{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T20:15:52Z","timestamp":1781295352651,"version":"3.54.1"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32101368"],"award-info":[{"award-number":["32101368"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2020JJ5709"],"award-info":[{"award-number":["2020JJ5709"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Plan Project for Natural Resources of Hunan Province","award":["2021-50"],"award-info":[{"award-number":["2021-50"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Microbiol"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s00203-022-02802-3","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T08:03:24Z","timestamp":1645603404000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A review on the effect of gut microbiota on metabolic diseases"],"prefix":"10.1007","volume":"204","author":[{"given":"Qiwei","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4079-9470","authenticated-orcid":false,"given":"Xian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"2802_CR1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1665-2681(19)30997-4","volume":"12","author":"L Abenavoli","year":"2013","unstructured":"Abenavoli L, Scarpellini E, Rouabhia S, Balsano C, Luzza F (2013) Probiotics in non-alcoholic fatty liver disease: which and when. Ann Hepatol 12:357\u2013363","journal-title":"Ann Hepatol"},{"key":"2802_CR2","first-page":"1","volume":"8","author":"M Alves-Bezerra","year":"2017","unstructured":"Alves-Bezerra M, Cohen DE (2017) Triglyceride metabolism in the liver. Compr Physiol 8:1\u20138","journal-title":"Compr Physiol"},{"key":"2802_CR3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11892-019-1180-z","volume":"19","author":"J Aron-Wisnewsky","year":"2019","unstructured":"Aron-Wisnewsky J, Cl\u00e9ment K, Nieuwdorp M (2019) Fecal microbiota transplantation: a future therapeutic option for obesity\/diabetes? Curr Diab Rep 19:51","journal-title":"Curr Diab Rep"},{"key":"2802_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5114\/ceh.2019.83151","volume":"5","author":"M Augustyn","year":"2019","unstructured":"Augustyn M, Grys I, Kukla M (2019) Small intestinal bacterial overgrowth and nonalcoholic fatty liver disease. Clin Exp Hepatol 5:1\u201310","journal-title":"Clin Exp Hepatol"},{"key":"2802_CR5","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/jcp.24636","volume":"229","author":"RA Britton","year":"2014","unstructured":"Britton RA, Irwin R, Quach D et al (2014) Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model. J Cell Physiol 229:1822\u20131830","journal-title":"J Cell Physiol"},{"key":"2802_CR6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1055\/s-0035-1562942","volume":"35","author":"AD Burt","year":"2015","unstructured":"Burt AD, Lackner C, Tiniakos DG (2015) Diagnosis and assessment of NAFLD: definitions and histopathological classification. Semin Liver Dis 35:207\u2013220","journal-title":"Semin Liver Dis"},{"key":"2802_CR7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41575-019-0239-2","volume":"17","author":"CD Byrne","year":"2020","unstructured":"Byrne CD, Targher G (2020) What\u2019s new in NAFLD pathogenesis, biomarkers and treatment? Nat Rev Gastroenterol Hepatol 17:70\u201371","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2802_CR8","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/S0140-6736(17)30058-2","volume":"389","author":"S Chatterjee","year":"2017","unstructured":"Chatterjee S, Khunti K, Davies MJ (2017) Type 2 diabetes. Lancet 389:2239\u20132251","journal-title":"Lancet"},{"key":"2802_CR9","doi-asserted-by":"crossref","first-page":"19076","DOI":"10.1038\/srep19076","volume":"6","author":"YM Chen","year":"2016","unstructured":"Chen YM, Liu Y, Zhou RF et al (2016) Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults. Sci Rep 6:19076","journal-title":"Sci Rep"},{"key":"2802_CR10","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1002\/jbmr.3729","volume":"34","author":"JN Farr","year":"2019","unstructured":"Farr JN, Rowsey JL, Eckhardt BA et al (2019) Independent roles of estrogen deficiency and cellular senescence in the pathogenesis of osteoporosis: evidence in young adult mice and older humans. J Bone Miner Res 34:1407\u20131418","journal-title":"J Bone Miner Res"},{"key":"2802_CR11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1017\/S0029665118002719","volume":"78","author":"F Fava","year":"2019","unstructured":"Fava F, Rizzetto L, Tuohy KM (2019) Gut microbiota and health: connecting actors across the metabolic system. Proc Nutr Soc 78:177\u2013188","journal-title":"Proc Nutr Soc"},{"key":"2802_CR12","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/ismej.2012.153","volume":"7","author":"N Fei","year":"2013","unstructured":"Fei N, Zhao L (2013) An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice. ISME J 7:880\u2013884","journal-title":"ISME J"},{"key":"2802_CR13","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1055\/s-0033-1358520","volume":"33","author":"C Fuchs","year":"2013","unstructured":"Fuchs C, Claudel T, Trauner M (2013) Bile acid-mediated control of liver triglycerides. Semin Liver Dis 33:330\u2013342","journal-title":"Semin Liver Dis"},{"key":"2802_CR14","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/hep4.1537","volume":"4","author":"B Gao","year":"2020","unstructured":"Gao B, Duan Y, Lang S et al (2020) Functional microbiomics reveals alterations of the gut microbiome and host co-metabolism in patients with alcoholic hepatitis. Hepatol Commun 4:1168\u20131182","journal-title":"Hepatol Commun"},{"key":"2802_CR15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.7150\/ijbs.25783","volume":"15","author":"Q Geng","year":"2019","unstructured":"Geng Q, Gao H, Yang R, Guo K, Miao D (2019) Pyrroloquinoline quinone prevents estrogen deficiency-induced osteoporosis by inhibiting oxidative stress and osteocyte senescence. Int J Biol Sci 15:58\u201368","journal-title":"Int J Biol Sci"},{"key":"2802_CR16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000481519","volume":"10","author":"CN Heiss","year":"2018","unstructured":"Heiss CN, Olofsson LE (2018) Gut microbiota-dependent modulation of energy metabolism. J Innate Immun 10:163\u2013171","journal-title":"J Innate Immun"},{"key":"2802_CR17","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s00223-017-0321-0","volume":"102","author":"E Hsu","year":"2018","unstructured":"Hsu E, Pacifici R (2018) From osteoimmunology to osteomicrobiology: how the microbiota and the immune system regulate bone. Calcif Tissue Int 102:512\u2013521","journal-title":"Calcif Tissue Int"},{"key":"2802_CR18","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1136\/gutjnl-2017-314307","volume":"67","author":"N Jiao","year":"2018","unstructured":"Jiao N, Baker SS, Chapa-Rodriguez A et al (2018) Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD. Gut 67:1881\u20131891","journal-title":"Gut"},{"key":"2802_CR19","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03469","author":"S Khalesi","year":"2014","unstructured":"Khalesi S, Sun J, Buys N, Jayasinghe R (2014) Effect of probiotics on blood pressure: a systematic review and meta-analysis of randomized, controlled trials. Hypertension. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.114.03469","journal-title":"Hypertension"},{"key":"2802_CR20","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.bbalip.2006.05.007","volume":"1761","author":"HY Lee","year":"2006","unstructured":"Lee HY, Park JH, Seok SH et al (2006) Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice. Biochim Biophys Acta 1761:736\u2013744","journal-title":"Biochim Biophys Acta"},{"key":"2802_CR21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-981-13-1117-8_13","volume":"1086","author":"L Li","year":"2018","unstructured":"Li L, Wang Z (2018) Ovarian aging and osteoporosis. Adv Exp Med Biol 1086:199\u2013215","journal-title":"Adv Exp Med Biol"},{"key":"2802_CR22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40168-016-0222-x","volume":"5","author":"J Li","year":"2017","unstructured":"Li J, Zhao F, Wang Y et al (2017) Gut microbiota dysbiosis contributes to the development of hypertension. Microbiome 5:14","journal-title":"Microbiome"},{"key":"2802_CR23","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1007\/s11427-017-9303-9","volume":"61","author":"F Li","year":"2018","unstructured":"Li F, Sun G, Wang Z et al (2018) Characteristics of fecal microbiota in non-alcoholic fatty liver disease patients. Sci China Life Sci 61:770\u2013778","journal-title":"Sci China Life Sci"},{"key":"2802_CR24","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1097\/HJH.0000000000002878","volume":"39","author":"P Louca","year":"2021","unstructured":"Louca P, Nogal A, Wells PM et al (2021) Gut microbiome diversity and composition is associated with hypertension in women. J Hypertens 39:1810\u20131816","journal-title":"J Hypertens"},{"key":"2802_CR25","doi-asserted-by":"crossref","first-page":"6911","DOI":"10.3748\/wjg.v19.i40.6911","volume":"19","author":"YY Ma","year":"2013","unstructured":"Ma YY, Li L, Yu CH, Shen Z, Chen LH, Li YM (2013) Effects of probiotics on nonalcoholic fatty liver disease: a meta-analysis. World J Gastroenterol 19:6911\u20136918","journal-title":"World J Gastroenterol"},{"key":"2802_CR26","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1038\/ncomms7734","volume":"6","author":"L Macia","year":"2015","unstructured":"Macia L, Tan J, Vieira AT et al (2015) Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat Commun 6:6734","journal-title":"Nat Commun"},{"key":"2802_CR27","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1161\/CIRCULATIONAHA.116.024545","volume":"135","author":"FZ Marques","year":"2017","unstructured":"Marques FZ, Nelson E, Chu PY et al (2017) High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice. Circulation 135:964\u2013977","journal-title":"Circulation"},{"key":"2802_CR28","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tem.2014.11.004","volume":"26","author":"C Ohlsson","year":"2015","unstructured":"Ohlsson C, Sjgren K (2015) Effects of the gut microbiota on bone mass. Trends Endocrinol Metab 26:69\u201374","journal-title":"Trends Endocrinol Metab"},{"key":"2802_CR29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s40168-019-0704-8","volume":"7","author":"K Oliphant","year":"2019","unstructured":"Oliphant K, Allen-Vercoe E (2019) Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health. Microbiome 7:91","journal-title":"Microbiome"},{"key":"2802_CR30","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1007\/s00253-016-7953-2","volume":"101","author":"S Park","year":"2017","unstructured":"Park S, Ji Y, Jung HY et al (2017) Lactobacillus plantarum HAC01 regulates gut microbiota and adipose tissue accumulation in a diet-induced obesity murine model. Appl Microbiol Biotechnol 101:1605\u20131614","journal-title":"Appl Microbiol Biotechnol"},{"key":"2802_CR31","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat9351","author":"C Petersen","year":"2019","unstructured":"Petersen C, Bell R, Klag KA et al (2019) T cell-mediated regulation of the microbiota protects against obesity. Science. https:\/\/doi.org\/10.1126\/science.aat9351","journal-title":"Science"},{"key":"2802_CR32","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.chom.2011.10.003","volume":"10","author":"CS Plottel","year":"2011","unstructured":"Plottel CS, Blaser MJ (2011) Microbiome and malignancy. Cell Host Microbe 10:324\u2013335","journal-title":"Cell Host Microbe"},{"key":"2802_CR33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cmet.2017.05.008","volume":"26","author":"TS Postler","year":"2017","unstructured":"Postler TS, Ghosh S (2017) Understanding the holobiont: how microbial metabolites affect human health and shape the immune system. Cell Metab 26:110\u2013130","journal-title":"Cell Metab"},{"key":"2802_CR34","doi-asserted-by":"crossref","first-page":"1241214","DOI":"10.1126\/science.1241214","volume":"341","author":"VK Ridaura","year":"2013","unstructured":"Ridaura VK, Faith JJ, Rey FE et al (2013) Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341:1241214","journal-title":"Science"},{"key":"2802_CR35","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/CIRCRESAHA.116.309006","volume":"120","author":"MM Santisteban","year":"2016","unstructured":"Santisteban MM, Qi Y, Zubcevic J et al (2016) Hypertension-linked pathophysiological alterations in the gut. Circ Res 120:312","journal-title":"Circ Res"},{"key":"2802_CR36","first-page":"798","volume":"28","author":"M Sch\u00fcnemann","year":"2015","unstructured":"Sch\u00fcnemann M, Oette M (2015) Fecal microbiota transplantation. Naturop Doctor News Review 28:798\u2013799","journal-title":"Naturop Doctor News Review"},{"key":"2802_CR37","first-page":"51","volume":"110","author":"DJ Sebasti\u00e1n","year":"2018","unstructured":"Sebasti\u00e1n DJ, S\u00e1nchez SC (2018) From the intestinal flora to the microbiome. Rev Esp Enferm Dig 110:51\u201356","journal-title":"Rev Esp Enferm Dig"},{"key":"2802_CR38","first-page":"51","volume":"1","author":"JJ Sebasti\u00e1n-Domingo","year":"2017","unstructured":"Sebasti\u00e1n-Domingo JJ, S\u00e1nchez-S\u00e1nchez C (2017) From the intestinal flora to the microbiome. Rev Esp Enferm Dig 1:51\u201356","journal-title":"Rev Esp Enferm Dig"},{"key":"2802_CR39","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1080\/1028415X.2017.1347746","volume":"21","author":"SY Shaaban","year":"2018","unstructured":"Shaaban SY, El GY, Mehanna NS, El-Senousy WM, El-Feki H, Saad K, El-Asheer OM (2018) The role of probiotics in children with autism spectrum disorder: a prospective, open-label study. Nutr Neurosci 21:676\u2013681","journal-title":"Nutr Neurosci"},{"key":"2802_CR40","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.kint.2016.09.040","volume":"91","author":"A Soleimani","year":"2017","unstructured":"Soleimani A, Zarrati MM, Bahmani F et al (2017) Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects. Kidney Int 91:435\u2013442","journal-title":"Kidney Int"},{"key":"2802_CR41","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-018-0617-x","volume":"562","author":"CJ Stewart","year":"2018","unstructured":"Stewart CJ, Ajami NJ, Brien JO et al (2018) Temporal development of the gut microbiome in early childhood from the TEDDY study. Nature 562:583\u2013588","journal-title":"Nature"},{"key":"2802_CR42","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.chom.2019.07.004","volume":"26","author":"LB Thingholm","year":"2019","unstructured":"Thingholm LB, R\u00fchlemann MC, Koch M et al (2019) Obese individuals with and without type 2 diabetes show different gut microbial functional capacity and composition. Cell Host Microbe 26:252\u2013264","journal-title":"Cell Host Microbe"},{"key":"2802_CR43","first-page":"91","volume":"44","author":"L Tianmin","year":"2019","unstructured":"Tianmin L, Zhao Y, Yunfeng B et al (2019) Screening of Lactobacillus with hypoglycemic activity and evaluation of assistant hypoglycemic effects. J Northeast Agric Sci 44:91\u201396","journal-title":"J Northeast Agric Sci"},{"key":"2802_CR44","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cmet.2015.07.009","volume":"22","author":"V Tremaroli","year":"2015","unstructured":"Tremaroli V, Karlsson F, Werling M et al (2015) Roux-en-Y gastric bypass and vertical banded gastroplasty induce long-term changes on the human gut microbiome contributing to fat mass regulation. Cell Metab 22:228\u2013238","journal-title":"Cell Metab"},{"key":"2802_CR45","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.64237","author":"AM Tyagi","year":"2021","unstructured":"Tyagi AM, Darby TM, Hsu E et al (2021) The gut microbiota is a transmissible determinant of skeletal maturation. Elife. https:\/\/doi.org\/10.7554\/eLife.64237","journal-title":"Elife"},{"key":"2802_CR46","doi-asserted-by":"crossref","first-page":"K2179","DOI":"10.1136\/bmj.k2179","volume":"361","author":"AM Valdes","year":"2018","unstructured":"Valdes AM, Walter J, Segal E, Spector TD (2018) Role of the gut microbiota in nutrition and health. BMJ 361:K2179","journal-title":"BMJ"},{"key":"2802_CR47","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41569-020-00437-9","volume":"18","author":"PL Valenzuela","year":"2021","unstructured":"Valenzuela PL, Carrera-Bastos P, G\u00e1lvez BG, Ruiz-Hurtado G, Ordovas JM, Ruilope LM, Lucia A (2021) Lifestyle interventions for the prevention and treatment of hypertension. Nat Rev Cardiol 18:251\u2013275","journal-title":"Nat Rev Cardiol"},{"key":"2802_CR48","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s13679-019-00352-2","volume":"8","author":"N Vallianou","year":"2019","unstructured":"Vallianou N, Stratigou T, Christodoulatos GS, Dalamaga M (2019) Understanding the role of the gut microbiome and microbial metabolites in obesity and obesity-associated metabolic disorders: current evidence and perspectives. Curr Obes Rep 8:317\u2013332","journal-title":"Curr Obes Rep"},{"key":"2802_CR49","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav1892","author":"AT Virtue","year":"2019","unstructured":"Virtue AT, McCright SJ, Wright JM et al (2019) The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs. Sci Transl Med. https:\/\/doi.org\/10.1126\/scitranslmed.aav1892","journal-title":"Sci Transl Med"},{"key":"2802_CR50","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1053\/j.gastro.2012.06.031","volume":"143","author":"A Vrieze","year":"2012","unstructured":"Vrieze A, Van Nood E, Holleman F et al (2012) Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 143:913\u2013916","journal-title":"Gastroenterology"},{"key":"2802_CR51","first-page":"101","volume":"57","author":"W Wang","year":"2018","unstructured":"Wang W, Shi LP, Shi L, Xu L (2018) Efficacy of probiotics on the treatment of non-alcoholic fatty liver disease. Zhonghua Nei Ke Za Zhi Chin J Intern Med 57:101\u2013106","journal-title":"Zhonghua Nei Ke Za Zhi Chin J Intern Med"},{"key":"2802_CR52","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fcimb.2019.00455","volume":"9","author":"H Wang","year":"2019","unstructured":"Wang H, Lu Y, Yan Y et al (2019) Promising treatment for type 2 diabetes: fecal microbiota transplantation reverses insulin resistance and impaired islets. Front Cell Infect Microbiol 9:455","journal-title":"Front Cell Infect Microbiol"},{"key":"2802_CR53","doi-asserted-by":"crossref","unstructured":"Wen Y, Zhu Y, Wan C, Gao X, Liu G (2016) Efficacy of probiotics in non-alcoholic fatty liver disease in adult and children: a meta-analysis of randomized controlled trials: 1226\u20131233","DOI":"10.1111\/hepr.12671"},{"key":"2802_CR54","doi-asserted-by":"crossref","first-page":"102138","DOI":"10.1016\/j.anaerobe.2019.102138","volume":"61","author":"F Wu","year":"2020","unstructured":"Wu F, Guo X, Zhang M et al (2020) An Akkermansia muciniphila subtype alleviates high-fat diet-induced metabolic disorders and inhibits the neurodegenerative process in mice. Anaerobe 61:102138","journal-title":"Anaerobe"},{"key":"2802_CR55","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1161\/HYPERTENSIONAHA.115.05315","volume":"65","author":"T Yang","year":"2015","unstructured":"Yang T, Santisteban MM, Rodriguez V et al (2015) Gut dysbiosis is linked to hypertension. Hypertension 65:1331\u20131340","journal-title":"Hypertension"},{"key":"2802_CR56","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41392-019-0074-5","volume":"4","author":"Z Zhang","year":"2019","unstructured":"Zhang Z, Tang H, Chen P, Xie H, Tao Y (2019) Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome. Signal Transduct Target Ther 4:41","journal-title":"Signal Transduct Target Ther"},{"key":"2802_CR57","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/s41598-017-01751-y","volume":"7","author":"D Zhou","year":"2017","unstructured":"Zhou D, Pan Q, Shen F, Cao HX, Ding WJ, Chen YW, Fan JG (2017) Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota. Sci Rep 7:1529","journal-title":"Sci Rep"}],"container-title":["Archives of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-022-02802-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-022-02802-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-022-02802-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T10:13:40Z","timestamp":1647598420000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00203-022-02802-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,23]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["2802"],"URL":"https:\/\/doi.org\/10.1007\/s00203-022-02802-3","relation":{},"ISSN":["0302-8933","1432-072X"],"issn-type":[{"value":"0302-8933","type":"print"},{"value":"1432-072X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,23]]},"assertion":[{"value":"19 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All authors approved the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Written informed consent for publication was obtained from all participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"192"}}