and persistence of Pseudomonas aeruginosain biofilms exposed to antibiotics: molecular mechanisms, antibiotic strategies and therapeutic perspectives. Front Microbiol 11:2057. https:\/\/doi.org\/10.3389\/fmicb.2020.02057","journal-title":"Front Microbiol"},{"key":"2747_CR43","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.3390\/molecules14062167","volume":"14","author":"B Sultana","year":"2009","unstructured":"Sultana B, Anwar F, Ashraf M (2009) Effect of extraction solvent\/technique on the antioxidant activity of selected medicinal plant extracts. Molecules 14:2167\u20132180. https:\/\/doi.org\/10.3390\/molecules14062167","journal-title":"Molecules"},{"issue":"9","key":"2747_CR44","doi-asserted-by":"publisher","first-page":"e00848","DOI":"10.1128\/AAC.00848-18","volume":"62","author":"E Sun","year":"2018","unstructured":"Sun E, Gill EE, Falsafi R, Yeung A, Liu S, Hancock REW (2018) Broad-spectrum adaptive antibiotic resistance associated with Pseudomonas aeruginosa mucin-dependent surfing motility. Antimicrob Agents Chemother 62(9):e00848-e918. https:\/\/doi.org\/10.1128\/AAC.00848-18","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"2747_CR45","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1111\/j.1574-6968.2010.02199.x","volume":"316","author":"O Tabbene","year":"2011","unstructured":"Tabbene O, Kalai L, Ben Slimene I, Karkouch I, Elkahoui S, Gharbi A, Cosette P, Mangoni ML, Jouenne T, Limam F (2011) Anti-candida effect of bacillomycin D-like lipopeptides from Bacillus subtilis B38. FEMS Microbiol Lett 316(2):108\u2013114. https:\/\/doi.org\/10.1111\/j.1574-6968.2010.02199.x","journal-title":"FEMS Microbiol Lett"},{"key":"2747_CR46","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/jam.13030","volume":"120","author":"O Tabbene","year":"2016","unstructured":"Tabbene O, Azaiez S, Di Grazia A, Karkouch I, Ben Slimene I, Elkahoui S, Alfeddy MN, Casciaro B, Luca V, Limam F, Mangoni ML (2016) Bacillomycin D and its combination with amphotericin B: promising antifungal compounds with powerful antibiofilm activity and wound healing potency. J Appl Microbiol 120:289\u2013300. https:\/\/doi.org\/10.1111\/jam.13030","journal-title":"J Appl Microbiol"},{"issue":"1","key":"2747_CR47","doi-asserted-by":"publisher","first-page":"S442","DOI":"10.1016\/S1995-7645(14)60272-8","volume":"7","author":"RS Tagne","year":"2014","unstructured":"Tagne RS, Telefo BP, Nyemb JN, Yemele DM, Njina SN, Goka SMC, Lienou LL, Kamdje AHN, Moundipa PF, Farooq AD (2014) Anticancer and antioxidant activities of methanol extracts and fractions of some Cameroonian medicinal plants. Asian Pac J Trop Med 7(1):S442\u2013S447. https:\/\/doi.org\/10.1016\/S1995-7645(14)60272-8","journal-title":"Asian Pac J Trop Med"},{"issue":"1","key":"2747_CR48","doi-asserted-by":"publisher","first-page":"8","DOI":"10.5812\/ijb.18562","volume":"12","author":"SSH Tehrani","year":"2014","unstructured":"Tehrani SSH, Shabani SHS, Enferadi ST, Rabiei Z (2014) Growth inhibitory impact of Peganum harmala L. on two breast cancer cell lines. Iran J Biotechnol 12(1):8\u201314. https:\/\/doi.org\/10.5812\/ijb.18562","journal-title":"Iran J Biotechnol"},{"issue":"5","key":"2747_CR49","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1631\/jzus.B1700356","volume":"19","author":"WD Wang","year":"2018","unstructured":"Wang WD, Zhang NN, Chanda W, Liu M, Din S, Diao YP, Liu L, Cao J, Wang XL, Li XY, Ning AH, Huang M, Zhong MT (2018) Antibacterial and anti-biofilm activity of the lipid extract from Mantidisootheca on Pseudomonas aeruginosa. J Zhejiang UnivSci B 19(5):364\u2013371. https:\/\/doi.org\/10.1631\/jzus.B1700356","journal-title":"J Zhejiang UnivSci B"}],"container-title":["Archives of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-021-02747-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-021-02747-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-021-02747-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T04:29:48Z","timestamp":1645072188000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00203-021-02747-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,9]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["2747"],"URL":"https:\/\/doi.org\/10.1007\/s00203-021-02747-z","relation":{},"ISSN":["0302-8933","1432-072X"],"issn-type":[{"value":"0302-8933","type":"print"},{"value":"1432-072X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,9]]},"assertion":[{"value":"6 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"133"}}