{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:33:12Z","timestamp":1779291192972,"version":"3.51.4"},"reference-count":110,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Microbiol"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1007\/s00203-024-03900-0","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T04:40:12Z","timestamp":1709008812000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Unveiling the hidden language of bacteria: anti-quorum sensing strategies for gram-negative bacteria infection control"],"prefix":"10.1007","volume":"206","author":[{"given":"Mahmoud A.","family":"Elfaky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"3900_CR1","doi-asserted-by":"publisher","unstructured":"Abdelghany AM, Ayaad DM, Mahmoud SM (2020) Antibacterial and Energy Gap Correlation of PVA\/SA Biofilms Doped. https:\/\/doi.org\/10.33263\/BRIAC105.62366244. With Selenium Nanoparticles","DOI":"10.33263\/BRIAC105.62366244"},{"issue":"1","key":"3900_CR2","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/S12906-019-2594-5\/TABLES\/3","volume":"19","author":"AA Ahmed","year":"2019","unstructured":"Ahmed AA, Salih FA (2019) Quercus infectoria gall extracts reduce quorum sensing-controlled virulence factors production and biofilm formation in Pseudomonas aeruginosa recovered from burn wounds. BMC Complement Altern Med 19(1):177. https:\/\/doi.org\/10.1186\/S12906-019-2594-5\/TABLES\/3","journal-title":"BMC Complement Altern Med"},{"issue":"12","key":"3900_CR3","doi-asserted-by":"publisher","first-page":"2800","DOI":"10.1021\/ACSCHEMBIO.9B00682\/ASSET","volume":"14","author":"I Aleksic","year":"2019","unstructured":"Aleksic I, Jeremic J, Milivojevic D, Ilic-Tomic T, \u0160egan S, Zlatovi\u0107 M, Opsenica DM, Senerovic L (2019) N-Benzyl derivatives of long-chained 4-Amino-7-chloro-quionolines as inhibitors of pyocyanin production in Pseudomonas aeruginosa. ACS Chem Biol 14(12):2800\u20132809. https:\/\/doi.org\/10.1021\/ACSCHEMBIO.9B00682\/ASSET.\/IMAGES\/LARGE\/CB9B00682_0005.JPEG.","journal-title":"ACS Chem Biol"},{"issue":"3","key":"3900_CR4","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/JOBM.201600175","volume":"57","author":"SG Ali","year":"2017","unstructured":"Ali SG, Ansari MA, Khan HM, Jalal M, Mahdi AA, Cameotra SS (2017) Crataeva Nurvala nanoparticles inhibit virulence factors and biofilm formation in clinical isolates of Pseudomonas aeruginosa. J Basic Microbiol 57(3):193\u2013203. https:\/\/doi.org\/10.1002\/JOBM.201600175","journal-title":"J Basic Microbiol"},{"issue":"9","key":"3900_CR6","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/CBIC.201500676","volume":"17","author":"N Amara","year":"2016","unstructured":"Amara N, Gregor R, Rayo J, Dandela R, Daniel E, Liubin N, Willems HME, Ben-Zvi A, Krom BP, Meijler MM (2016) Fine-tuning covalent inhibition of bacterial quorum sensing. ChemBioChem 17(9):825\u2013835. https:\/\/doi.org\/10.1002\/CBIC.201500676","journal-title":"ChemBioChem"},{"key":"3900_CR7","doi-asserted-by":"publisher","unstructured":"Atanasov AG, Zotchev SB, Dirsch VM, Orhan IE, Banach M, Rollinger JM, Barreca D, Weckwerth W, Bauer R, Bayer EA, Majeed M, Bishayee A, Bochkov V, Bonn GK, Braidy N, Bucar F, Cifuentes A, D\u2019Onofrio G, Bodkin M, Diederich M, Dinkova-Kostova AT, Efferth T, El Bairi K, Arkells N, Fan TP, Fiebich BL, Freissmuth M, Georgiev MI, Gibbons S, Godfrey KM, Gruber CW, Heer J, Huber LA, Ibanez E, Kijjoa A, Kiss AK, Lu A, Macias FA, Miller MJS, Mocan A, M\u00fcller R, Nicoletti F, Perry G, Pittal\u00e0 V, Rastrelli L, Ristow M, Russo GL, Silva AS, Schuster D, Sheridan H, Skalicka-Wo\u017aniak K, Skaltsounis L, Sobarzo-S\u00e1nchez E, Bredt DS, Stuppner H, Sureda A, Tzvetkov NT, Vacca RA, Aggarwal BB, Battino M, Giampieri F, Wink M, Wolfender JL, Xiao J, Yeung AWK, Lizard G, Popp MA, Heinrich M, Berindan-Neagoe I, Stadler M, Daglia M, Verpoorte R, Supuran CT (2021) Natural products in drug discovery: advances and opportunities. Nature Reviews Drug Discovery 2021 20:3 20(3):200\u2013216. https:\/\/doi.org\/10.1038\/s41573-020-00114-z","DOI":"10.1038\/s41573-020-00114-z"},{"key":"3900_CR8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/J.JGAR.2017.03.006","volume":"10","author":"S Bahari","year":"2017","unstructured":"Bahari S, Zeighami H, Mirshahabi H, Roudashti S, Haghi F (2017) Inhibition of Pseudomonas aeruginosa quorum sensing by subinhibitory concentrations of curcumin with gentamicin and azithromycin. J Glob Antimicrob Resist 10:21\u201328. https:\/\/doi.org\/10.1016\/J.JGAR.2017.03.006","journal-title":"J Glob Antimicrob Resist"},{"key":"3900_CR9","doi-asserted-by":"publisher","first-page":"130319","DOI":"10.1016\/J.JHAZMAT.2022.130319","volume":"443","author":"P Bhatt","year":"2023","unstructured":"Bhatt P, Bhatt K, Chen WJ, Huang Y, Xiao Y, Wu S, Lei Q, Zhong J, Zhu X, Chen S (2023) Bioremediation potential of laccase for catalysis of glyphosate, isoproturon, lignin, and parathion: molecular docking, dynamics, and simulation. J Hazard Mater 443:130319. https:\/\/doi.org\/10.1016\/J.JHAZMAT.2022.130319","journal-title":"J Hazard Mater"},{"key":"3900_CR10","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/J.JEP.2018.01.031","volume":"216","author":"O Bodede","year":"2018","unstructured":"Bodede O, Shaik S, Chenia H, Singh P, Moodley R (2018) Quorum sensing inhibitory potential and in silico molecular docking of flavonoids and novel terpenoids from Senegalia nigrescens. J Ethnopharmacol 216:134\u2013146. https:\/\/doi.org\/10.1016\/J.JEP.2018.01.031","journal-title":"J Ethnopharmacol"},{"issue":"9","key":"3900_CR11","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1021\/ACSCHEMBIO.8B00577\/ASSET\/IMAGES\/LARGE\/CB-2018-00577M_0003.JPEG","volume":"13","author":"ME Boursier","year":"2018","unstructured":"Boursier ME, Moore JD, Heitman KM, Shepardson-Fungairino SP, Combs JB, Koenig LC, Shin D, Brown EC, Nagarajan R, Blackwell HE (2018) Structure-function analyses of the N-Butanoyl L-Homoserine lactone quorum-sensing Signal define features critical to activity in RhlR. ACS Chem Biol 13(9):2655\u20132662. https:\/\/doi.org\/10.1021\/ACSCHEMBIO.8B00577\/ASSET\/IMAGES\/LARGE\/CB-2018-00577M_0003.JPEG","journal-title":"ACS Chem Biol"},{"key":"3900_CR12","doi-asserted-by":"publisher","unstructured":"Breijyeh Z, Jubeh B, Karaman R (2020) Resistance of Gram-negative Bacteria to current Antibacterial agents and approaches to resolve it. Molecules 25(6). https:\/\/doi.org\/10.3390\/MOLECULES25061340","DOI":"10.3390\/MOLECULES25061340"},{"issue":"1","key":"3900_CR13","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S1473-3099(18)30605-4","volume":"19","author":"A Cassini","year":"2019","unstructured":"Cassini A, H\u00f6gberg LD, Plachouras D, Quattrocchi A, Hoxha A, Simonsen GS, Colomb-Cotinat M, Kretzschmar ME, Devleesschauwer B, Cecchini M, Ouakrim DA, Oliveira TC, Struelens MJ, Suetens C, Monnet DL, Strauss R, Mertens K, Struyf T, Catry B, Latour K, Ivanov IN, Dobreva EG, Tambic Andra\u0161evic A, Soprek S, Budimir A, Paphitou N, \u017demlickov\u00e1 H, Schytte Olsen S, Wolff S\u00f6nksen U, M\u00e4rtin P, Ivanova M, Lyytik\u00e4inen O, Jalava J, Coignard B, Eckmanns T, Abu Sin M, Haller S, Daikos GL, Gikas A, Tsiodras S, Kontopidou F, T\u00f3th \u00c1, Hajdu \u00c1, Gu\u00f3laugsson \u00d3, Kristinsson KG, Murchan S, Burns K, Pezzotti P, Gagliotti C, Dumpis U, Liuimiene A, Perrin M, Borg MA, de Greeff SC, Monen JC, Koek MB, Elstr\u00f8m P, Zabicka D, Deptula A, Hryniewicz W, Cani\u00e7a M, Nogueira PJ, Fernandes PA, Manageiro V, Popescu GA, Serban RI, Schr\u00e9terov\u00e1 E, Litvov\u00e1 S, \u0160tefkovicov\u00e1 M, Kolman J, Klavs I, Koro\u0161ec A, Aracil B, Asensio A, P\u00e9rez-V\u00e1zquez M, Billstr\u00f6m H, Larsson S, Reilly JS, Johnson A, Hopkins S (2019) Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. Lancet Infect Dis 19(1):56\u201366. https:\/\/doi.org\/10.1016\/S1473-3099(18)30605-4","journal-title":"Lancet Infect Dis"},{"issue":"21","key":"3900_CR14","doi-asserted-by":"publisher","first-page":"13088","DOI":"10.3390\/IJMS232113088","volume":"23","author":"S Cavalu","year":"2022","unstructured":"Cavalu S, Elbaramawi SS, Eissa AG, Radwan MF, Ibrahim S, Khafagy T, Lopes ES, Ali BS, Hegazy MAM, Elfaky WAH MA (2022) Characterization of the Anti-biofilm and Anti-quorum sensing activities of the \u03b2-Adrenoreceptor antagonist atenolol against Gram-negative bacterial pathogens. Int J Mol Sci 2022 23(21):13088. https:\/\/doi.org\/10.3390\/IJMS232113088","journal-title":"Int J Mol Sci 2022"},{"key":"3900_CR15","doi-asserted-by":"publisher","unstructured":"Chadha J, Khullar L, Gulati P, Chhibber S, Harjai K (2023) Repurposing Albendazole as a potent inhibitor of Quorum sensing-regulated virulence in Pseudomonas Aeruginosa: novel prospects of a classical drug. https:\/\/doi.org\/10.2139\/SSRN.4579720","DOI":"10.2139\/SSRN.4579720"},{"issue":"1 4","key":"3900_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep07245","volume":"4","author":"CY Chang","year":"2014","unstructured":"Chang CY, Krishnan T, Wang H, Chen Y, Yin WF, Chong YM, Tan LY, Chong TM, Chan KG (2014) Non-antibiotic quorum sensing inhibitors acting against N-acyl homoserine lactone synthase as druggable target. Sci Rep 2014 4(1 4):1\u20138. https:\/\/doi.org\/10.1038\/srep07245","journal-title":"Sci Rep 2014"},{"issue":"9","key":"3900_CR17","doi-asserted-by":"publisher","first-page":"536","DOI":"10.3760\/CMA.J.ISSN.1009-2587.2016.09.005","volume":"32","author":"Z Chen","year":"2016","unstructured":"Chen Z, Xiang J (2016) Advances in the research of LuxR family protein in quorum-sensing system of gram-negative bacteria. Chin J Burns 32(9):536\u2013538. https:\/\/doi.org\/10.3760\/CMA.J.ISSN.1009-2587.2016.09.005","journal-title":"Chin J Burns"},{"key":"3900_CR18","doi-asserted-by":"publisher","unstructured":"Chu C, Deng J, Man Y, Qu Y (2017) Green tea extracts Epigallocatechin-3-gallate for different treatments. Biomed Res Int 2017. https:\/\/doi.org\/10.1155\/2017\/5615647","DOI":"10.1155\/2017\/5615647"},{"key":"3900_CR20","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/J.BIOORG.2017.05.011","volume":"73","author":"RE D\u2019Almeida","year":"2017","unstructured":"D\u2019Almeida RE, Molina RRDI, Viola CM, Luciardi MC, Nieto Pe\u00f1alver C, Bard\u00f3n A, Arena ME (2017) Comparison of seven structurally related coumarins on the inhibition of Quorum sensing of Pseudomonas aeruginosa and Chromobacterium violaceum. Bioorg Chem 73:37\u201342. https:\/\/doi.org\/10.1016\/J.BIOORG.2017.05.011","journal-title":"Bioorg Chem"},{"key":"3900_CR19","doi-asserted-by":"publisher","unstructured":"Dai L, Wu T, qi, Xiong Y, song, Ni H bing, Ding Y, Zhang W, chen, Chu S, peng, Ju S, qing, Yu J (2019) Ibuprofen-mediated potential inhibition of biofilm development and quorum sensing in Pseudomonas aeruginosa. Life Sci 237:116947. https:\/\/doi.org\/10.1016\/J.LFS.2019.116947","DOI":"10.1016\/J.LFS.2019.116947"},{"key":"3900_CR5","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/J.MICPATH.2018.05.014","volume":"121","author":"FA de Almeida","year":"2018","unstructured":"de Almeida FA, Vargas ELG, Carneiro DG, Pinto UM, Vanetti MCD (2018) Virtual screening of plant compounds and nonsteroidal anti-inflammatory drugs for inhibition of quorum sensing and biofilm formation in Salmonella. Microb Pathog 121:369\u2013388. https:\/\/doi.org\/10.1016\/J.MICPATH.2018.05.014","journal-title":"Microb Pathog"},{"issue":"7","key":"3900_CR21","doi-asserted-by":"publisher","first-page":"e1000989","DOI":"10.1371\/JOURNAL.PPAT.1000989","volume":"6","author":"T Defoirdt","year":"2010","unstructured":"Defoirdt T, Boon N, Bossier P (2010) Can Bacteria evolve resistance to Quorum sensing disruption? PLoS Pathog 6(7):e1000989. https:\/\/doi.org\/10.1371\/JOURNAL.PPAT.1000989","journal-title":"PLoS Pathog"},{"issue":"7","key":"3900_CR22","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nrd.2017.23","volume":"16","author":"SW DIckey","year":"2017","unstructured":"DIckey SW, Cheung GYC, Otto M (2017) Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Reviews Drug Discovery 2017 16(7):7. https:\/\/doi.org\/10.1038\/nrd.2017.23","journal-title":"Nat Reviews Drug Discovery 2017"},{"issue":"11","key":"3900_CR23","doi-asserted-by":"publisher","first-page":"3763","DOI":"10.1007\/S00253-023-12522-3\/METRICS","volume":"107","author":"MA Elfaky","year":"2023","unstructured":"Elfaky MA, Elbaramawi SS, Eissa AG, Ibrahim TS, Khafagy ES, Ali MAM, Hegazy WAH (2023) Drug repositioning: doxazosin attenuates the virulence factors and biofilm formation in Gram-negative bacteria. Appl Microbiol Biotechnol 107(11):3763\u20133778. https:\/\/doi.org\/10.1007\/S00253-023-12522-3\/METRICS","journal-title":"Appl Microbiol Biotechnol"},{"issue":"4","key":"3900_CR24","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1111\/JAM.15609","volume":"133","author":"SL Elshaer","year":"2022","unstructured":"Elshaer SL, Shaldam MA, Shaaban MI (2022) Ketoprofen, piroxicam and indomethacin-suppressed quorum sensing and virulence factors in Acinetobacter baumannii. J Appl Microbiol 133(4):2182\u20132197. https:\/\/doi.org\/10.1111\/JAM.15609","journal-title":"J Appl Microbiol"},{"key":"3900_CR25","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/J.JBIOTEC.2014.09.001","volume":"201","author":"S Fetzner","year":"2015","unstructured":"Fetzner S (2015) Quorum quenching enzymes. J Biotechnol 201:2\u201314. https:\/\/doi.org\/10.1016\/J.JBIOTEC.2014.09.001","journal-title":"J Biotechnol"},{"issue":"3","key":"3900_CR26","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1128\/AAC.02533-15","volume":"60","author":"A Furiga","year":"2015","unstructured":"Furiga A, Lajoie B, Hage S, El, Baziard G, Roques C (2015) Impairment of Pseudomonas aeruginosa Biofilm Resistance to Antibiotics by combining the drugs with a New Quorum-sensing inhibitor. Antimicrob Agents Chemother 60(3):1676\u20131686. https:\/\/doi.org\/10.1128\/AAC.02533-15","journal-title":"Antimicrob Agents Chemother"},{"key":"3900_CR27","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.2147\/IDR.S247271","volume":"13","author":"P Gholizadeh","year":"2020","unstructured":"Gholizadeh P, K\u00f6se \u015e, Dao S, Ganbarov K, Tanomand A, Dal T, Aghazadeh M, Ghotaslou R, Rezaee MA, Yousefi B, Kafil HS (2020) <\u2009p\u2009>\u2009how CRISPR-Cas System could be used to Combat Antimicrobial Resistance. Infect Drug Resist 131111\u20131121. https:\/\/doi.org\/10.2147\/IDR.S247271.","journal-title":"Infect Drug Resist"},{"issue":"1","key":"3900_CR29","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1093\/FEMSRE\/FUV038","volume":"40","author":"C Grandcl\u00e9ment","year":"2016","unstructured":"Grandcl\u00e9ment C, Tanni\u00e8res M, Mor\u00e9ra S, Dessaux Y, Faure D (2016) Quorum quenching: role in nature and applied developments. FEMS Microbiol Rev 40(1):86\u2013116. https:\/\/doi.org\/10.1093\/FEMSRE\/FUV038","journal-title":"FEMS Microbiol Rev"},{"issue":"4","key":"3900_CR30","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nchembio.153","volume":"5","author":"JA Gutierrez","year":"2009","unstructured":"Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL (2009) Transition state analogs of 5\u2032-methylthioadenosine nucleosidase disrupt quorum sensing. Nat Chem Biology 2009 5(4):251\u2013257. https:\/\/doi.org\/10.1038\/nchembio.153","journal-title":"Nat Chem Biology 2009"},{"key":"3900_CR31","doi-asserted-by":"publisher","unstructured":"Hegazy WAH, Khayat MT, Ibrahim TS, Nassar MS, Bakhrebah MA, Abdulaal WH, Alhakamy NA, Bendary MM (2020a) Repurposing Anti-diabetic Drugs to Cripple Quorum Sensing in Pseudomonas aeruginosa. Microorganisms 2020, Vol 8, Page 1285 8(9):1285. https:\/\/doi.org\/10.3390\/MICROORGANISMS8091285","DOI":"10.3390\/MICROORGANISMS8091285"},{"key":"3900_CR32","doi-asserted-by":"publisher","unstructured":"Hegazy WAH, Khayat MT, Ibrahim TS, Nassar MS, Bakhrebah MA, Abdulaal WH, Alhakamy NA, Bendary MM (2020b) Repurposing Anti-diabetic Drugs to Cripple Quorum Sensing in Pseudomonas aeruginosa. Microorganisms 2020, Vol 8, Page 1285 8(9):1285. https:\/\/doi.org\/10.3390\/MICROORGANISMS8091285","DOI":"10.3390\/MICROORGANISMS8091285"},{"key":"3900_CR33","doi-asserted-by":"publisher","unstructured":"Hegazy WAH, Salem IM, Alotaibi HF, Khafagy ES, Ibrahim D (2022) Terazosin Interferes with Quorum Sensing and Type Three Secretion System and Diminishes the Bacterial Espionage to Mitigate the Salmonella Typhimurium Pathogenesis. Antibiotics 2022, Vol 11, Page 465 11(4):465. https:\/\/doi.org\/10.3390\/ANTIBIOTICS11040465","DOI":"10.3390\/ANTIBIOTICS11040465"},{"key":"3900_CR34","doi-asserted-by":"publisher","unstructured":"Hirakawa H, Tomita H (2013) Interference of bacterial cell-to-cell communication: a new concept of antimicrobial chemotherapy breaks antibiotic resistance. Front Microbiol 4(MAY). https:\/\/doi.org\/10.3389\/FMICB.2013.00114","DOI":"10.3389\/FMICB.2013.00114"},{"issue":"5","key":"3900_CR35","doi-asserted-by":"publisher","first-page":"6058","DOI":"10.33263\/BRIAC105.60586075","volume":"10","author":"P Hooshdar","year":"2020","unstructured":"Hooshdar P, Kermanshahi RK, Ghadam P, Khosravi-Darani K (2020) A review on production of Exopolysaccharide and Biofilm in Probiotics like Lactobacilli and methods of analysis. Review 10(5):6058\u20136075. https:\/\/doi.org\/10.33263\/BRIAC105.60586075","journal-title":"Review"},{"issue":"1","key":"3900_CR36","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1073\/PNAS.1617415113","volume":"114","author":"NM H\u00f8yland-Kroghsbo","year":"2017","unstructured":"H\u00f8yland-Kroghsbo NM, Paczkowski J, Mukherjee S, Broniewski J, Westra E, Bondy-Denomy J, Bassler BL (2017) Quorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune system. Proc Natl Acad Sci U S A 114(1):131\u2013135. https:\/\/doi.org\/10.1073\/PNAS.1617415113","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3900_CR37","doi-asserted-by":"publisher","unstructured":"Husain FM, Ahmad I, Khan MS, Al-Shabib NA (2015) Trigonella foenum-graceum (seed) extract interferes with quorum sensing regulated traits and biofilm formation in the strains of pseudomonas aeruginosa and Aeromonas hydrophila. Evidence-based Complement Altern Med 2015. https:\/\/doi.org\/10.1155\/2015\/879540","DOI":"10.1155\/2015\/879540"},{"issue":"1\u201302","key":"3900_CR38","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1055\/S-0042-107674","volume":"83","author":"T Ilic-Tomic","year":"2017","unstructured":"Ilic-Tomic T, Sokovic M, Vojnovic S, Ciric A, Veljic M, Nikodinovic-Runic J, Novakovic M (2017) Diarylheptanoids from Alnus viridis ssp. viridis and Alnus glutinosa: modulation of Quorum sensing activity in Pseudomonas aeruginosa. Planta Med 83(1\u201302):117\u2013125. https:\/\/doi.org\/10.1055\/S-0042-107674","journal-title":"Planta Med"},{"issue":"5","key":"3900_CR39","doi-asserted-by":"publisher","first-page":"2314","DOI":"10.1128\/AAC.05919-11","volume":"56","author":"TH Jakobsen","year":"2012","unstructured":"Jakobsen TH, Van Gennip M, Phipps RK, Shanmugham MS, Christensen LD, Alhede M, Skindersoe ME, Rasmussen TB, Friedrich K, Uthe F, Jensen P\u00d8, Moser C, Nielsen KF, Eberl L, Larsen TO, Tanner D, H\u00f8iby N, Bjarnsholt T, Givskov M (2012) Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing. Antimicrob Agents Chemother 56(5):2314\u20132325. https:\/\/doi.org\/10.1128\/AAC.05919-11","journal-title":"Antimicrob Agents Chemother"},{"issue":"11","key":"3900_CR40","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1021\/ACSCHEMBIO.6B00575\/ASSET\/IMAGES\/LARGE\/CB-2016-00575V_0004.JPEG","volume":"11","author":"C Ji","year":"2016","unstructured":"Ji C, Sharma I, Pratihar D, Hudson LL, Maura D, Guney T, Rahme LG, Pesci EC, Coleman JP, Tan DS (2016) Designed small-molecule inhibitors of the anthranilyl-CoA synthetase PqsA block quinolone biosynthesis in pseudomonas aeruginosa. ACS Chem Biol 11(11):3061\u20133067. https:\/\/doi.org\/10.1021\/ACSCHEMBIO.6B00575\/ASSET\/IMAGES\/LARGE\/CB-2016-00575V_0004.JPEG","journal-title":"ACS Chem Biol"},{"key":"3900_CR41","doi-asserted-by":"publisher","unstructured":"Jones A, Halliday MN (2014) The infective pulmonary exacerbation in cystic fibrosis: an ecological perspective. https:\/\/doi.org\/10.25560\/19230","DOI":"10.25560\/19230"},{"key":"3900_CR42","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/978-1-60761-971-0_22\/FIGURES\/2_22","volume":"692","author":"GF Kaufmann","year":"2011","unstructured":"Kaufmann GF, Park J, Mayorov AV, Kubitz DM, Janda KD (2011) Generation of Quorum quenching antibodies. Methods Mol Biol 692:299\u2013311. https:\/\/doi.org\/10.1007\/978-1-60761-971-0_22\/FIGURES\/2_22","journal-title":"Methods Mol Biol"},{"issue":"12","key":"3900_CR44","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.3390\/MICROORGANISMS10122455\/S1","volume":"10","author":"MT Khayat","year":"2022","unstructured":"Khayat MT, Ibrahim TS, Darwish KM, Khayyat AN, Alharbi M, Khafagy ES, Ali MAM, Hegazy WAH, Abbas HA (2022) Hiring of the Anti-quorum sensing activities of hypoglycemic Agent Linagliptin to alleviate the Pseudomonas aeruginosa Pathogenesis. Microorganisms 10(12):2455. https:\/\/doi.org\/10.3390\/MICROORGANISMS10122455\/S1","journal-title":"Microorganisms"},{"key":"3900_CR43","doi-asserted-by":"publisher","unstructured":"Khayat MT, Abbas HA, Ibrahim TS, Elbaramawi SS, Khayyat AN, Alharbi M, Hegazy WAH, Yehia FA, zahraa A (2023) Synergistic Benefits: Exploring the Anti-Virulence Effects of Metformin\/Vildagliptin Antidiabetic Combination against Pseudomonas aeruginosa via Controlling Quorum Sensing Systems. Biomedicines 2023, Vol 11, Page 1442 11(5):1442. https:\/\/doi.org\/10.3390\/BIOMEDICINES11051442","DOI":"10.3390\/BIOMEDICINES11051442"},{"key":"3900_CR45","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/J.MICPATH.2017.07.018","volume":"110","author":"H Kordbacheh","year":"2017","unstructured":"Kordbacheh H, Eftekhar F, Ebrahimi SN (2017) Anti-quorum sensing activity of Pistacia atlantica against Pseudomonas aeruginosa PAO1 and identification of its bioactive compounds. Microb Pathog 110:390\u2013398. https:\/\/doi.org\/10.1016\/J.MICPATH.2017.07.018","journal-title":"Microb Pathog"},{"issue":"1","key":"3900_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S12088-015-0558-0","volume":"56","author":"S Koul","year":"2015","unstructured":"Koul S, Prakash J, Mishra A, Kalia VC (2015) Potential emergence of Multi-quorum sensing inhibitor resistant (MQSIR) Bacteria. Indian J Microbiol 2015 56(1):1\u201318. https:\/\/doi.org\/10.1007\/S12088-015-0558-0","journal-title":"Indian J Microbiol 2015"},{"key":"3900_CR47","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/J.FITOTE.2015.02.002","volume":"102","author":"L Kumar","year":"2015","unstructured":"Kumar L, Chhibber S, Kumar R, Kumar M, Harjai K (2015) Zingerone silences quorum sensing and attenuates virulence of Pseudomonas aeruginosa. Fitoterapia 102:84\u201395. https:\/\/doi.org\/10.1016\/J.FITOTE.2015.02.002","journal-title":"Fitoterapia"},{"issue":"1","key":"3900_CR48","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1128\/MMBR.00046-12\/ASSET\/9D5D2A68-DFA1-462D-94E0-9F2057082018\/ASSETS\/GRAPHIC\/ZMR9990923210007.JPEG","volume":"77","author":"B LaSarre","year":"2013","unstructured":"LaSarre B, Federle MJ (2013) Exploiting Quorum sensing to confuse bacterial pathogens. Microbiol Mol Biol Rev 77(1):73\u2013111. https:\/\/doi.org\/10.1128\/MMBR.00046-12\/ASSET\/9D5D2A68-DFA1-462D-94E0-9F2057082018\/ASSETS\/GRAPHIC\/ZMR9990923210007.JPEG","journal-title":"Microbiol Mol Biol Rev"},{"key":"3900_CR49","doi-asserted-by":"publisher","first-page":"676510","DOI":"10.3389\/FMICB.2021.676510\/BIBTEX","volume":"12","author":"V Lazar","year":"2021","unstructured":"Lazar V, Holban AM, Curutiu C, Chifiriuc MC (2021) Modulation of Quorum Sensing and Biofilms in Less investigated Gram-negative ESKAPE pathogens. Front Microbiol 12:676510. https:\/\/doi.org\/10.3389\/FMICB.2021.676510\/BIBTEX","journal-title":"Front Microbiol"},{"issue":"1","key":"3900_CR50","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/S13238-014-0100-X","volume":"6","author":"J Lee","year":"2015","unstructured":"Lee J, Zhang L (2015) The hierarchy quorum sensing network in Pseudomonas aeruginosa. Protein Cell 6(1):26\u201341. https:\/\/doi.org\/10.1007\/S13238-014-0100-X","journal-title":"Protein Cell"},{"issue":"4","key":"3900_CR53","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1159\/000479411","volume":"42","author":"YT Li","year":"2017","unstructured":"Li YT, Huang JR, Li LJ, Liu LS (2017) Synergistic activity of Berberine with azithromycin against Pseudomonas Aeruginosa isolated from patients with cystic fibrosis of lung in Vitro and in vivo. Cell Physiol Biochem 42(4):1657\u20131669. https:\/\/doi.org\/10.1159\/000479411","journal-title":"Cell Physiol Biochem"},{"key":"3900_CR52","doi-asserted-by":"publisher","unstructured":"Li S, Yao J, Li H (2019) Plantain Herb extracts significantly attenuate the quorum sensing-controlled virulence factors and inhibit biofilm formation in Pseudomonas aeruginosa PAO1. E3S Web Conferences 78(01004). https:\/\/doi.org\/10.1051\/E3SCONF\/20197801004","DOI":"10.1051\/E3SCONF\/20197801004"},{"key":"3900_CR51","doi-asserted-by":"publisher","unstructured":"Li Q, Mao S, Wang H, Ye X (2022) The Molecular Architecture of Pseudomonas aeruginosa Quorum-Sensing Inhibitors. Marine Drugs 2022, Vol 20, Page 488 20(8):488. https:\/\/doi.org\/10.3390\/MD20080488","DOI":"10.3390\/MD20080488"},{"key":"3900_CR54","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/J.TIFS.2019.11.006","volume":"95","author":"X Liao","year":"2020","unstructured":"Liao X, Ma Y, Daliri EBM, Koseki S, Wei S, Liu D, Ye X, Chen S, Ding T (2020) Interplay of antibiotic resistance and food-associated stress tolerance in foodborne pathogens. Trends Food Sci Technol 95:97\u2013106. https:\/\/doi.org\/10.1016\/J.TIFS.2019.11.006","journal-title":"Trends Food Sci Technol"},{"key":"3900_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1021\/BK-2019-1323.CH001\/ASSET\/IMAGES\/LARGE\/BK-2018-007742_G002.JPEG","volume":"1323","author":"J Lin","year":"2019","unstructured":"Lin J, Cheng J (2019) Quorum sensing in Pseudomonas aeruginosa and its relationship to Biofilm Development. ACS Symp Ser 1323:1\u201316. https:\/\/doi.org\/10.1021\/BK-2019-1323.CH001\/ASSET\/IMAGES\/LARGE\/BK-2018-007742_G002.JPEG","journal-title":"ACS Symp Ser"},{"issue":"SEP","key":"3900_CR57","doi-asserted-by":"publisher","first-page":"276521","DOI":"10.3389\/FMICB.2017.01860\/BIBTEX","volume":"8","author":"L Liu","year":"2017","unstructured":"Liu L, Wu R, Zhang J, Shang N, Li P (2017) D-ribose interferes with quorum sensing to inhibit biofilm formation of Lactobacillus paraplantarum L-ZS9. Front Microbiol 8(SEP):276521. https:\/\/doi.org\/10.3389\/FMICB.2017.01860\/BIBTEX","journal-title":"Front Microbiol"},{"issue":"1","key":"3900_CR56","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1007\/S11427-017-9112-0","volume":"61","author":"J Liu","year":"2018","unstructured":"Liu J, Yu H, Huang Y, Yu Z, Fan G, Jin J, Liu X, Wang G (2018) Complete genome sequence of a novel bacteriophage infecting Bradyrhizobium diazoefficiens USDA110. Sci China Life Sci 61(1):118\u2013121. https:\/\/doi.org\/10.1007\/S11427-017-9112-0","journal-title":"Sci China Life Sci"},{"key":"3900_CR58","doi-asserted-by":"publisher","unstructured":"Maeda T, Garc\u00eda-Contreras R, Pu M, Sheng L, Garcia LR, Tom\u00e1s M, Wood TK (2011) Quorum quenching quandary: resistance to antivirulence compounds. The ISME Journal 2012 6:3 6(3):493\u2013501. https:\/\/doi.org\/10.1038\/ismej.2011.122","DOI":"10.1038\/ismej.2011.122"},{"key":"3900_CR59","doi-asserted-by":"publisher","unstructured":"Maisuria VB, Los Santos YL, De, Tufenkji N, D\u00e9ziel E (2016) Cranberry-derived proanthocyanidins impair virulence and inhibit quorum sensing of Pseudomonas aeruginosa. Scientific Reports 2016 6:1 6(1):1\u201312. https:\/\/doi.org\/10.1038\/srep30169","DOI":"10.1038\/srep30169"},{"key":"3900_CR60","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/J.MIB.2016.06.001","volume":"33","author":"D Maura","year":"2016","unstructured":"Maura D, Ballok AE, Rahme LG (2016) Considerations and caveats in anti-virulence drug development. Curr Opin Microbiol 33:41\u201346. https:\/\/doi.org\/10.1016\/J.MIB.2016.06.001","journal-title":"Curr Opin Microbiol"},{"issue":"16","key":"3900_CR61","doi-asserted-by":"publisher","first-page":"4820","DOI":"10.1016\/J.BMC.2011.06.071","volume":"19","author":"CE McInnis","year":"2011","unstructured":"McInnis CE, Blackwell HE (2011) Thiolactone modulators of quorum sensing revealed through library design and screening. Bioorg Med Chem 19(16):4820\u20134828. https:\/\/doi.org\/10.1016\/J.BMC.2011.06.071","journal-title":"Bioorg Med Chem"},{"key":"3900_CR62","doi-asserted-by":"publisher","first-page":"489012","DOI":"10.3389\/FMICB.2019.02355\/BIBTEX","volume":"10","author":"M Mellini","year":"2019","unstructured":"Mellini M, Di Muzio E, D\u2019Angelo F, Baldelli V, Ferrillo S, Visca P, Leoni L, Polticelli F, Rampioni G (2019) In silico selection and experimental validation of FDA-Approved drugs as Anti-quorum Sensing agents. Front Microbiol 10:489012. https:\/\/doi.org\/10.3389\/FMICB.2019.02355\/BIBTEX","journal-title":"Front Microbiol"},{"issue":"2","key":"3900_CR63","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/MRM.0000000000000100","volume":"28","author":"MY Memar","year":"2017","unstructured":"Memar MY, Raei P, Alizadeh N, Aghdam MA, Kafil HS (2017) Carvacrol and thymol: strong antimicrobial agents against resistant isolates. Reviews Res Med Microbiol 28(2):63\u201368. https:\/\/doi.org\/10.1097\/MRM.0000000000000100","journal-title":"Reviews Res Med Microbiol"},{"issue":"1","key":"3900_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-023-42833-4","volume":"13","author":"M Murali","year":"2023","unstructured":"Murali M, Ahmed F, Gowtham HG, Aribisala JO, Abdulsalam RA, Shati AA, Alfaifi MY, Sayyed RZ, Sabiu S, Amruthesh KN (2023) Exploration of CviR-mediated quorum sensing inhibitors from Cladosporium spp. against Chromobacterium violaceum through computational studies. Sci Rep 2023 13(1):1\u201318. https:\/\/doi.org\/10.1038\/s41598-023-42833-4","journal-title":"Sci Rep 2023"},{"issue":"4","key":"3900_CR66","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1159\/000320185","volume":"56","author":"KS Musthafa","year":"2010","unstructured":"Musthafa KS, Ravi AV, Annapoorani A, Packiavathy ISV, Pandian SK (2010) Evaluation of anti-quorum-sensing activity of edible plants and fruits through inhibition of the N-acyl-homoserine lactone system in Chromobacterium violaceum and Pseudomonas aeruginosa. Chemotherapy 56(4):333\u2013339. https:\/\/doi.org\/10.1159\/000320185","journal-title":"Chemotherapy"},{"issue":"6","key":"3900_CR65","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1002\/JOBM.201100292","volume":"52","author":"KS Musthafa","year":"2012","unstructured":"Musthafa KS, Balamurugan K, Pandian SK, Ravi AV (2012) 2,5-Piperazinedione inhibits quorum sensing-dependent factor production in Pseudomonas aeruginosa PAO1. J Basic Microbiol 52(6):679\u2013686. https:\/\/doi.org\/10.1002\/JOBM.201100292","journal-title":"J Basic Microbiol"},{"issue":"44","key":"3900_CR68","doi-asserted-by":"publisher","first-page":"17981","DOI":"10.1073\/PNAS.1316981110\/SUPPL_FILE\/SAPP.PDF","volume":"110","author":"CT O\u2019Loughlin","year":"2013","unstructured":"O\u2019Loughlin CT, Miller LC, Siryaporn A, Drescher K, Semmelhack MF, Bassler BL (2013) A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation. Proc Natl Acad Sci U S A 110(44):17981\u201317986. https:\/\/doi.org\/10.1073\/PNAS.1316981110\/SUPPL_FILE\/SAPP.PDF","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"3900_CR67","doi-asserted-by":"publisher","first-page":"138","DOI":"10.5455\/JICE.20140710031312","volume":"3","author":"P Okusa","year":"2014","unstructured":"Okusa P, Rasamiravaka T, Vandeputte O, Stvigny C, Jaziri M, Duez P (2014) Extracts of Cordia gilletii de wild (Boraginaceae) quench the quorum sensing of Pseudomonas aeruginosa PAO1. J Intercult Ethnopharmacol 3(4):138. https:\/\/doi.org\/10.5455\/JICE.20140710031312","journal-title":"J Intercult Ethnopharmacol"},{"issue":"10","key":"3900_CR69","doi-asserted-by":"publisher","first-page":"4064","DOI":"10.1074\/jbc.M116.770552","volume":"292","author":"JE Paczkowski","year":"2017","unstructured":"Paczkowski JE, Mukherjee S, McCready AR, Cong JP, Aquino CJ, Kim H, Henke BR, Smith CD, Bassler BL (2017) Flavonoids suppress Pseudomonas aeruginosa virulence through allosteric inhibition of quorum-sensing receptors. J Biol Chem 292(10):4064\u20134076. https:\/\/doi.org\/10.1074\/jbc.M116.770552","journal-title":"J Biol Chem"},{"issue":"2","key":"3900_CR70","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1128\/AEM.02912-13","volume":"80","author":"S Palliyil","year":"2014","unstructured":"Palliyil S, Downham C, Broadbent I, Charlton K, Porter AJ (2014) High-sensitivity monoclonal antibodies specific for Homoserine lactones protect mice from Lethal Pseudomonas aeruginosa infections. Appl Environ Microbiol 80(2):462\u2013469. https:\/\/doi.org\/10.1128\/AEM.02912-13","journal-title":"Appl Environ Microbiol"},{"issue":"1","key":"3900_CR71","doi-asserted-by":"publisher","first-page":"012031","DOI":"10.1088\/1757-899X\/858\/1\/012031","volume":"858","author":"A Pangastuti","year":"2020","unstructured":"Pangastuti A, Sari SLA, Nugraheni ER, Astuti RT (2020) Inhibition of Pseudomonas aeruginosa virulence factors expression regulated by Quorum Sensing System using Ethyl acetate extract of Temu Ireng (Curcuma Aeruginosa). IOP Conf Ser Mater Sci Eng 858(1):012031. https:\/\/doi.org\/10.1088\/1757-899X\/858\/1\/012031","journal-title":"IOP Conf Ser Mater Sci Eng"},{"issue":"9","key":"3900_CR72","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/nrmicro.2016.89","volume":"14","author":"K Papenfort","year":"2016","unstructured":"Papenfort K, Bassler BL (2016) Quorum sensing signal\u2013response systems in Gram-negative bacteria. Nat Reviews Microbiol 2016 14(9):576\u2013588. https:\/\/doi.org\/10.1038\/nrmicro.2016.89","journal-title":"Nat Reviews Microbiol 2016"},{"key":"3900_CR73","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/J.FOODCONT.2014.04.024","volume":"45","author":"H Park","year":"2014","unstructured":"Park H, Yeo S, Ji Y, Lee J, Yang J, Park S, Shin H, Holzapfel W (2014) Autoinducer-2 associated inhibition by Lactobacillus sakei NR28 reduces virulence of enterohaemorrhagic Escherichia coli O157:H7. Food Control 45:62\u201369. https:\/\/doi.org\/10.1016\/J.FOODCONT.2014.04.024","journal-title":"Food Control"},{"issue":"2","key":"3900_CR74","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/J.1574-6976.2012.00345.X","volume":"37","author":"CS Pereira","year":"2013","unstructured":"Pereira CS, Thompson JA, Xavier KB (2013) AI-2-mediated signalling in bacteria. FEMS Microbiol Rev 37(2):156\u2013181. https:\/\/doi.org\/10.1111\/J.1574-6976.2012.00345.X","journal-title":"FEMS Microbiol Rev"},{"issue":"2","key":"3900_CR75","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1080\/08927014.2016.1272104","volume":"33","author":"M P\u00e9rez-P\u00e9rez","year":"2017","unstructured":"P\u00e9rez-P\u00e9rez M, Jorge P, P\u00e9rez Rodr\u00edguez G, Pereira MO, Louren\u00e7o A (2017) Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights through network mining. Biofouling 33(2):128\u2013142. https:\/\/doi.org\/10.1080\/08927014.2016.1272104","journal-title":"Biofouling"},{"key":"3900_CR76","doi-asserted-by":"publisher","unstructured":"Prateeksha, Singh BR, Shoeb M, Sharma S, Naqvi AH, Gupta VK, Singh BN (2017) Scaffold of Selenium Nanovectors and Honey Phytochemicals for Inhibition of Pseudomonas aeruginosa Quorum Sensing and Biofilm Formation. Front Cell Infect Microbiol 7(MAR). https:\/\/doi.org\/10.3389\/FCIMB.2017.00093","DOI":"10.3389\/FCIMB.2017.00093"},{"issue":"3","key":"3900_CR77","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.15190\/D.2019.13","volume":"7","author":"VG Preda","year":"2019","unstructured":"Preda VG, S\u0103ndulescu O (2019) Communication is the key: biofilms, quorum sensing, formation and prevention. Discoveries 7(3):e10. https:\/\/doi.org\/10.15190\/D.2019.13","journal-title":"Discoveries"},{"issue":"1","key":"3900_CR78","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nrd.2018.168","volume":"18","author":"S Pushpakom","year":"2018","unstructured":"Pushpakom S, Iorio F, Eyers PA, Escott KJ, Hopper S, Wells A, Doig A, Guilliams T, Latimer J, McNamee C, Norris A, Sanseau P, Cavalla D, Pirmohamed M (2018) Drug repurposing: progress, challenges and recommendations. Nat Reviews Drug Discovery 2018 18(1):41\u201358. https:\/\/doi.org\/10.1038\/nrd.2018.168","journal-title":"Nat Reviews Drug Discovery 2018"},{"issue":"7","key":"3900_CR79","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1007\/S10529-018-2557-9","volume":"40","author":"J Rajkumari","year":"2018","unstructured":"Rajkumari J, Borkotoky S, Murali A, Suchiang K, Mohanty SK, Busi S (2018) Cinnamic acid attenuates quorum sensing associated virulence factors and biofilm formation in Pseudomonas aeruginosa PAO1. Biotechnol Lett 40(7):1087\u20131100. https:\/\/doi.org\/10.1007\/S10529-018-2557-9","journal-title":"Biotechnol Lett"},{"key":"3900_CR80","doi-asserted-by":"publisher","unstructured":"Rehman ZU, Leiknes TO (2018) Quorum-quenching bacteria isolated from red sea sediments reduce biofilm formation by Pseudomonas aeruginosa. Front Microbiol 9(JUL). https:\/\/doi.org\/10.3389\/FMICB.2018.01354\/FULL","DOI":"10.3389\/FMICB.2018.01354\/FULL"},{"key":"3900_CR81","doi-asserted-by":"publisher","unstructured":"Roudashti S, Zeighami H, Mirshahabi H, Bahari S, Soltani A, Haghi F (2017) Synergistic activity of sub-inhibitory concentrations of curcumin with ceftazidime and ciprofloxacin against Pseudomonas aeruginosa quorum sensing related genes and virulence traits. World J Microbiol Biotechnol 33(3). https:\/\/doi.org\/10.1007\/S11274-016-2195-0","DOI":"10.1007\/S11274-016-2195-0"},{"issue":"1","key":"3900_CR82","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1080\/21505594.2017.1313372","volume":"9","author":"R Roy","year":"2018","unstructured":"Roy R, Tiwari M, Donelli G, Tiwari V (2018) Strategies for combating bacterial biofilms: a focus on anti-biofilm agents and their mechanisms of action. Virulence 9(1):522\u2013554. https:\/\/doi.org\/10.1080\/21505594.2017.1313372","journal-title":"Virulence"},{"key":"3900_CR83","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/J.EJMECH.2015.04.007","volume":"96","author":"JH Sahner","year":"2015","unstructured":"Sahner JH, Empting M, Kamal A, Weidel E, Groh M, B\u00f6rger C, Hartmann RW (2015) Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosa. Eur J Med Chem 96:14\u201321. https:\/\/doi.org\/10.1016\/J.EJMECH.2015.04.007","journal-title":"Eur J Med Chem"},{"issue":"1","key":"3900_CR84","doi-asserted-by":"publisher","first-page":"18","DOI":"10.21608\/ODR.2023.199244.1023","volume":"3","author":"MM Saleh","year":"2023","unstructured":"Saleh MM, Ramadan M, Zaki I, Salah M (2023) Disruption of the Quorum-sensing system in Pseudomonas aeruginosa using the PPI Esomeprazole: an exceptional and promising role. Octahedron Drug Res 3(1):18\u201329. https:\/\/doi.org\/10.21608\/ODR.2023.199244.1023","journal-title":"Octahedron Drug Res"},{"key":"3900_CR85","doi-asserted-by":"publisher","first-page":"105097","DOI":"10.1016\/J.MICPATH.2021.105097","volume":"158","author":"NM Seleem","year":"2021","unstructured":"Seleem NM, Atallah H, Abd El Latif HK, Shaldam MA, El-Ganiny AM (2021) Could the analgesic drugs, Paracetamol and indomethacin, function as quorum sensing inhibitors? Microb Pathog 158:105097. https:\/\/doi.org\/10.1016\/J.MICPATH.2021.105097","journal-title":"Microb Pathog"},{"key":"3900_CR86","doi-asserted-by":"publisher","first-page":"1185224","DOI":"10.3389\/FCHEM.2023.1185224\/BIBTEX","volume":"11","author":"Q Shi","year":"2023","unstructured":"Shi Q, Wen H, Xu Y, Zhao X, Zhang J, Li Y, Meng Q, Yu F, Xiao J, Li X (2023) Virtual screening\u2013based discovery of AI-2 quorum sensing inhibitors that interact with an allosteric hydrophobic site of LsrK and their functional evaluation. Front Chem 11:1185224. https:\/\/doi.org\/10.3389\/FCHEM.2023.1185224\/BIBTEX","journal-title":"Front Chem"},{"issue":"13","key":"3900_CR88","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/J.PHYMED.2010.03.015","volume":"17","author":"Z Song","year":"2010","unstructured":"Song Z, Kong KF, Wu H, Maricic N, Ramalingam B, Priestap H, Schneper L, Quirke JME, H\u00f8iby N, Mathee K (2010) Panax ginseng has anti-infective activity against opportunistic pathogen Pseudomonas aeruginosa by inhibiting quorum sensing, a bacterial communication process critical for establishing infection. Phytomedicine 17(13):1040\u20131046. https:\/\/doi.org\/10.1016\/J.PHYMED.2010.03.015","journal-title":"Phytomedicine"},{"issue":"6","key":"3900_CR87","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1111\/1751-7915.13312","volume":"11","author":"Y Song","year":"2018","unstructured":"Song Y, Cai ZH, Lao YM, Jin H, Ying KZ, Lin GH, Zhou J (2018) Antibiofilm activity substances derived from coral symbiotic bacterial extract inhibit biofouling by the model strain Pseudomonas aeruginosa PAO1. Microb Biotechnol 11(6):1090\u20131105. https:\/\/doi.org\/10.1111\/1751-7915.13312","journal-title":"Microb Biotechnol"},{"key":"3900_CR89","doi-asserted-by":"publisher","unstructured":"Sousa AM, Pereira MO (2014) Pseudomonas aeruginosa Diversification during Infection Development in Cystic Fibrosis Lungs\u2014A Review. Pathogens 2014, Vol 3, Pages 680\u2013703 3(3):680\u2013703. https:\/\/doi.org\/10.3390\/PATHOGENS3030680","DOI":"10.3390\/PATHOGENS3030680"},{"issue":"1","key":"3900_CR90","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1021\/CR100064S\/ASSET","volume":"111","author":"AM Stevens","year":"2011","unstructured":"Stevens AM, Queneau Y, Soul\u00e8re L, Bodman S, Von, Doutheau A (2011) Mechanisms and synthetic modulators of AHL-dependent gene regulation. Chem Rev 111(1):4\u201327. https:\/\/doi.org\/10.1021\/CR100064S\/ASSET.\/IMAGES\/MEDIUM\/CR-2010-00064S_0037.GIF.","journal-title":"Chem Rev"},{"key":"3900_CR91","doi-asserted-by":"publisher","unstructured":"Sully EK, Malachowa N, Elmore BO, Alexander SM, Femling JK, Gray BM, DeLeo FR, Otto M, Cheung AL, Edwards BS, Sklar LA, Horswill AR, Hall PR, Gresham HD (2014) Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. PLoS Pathog 10(6). https:\/\/doi.org\/10.1371\/JOURNAL.PPAT.1004174","DOI":"10.1371\/JOURNAL.PPAT.1004174"},{"key":"3900_CR92","doi-asserted-by":"publisher","unstructured":"Sweeney EG, Nishida A, Weston A, Ba\u00f1uelos MS, Potter K, Conery J, Guillemin K (2019) Agent-based modeling demonstrates how local Chemotactic Behavior can shape Biofilm Architecture. mSphere 4(3). https:\/\/doi.org\/10.1128\/MSPHERE.00285-19\/SUPPL_FILE\/MSPHERE.00285-19-S0001.PDF","DOI":"10.1128\/MSPHERE.00285-19\/SUPPL_FILE\/MSPHERE.00285-19-S0001.PDF"},{"issue":"1","key":"3900_CR93","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1021\/CR100045M","volume":"111","author":"M Teplitski","year":"2011","unstructured":"Teplitski M, Mathesius U, Rumbaugh KP (2011) Perception and degradation of N-acyl homoserine lactone quorum sensing signals by mammalian and plant cells. Chem Rev 111(1):100\u2013116. https:\/\/doi.org\/10.1021\/CR100045M","journal-title":"Chem Rev"},{"key":"3900_CR94","doi-asserted-by":"publisher","unstructured":"Thabit AK, Eljaaly K, Zawawi A, Ibrahim TS, Eissa AG, Elbaramawi SS, Hegazy WAH, Elfaky MA (2022a) Muting Bacterial Communication: Evaluation of Prazosin Anti-Quorum Sensing Activities against Gram-Negative Bacteria Pseudomonas aeruginosa, Proteus mirabilis, and Serratia marcescens. Biology 2022, Vol 11, Page 1349 11(9):1349. https:\/\/doi.org\/10.3390\/BIOLOGY11091349","DOI":"10.3390\/BIOLOGY11091349"},{"issue":"10","key":"3900_CR95","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.3390\/MICROORGANISMS10101976\/S1","volume":"10","author":"AK Thabit","year":"2022","unstructured":"Thabit AK, Eljaaly K, Zawawi A, Ibrahim TS, Eissa AG, Elbaramawi SS, Hegazy WAH, Elfaky MA (2022b) Silencing of Salmonella typhimurium pathogenesis: Atenolol acquires efficient anti-virulence activities. Microorganisms 10(10):1976. https:\/\/doi.org\/10.3390\/MICROORGANISMS10101976\/S1","journal-title":"Microorganisms"},{"issue":"4","key":"3900_CR96","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1080\/08927014.2015.1137289","volume":"32","author":"A Vadekeetil","year":"2016","unstructured":"Vadekeetil A, Saini H, Chhibber S, Harjai K (2016) Exploiting the antivirulence efficacy of an ajoene-ciprofloxacin combination against Pseudomonas aeruginosa biofilm associated murine acute pyelonephritis. Biofouling 32(4):371\u2013382. https:\/\/doi.org\/10.1080\/08927014.2015.1137289","journal-title":"Biofouling"},{"issue":"1","key":"3900_CR97","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1093\/EMPH\/EOW012","volume":"2016","author":"PF Vale","year":"2016","unstructured":"Vale PF, McNally L, Doeschl-Wilson A, King KC, Popat R, Domingo-Sananes MR, Allen JE, Soares MP, K\u00fcmmerli R (2016) Beyond killing: can we find new ways to manage infection? Evol Med Public Health 2016(1):148\u2013157. https:\/\/doi.org\/10.1093\/EMPH\/EOW012","journal-title":"Evol Med Public Health"},{"issue":"7","key":"3900_CR98","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1007\/S00134-012-2559-3\/TABLES\/5","volume":"38","author":"C Van Delden","year":"2012","unstructured":"Van Delden C, K\u00f6hler T, Brunner-Ferber F, Fran\u00e7ois B, Carlet J, Pech\u00e8re JC (2012) Azithromycin to prevent Pseudomonas aeruginosa ventilator-associated pneumonia by inhibition of quorum sensing: a randomized controlled trial. Intensive Care Med 38(7):1118\u20131125. https:\/\/doi.org\/10.1007\/S00134-012-2559-3\/TABLES\/5","journal-title":"Intensive Care Med"},{"issue":"1","key":"3900_CR99","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1128\/AEM.01059-09","volume":"76","author":"OM Vandeputte","year":"2010","unstructured":"Vandeputte OM, Kiendrebeogo M, Rajaonson S, Diallo B, Mol A, Jaziri M, El, Baucher M (2010) Identification of catechin as one of the flavonoids from Combretum albiflorum bark extract that reduces the production of quorum-sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1. Appl Environ Microbiol 76(1):243\u2013253. https:\/\/doi.org\/10.1128\/AEM.01059-09","journal-title":"Appl Environ Microbiol"},{"issue":"5","key":"3900_CR100","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/1348-0421.12150","volume":"58","author":"HS Vasavi","year":"2014","unstructured":"Vasavi HS, Arun AB, Rekha PD (2014) Anti-quorum sensing activity of Psidium guajava L. flavonoids against Chromobacterium violaceum and Pseudomonas aeruginosa PAO1. Microbiol Immunol 58(5):286\u2013293. https:\/\/doi.org\/10.1111\/1348-0421.12150","journal-title":"Microbiol Immunol"},{"key":"3900_CR101","doi-asserted-by":"publisher","unstructured":"Wang J, Lin J, Zhang Y, Zhang J, Feng T, Li H, Wang X, Sun Q, Zhang X, Wang Y (2019) Activity improvement and vital amino acid identification on the Marine-Derived Quorum quenching enzyme MomL by Protein Engineering. Mar Drugs 17(5). https:\/\/doi.org\/10.3390\/MD17050300","DOI":"10.3390\/MD17050300"},{"issue":"4","key":"3900_CR102","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1021\/JA5110798\/SUPPL_FILE\/JA5110798_SI_001.PDF","volume":"137","author":"MA Welsh","year":"2015","unstructured":"Welsh MA, Eibergen NR, Moore JD, Blackwell HE (2015) Small molecule disruption of quorum sensing cross-regulation in Pseudomonas aeruginosa causes major and unexpected alterations to virulence phenotypes. J Am Chem Soc 137(4):1510\u20131519. https:\/\/doi.org\/10.1021\/JA5110798\/SUPPL_FILE\/JA5110798_SI_001.PDF","journal-title":"J Am Chem Soc"},{"issue":"7680","key":"3900_CR103","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nature24624","volume":"551","author":"M Whiteley","year":"2017","unstructured":"Whiteley M, Diggle SP, Greenberg EP (2017) Progress in and promise of bacterial quorum sensing research. Nature 551(7680):313\u2013320. https:\/\/doi.org\/10.1038\/nature24624","journal-title":"Nature"},{"issue":"7","key":"3900_CR104","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1007\/S00018-019-03326-8","volume":"77","author":"S Wu","year":"2020","unstructured":"Wu S, Liu J, Liu C, Yang A, Qiao J (2020) Quorum sensing for population-level control of bacteria and potential therapeutic applications. Cell Mol Life Sci 77(7):1319\u20131343. https:\/\/doi.org\/10.1007\/S00018-019-03326-8","journal-title":"Cell Mol Life Sci"},{"issue":"MAY","key":"3900_CR105","doi-asserted-by":"publisher","first-page":"353980","DOI":"10.3389\/FCIMB.2018.00138\/BIBTEX","volume":"8","author":"MK Yadav","year":"2018","unstructured":"Yadav MK, Vidal JE, Go YY, Kim SH, Chae SW, Song JJ (2018) The LuxS\/AI-2 quorum-sensing system of Streptococcus pneumoniae is required to cause disease, and to regulate virulence- and metabolism-related genes in a rat model of middle ear infection. Front Cell Infect Microbiol 8(MAY):353980. https:\/\/doi.org\/10.3389\/FCIMB.2018.00138\/BIBTEX","journal-title":"Front Cell Infect Microbiol"},{"key":"3900_CR106","doi-asserted-by":"publisher","unstructured":"Zhang W, Li C (2016) Exploiting quorum sensing interfering strategies in gram-negative bacteria for the enhancement of environmental applications. Front Microbiol 6(JAN). https:\/\/doi.org\/10.3389\/FMICB.2015.01535\/FULL","DOI":"10.3389\/FMICB.2015.01535\/FULL"},{"key":"3900_CR107","doi-asserted-by":"publisher","unstructured":"Zhao X, Yu Z, Ding T (2020) Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria. Microorganisms 2020, Vol 8, Page 425 8(3):425. https:\/\/doi.org\/10.3390\/MICROORGANISMS8030425","DOI":"10.3390\/MICROORGANISMS8030425"},{"issue":"4","key":"3900_CR111","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/S10529-012-1126-X","volume":"35","author":"L Zhou","year":"2013","unstructured":"Zhou L, Zheng H, Tang Y, Yu W, Gong Q (2013) Eugenol inhibits quorum sensing at sub-inhibitory concentrations. Biotechnol Lett 35(4):631\u2013637. https:\/\/doi.org\/10.1007\/S10529-012-1126-X","journal-title":"Biotechnol Lett"},{"issue":"7","key":"3900_CR109","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1021\/ACS.JAFC.7B05035","volume":"66","author":"JW Zhou","year":"2018","unstructured":"Zhou JW, Luo HZ, Jiang H, Jian TK, Chen ZQ, Jia AQ (2018) Hordenine: a Novel Quorum sensing inhibitor and Antibiofilm Agent against Pseudomonas aeruginosa. J Agric Food Chem 66(7):1620\u20131628. https:\/\/doi.org\/10.1021\/ACS.JAFC.7B05035","journal-title":"J Agric Food Chem"},{"issue":"15","key":"3900_CR110","doi-asserted-by":"publisher","first-page":"6271","DOI":"10.1007\/S00253-019-09878-W\/FIGURES\/8","volume":"103","author":"JW Zhou","year":"2019","unstructured":"Zhou JW, Muhammad J, Sun B, Yang R, Wadood A, Wang JS, Jia AQ (2019a) Metabolomic analysis of quorum sensing inhibitor hordenine on Pseudomonas aeruginosa. Appl Microbiol Biotechnol 103(15):6271\u20136285. https:\/\/doi.org\/10.1007\/S00253-019-09878-W\/FIGURES\/8","journal-title":"Appl Microbiol Biotechnol"},{"issue":"3","key":"3900_CR28","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1292\/JVMS.18-0523","volume":"81","author":"S Zhou","year":"2019","unstructured":"Zhou S, Zhang A, Chu W (2019b) Phillyrin is an effective inhibitor of quorum sensing with potential as an anti-pseudomonas aeruginosa infection therapy.J Vet Med Sci81((3):):473\u2013479. https:\/\/doi.org\/10.1292\/JVMS.18-0523","journal-title":"J Vet Med Sci"}],"container-title":["Archives of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-024-03900-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-024-03900-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-024-03900-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T08:49:54Z","timestamp":1710406194000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00203-024-03900-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,27]]},"references-count":110,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["3900"],"URL":"https:\/\/doi.org\/10.1007\/s00203-024-03900-0","relation":{},"ISSN":["0302-8933","1432-072X"],"issn-type":[{"value":"0302-8933","type":"print"},{"value":"1432-072X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,27]]},"assertion":[{"value":"3 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"124"}}